CHRISTINE ORTIZ, Ph.D.
Higher Education Leader
| Board Director | Nonprofit Trustee
Professor | Engineer | Scientist | Social Entrepreneur
Morris Cohen Professor of
Materials Science and Engineering
Massachusetts Institute of
Technology
Founder, Station1
cortiz@mit.edu | LinkedIn
| Twitter
Biography
Christine Ortiz is a higher
education leader, board director, nonprofit trustee, professor, engineer,
former dean, and social entrepreneur. Dr. Ortiz has over 25 years of experience
in higher education and a passion for emerging integrative research, transformative
pedagogies, social mobility and impact. As the Morris
Cohen Professor of Materials Science and Engineering at the Massachusetts
Institute of Technology, she is an internationally recognized academic who has made pioneering advancements
in the areas of biotechnology and biomaterials, nanotechnology, design of
novel and multifunctional materials, multiscale mechanics of
materials, multiscale computational modeling of materials, advanced and
additive manufacturing, surface science, coatings, and tribology,socioresilient
and sustainable approaches to materials design, and socially-directed science and technology. She has given invited talks in over 40 countries, has over
200 scholarly publications (including features on the covers of the journals Science,
Nature Materials, The Journal of Structural Biology), supervised
the research projects of more than 100 students from 10 different academic
disciplines, and received more than 30 national and international honors
including the Presidential Early Career Award in Science and Engineering which
was awarded to her at the White House by U.S. President George W. Bush and
prestigious Vannevar Bush Faculty Fellowship. Dr. Ortiz has led large
cross-disciplinary teams and research grants which have included engineers,
scientists, physicians, architects, historians, linguists, civic designers, and
urban planners. Dr. Ortiz has been served on over 50 scientific advisory boards
and expert panels collectively overseeing in excess of
$200M in research funds.
Dr. Ortiz served as Dean for
Graduate Education at MIT between 2010-2016 where she supported more than 7,000
graduate students from 100+ countries enrolled in 45 graduate degree programs
in 5 academic schools. Inclusive collaboration across schools, academic
departments, administrative offices, and stakeholder groups was a hallmark of
her tenure as dean and resulted in the development and implementation of a five-year
strategic plan. She was the founding principal investigator of the MIT
University Center of Exemplary Mentoring sponsored by the Alfred P. Sloan
Foundation, created an infrastructure for advancing the funding acquisition of
graduate fellowships, and led the development of innovative global education
and research opportunities (e.g. internships in
international startup ecosystems, cross-cultural and cross-disciplinary
programming, global community-based participatory research, etc.). During this time, she served on the board of
directors of the Council for Graduate Schools and was invited to speak
worldwide including, for example, at the League of European Research
Universities (Zurich, Switzerland), the European Union Council for Doctoral
Education (Reykjavík, Iceland), the Vitae Researcher Development International
Conference (Manchester, UK), the Association of Chinese Graduate Schools
(Hangzhou, China), and the Workshop for Higher Education for the 21st Century
(Kingdom of Bahrain).
In 2016, Dr. Ortiz founded Station1 (www.station1.org). Station1 is a startup
nonprofit higher education institution based in Massachusetts that has
developed a new model of frontier learning and research — socially-directed
science and technology. Based upon a foundation of inclusion, equality, and
justice this model integrates science, technology, engineering, and math with
humanistic fields and the social sciences in order to interrogate, understand,
and shape technologically-driven societal impact
towards more just, ethical, and sustainable outcomes. Station1 designs and
delivers transformative education, research, and innovation programs and leads
higher education collective impact systems change initiatives. Core to this
work has been broadening participation for students of color, those from low
income and immigrant backgrounds, and those who are first generation to
college. By assembling a cross-disciplinary team of educators and researchers,
this work has resulted in a stream of innovations including, for example,
design and construction of a novel learning space in a historic wool mill, a
digitally-enabled curriculum on socially-directed science and technology that
incorporates inclusive pedagogies, active learning, and local-global social context,
new forms of cross-sector partnership and experiential learning with startup
companies and within innovation ecosystems across the U.S., the development of
shared leadership models and a multi-institutional collective impact initiative
(eight (8) leading STEM higher education institutions with members overseeing
thirty (30) programs and 30,000 students), and new multi-investigator
cross-disciplinary collaborative research projects on socially-directed science
and technology (e.g. socioresilient infrastructure,
socially-directed circular materials, computationally-driven origins of human
language, etc.). Station1 has garnered the support from over 80 individuals,
foundations, nonprofit organizations, and corporate sponsors for example, the
ECMC Foundation, the Analog Devices Corporate Foundation, the Siegel Family
Endowment, the Hopper-Dean Foundation, LabCentral
(one of the largest biotechnology startup accelerators in the U.S.), Craig
Newmark Philanthropies, The Amelia Peabody Foundation, The Spencer Foundation,
The Abbot and Dorothy H. Stevens Foundation, New Profit (venture philanthropy
firm), and many more. Since this time, Dr. Ortiz has received hundreds of
speaking invitations from all over the world and accepted invitations to speak
at The United Nations Conference on Frontier Technologies (New York City),The
