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Recent Publications (for full list see PubMed):

Grodzinsky, AJ, Fields, Forces and Flows in Biological Systems, Garland Science (Taylor and Francis), March 8, 2011, textbook, ISBN-13: 9780815342120.

Journal Articles and Reviews:

Wang, Y, Grodzinsky AJ, The response of cartilage to injury, in Post-Traumatic Arthritis: Pathogenesis, Diagnosis, and Management, F. Guilak and S. Olson, eds, Springer, New York, 2014 (in press).

Ogawa, H, Kozhemyakina, E, Hung, HH, Grodzinsky, AJ, Lassar, AB, Mechanical motion promotes expression of Prg4 in articular cartilage via multiple CREB-dependent, fluid flow shear stress-induced signaling pathways, Genes and Development, 2014 (in press).

Nia, HT, Ortiz, C, Grodzinsky AJ, Aggrecan: Approaches to study biophysical and biomechanical properties, in Methods in Molecular Biology, K Balagurunathan, ed., 2014 (in press).

Wagner, T, Uri Eden, U, Rushmore, J, Russo, CJ, Dipietro, L, Fregni, F, Simon, S, Rotman, S, Pitskel, NB, Ramos-Estebanez, C, Pascual-Leone, A, Grodzinsky, AJ, Zahn, M,Valero-Cabre, A, Impact of brain tissue filtering on neurostimulation fields: a modeling study, NeuroImage, 85:1048-1057, 2014.

Bajpayee, AG, Wong, CR, Bwendi, MG, Frank, EH, Grodzinsky, AJ, Avidin as a model for charge driven transport into cartilage and drug delivery for treating early stage post-traumatic osteoarthritis, Biomaterials, 35:538-549, 2014.

Li, Y, Frank, EH, Wang, Y, Chubinskaya, S, Huang, HK, Grodzinsky, AJ, Moderate dynamic compression inhibits pro-catabolic response of cartilage to mechanical injury, TNFa and Il-6, but accentuates degradation above a strain threshold, Osteoarthritis and Cartilage, 21:1933-1941, 2013.

Byun, S, Sinskey, YL, Lu, YCS, Frank, EH, Grodzinsky, AJ, Transport and binding of tumor-necrosis factor-α in articular cartilage depend on protein quaternary structure, Archiv Biochem Biophys, 540:1-8, 2013.

Imgenberg, J, Rolauffs, B, Grodzinsky AJ, Schunke, M, Kurz, B, Estrogen reduces mechanical injury-related cell death and proteoglycan degradation in mature articular cartilage tissue independent of the presence of the superficial zone tissue, Osteoarthritis Cartilage, 21: 1738-1745, 2013.

Rolauffs, B, Kurz, B, Aurich, M, Felka, T, Stoeckle, U, Badke, A, Frank, E, Aicher, WK, Grodzinsky, AJ, Stress-vs-time signals allow the prediction of structurally catastrophic events during fracturing of immature cartilage and predetermine the biomechanical, biochemical and structural impairment, J Structural Biology, 183:501-511, 2013.

Zhang, L, Smith, DW, Gardiner, BS, Grodzinsky, AJ, Modeling the Insulin-Like Growth Factor System in Articular Cartilage, PLoS, 8(6):1-22, 2013 (e66870).

Smith, DW, Gardiner, B, Davidson, J, Grodzinsky, AJ, Computational model for the analysis of cartilage and cartilage tissue constructs, J Tissue Eng Regenerative Med, 2013 (Epub online: doi: 10.1002/term.1751).

Matheney, T, Sandell, L, Foucher, K, Lamontagne, M, Grodzinsky, AJ, Peters, C, Motion analysis, cartilage mechanics, and biology in femoroacetabular impingement: current understanding and areas of future research, J Amer Acad Orthop Surgeons, 21:S27-S32, 2013.

