The Division of Comparative Medicine

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Selected Publications 2000-2012


Selected Publications 2000-2012

Wang TC, Dangler CA, Chen D, Goldenring JR, Koh T, Raychowdhury R, Coffey RJ, Ito S, Varro A, GJ Dockray, Fox JG. Synergistic interaction between hypergastrinemia and helicobacter infection in a mouse model of gastric cancer. Gastroenterology 118: 36-47, 2000.

Fox JG, Beck P, Dangler CA, Whary MT, Wang TC, Shi HN, Nagler-Anderson, C. Concurrent enteric helminth infection modulates inflammation and gastric immune response and reduces helicobacter-induced gastric atrophy. Nat Med 6: 536-542, 2000.

Fox JG, Wang TC. Helicobacter pylori is a bad bug after all (editorial). N Engl J Med 345: 829-832, 2001.

Fox JG. The non- H. pylori helicobacters: Their expanding role in gastrointestinal and systemic diseases. Gut 50: 273-283, 2002.

Harper C, Feng Y, Xu S, Taylor NS, Kinsel M, Dewhirst FE, Paster B, Greenwell M, Levine G, Rogers A, Fox JG. Helicobacter cetorum sp. nov., a urease positive Helicobacter species isolated dolphins and whales. J Clin Microbiol 40: 4536-4543, 2002.

Garcia A, Marini RP, Feng Y, Vitsky A, Taylor NS, Schauer DB, Fox JG. A naturally occurring rabbit model of enterohemorrhagic Escherichia coli-induced disease. J Infect Dis 186:1682-1686, 2002.

Erdman SE, Poutahidis T, Rogers AB, Tomczak M,Cormier K, Horwitz BH, Fox JG. CD4+ CD45Rblo regulatory T lymphocytes inhibit microbially-induced colon cancer in Rag2-deficient mice. Am J Pathol 162: 691-702, 2003.

Fox JG, Wang TC, Rogers AB, Taylor NS, Dangler CA, Ge Z, Israel DA, Krishna U, Gaus K, Peek, RM. Host and microbial determinants influence Helicobacter pylori-induced gastric carcinogenesis in murine model of hypergastrinemia. Gastroenterology 124: 1879-1890, 2003.

Garcia A, Fox JG. The rabbit as a new reservoir host of enterohemorrhagic Escherichia coli. Emerg Infect Dis 9:1592- 1597, 2003.

Suerbaum S, Josenhans C, Sterzenbach T, Bell M, Brandt P, Chevreux B, Drescher B, Droege M, Fartmann B, Fischer HP, Ge Z, Shen Z, Hörster A, Holland R, Mendz G, Macko L, Nyakatura G, Paquette J, Schauer D, Weber J, Frosch M, Fox JG. The complete genome sequence of the carcinogenic bacterium Helicobacter hepaticus. Proc Natl Acad Sci 100: 790, 7906, 2003.

Marini RP, Stevens MM, Langer R, Shastri VP. Hydraulic elevation of the periosteum: a novel technique for periosteal harvest. J Invest Surg, 17(4):229-33, 2004

Rogers AB, Fox JG. Rodent models of infectious gastrointestinal and liver cancer. Am J Physiol Gastrointest Liver Physiol 286: G361-G366, 2004.

Sarma-Rupavtarm RB, Ge Z, Schauer DB, Fox JG, Polz MF. Spatial distribution and stability of the eight microbial species of the Altered Schaedler Flora in the gastrointestinal tract of mice. Applied Environ Microbiol 70: 2791-2800, 2004.

Aspholm-Hurtig M, Dailide G, Ilver D, Lahmann M, Roche N, Vikstrom S, Mahdavi J, Arnqvist A, Linden S, Nilsson U, Velapatino B, Gilman R, Gerhard M, Alarcon T, Lopez Brea M, Nakazawa T, Parkinson AJ, Fox JG et al. Functional adaptation of BabA, the H. pylori ABO blood group antigen binding adhesin. Science 305: 519-522 2004.

Whary MT, Fox JG. Th1-mediated pathology in mouse models of human disease is ameliorated by concurrent Th2 responses to parasite antigens. Current Topics in Medicinal Chemistry 4: 531, 538, 2004.

Rogers AB, Boutin SR, Whary MT, Sundina N, Ge Z, Cormier K, Shen Z, Fox JG. Progression of chronic hepatitis and preneoplasia in Helicobacter hepaticus-infected A/JCr mice. Toxicol Path 32: 668- 677, 2004.

Houghton J, Stoicov C, Nomura S, Rogers AB, Carlson J, Li H, Cai X, Fox JG, Goldenring JR, Wang TC. Gastric cancer originating from bone marrow derived stem cells. Science 306: 1568- 1571, 2004.

