|
|
 |
|
Annelise Beck ‘09 has been awarded a 2008 Barry M. Goldwater Scholarship. Congress established the Barry M. Goldwater Scholarship and Excellence in Education Program in 1986 to honor Senator Barry M. Goldwater, who served his country for 56 years as a soldier and statesman, including 30 years of service in the U.S. Senate. The purpose of the Goldwater Foundation is to provide a continuing source of highly qualified scientists, mathematicians, and engineers by awarding scholarships to outstanding undergraduate college students who intend to pursue careers in these fields. |
 |
|
Professor Mohammad Movassaghi has been selected as an Alfred P. Sloan Research Fellow for 2008. These awards are intended to enhance the careers of the very best young faculty members in specified fields of science. Currently a total of 118 fellowships are awarded annually in seven fields: chemistry, computational and evolutionary molecular biology, computer science, economics, mathematics, neuroscience, and physics. |
 |
|
The Ting lab is interested in developing new site-specific reactions for protein labeling, using enzymes that recognize an acceptor sequence with exquisite specificity but that can utilize unnatural probes with useful bioorthogonal functional groups for labeling, such as azides and alkynes. We cloned, expressed, and purified biotin ligases from nine different species, and screened them for the ability to ligate unnatural analogues of biotin onto a specific lysine residue of the human p67 biotin acceptor protein. Unique among our panel, the biotin ligases of Saccharomyces cerevisiae (yeast) and Pyrococcus horikoshii accept alkyne and azide derivatives of biotin, respectively. These new ligation reactions demonstrate the differential substrate specificities of biotin ligases from different organisms and could be useful for new protein labeling applications.
Journal of the American Chemical Society 2008, 130, 1160-1162.
S. A. Slavoff, I. Chen, Y.-A. Choi, and A. Y. Ting. |
|
|
|
|
