The Division of Comparative Medicine

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Current Grant Support

DCM Paw

Current Grant Support

PI: James G. Fox
Grant Period: 7/1/11 - 5/31/16
Funded by: NIH
Title: Diagnosis and Pathobiology of Emerging Enterohepatic Helicobacter spp. in Mice
The proposal addresses molecular targets for diagnosis and characterization of EHS and will take advantage of sequenced EHS that colonize mice to probe virulence determinants shared among these EHS isolated from both mice and humans. Role: PI.

 

PI: James G. Fox
Grant Period: 5/1/08 - 4/30/18
Funded by: NIH
Title: Biomedical Research Training for Veterinary Scientists
Description: Train veterinarians for careers in biomedical research.

 

PI: Wilson, Co PI, James G. Fox

Grant Period: 7/01/15 - 6/30/20
Funded by: NIH
Title: Etiological Studies of Gastric Carcinoma (Project 2)
Description: This project tests the hypothesis that progression to gastric cancer is influenced not only by the genotype of H. pylori but also by concurrent infection with parasites which can modulate systemic immune repsonses and the Th1/Th2 gastric cytokine profile.

 

PI: Susan Erdman

Grant Period: 8/01/05 - 1/31/16
Funded by: NIH
Title: Interrelated Roles of IL10 and TGFB1in Colon Cancer
Description: Investigate how CD4+DC25+ regulatory cells are able to treat colon cancer.

 

PI: Susan Erdman

Grant Period: 7/1/12 - 8/31/17
Funded by: NIH
Title: GI Tract Dysbiosis and Breast Cancer
Examine how pathogenic GI tract microbes trigger extra intestinal cancer in tissues such as breast.

 

PI: Eric Alm, Susan Erdman

Grant Period: 7/01/14 - 03/31/16
Funded by: NIH
Title: Can Microbiome Therapy Cure IBD in Sick Dogs?
Description: The primary goal of this project is to test whether Fecal Microbiota Transplant can cure Inflammatory Bowel Disease in canine patients. The secondary goal of this project is to generate preliminary data for an Investigational New Drug application for human trials. Role Co-PI.

 

PI: Bailey

Grant Period: 5/1/12 - 4/30/17
Funded by: NIH, Subcontract from Nationwide Chrildren's Hospital
Title: Role of stress induced reduction in Lactobacillus reuteri on colonic inflammation.
This project focuses on the role of lactobacillus reuteri in colonic inflammation.

 

PI: Peter Dedon

Grant Period: 7/01/15 - 6/30/17
Funded by: NIH
Title: Sulfur DNA Modifications in Gut Microbes Confer Resistance to Oxidative Stress
Description: The goal of these exploratory studies is to test the hypothesis that gut microbes possessing phosphorothioate (PT) modifications of their genomes have a selective advantage during the inflammation and oxidative stress of colitis. Dr. Fox will provide expertise in mouse models and interpretation of experimental data. Role: Co-Investigator

 

PI: John Essigmann

Grant Period: 04/01/05 - 03/30/16
Funded by: MIT Center for Environmental Health Sciences Core Grant
Title: Animal Models and Pathology Core (Fox)
Description: The goal of this project is to understand how toxic environmental agents perturb biological systems and to determine how such perturbations may affect human health.

 

PI: John Essigmann

Grant Period: 07/01/14 - 03/31/16
Funded by: NIH
Title: MIT Center for Environmental Health Sciences Core Grant Pilot Project
Description: The goal of this project is to characterize gut microbes that possess phosphorothioate (PT) modifications of their genomes and to assess the impact of PT modifications and the compositions of the gut microbiome during inflammation. Role Co-PI.

 

PI: Jon Runstadler

Grant Period: 1/1/15 - 6/30/17
Funded by: North Pacific Research Board
Title: Influenza in Synanthropic Gulls: Are Congregation Sites Hotspots for Viral Evolution?
Description: Gulls epitomize the growing challenge associated with human-wildlife interactions and offer a valuable model for testing hypotheses regarding dynamics of emerging disease. This study will identify habitats of gulls associated with hotspots of viral evolution findings generalizable beyond Alaska that can guide surveillance and control efforts of pest bird populations worldwide.

 

PI: Jon Runstadler

Grant Period: 8/31/11 - 4/31/21
Funded by: NIH
Title: Center for Excellence for Influenza Research and Surveillance
Description: Study the viral ecology, epizootiology and evolution in influenza animal and environmental reservoirs.

 

PI: Wang

Grant Period: 6/01/07 - 8/31/18
Subcontract from Columbia University
Title: Role of Inflammation in Mouse Models of Gastric Cancer
Description: Study the role of Helicobacter as a tumor promoter in gastric cancer and examine the mechanisms by which it contributes to the malignant process
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