Histology Lab, Histology Technician, Current Grant Support
| PI: James G. Fox |
| Grant Period: 7/1/04 - 11/30/09 |
| Funded by: NIH |
| Title: Pathogenesis of Helicobacter Induced Hepatitis and Tumorigensis |
| Description: To determine the oncogenic potential of H. hepaticus and study in vivo molecular events operable in the tumorigenic process. |
| PI: James G. Fox |
| Grant Period: 5/1/08 - 4/30/13 |
| Funded by: NIH |
| Title: Biomedical Research Training for Veterinary Scientists |
| Description: Train veterinarians for careers in biomedical research. |
| PI: David Schauer |
| Grant Period: 7/01/03 - 6/30/08 |
| Funded by: NIH |
| Title: Helicobacter hepaticus: Pathogenesis of Inflammatory Bowel Disease |
| Description: To characterize the mechanism by which infection with a single bacterial species can affect expression of disease in mouse models of IBD. |
| PI: Steven Tannenbaum, Co PI, David Schauer/ Susan Erdman |
| Grant Period: 1/1/09 - 12/31/14 |
| Funded by: NIH |
| Title: Endogenous Nitrite Carcinogenesis in Man, Project 4 |
| Description: Devolop biomarkers for mutagenic and cytotoxic effects of nitric oxide in inflammatory disease. |
| PI: Steven R. Tannenbaum, Co PI, James G. Fox |
| Grant Period: 1/1/09 - 12/31/14 |
| Funded by: NCI |
| Title: Endogenous Nitrite Carcinogenesis in Man (Core2) |
| Description: To investigate the role nitrite and N-nitroso compounds play in the etiology of human cancer; to use murine models to study endogenous reactions. |
PI: James G. Fox |
| Grant Period: 6/01/05 - 2/28/10 |
| Funded by: NIH/NIAID |
| Title: In vivo Pathogenesis of Helicobacter pylori |
| Description: Develop, characterize and validate Helicobacter pylori infected models of Helicobacter associated gastritis and investigate putative virulence factors. |
| PI: Timothy Wang, Co PI, James G. Fox |
| Grant Period: 10/01/06 - 9/30/11 |
| Funded by: NIH |
| Title: Stem Cells and Gastric Cancer |
| Description: The goal of this study is to investigate mechanisms involved in Helicobacter - dependent loss of parietal cells, which is the first step in progression to gastric cancer. |
PI: James G. Fox |
| Grant Period: 06/01/03 - 05/31/08 |
| Funded by: NIH (subcontracted from Dr. Susan Hagen, Beth Israel Deaconess Hospitall) |
| Title: GI Mucosal Barriers in Health and Surgical Diseases |
Description: This study focuses on mechanisms by which surface and other epithelial cells of the stomach are injured and are repaired including an examination of the process by which H. pylori infection alters epithelial cells to facilitate cell death and cell survival. |
PI: Leona Samson |
| Grant Period: 04/01/05 - 03/30/10 |
| Funded by: MIT Center for Environmental Health Sciences Core Grant |
| Title: Animal Models and Pathology Core (Fox) |
Description: The goal of this project is to understand how toxic environmental agents perturb biological systems and to determine how such perturbations may affect human health. |
PI: Susan Erdman |
| Grant Period: 8/01/05 - 11/30 /09 |
| Funded by: NIH |
| Title: Interrelated Roles of IL10 and TGFB1in Colon Cancer |
Description: Investigate how CD4+DC25+ regulatory cells are able to treat colon cancer. |
PI: James Versalovic |
| Grant Period: 2/01/07 - 1/31/11 |
| subcontract from Baylor University |
| Title: Intestinal Lactobacillus and Mucosal Immunomodulation |
Description: Identification of probiotic Lactobacillus strains for new treatment and prevention strategies in inflammatory bowel disease. |
PI: Wang |
| Grant Period: 6/01/07 - 5/31/12 |
| subcontract from Columbia University |
| Title: Role of Inflammation in Mouse Models of Gastric Cancer |
Description: Study the role of Helicobacter as a tumor promoter in gastric cancer and examine the mechanisms by which it contributes to the malignant process |
PI: Fox |
| Grant Period: 9/28/07 - 8/31/09 |
| Funded by: NIH |
| Title: HUS Pathogenesis & Clinical Outcome in an in vivo Model |
Description: The overall aim of this project is to develop and utilize a new animal model of enterohemorhagic E. coli (EHEC) infection. |
PI: Correa, Co PI, James G. Fox |
| Grant Period: 7/01/09 - 6/30/14 |
| Funded by: NIH |
| Title: Etiological Studies of Gastric Carcinoma (Project 2) |
Description: This project tests the hypothesis that progression to gastric cancer is influenced not only by the genotype of H. pylori but also by concurrent infection with parasites which can modulate systemic immune repsonses and the Th1/Th2 gastric cytokine profile. |