Stevens MM, Marini RP, Schaefer D, Aronson J, Langer R, Shastri VP. In vivo engineering of organs: the bone bioreactor. PNAS, 102(32):11450-11455, 2005.

Niess JH, Brand S, Gu X, Jung S, McCormick B, Vyas JM, Boes M, Ploegh HL, Fox JG, Littman DR, Reinecker HC. CX3CR1 expression distinguishes two lamina propria dendritic cell populations responsible for lumina antigen sampling and mucosal defense. Science 307: 254-258, 2005.

Maurer KJ, Ihrig MM, Rogers AB, Ng V, Bouchard G, Carey MC, Fox JG. Identification of cholelitogenic enterohepatic Helicobacter species and their role in murine cholesterol gallstone formation.  Gastroenterology 128: 1023-1033, 2005.

Ge Z, Feng Y, Whary MT, Nambiar P, Xu S, Ng V, Taylor N, Fox JG. Cytolethal distending toxin is essential for Helicobacter hepaticus colonization in outbred Swiss Webster mice. Infect Immun 73:3559-3567, 2005.

Ihrig M, Whary MT, Dangler CA, Fox JG. Gastric helicobacter infection induces a Th2 phenotype but does not elevate serum cholesterol in mice lacking inducible nitric oxide synthaseInfect Immun 73: 1664-1670, 2005.

Erdman SE, Sohn JJ, Rao VP, Nambiar PR, Ge Z, Fox JG, Schauer DB. CD4+CD25+ regulatory lymphocytes induce regression of intestinal tumors in ApcMin/+ mice. Cancer Res 65: 3998-4004, 2005.

Whary MT, Sundina N, Bravo LE, Correa P, Quinones F, Caro, F, Fox JG. Intestinal helminthiasis in Colombian children promotes a Th2 response to Helicobacter pylori: Possible implications for gastric carcinogenesis. Cancer Epidemiol Biomarkers Prev 14: 1464-1469, 2005.

Franco AT, Israel DA, Washington MK, Krishna U, Fox JG, Rogers AB, Neish AS, Collier Hyams L, Perez-Perez GI, Hatakeyama M, Whitehead R, Gaus K, O’Brien DP, Romero Gallo J, Peek RM Jr. Activation of {beta}-catenin by carcinogenic Helicobacter pylori. Proc Natl Acad Sci U S A.102:10646-51, 2005

Rogers AB, Taylor NS, Whary MT, Stefanich ED, Wang TC, Fox JG. Helicobacter pylori but not high-salt induces gastric intraepithelial neoplasia. Cancer Res 65: 10709-10715, 2005.

Maurer KJ, Rogers AB, Ge Z, Wiese AJ, Carey MC, Fox JG. Helicobacter pylori and cholesterol gallstone formation in C57L/J mice: a prospective study. Am J Physiol Gastrointest Liver Physiol 290: G175-182, 2006.

Nambiar PR, Kirchain SM, Cormier K, Xu S, Taylor NS, Theve EJ, Patterson MM, Fox JG. Progressive proliferative and dysplastic typhlocolitis in aging Syrian hamsters naturally infected with Helicobacter spp: a spontaneous model of inflammatory bowel disease Veth Pathol 43:2-14, 2006.

Rao VP, Poutahidis T, Ge Z, Nambiar PR, Horwitz BH, Fox JG, Erdman SE. Pro-inflammatory CD4+CD45RBhi lymphocytes promote mammary and intestinal carcinogenesis in ApcMin/+ mice. Cancer Res 66 : 57-61, 2006.

Rogers AB, Cormier KS, Fox JG. Thiol-reactive compounds prevent nonspecific antibody binding in immunohistochemistry. Lab Invest 86: 526-533, 2006.

García A, Rogers AB, Fox JG. Renal injury is a consistent finding in Dutch Belted rabbits experimentally infected with enterohemorrhagic Escherichia coli. J Infect Dis 193:1125-1134, 2006.

García A, Bosques CJ, Wishnok JS, Feng Y, Karalius BJ, Butterton JR, Schauer DB, Rogers AB, Fox JG. Renal injury is a consistent finding in Dutch Belted rabbits experimentally infected with enterohemorrhagic Escherichia coli. J Infect Dis 193:1125-1134, 2006.

Whary MT, Danon SJ, Feng Y, Ge Z, Sundina N, Ng V, Rogers AB, Fox JG. Rapid onset of ulcerative typhlocolitis in B6.129P2-IL10tm1Cgn (IL-10-/-) mice infected with Helicobacter trogontum is associated with decreased colonization by altered Schaedler’s Flora. Infect Immun 74:6615-6623, 2006.