United Nations Educational, Scientific and Cultural Organization (UNESCO)
(Paris, France), the League of European Research Universities (Edinburgh,
Scotland), Semesp (a national organization for
Brazilian Higher Education) (São Paulo, Brazil), Bankinter
Foundation Future Trends Forum (Madrid, Spain), Edtech
Sweden (Stockholm, Sweden), Innovative Europe (Lodz, Poland), Workshop on the
Future of Higher Education (Brisbane, Australia), Eisenhower Global Conference
on the Future of Work (Cartagena, Colombia), The National Science Foundation
(NSF) agency-wide lecture on the Future of Education, the National Institutes
of Health (NIH) plenary on socially-directed research, the National Academies
of Science, Engineering, and Medicine (NASEM) Future of STEM Education
Conference, among other venues. Dr. Ortiz has an extensive professional network
with over 30,000 followers on social media.
Dr. Ortiz also participates in
board service across sectors and has experience in executive leadership,
corporate governance, financial / capital allocation, government and regulatory
affairs, international business, strategic planning, digital transformation,
human capital management, environmental-social-governance, corporate social
responsibility, diversity, equity, and inclusion marketing and branding,
communications, enterprise risk management, social entrepreneurship,
organizational culture and development, cross-sector collaboration (academic,
nonprofit, industrial), stakeholder, civic, and community engagement. She
serves as a corporate board director for the publicly traded water
infrastructure and technology company, Mueller Water Products (NYSA MWA, Market
Cap $1.922B) and a trustee of the Essex County Community Foundation (private
foundation, assets $97M, region covering 34 cities). She has served as
Secretary and Board of Directors, National Consortium for Graduate Degrees for
Minorities in Science and Engineering (The National GEM Consortium) (national
nonprofit organization, assets $7.8M), on the Board of Directors, Materials
Research Society (international nonprofit scientific society with assets $15.5M
and 14,000 members), and the Board of Directors, Council for Graduate Schools
(national nonprofit organization with assets $15M, membership includes 500
universities). She also served as a regional accreditation commissioner for the
Commission on Institutions of Higher Education, New England Association of
Schools and Colleges which reviews and oversees all aspects of approximately
250 colleges and universities.
Dr. Ortiz received a B.S. in Materials Science and Engineering from Rensselaer Polytechnic Institute, a M.S. and Ph.D. in Materials Science and Engineering with a minor in Theoretical and Applied Mechanics from Cornell University.
Research Summary
The focus of Ortiz's research is on structural or load-bearing biological and bio-inspired materials, in particular musculoskeletal (internal to the body) and exoskeletal (external to the body) tissues. A powerpoint summary can be found here. Such systems have developed hierarchical and heterogeneous composite structures over millions of years of evolution in order to sustain the mechanical loads experienced in their specific environment. For this reason, they have enjoyed a long and distinguished history in the literature of more than a century with an emphasis on macroscopic, continuum-level biomechanics. Ortiz studies these fascinating systems using expertise in high resolution materials analysis and multiscale mechanics, including “nanomechanics”: the measurement and prediction of extremely small forces and displacements, the quantification of nanoscale spatially-varying mechanical properties, the identification of local constitutive laws, the formulation of molecular-level structure-property relationships, and the investigation of new mechanical phenomena existing at small length scales. Novel experimental and theoretical methods are employed involving increasing levels of complexity from individual molecules to biomimetic molecular assemblies to single cells to the nanoscale properties of the in-tact tissue. In addition, the classical materials science methods, the Ortiz group has specialized expertise in atomic force microscopy-based nanomechanics, nanoindentation, nanorheology, single cell mechanics, finite element analysis, micro and nanocomputed tomography, X-ray synchrotron, computational design, and additive manufacturing (3D printing). The result, and ultimate objective of this research is a fundamental, mechanistic-based understanding of tissue function, quality, and pathology. The scientific foundation being formed has relevance to both the medical and engineering fields. Nanotechnological methods applied to the field of musculoskeletal tissues and tissue engineering hold great promise for significant and rapid advancements towards tissue repair and/or replacement, improved treatments, and possibly even a cure for people afflicted with diseases such as osteoarthritis. In addition, the discovery of new nanoscale design principles and energy-dissipating mechanisms will enable the production of improved and increasingly advanced biologically-inspired structural engineering materials and protective defense technologies that exhibit "mechanical property amplification" - that is, dramatic improvements in mechanical properties (e.g. increases in strength and toughness) for a material relative to its constituents. The work in musculoskeletal tissues focuses on articular cartilage, bone, and intervertebral disc. The work in exoskeletal structures involves; natural flexible armor, transparent armor, armor for biochemical toxin resistance, kinetic attacks, thermal regulation, and blast dissipation. Model systems include armored fish, deep sea hydrothermal vent and antarctic molluscs, molluscs and echinoderms with articulating plate armor. More recently, we have applied new methods in computational design and additive manufacturing to achieve bio-inspired systems with tunable and unique mechanical behavior by precise control of both the material (structure and properties) and morphometry (shape).
