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Publications

Kung Y, Doukov TI, Seravalli J, Ragsdale SW, Drennan CL. (2009) Crystallographic Snapshots of Cyanide- and Water-Bound C-Clusters from Bifunctional Carbon Monoxide Dehydrogenase/Acetyl-CoA Synthase. Biochemistry. 48(31):7432-7440.

Phillips CM, Nerenberg PS, Drennan CL, Stultz CM. (2009) Physical Basis of Metal-Binding Specificity in Escherichia coli NikR. J. Am. Chem. Soc. 131(29):10220-10228.

Ryan KS and Drennan CL. (2009) Divergent Pathways in the Biosynthesis of Bisindole Natural Products. Chem. Biol. 16:351-364.

Wong C, Fujimori DG, Walsh CT, Drennan CL. (2009) Structural Analysis of an Open Active Site Conformation of Nonheme Iron Halogenase CytC3. J. Am. Chem. Soc. 191:4972-4979.

Blasiak, LC and Drennan CL. (2009) Structural Perspective on Enzymatic Halogenation. Acc. Chem. Res. 42(1):147-155.

Ryan KS, Chakraborty S, Howard-Jones AR, Walsh CT, Ballou DP, Drennan CL. (2008) The FAD Cofactor of RebC Shifts to an IN Conformation upon Flavin Reduction. Biochemistry. 47:14506-13513.

Vey JL, Yang J, Li M, Broderick WE, Broderick JB, Drennan CL. (2008) Structural Basis for glycyl radical formation by pyruvate formate-lyase activating enzyme. Proc. Natl. Acad. Sci. U.S.A. 105(42):16137-16141.

Phillips CM and Drennan CL. (2008) Nickel regulatory transcription factor, NikR. Handbook of Metalloproteins.

Blasiak LC and Drennan CL. (2008) Nonheme iron halogenases. Handbook of Metalloproteins.

Hernandez HH, Jaquez OA, Hamill MJ, Elliott SJ, Drennan CL. (2008) Thioredoxin Reductase from Thermoplasma acidophilum: A New Twist on Redox Regulation. Biochemistry. 47(37):9728-9737.

Hamill MJ, Chobot SE, Hernandez HH, Drennan CL, Elliott SJ. (2008) Direct Electrochemical Analyses of a Thermophilic Thioredoxin Reductase: Interplay between Conformational Change and Redox Chemistry. Biochemistry. 47(37):9738-9746.

Ryan KS, Balibar CJ, Turo KE, Walsh CT, Drennan CL. (2008) The Violacein Biosynthetic Enzyme VioE Shares a Fold with Lipoprotein Transporter Proteins. J. Biol. Chem. 283(10):6467-6475.

Doukov TI, Blasiak LC, Seravalli J, Ragsdale SW, Drennan CL. (2008) Xenon in and at the End of the Tunnel of Bifunctional Carbon Monoxide Dehydrogenase/Acetyl-CoA Synthase. Biochemistry. 47(11):3474-3483.

Phillips CM, Schreiter ER, Guo Y, Wang SC, Zamble DB, Drennan CL. (2008) Structural Basis of the Metal Specificity for Nickel Regulatory Protein NikR. Biochemistry. 47(7):1938-1946.

Hubbard PA, Padovani D, Labunska T, Mahlstedt SA, Banerjee R, Drennan CL. (2007) Crystal Structure and Mutagenesis of the Metallochaperone MeaB. J. Biol. Chem. 282(43):31308-31316.

Ryan KS, Howard-Jones AR, Hamill MJ, Elliott SJ, Walsh CT, Drennan CL. (2007) Crystallographic trapping in the rebeccamycin biosynthetic enzyme RebC. Proc. Natl. Acad. Sci. U.S.A. 104(39):15311-15316.

Schreiter ER and Drennan CL. (2007) Ribbon-helix-helix transcription factors: variations on a theme. Nat. Rev. Microbiol. 5(9):710-720.

Chobot SE, Hernandez HH, Drennan CL, Elliott SJ. (2007) Direct Electrochemical Characterization of Archeael Thioredoxins. Angew. Chem. Int. Ed. Engl. 46(22):4145-4147.

Doukov TI, Hemmi H, Drennan CL, Ragsdale SW. (2007) Structural and Kinetic Evidence for an Extended Hydrogen-bonding Network in Catalysis of Methyl Group Transfer: Role of an active site asparagine residue in activation of methyl transfer by methyltransferases.J. Biol. Chem. 282(9):6609-6618.