Sankar, W, Sandell, L, Kim, Y-J, Arden, N, Grodzinsky, AJ, Scanzello, C, Siebenrock, K, Staging of hip osteoarthritis for clinical trials on femoroacetabular impingement, J Amer Acad Orthop Surgeons, 21:S33-S38, 2013.

Kopesky, PW, Byun, S, Vanderploeg, EJ, Kisiday, JD, Frisbie, DD, Grodzinsky, AJ, Sustained delivery of bioactive TFG-1 from self-assembling peptide hydrogels induces chondrogenesis of encapsulated bone marrow stromal cells, J Biomed Mater Res-A, 2013 (in press; epub online May, 2013).

Nia, HT, Bozchalooi, IS, Li, Y, Han, L, Hung, H-H, Frank, EH, Yousef-Toumi, K, Ortiz, C, Grodzinsky, AJ, High bandwidth AFM-based rheology reveals that cartilage is most sensitive to high loading rates at early stages of impairment, Biophysical J, 104:1529-1537, 2013.

Lee, CM, Kisiday, JD, McIlwraith, W, Grodzinsky, AJ, Frisbie, DD, Synoviocytes protect cartilage from the effects of injury in vitro, BMC Musculoskeletal Disorders, 14:54, 1-14, 2013 (doi:10.1186/1471-2474-14-54).

Byun, S, Sinskey, YL, Lu, YCS, Ort, T, Kavalkovich,K, Sivakumar,P, Hunziker,EB, Frank,EH, Grodzinsky, AJ, Mechanical injury and inflammatory cytokines alter transport of anti-Il-6 antigen binding fragments into cartilage, 2013 (in press).

Lee, H-Y, Han, L, Roughley, P, Grodzinsky, AJ, Ortiz, C, Age-related nanostructural and nanomechanical changes of individual human cartilage aggrecan monomers and their glycosaminoglycan side chains, J Structural Biol, 2013 (in press).

Hufeland, M, Schünke, M, Grodzinsky, AJ, Kurz, B, Response of mature meniscal tissue to a single injurious compression and interleukin-1 in vitro, Osteoarthritis and Cartilage, 2013 (in press).

Lee, CM, Kisiday, JD, McIlwraith, Grodzinsky, AJ, Frisbie, DD, Development of an in vitro model of injury induced osteoarthritis in adult equine cartilage using single impact compressive overload, Amer J Vet Res, 74:40-47, 2013.

Florine, EM, Miller, RE, Porter, RM, Evans, CH, Kurz, B, Grodzinsky, AJ, Effects of dexamethasone on mesenchymal stromal cell chondrogenesis and ADAMTS activity: comparison of agarose and self-assembling peptide scaffolds, Cartilage, 4:63-74, 2013.

Ahn, AC, Gow, B, Martinsen, OG, Zhao, M, Grodzinsky, AJ, Baikie, I, Applying the Kelvin probe to biological tissues: theoretical and computational analyses, Physical Review E, 85:061901-1-13, 2012.

Florine, EM, Grodzinsky, AJ, The role of chondrogenic factors in differentiation of bone marrow stromal cells to the cartilage lineage, in Stem Cells And Cancer Stem Cells: Therapeutic Applications in Disease and Injury, Volume 7, M.A. Hayat, ed., Springer Verlag, 2012, pp. 171-178.

Gardiner, BS, Zhang, L, Smith, DW, Pivonka, P, Grodzinsky AJ, A mathematical model for targeting chemicals to tissues by exploiting complex degradation, Biology Direct, 6:46, 1-16, 2011.

Nia, HK, Han, L, Ortiz, C, Grodzinsky, AJ, Poroelasticity of cartilage at the nanoscale, Biophys J, 101:2304-2313, 2011.

Lu, YCS, Evans, C, Grodzinsky, AJ, Effects of short-term glucocorticoid treatment on changes in cartilage matrix degradation and chondrocyte gene expression induced by mechanical injury and inflammatory cytokines, Arthritis Research Therapy, 13:1-15, R142, 2011.