Chen ML, Ge Z, Fox JG, Schauer DB. Disruption of tight junctions and induction of proinflammatory cytokine responses in colonic epithelial cells by Campylobacter jejuni. Infect Immun 74:6581-6589, 2006.

Fox JG, Wang TC. Inflammation, atrophy, and gastric cancer. (Invited review). J Clin Invest 117:60-69, 2007.

Rao VP, Poutahidis T, Fox JG, Erdman SE. Breast cancer: should gastrointestinal bacteria be on our radar screen? (Invited review). Cancer Res 67:847-850, 2007.

Ge Z, Rogers AB, Feng Y, Lee A, Xu S, Taylor NS, Fox JG. Bacterial cytolethal distending toxin promotes the development of dysplasia in a model of microbially induced hepatocarcinogenesis. Cell Microbiol 9:2070-2080, 2007.

Maurer KJ, Rao VP, Ge Z, Rogers AB, Oura TJ, Carey MC, Fox JG. T cell function is critical for murine cholesterol gallstone formation. Gastroenterology 133:1304-1315, 2007.

Fox JG, Rogers AB, Whary MT, Ge Z, Ohtani M, Jones EK, Wang TC. Accelerated progression of gastritis to dysplasia in the pyloric antrum of TFF2-/- C57BL6 x Sv129 Helicobacter pylori-infected mice. Am J Pathol 171:1520-1528, 2007.

Rogers AB, Theve EJ, Feng Y, Fry RC, Taghizadeh K, Clapp KM, Boussahmain C, Cormier KS, Fox JG. Hepatocellular carcinoma associated with liver-gender disruption in male mice. Cancer Res 67:11536-11546, 2007.

Fox JG, Boutin SR, Handt LK, Taylor NS, Xu S, Rickman BH, Marini RP, Dewhirst FE, Paster BJ, Motzel S, Klein HJ. Isolation and characterization of a novel Helicobacter species, “Helicobacter macacae,” from rhesus monkeys with and without chronic idiopathic colitis. J Clin Microbiol 45:4061 4063, 2007.

García A, Ihrig MM, Fry RC, Feng Y, Xu S, Boutin SR, Rogers AB, Muthupalani S, Samson LD, Fox JG. Genetic susceptibility to chronic hepatitis is codominantly inherited in Helicobacter hepaticus infected AB6F1 and B6AF1 hybrid male mice and progression to hepatocellular carcinoma is linked to hepatic expression of lipogenic genes and immune associated networks. Infect Immun 76:1866-1876, 2008.

Lee CW, Rickman BH, Rogers AB, Ge Z, Wang TC, Fox JG. Helicobacter pylori eradication prevents progression of gastric cancer in hypergastrinemic INS-GAS mice. Cancer Res 68:3540-3548, 2008.

Bridgeford EC, Marini RP, Feng Y, Parry NMA, Rickman B, Fox JG. Gastric Helicobacter species as a cause of feline gastric lymphoma: A viable hypothesis. Vet Immunol Immunop 23:106-113, 2008.

Meira LB, Bugni JM, Green SL, Lee CW, Pang B, Borenshtein D, Rickman BH, Rogers AB, Moroski CA, McFaline JL, Schauer DB, Dedon PC, Fox JG, Samson LD. DNA damage induced by chronic inflammation is a major contributor to carcinogenesis. J Clin Invest 118:2516-2525, 2008.

Lemke L, Rogers AB, Nambiar PR, Fox JG. Obesity and noninsulin dependent diabetes mellitus in Swiss Webster mice associated with late-onset hepatocellular carcinoma. J Endocrinol 199:21-32, 2008. PMID: 18667586.

Erdman SE, Rao VP, Poutahidis T, Rogers AB, Taylor CL, Jackson EA, Ge Z, Lee C-W, Schauer DB, Wogan GN, Tannenbaum SR, Fox JG. Nitric oxide and TNF-alpha trigger colonic inflammation and carcinogenesis in Helicobacter hepaticus-infected, Rag2-deficient mice. PNAS: 106:1027-1032. 2009. PMID: 19164562

Maurer KJ, Carey MC, Fox JG. Roles of Infection, Inflammation, and the Immune System in Cholesterol Gallstone Formation. Gastroenterology 136:425-440. 2009. PMID: 19109959.

