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New IRG concept inspires exciting research on cell-membrane penetration

Surface-structure-regulated cell-membrane penetration by monolayer-protected nanoparticles
A. Verma, O. Uzun, Y. Hu, Y. Hu, H.-S. Han, N. Watson, S. Chen, D. Irvine, and F. Stellacci
Nature Materials (25 May 2008), doi: 10.1038/nmat2202

Members of our proposed IRG on engineering living cells via nanomaterials have recently published an important paper in Nature Materials (see citation in figure caption). The work is a direct outgrowth of the intellectual foundation of this group.

Abstract:
Nanoscale objects are typically internalized by cells into membrane-bounded endosomes and fail to access the cytosolic cell machinery. Whereas some biomacromolecules may penetrate or fuse with cell membranes without overt membrane disruption, no synthetic material of comparable size has shown this property yet. Cationic nano-objects pass through cell membranes by generating transient holes, a process associated with cytotoxicity. Studies aimed at generating cell-penetrating nanomaterials have focused on the effect of size, shape and composition. Here, we compare membrane penetration by two nanoparticle ‘isomers’ with similar composition (same hydrophobic content), one coated with subnanometre striations of alternating anionic and hydrophobic groups, and the other coated with the same moieties but in a random distribution. We show that the former particles penetrate the plasma membrane without bilayer disruption, whereas the latter are mostly trapped in endosomes. Our results offer a paradigmfor analysing the fundamental problem of cell-membrane-penetrating bio- and macro-molecules.

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