Han, L, Grodzinsky AJ, Ortiz, C, Nanomechanics of cartilage extracellular matrix, Ann Review Materials Res, 41:133-168, 2011.

Rolauffs, B, Rothdiener, M, Bahrs, C, Badke, A, Weise, K, Kuettner, KE, Baddeley, A, Kurz, B, Aurich, M, Grodzinsky, AJ, Aicher, WK, Onset of pre-clinical osteoarthritis: the angular spatial organization permits early diagnosis, Arthritis Rheumatism, 63:1637-1647, 2011.

Miller, RE, Kopesky, PW, Grodzinsky, AJ, Growth factor delivery via self-assembling peptide scaffolds, Clinical Orthop Rel Res, 469:2716-2724, 2011.

Han, L, Frank, EH, Greene, JJ, Lee, H-Y, Hung, HK, Grodzinsky, AJ, Ortiz, C, Time-Dependent Nanomechanics of Cartilage, Biophysical J, 100:1846-1854, 2011.

Kopesky, PW, Vanderploeg, EJ, Kisiday, JD, Frisbie, DD, Sandy, JS, Grodzinsky, AJ, Controlled delivery of TGF-b1 by self-assembling peptide hydrogels induces chondrogenesis of bone marrow stromal cells via Smad2/3 signaling, Tissue Engineering A, 17:83-92, 2011.

Rolauffs, B, Badke, A, Weise, K, Grodzinsky, AJ, Aicher, WK, Stem cells and cartilage repair, in Stem Cell Based Tissue Repair, Goradetsky R and Schafer R, Eds, Royal Soc Chemistry Publishing, London, DOI:10.1039/9781849732246-00248, pp. 248-272, 2010.

Miller, RE, Grodzinsky AJ, Vanderploeg, EJ, Lee C, Ferris, DJ, Barrett, MF, Kisiday, JD, Frisbie, DD, Repair of full-thickness articular cartilage defect using self-assembling peptide, chondrogenic factors, and bone marrow derived stromal cells, Osteoarthritis Cartilage, 18:1608-1619, 2010.

Miller, RE, Grodzinsky, AJ, Cummings, K, Plaas, AHK, Cole, AA, Lee, RT, Patwari, P, Intra-articular injection of heparin-binding insulin-like growth factor-1 sustains delivery of insulin-like growth factor 1 to cartilage through binding to chondroitin sulfate, Arthritis Rheumatism, 62:3686-3694, 2010.

Lee, H-Y, Kopesky, PK, Plaas, AHK, Sandy, JD, Kisiday, JD, Frisbie, DD, Grodzinsky, AJ, Ortiz, C, Adult bone marrow stromal cell-based tissue-engineered aggrecan exhibits ultrastructure and nanomechanical properties superior to native cartilage, Osteoarthritis Cartilage, 18:1477-1486, 2010.

Rolauffs, R, Muehleman, C, Li, J, Kurz, B, Kuettner, KE, Frank, EH, Grodzinsky, AJ, Vulnerability of the superficial zone of immature articular cartilage to compressive injury, Arthritis Rheumatism, 62: 3016-3027, 2010.

Zhang, L, Smith, DW, Gardiner, GS, Pivonka, P, Grodzinsky, AJ, The transport of insulin-like growth factor through cartilage, in Porous Media: Applications in Biological Systems and Biotechnology, ed., K Vafai, CRC Press, 2010, pp. 399-453.

Hosseini, A, Van de Velde, SK, Kozanek, M, Gill, TJ, Grodzinsky, AJ, Rubash, HE, Li, G, In-vivo timedependent articular cartilage contact behavior of the tibiofemoral joint, Osteoarthritis Cartilage, 18:909- 916, 2010.

Byun, S, Tortorella, MD, Malfait, AM, Fok, K, Frank, EH, Grodzinsky, AJ, Transport and equilibrium uptake of a peptide inhibitor of pace4 into articular cartilage is dominated by electrostatic interactions, Archiv Biochem Biophys, 499:32-39, 2010.