Lee C-W, Rickman B, Muthupalani S, Takaishi S, Yang P, Wang TC, Fox JG. A Combination of Sulindac and Antimicrobial Eradication of H. pylori Prevents Progression of Gastric Cancer in Hypergastrinemic INS-GAS Mice. Can Res 69: 8166-74. 2009. PMID: 19826057

Erdman SE, Rao VP, Olipitz W, Taylor CL, Lee CW, Jackson EA, Levkovich T, Horwitz BH, Fox JG, Ge Z, Poutahidis T. Unifying roles for regulatory T cells and inflammation in cancer. Int J Cancer 126: 1651-65. 2010. PMID: 19795459.

Fox JG, Feng Y, Theve EJ, Fiala JAL, Fry RC, Doernte AL, Williams M, Raczynski AR, McFaline JL, Essigmann JM, Schauer DB, Tannenbaum SR, Dedon PC, Rogers AB. Gut microbes define liver cancer risk in mice exposed to chemical and viral transgenic hepatocarcinogens. Gut 59: 88-97. 2010. PMID: 19850960.

Garcia A, Fox JG, Besser TE.  Zoonotic Enterohemorrhagic Escherichia coli: A One Health Perspective.  ILAR J 51: 221-232. 2010. PMID: 21131723

Lofgren JL, Whary MT, Ge Z, Muthupalani S, Taylor NS, Mobley M, Potter A, Varro A, Wang TC, Fox JG. Lack of commensal flora in H. pylori-infected ins-gas mice reduces gastritis and delays intraepithelial neoplasia. Gastroenterology 140: 210-220. 2011. PMID: 20950613.

Fox JG, Ge Z, Whary MT, Erdman SE, Horwitz BH. Helicobacter hepaticus infection in mice: models for understanding lower bowel inflammation and cancer. Mucosal Immun 4: 22-30. 2011.

Garcia A, Zeng Y, Muthupalani S, Ge Z, Potter A, Mobley MW, Boussahmain C, Feng Y, Wishnok JS, Fox JG. Enhanced H. hepaticus liver tumor promotion during constitutive androstane receptor deficiency is associated with increased serum bile acid and a persistent microbial induced immune response. Can Res. 71:2529-2540. 2011.

Whary MT, Taylor NS, Ge Z, Muthupalani S, Versalovic J, Fox JG. Innate immune response to Lactobacillus reuteri promotes Helicobacter hepaticus – associated typhlocolitis in gnotobiotic B6.129P2-IL10tm1Cgn (IL10-/-) mice. Immunology 133:165-78. 2011. PMID: 21426337

Ge Z, Feng Y, Muthupalani S, Lemke L.B, Taylor N, Whary M.T, Fox JG. Co-infection with enterohepatic Helicobacter species can ameliorate or promote Helicobacter pylori- induced gastric pathology in C57BL/6 mice. Inf&Immun 79:3861-3871. 2011. PMID: 21788386

Turk ML, Cacioppo LD, Ge Z, Shen Z, Whary MT, Parry N, Boutin SR, Klein HJ, Fox JG. Persistent Helicobacter pullorum colonization in C57BL/6NTac mice: A new mouse model for an emerging zoonosis. J Med Microbiol 61(5):720-8. 2012. PMID: 22301616

Mangerich A, Knuston CG, Parry N, Muthupalani S, Ye W, Prestwich EG, Cui L, McFaline JL, Mobley MW, Taghizadeh K, Wishnok JS, Wogan GN, Fox JG, Tannenbaum SR, Dedon PC. Infection-induced colitis in mice causes dynamic and tissue-specific changes in stress response and DNA damage leading to colon cancer. PNAS 109(27):E1820-9. 2012

Swennes AG, Buckley EM, Parry NMA, Madden CM, García A, Morgan PB, Astrofsky KM, Fox JG. Enzootic enteropathogenic Escherichia coli infection in laboratory rabbits. J Clin Micro 50(7):2353-8. 2012

Wogan GN, Dedon PC, Tannenbaum SR, Fox JG. Infection, inflammation and colon carcinogenesis (Invited Review). Oncotarget 3(8):737-8. 2012

Lu K, Knutson CG, Wishnok JS, Fox JG, Tannenbaum SR. Serum metabolomics in a Helicobacter hepaticus mouse model of Inflammatory Bowel Disease reveals important changes originating in the microbiome, serum peptides, and intermediary metabolism. J Proteome Res 11(10):4916-26. 2012. PMID: 22957933

Muthupalani S, Ge Z, Feng Y, Rickman B, Mobley M, Potter A, Van Rooijen N, Fox JG. Systemic macrophage depletion inhibits Helicobacter bilis induced pro-inflammatory cytokine mediated typhlocolitis and impairs bacterial colonization dynamics in a BALB/c Rag2-/- mouse model of IBD. Infect Immun 80(12):4388-97. 2012. PMID:23027534

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