Debbie Lindell

Postdoctoral Associate
Civil and Environmental Engineering
MIT 48-424
15 Vassar Street
Cambridge, MA 02139
Phone: (617) 253-8686
Fax: (617) 258-7009
Email: dlindell at mit.edu

Education:

1988 B.S. Biology, Hebrew University of Jerusalem
1993 M.S. Microbial and Molecular Ecology, Hebrew University of Jerusalem
2000 Ph.D. Microbial and Molecular Ecology, Hebrew University of Jerusalem,

Research Interests:
I am interested in the effects of environmental factors (biotic and abiotic) on the physiology of phytoplankton and micro-organisms, in particular cyanobacteria, and the influence of these environmental factors on their population dynamics, diversity and evolution. I am currently assessing the impact of viruses on cyanobacterial host physiology and evolution from whole genome sequence analyses and microarray gene expression of both host and virus during infection. My future research goals include the development of a suite of molecular diagnostic indicators to assess the variables that affect the population structure of cyanobacteria and to investigate the impact of viruses on host dynamics and evolution.

Publications:

Sullivan*, M.B., D. Lindell*, J.A. Lee, L. Thompson, J. Bielawski, S.W. Chisholm (2006).
Prevalence and evolution of core photosystem II genes in marine cyanobacterial viruses and their hosts.
PLoS Biology, In press.
*contributed equally to this work

Penno, S., D. Lindell, A.F. Post (2006).
Biodiversity of Synechococcus and Prochlorococcus populations determined from DNA sequences of the N-regulatory gene ntcA.
Environmental Microbiology Early online doi:10.1111/j.1462-2920.2006.01010.x.

Lindell, D., J.D. Jaffe, Z.I. Johnson, G.M. Church, S.W. Chisholm. (2005)
Photosynthesis genes in marine viruses yield proteins during host infection.
Nature 438(7064):86-89; Advanced Online Publication - 12 October 2005. doi:10.1038/nature04111

Lindell, D., S. Penno, M. Al-Qutob, E. David, T. Korpal, B. Lazar, and A. F. Post. (2005)
Expression of the nitrogen stress response gene ntcA reveals nitrogen sufficient Synechococcus populations in the oligotrophic northern Red Sea.
Limnol. and Oceanogr. 50(6):1932-1944

Lindell*, D., M. B. Sullivan*, Z. I. Johnson, A. C. Tolonen F. Rohwer and S. W. Chisholm. (2004)
Transfer of photosynthesis genes to and from Prochlorococcus viruses
Proc. Nat. Acad. Sci. 101(30):11013-11018
*these authors contributed equally to this work

Rocap G., Larimer F.W., Lamerdin J., Malfatti S., Chain P., Ahlgren N.A., Arellano A., Coleman M, Hauser L., Hess W.R., Johnson Z.I., Land M., Lindell D., Post A.F., Regala W., Shah M., Shaw S.L., Steglich C., Sullivan M.B., Ting C.S., Tolonen A., Webb E.A., Zinser E. and Chisholm S.W. (2003)
Genome divergence in two Prochlorococcus ecotypes reflects Oceanic niche differentiation
Nature 424(6952), 1042-1047

Lindell, D., D. Erdner, D. Marie, O. Prasil, M. Koblizek, F. Le Gall, R. Rippka, F. Partensky, D. J. Scanlan, and A. F. Post. (2002)
The nitrogen stress response of Prochlorococcus strain PCC 9511 (Oxyphotobacteria) involves contrasting regulation of ntcA and amt1
Journal of Phycology 38(6): 1113-1124

Lindell, D., and A.F. Post (2001)
Ecological aspects of ntcA gene expression and its use as an indicator of the nitrogen status of marine Synechococcus spp.
Appl. Environ. Microbiol. 67(8):2240-2249

Angel, D.L., S. Verghese, J.J. Lee, A.M. Saleh, D. Zuber, D. Lindell, and A. Symons. (2000)
Impact of a Net Cage Fish Farm on the Distribution of Benthic Foraminifera in the Northern Gulf of Eilat (Aqaba, Red Sea)
Journal Foramin. Res. 30(1):54-65

Lindell, D., E. Padan and A.F. Post (1999)
Effect of ammonium on nitrate/nitrite uptake and ntcA expression in Synechococcus sp. strain WH 7803. In: Marine Cyanobacteria
Charpy L. & Larkum AWD (eds)
Bulletin de l'Institut Oceanographie, Monaco, No. 19:273-278

Lindell, D., E. Padan and A.F. Post (1998)
Regulation of ntcA expression and nitrite uptake in the marine Synechococcus sp. strain WH 7803
J. Bacteriol. 180(7):1878-1886

Lindell, D., and A.F. Post (1995)
Ultraphytoplankton succession is triggered by deep winter mixing in the Gulf of Aqaba (Eilat), Red Sea
Limnol. Oceanogr. 40(6): 1130-1141

Knibb, W., A., A. Colorni, M. Ankaoua, D. Lindell, A. Diamant and H. Gordin (1993)
Detection and identification of a pathogenic marine mycobacterium from the European seabass Dicentrarchus labrax using PCR and direct sequencing of 16S rDNA sequences
Mol. Mar. Biol. Biotech. 2(4):225-232