Lemke, AK, Sandy, JD, Voigt, H, Dreier, R, Lee, JH, Grodzinsky, AJ, Mentlein, R, Fay, J, Schünke, M, Kurz, B, Interleukin-1? treatment of meniscal explants stimulates the production and release of aggrecanase-generated GAG-substituted aggrecan products and also the release of pre-formed aggrecanase generated G1 and m-calpain generated G1-G2, Cell Tissue Res, 340:179-188, 2010.

Bao, G, Kamm, RD, Thomas, W, Hwang, W, Fletcher, DA, Grodzinsky, AJ, Zhu, C, Mofrad, MRK, Molecular biomechanics: the molecular basis of how forces regulate cellular function, Cellular and Molecular Bioengineering, 3:91-105, 2010.

Kopesky, PW; Lee, H.-Y.; Vanderploeg, EJ; Kisiday, JD; Frisbie, DD; Ortiz, C; Grodzinsky, AJ, Adult equine bone-marrow stromal cells produce a cartilage-like ECM superior to animal-matched adult chondrocytes, Matrix Biology, 29:427-438, 2010.

Kisiday, JD, Vanderploeg, EJ, McIlwraith, CW, Grodzinsky, AJ, Frisbie, DD, Mechanical Injury of Explants from the Articulating Surface of the Inner Meniscus, Arch Biochem Biophys, 494:138-144, 2010.

Zhang, L, Gardiner, BS, Smith, DW, Pivonka, P, Grodzinsky, AJ, On the role of diffusible binding partners in modulating the transport and concentration of proteins in tissues, J Theoretical Biol, 263:20- 29, 2010.

Kopesky PW, Vanderploeg, EJ, Sandy JD, Kurz, B, Grodzinsky, AJ, Self-assembling peptide Selfassembling peptide hydrogels modulate in vitro chondrogenesis of bovine bone marrow stromal cells, Tissue Engineering A, 16:465-477, 2010.

Chai, DH, Arner, EC, Griggs, DW, Grodzinsky, AJ, av and b1 integrins regulate dynamic compression– induced proteoglycan synthesis in 3D gel culture by distinct complementary pathways, Osteoarthritis Cartilage, 18, 249-256, 2010.

Rolauffs, B, Williams, JM, Grodzinsky AJ, Aurich, M, Kuettner, KE, Cole, AA, Proliferative remodeling of the spatial organization of human superficial chondrocytes distant to focal early osteoarthritis (OA), Arthritis Rheumatism, 62:489-498, 2010.

Lee BB, Han, L, Frank, EH, Chubinskaya, S, Ortiz, C, Grodzinsky, AJ, Dynamic mechanical properties of the tissue-engineered matrix associated with individual chondrocytes, J Biomech, 43:469-476, 2010.

Lee, JH, Fitzgerald, JB, DiMicco, MA, Flannery, CR, Cheng, DM, Sandy, JD, Plaas, AH, Grodzinsky, AJ, Co-culture of mechanically injured cartilage with joint capsule tissue alters chondrocyte expression patterns and increases ADAMTS5 production, Archiv Biochem Biophys, 489:118-126, 2009. 11

Sui, Y Lee, JH, DiMicco, MA, Vanderploeg, EJ, Blake, SM, Hung, H-H, Plaas, AHK, James, IE, Song, X-Y, Lark, MW, Grodzinsky, AJ, Mechanical injury potentiates proteoglycan catabolism induced by IL- 6/sIL-6r and TNF-a in immature bovine and adult human articular cartilage, Arthritis Rheumatism, 60:2985-2996, 2009.

Vanderploeg, EJ and Grodzinsky, AJ, Can the meniscus affect the nature of a chondrocyte, Osteoarthritis and Cartilage, 17:969-970, 2009.