Commitment to Diversity, Equity, and Inclusion
The The Ortiz Research group values, is committed to, and aims to foster diversity, equity, inclusion, and justice, including embracing the strengths of social, cultural, and identity-based differences, in all aspects of its research, collaboration, education, and external activities.
Publications
1. Katia Zolotovsky Swati
Varshney, Steffen Reichert, Eric M. Arndt, Ming Dao, Mary C. Boyce, and
Christine Ortiz, “Fish-inspired flexible protective material systems with anisotropic
bending stiffness,” Communication Materials,
2021, in press.
2. Spero, Ellan F., and Christine
Ortiz, "Navigating Dimensions across Materials and History: Scale as a
Lens to Understand Dynamic and Cumulative Sociotechnical
Relationships." Diseña 18 (2021), 1-1.
3. Datta, B. and
C. Ortiz, "Methods for Design and Fabrication of Bio-Inspired
Nanostructures Exhibiting Structural Coloration," Advanced Fabrication Technologies for Micro/Nano Optics and
Photonics XIII, Vol. 11292, International Society for Optics and Photonics,
2020.
4. Qua, F.J.S.,
"(Im) Material: A Qualitative Study on Sustainable Materials for Design
Through a Comparative Review of Leather and its Modern Alternatives," Qua,
Frances Jillian S. 2019 Thesis: S.M. in Engineering and Management,
Massachusetts Institute of Technology, System Design and Management Program,
2019.
5. Connors, M.,
T. Yang, A. Hosny, Z. Deng, F. Yazdandoost, H. Massaadi, D. Eernisse, R.
Mirzaeifar, M.N. Dean, and J.C. Weaver, "Bioinspired Design of Flexible
Armor Based on Chiton Scale," Nature Communications, 10(1), p. 1-13, 2019.
6. Zolotovsky,
K., Gazit, M., & Ortiz, C., "Guided
Growth of Bacterial Cellulose Biofilms," In Conference on Biomimetic and Biohybrid
Systems, (pp. 538-548), Springer Nature, July 2018.
7. Oftadeh, R.,
Connizzo, B. K., Nia, H. T., Ortiz, C., & Grodzinsky, A., "Biological
Connective Tissues Exhibit Viscoelastic and Poroelastic Behavior at Different
Frequency Regimes: Application to Tendon and Skin Biophysics,"
Acta Biomaterialia, 70, 249-259, 2018.
8. Xia, L., "Design and Analysis of
Bio-Inspired 3D Printing Body Armor for Neck Support and Protection,"
Thesis S.M. In Engineering and Management, System Design and Management
Program, Massachusetts Institute of Technology, 2018.
9. "Graduate STEM Education for the 21st Century,” National Academies of
Sciences, Engineering, and Medicine; Policy and Global Affairs; Board on Higher
Education and Workforce; Committee on Revitalizing Graduate STEM Education for
the 21st Century; Alan Leshner and Layne Scherer, Editors. Authros: A. Leshner,
Sherilynn Black, Mary Sue Coleman, Jamie Curtis-Fisk, Kenneth Gibbs, Maureen
Grasso, Sally Mason, Mary Maxon, Suzanne Ortega, Christine Ortiz, Melanie
Roberts, Henry Sauermann, Barbara Ann Schaal, Subhash Singhal, Kate Stoll,
James Tein, Keith Yamamoto. 2018.
10. Gazit, M., C.
Ortiz, and K. Zolotovsky,
"Guided Growth: The Interplay among Life, Material, and Scaffolding,"
Active Matter, p. 83, 2017.