Yeh E, Blasiak LC, Koglin A, Drennan CL, Walsh CT. (2007) Chlorination by a Long-Lived Intermediate in the Mechanism of Flavin-Dependent Halogenases. Biochemistry. 46(5):1284-1292.

Frick LE, Delaney JC, Wong C, Drennan CL, Essigmann JM. (2007) Alleviation of 1,N6-ethanoadenine genotoxicity by the Escherichia coli adaptive response protein AlkB. Proc. Natl. Acad. Sci. U.S.A. 104(3):755-760.

Blasiak LC, Vaillancourt FH, Walsh CT, Drennan CL. (2006) Crystal structure of the non-haem iron halogenase SyrB2 in syringomycin biosynthesis. Nature. 440:368-371.

Schreiter ER, Wang SC, Zamble DB, Drennan CL. (2006) NikR-operator Complex Structure and the Mechanism of Repressor Activiation by Metal Ions. Proc. Natl. Acad. Sci. U.S.A. 103(37):13676-13681.

Delaney JC, Smeester L, Wong C, Frick LE, Taghizadeh L, Wishnok JS, Drennan CL, Samson LD, Essigmann JM. (2005) AlkB reverses etheno DNA lesions caused by lipid oxidation in vitro and in vivo. Nat. Struct. Mol. Biol. 12(10):855-860.

Higgins LJ, Yan F, Liu P, Liu H-W, Drennan CL. (2005) Structural Insight into Antibiotic Fosfomycin Biosynthesis by a Mononuclear Iron Enzyme. Nature. 437:838-844.

Berkovitch F, Behshad E, Tang KH, Enns EA, Frey PA, Drennan CL. (2004) A locking mechanism preventing radical damage in the absence of substrate, as revealed by the X-ray structure of lysine-5,6-aminomutase. Proc. Natl. Acad. Sci. U.S.A. 101(45):15870-15875.

Midelfort KS, Hernandez HH, Lippow SM, Tidor B, Drennan CL, Wittrup KD. (2004) Substantial energetic improvement with minimal structural perturbation in a high affinity mutant antibody. J. Mol. Biol. 343(3):685-701.

Tirupati B, Vey JL, Drennan CL, Bollinger JM, Jr. (2004) Kinetic and Structural Characterization of Slr0077/SufS, the Essential Cysteine Desulfurase from Synechocystis sp. PCC 6803. Biochemistry. 43:12210-12219.

Nicolet Y and Drennan CL. (2004) AdoMet Radical Proteins - from Structure to Evolution - Alignment of Divergent Protein Sequences Reveals Strong Secondary Structure Element Conservation. Nucleic Acids Res. 32:4015-4025.

Drennan CL, Doukov TI, Ragsdale SW. (2004) The Metalloclusters of Carbon Monoxide Dehydrogenase/Acetyl-CoA Synthase: A Story in Pictures. J. Biol. Inorg. Chem. 9:511-515.

Berkovitch F, Nicolet Y, Wan JT, Jarrett JT, Drennan CL. (2004) Crystal structure of biotin synthase, an S-adenosylmethionine-dependent radical enzyme. Science. 303(5654):76-79.

Schreiter ER, Sintchak MD, Guo Y, Chivers PT, Sauer RT, Drennan CL. (2003) Crystal structure of the nickel-responsive transcription factor NikR. Nat. Struct. Biol. 10(10):794-799.

Drennan CL and Peters JW. (2003) Surprising cofactors in metalloenzymes. Curr. Opin. Struct. Biol. 13(2):220-226.

Doukov TI, Iverson TM, Seravalli J, Ragsdale SW, Drennan CL. (2002) A Ni-Fe-Cu center in a bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase. Science. 298(5593):567-572.

Sintchak MD, Arjara G, Kellogg BA, Stubbe J, Drennan CL. (2002) The crystal structure of class II ribonucleotide reductase reveals how an allosterically regulated monomer mimics a dimer. Nat. Struct. Biol. 9(4):293-300.

Drennan CL, Heo J, Sintchak MD, Schreiter E, Ludden PW. (2001) Life on carbon monoxide: X-ray structure of Rhodospirillum rubrum Ni-Fe-S carbon monoxide dehydrogenase. Proc. Natl. Acad. Sci. U.S.A. 98(21):11973-11978.

Marsh EN, Drennan CL. (2001) Adenosylcobalamin-dependent isomerases: New insights into structure and mechanism. Curr. Opin. Chem. Biol. 5(5):499-505.