Kisiday, JD, Lee, JH, Siparsky, PN, Frisbie, DD, Flannery, CR, Sandy, JD, Grodzinsky, AJ, Catabolic responses of chondrocyte-seeded peptide hydrogel to dynamic compression, Annals Biomed Eng, 37:1368-75, 2009.

Ahn, AC, Grodzinsky, AJ, Relevance of collagen piezoelectricity to “Wolff’s Law”: a critical review, Medical Engineering and Physics, 31:733-741, 2009.

Kisiday, JD, Frisbie, DD, McIlwraith, CW, Grodzinsky, AJ, Dynamic compression stimulates proteoglycan synthesis by mesenchymal stem cells in the absence of chondrogenic cytokines, Tissue Engineering Part A, 15:2817-2824, 2009.

Wheeler, CA, Jafarzadeh, SR, Rocke, DM, Grodzinsky, AJ, IGF-1 does not moderate the time-dependent transcriptional patterns of key homeostatic genes induced by sustained compression of bovine cartilage, Osteoarthritis Cartilage, 17:930-938, 2009.

Stevens, AL, Wishnok, JS, White, FM, Grodzinsky, AJ, Tannenbaum, SR, Mechanical injury and cytokines cause loss of cartilage integrity and upregulate proteins associated with catabolism, immunity, inflammation, and repair, Molecular Cell Proteomics, 8:1475–1489, 2009.

Patwari, P, Lin, SN, Kurz, B, Cole AA, Kumar, S, Grodzinsky, AJ, Cartilage biosynthesis is inhibited by coincubation with normal joint capsule tissue through an IL-1-independent pathway, Scand J Med Sci in Sports, 19:528-535, 2009.

Jones, ARC, Chen, S, Chai, D, Stevens, AL, Gleghorn, JP, Bonassar, LB, Grodzinsky, AJ, Flannery, CR, Modulation of lubricin biosynthesis and tissue surface properties following cartilage mechanical injury, Arthritis Rheum, 60:133-42, 2009.

Zhang, L, Gardiner, B, Smith, D, Pivonka, P, Grodzinsky, AJ, An Integrated model of IGF-I mediated biosynthesis in deforming articular cartilage, Journal of Engineering Mechanics, 135:439-449, 2009.

Han, L, Dean, D, Daher, LA, Grodzinsky, AJ, Ortiz, Cartilage aggrecan can undergo self-adhesion, Biophysical J, 95:4862-70, 2008.

Lin, Z, Fitzgerald, JB, Xu, J, Willers, C, Wood, D, Grodzinsky, AJ, Zheng MH, Gene expression profiles of chondrocytes during passaged monolayer cultivation, J Orthop Res, 26:1230-1237, 2008.

Pfeiffer, E, Vickers, SM, Frank, EH, Grodzinsky, AJ, Spector, M, The effects of glycosaminoglycan content on the compressive modulus of cartilage engineered in type ii collagen scaffolds, Osteoarthritis Cartilage, 16:1237-44, 2008.

Zhang, L, Gardiner, B, Smith, D, Pivonka, P, Grodzinsky, AJ, A fully coupled poroelastic reactive transport model of cartilage, Molecular Cellular Biomech, 5:133-153, 2008.

Rolauffs, B, Williams, JM, Grodzinsky, AJ, Kuettner, KE, Cole, AA, Distinct horizontal patterns in the spatial organization of superficial zone chondrocytes of human joints, J Struc Biol, 162:335-44, 2008.

Tokunou, T, Miller, R, Patwari, P, Davis, ME, Segers, VFM, Grodzinsky, AJ, Lee, RT, Engineering insulin-like growth factor-1 for local delivery, FASEB J, 22:1886-1893, 2008.

Wagner T, Eden, U, Fregni, F, Valero-Cabre, A, Ramos-Estebanez, C, Pronio-Stelluto, V, Grodzinsky, AJ, Zahn, M, Pascual-Leone, A, Transcranial magnetic stimulation and brain atrophy: a computer-based human brain model study, Exp Brain Res, 186(4):539-50, 2008.