11. Zolotovsky, K., "Guided Growth: Design and Computation
of Biologically Active Materials," (Doctoral Dissertation), Department of
Architecture, Massachusetts Institute of Technology, 2017.
12. Cranford, S.W., L. Han, C. Ortiz, and M.J. Buehler,
"Mutable Polyelectrolyte Tube Arrays: Mesoscale Modeling and Lateral Force
Microscopy," Soft Matter, 13(33), p. 5543-5557, 2017.
13. Liu, L., Y. Jiang, M. Boyce, C. Ortiz, J. Baur, J. Song,
and Y. Li, "The Effects of Morphological Irregularity on the Mechanical
Behavior of Interdigitated Biological Sutures under Tension,"
Journal of Biomechanics, 58: p. 71-78, 2017.
14. Lee, W.L., H.Y. Low, and C. Ortiz, "Geometry-Dependent
Compressive Responses in Nanoimprinted Submicron-Structured Shape Memory
Polyurethane," Soft Matter, 13(18), p. 3314-3327, 2017.
15. Azadi, M., H.T. Nia, S.J. Gauci, C. Ortiz, A.J. Fosang, and
A.J. Grodzinsky, "Wide Bandwidth Manomechanical Assessment of Murine
Cartilage Reveals Protection of Aggrecan Knock-in Mice from Joint-Overuse," Journal of Biomechanics, 49(9),
p. 1634-1640, 2016.
16. Varshney,
S.S.R., "Biological and Bio-Inspired Morphometry as a Route to Tunable and
Enhanced Materials Design," (Ph.D Dissertation), Department of Mateiials
Science and Engineering, Massachusetts Institute of Technology, 2016.
17. Li, L., M.J.
Connors, M. Kolle, G.T. England, D.I. Speiser, X. Xiao, J. Aizenberg, and C.
Ortiz, "Multifunctionality of Chiton Biomineralized Armor with an
Integrated Visual System," Science 350(6263), p. 952-956, 2015.
18. Arndt, E.M.,
W. Moore, W.-K. Lee, and C. Ortiz, "Mechanistic Origins of Bombardier
Beetle (Brachinini) Explosion-Induced Defensive Spray Pulsation," Science 348(6234), p. 563-567, 2015.
19. Li, L., S.
Kolle, J.C. Weaver, C. Ortiz, J. Aizenberg, and M. Kolle, “A Highly Conspicuous Mineralized
Composite Photonic Architecture in the Translucent Shell of the Blue-Rayed
Limpet,” Nature Communications 6(1),
6322, p. 1-11, 2015..
19. Li, L. and C. Ortiz, "A Natural 3D Interconnected
Laminated Composite with Enhanced Damage Resistance," Advanced Functional Materials, 25(23), p. 3463-3471, 2015.
20. Li, L., J.C. Weaver, and C. Ortiz, "Hierarchical
Structural Design for Fracture Resistance in the Shell of the Pteropod Clio
Pyramidata," Nature Communications, 6(1), 6216, p. 1-10,
2015.
21. Li, Q., B. Doyran, L.W. Gamer, X.L. Lu, L. Qin, C. Ortiz,
A.J. Grodzinsky, V. Rosen, and L. Han, "Biomechanical Properties of Murine
Meniscus Surface via AFM-Based Nanoindentation," Journal of Biomechanics,
48(8), p. 1364-1370, June 2015.
22. Nia, H.T., S.J. Gauci, M. Azadi, H.-H. Hung, E. Frank, A.J.
Fosang, C. Ortiz, and A.J. Grodzinsky, “High-Bandwidth AFM-based Rheology is a
Sensitive Indicator of Early Cartilage Aggrecan Degradation Relevant to Mouse
Models of Osteoarthritis,” Journal of Biomechanics, 48(1), p. 162-165, 2015.
23. Ortiz, C., M.C. Boyce, J. Song, and S.H. Reichert,
"Articulating Protective System for Resisting Mechanical Loads,"
U.S. Patent 8,978, 535 March 17th, 2015.
24. Oxman, N., C. Ortiz, F. Gramazio, and M. Kohler,
"Material ecology," Computer-Aided Design 60, 1-2,
2015.
25. Rudykh, S., C. Ortiz, and M.C. Boyce, "Flexibility and
Protection by Design: Imbricated Hybrid Microstructures of Bio-inspired
Armor," Soft Matter 11(13), p.
2547-2554, 2015.
26. Varshney, S., J. Song, Y. Li, M.C. Boyce, and C. Ortiz,
"Morphometric Structural Diversity of a Natural Armor Assembly
Investigated by 2D Continuum Strain Analysis," Journal of Structural Biology, 192(3), p. 487-499, 2015.
