The Division of Comparative Medicine

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Current Grant Support

DCM Paw

Current Grant Support

PI: James G. Fox
Grant Period: 7/1/11 - 6/30/16
Funded by: NIH
Title: Diagnosis and Pathobiology of Emerging Enterohepatic Helicobacter spp. in Mice
The proposal addresses molecular targets for diagnosis and characterization of EHS and will take advantage of sequenced EHS that colonize mice to probe virulence determinants shared among these EHS isolated from both mice and humans. Role: PI.

 

PI: James G. Fox
Grant Period: 5/1/08 - 4/30/18
Funded by: NIH
Title: Biomedical Research Training for Veterinary Scientists
Description: Train veterinarians for careers in biomedical research.

 

PI: Steven Tannenbaum, Co PI, James G. Fox
Grant Period: 1/1/09 - 12/31/14
Funded by: NIH
Title: Endogenous Nitrite Carcinogenesis in Man, Project 4
Description: Develop biomarkers for mutagenic and cytotoxic effects of nitric oxide in inflammatory disease.

 

PI: Steven R. Tannenbaum, Co PI, James G. Fox
Grant Period: 1/1/09 - 12/31/14
Funded by: NCI
Title: Endogenous Nitrite Carcinogenesis in Man (Core2)
Description: To investigate the role nitrite and N-nitroso compounds play in the etiology of human cancer; to use murine models to study endogenous reactions.

 

PI: Leona Samson

Grant Period: 04/01/05 - 03/30/16
Funded by: MIT Center for Environmental Health Sciences Core Grant
Title: Animal Models and Pathology Core (Fox)

Description: The goal of this project is to understand how toxic environmental agents perturb biological systems and to determine how such perturbations may affect human health.

 

PI: Susan Erdman

Grant Period: 8/01/05 - 1/31/15
Funded by: NIH
Title: Interrelated Roles of IL10 and TGFB1in Colon Cancer

Description: Investigate how CD4+DC25+ regulatory cells are able to treat colon cancer.

 

PI: James Versalovic

Grant Period: 9/1/10 - 8/31/14
subcontract from Baylor University
Title: Modulation of NF-kB Signalling by Immunoprobiotics

Description: Explore role of human-derived Lactobacillus reuteri to activate innate immunity in unchallenged or healthy state and to suppress inflammation when challenged with pro-inflammatory stimuli.

 

PI: Wang

Grant Period: 6/01/07 - 8/31/18
subcontract from Columbia University
Title: Role of Inflammation in Mouse Models of Gastric Cancer

Description: Study the role of Helicobacter as a tumor promoter in gastric cancer and examine the mechanisms by which it contributes to the malignant process

 

PI: Correa, Co PI, James G. Fox

Grant Period: 7/01/09 - 8/31/15
Funded by: NIH
Title: Etiological Studies of Gastric Carcinoma (Project 2)

Description: This project tests the hypothesis that progression to gastric cancer is influenced not only by the genotype of H. pylori but also by concurrent infection with parasites which can modulate systemic immune repsonses and the Th1/Th2 gastric cytokine profile.

 


PI: Jon Runstadler

Grant Period: 8/31/11 - 4/31/14
Funded by: NIH
Title: Center for Excellence for Influenza Research and Surveillance

Description: Study the viral ecology, epizootiology and evolution in influenza animal and environmental reservoirs.

 

PI: Susan Erdman

Grant Period: 7/1/12 - 8/31/17
Funded by: NIH
Title: GI Tract Dysbiosis and Breast Cancer

Examine how pathogenic GI tract microbes trigger extra intestinal cancer in tissues such as breast.

 

PI: Alex Sheh

Grant Period: 7/1/13 - 6/30/14
Funded by: ACLAM
Title: Diagnosis of fur mite infection by quantitative PCR and Rt-PCR.

Develop a reverse transcription of PCR (Rt-qPCR) and of PCR panel to sensitively detect common mouse for mites which address the limitations of current detection methods. .

 

PI: Bailey

Grant Period: 5/1/12 - 4/30/17
Funded by: NIH, Subcontract from Ohio State University
Title: Role of stress induced reduction in Lactobacillus reuteri on colonic inflammation.

This project focuses on the role of lactobacillus reuteri in colonic inflammation.

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