Zhang, L, Gardiner, B, Smith, D, Pivonka, P, Grodzinsky, AJ, Growth factor uptake with competitive binding in articular cartilage, J Biological Systems, 16:175-195, 2008.

Fitzgerald, JB, Jin, M, Chai, D, Siparsky, P, Fanning, P, Grodzinsky, AJ, Shear and compression-induced chondrocyte transcription requires MAPK activation in cartilage explants, J Biol Chem,
283:6735-6743, 2008.

Stevens, A, Wishnok, JS, Chai, D, Grodzinsky, AJ, Tannenbaum, SR, An SDS-PAGE-LC/MS/MS analysis of cartilage tissue response to mechanical compression injury and the inflammatory cytokines TNF-a and IL-1b, Arthritis Rheum, 58:489-500, 2008.

Stevens, A, Wheeler, CA, Tannenbaum, SR, Grodzinsky, AJ, The role of nitric oxide in TNF-a-induced, chondrocyte-mediated extracellular matrix damage compared to IL-1b in bovine cartilage explant cultures, Osteoarthritis Cartilage, 16:489-497, 2008.

Kisiday, JD, Kopesky, PW, Evans, CH, Grodzinsky, AJ, McIlwraith, CW, Frisbie, DD, Evaluation of adult equine bone marrow- and adipose-derived progenitor cell chondrogenesis in hydrogel cultures, J Orthop Res, 26:322-331, 2008.

Han, L, Dean, D, Mao, P, Ortiz, C, Grodzinsky, AJ, Nanoscale shear deformation mechanisms of
opposing cartilage aggrecan macromolecules, Biophysical J, 93:L22-25, 2007.

Chai, D, Stevens, AL, Grodzinsky, AJ, Joint Injury and Osteoarthritis, in Bone and Osteoarthritis, F Bronner and M.C. Farach-Carson, Eds., Springer, London, 2007, pp. 165-179.

DiMicco, MA, Kisiday, JD, Gong, H, Grodzinsky, AJ, Structure of pericellular matrix around agarose-embedded chondrocytes, Osteoarthritis and Cartilage, 15:1207-1216, 2007.

Gardner, BS, Smith, DW, Pivonka, P, Grodzinsky, AJ, Frank, EH, Zhang, L, Solute transport in cartilage undergoing cyclic deformation, Comp Meth Biomech Biomed Eng, 10:265-78, 2007.

Mankin, HJ, Grodzinsky, AJ, Buckwalter, JA, Articular cartilage and osteoarthritis, in Orthopaedic Basic Science, Foundations of Clinical Practice, 3rd Ed., TA Einhorn, RJ O'Keefe, and JA Buckwalter, eds., American Academy of Orthopaedic Surgeons pub., Rosemont IL, Chapter 9, pp. 161-174, 2007.

Wagner, T, Fregni, F, Fecteau, S, Grodzinsky, AJ, Zahn, M, Pascual-Leone, A, Transcranial Direct Current Stimulation: A computer based human model study, NeuroImage, 35:1113-1124, 2007.

Han, L, Dean, D, Ortiz, C, Grodzinsky, AJ, Lateral nanomechanics of cartilage aggrecan
macromolecules, Biophysical J, 92:1384-98, 2007.

Zhang, L, Gardner, BS, Smith, DW, Pivonka, P, Grodzinsky, The effects of cyclic deformation and solute binding on solute transport in cartilage, Archiv Biochem Biophys, 457:47-56, 2007.

Ng, L, Hung, HH, Sprunt, A, Chubinskaya, S, Ortiz, C, Grodzinsky, AJ, Nanomechanical properties of individual chondrocytes and their developing growth factor-stimulated pericellular matrix, J. Biomechanics, 40:1011-23, 2007.


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