27. Duro-Royo, J., K. Zolotovsky, L. Mogas-Soldevila, S.
Varshney, N. Oxman, M.C. Boyce, and C. Ortiz, “MetaMesh: A Hierarchical Computational Model for Design and
Fabrication of Biomimetic Armored Surfaces,” Computer-Aided Design 60,
p. 14-27, 2015.
28. Arndt, E.M., "How Beetles Explode: New Insights into
the Operation, Structure, and Materials of Bombardier Beetle (Brachinini)
Defensive Glands," Thesis: Ph.D., Department of Materials
Science and Engineering, Massachusetts Institute of Technology, 2015.
29. Lee, B., L. Han, E.H. Frank, A.J. Grodzinsky, and C. Ortiz,
“Dynamic Nanomechanics of Individual Bone Marrow Stromal Cells and Cell-Matrix
Composites During Chondrogenic Differentiation,” Journal of biomechanics,
48(1), p. 171-175, 2015.
30. Azadi, M., Tavakoli-Nia, H., Grodzinsky, A., and C. Ortiz, “Comparison of Nano and Micro scale
Mechanics of Murine Articular Cartilage,” 36th Annual International Conference
of the IEEE Engineering in Medicine and Biology Society (EMBC’14),
Nano-Biomechanics mini-symposium, August 26-30, 2014 Chicago, Illinois, USA.
2014.
31. Nia, H.T., Gauci, S., Hung, H.-H., Azadi, N., Frank, E.,
Fosang, A., Ortiz, C. and A. Grodzinsky, “High Bandwidth AFM-based Rheology is a
Sensitive Differentiator of GAG-Depletion in Mouse Cartilage," The Annual Transactions of the 60th Annual Orthopaedic Research
Society, New Orleans, Louisiana, Vol. 39, Paper 1305, Poster Presentation, 2014.
32. Batista, M.A.,
H.T. Nia, P. Önnerfjord, K.A. Cox, C. Ortiz, A.J. Grodzinsky, D. Heinegård, and
L. Han, “Nanomechanical Phenotype of Chondroadherin-null Murine Articular
Cartilage,” Matrix Biology 38, p. 84-90, 2014.
33. Lin, E., Y.
Li, C. Ortiz, and M.C. Boyce, “3D Printed, Bio-inspired Prototypes and
Analytical Models for Structured Suture Interfaces with Geometrically-Tuned
Deformation and Failure Behavior,” Journal of the Mechanics and Physics of
Solids, 73 (15), p. 166-182, 2014.
34. Rojas, F.P.,
M.A. Batista, C.A. Lindburg, D. Dean, A.J. Grodzinsky, C. Ortiz, and L. Han, “Molecular Adhesion Between Cartilage
Extracellular Matrix Macromolecules,” Biomacromolecules 15(3), p. 772-780, 2014.
35. Lin, E., Y.
Li, J.C. Weaver, C. Ortiz, and M.C. Boyce, “Tunability and Enhancement of Mechanical Behavior with
Additively Manufactured Bio-inspired Hierarchical Suture Interfaces,” Journal of
Materials Research 29(17), p. 1867-1875, 2014.
36. Li, L. and C.
Ortiz, “Pervasive Nanoscale
Deformation Twinning as a Catalyst for Efficient Energy Dissipation in a
Bioceramic Armour,” Nature Materials 13(5), p. 501-507, 2014.
37. Yao, H. and C. Ortiz, "Protective
Articles for Resisting Mechanical Loads and Related Methods," U.S. Patent
8,365,315 B2, February 5th, 2013.
38. Browning, A.,
C. Ortiz, and M.C. Boyce, “Mechanics of Composite Elasmoid Fish Scale
Assemblies and their Bioinspired Analogues," Journal of the Mechanical
Behavior of Biomedical Materials 19, p. 75-86, 2013.
39. Lee, H.-Y., L.
Han, P.J. Roughley, A.J. Grodzinsky, and C. Ortiz, “Age-Related Nanostructural
and Nanomechanical Changes of Individual Human Cartilage Aggrecan Monomers and
Their Glycosaminoglycan Side Chains,” Journal of Structural Biology 181(3), p.
264-273, 2013.
40. Rubin, D.J.,
H.T. Nia, T. Desire, P.Q. Nguyen, M. Gevelber, C. Ortiz, and N.S. Joshi, “Mechanical Reinforcement of Polymeric
Fibers through Peptide Nanotube Incorporation,” Biomacromolecules 14(10), p.
3370-3375, 2013.
41. Li, Y., C.
Ortiz, and M.C. Boyce, “A Generalized Mechanical Model for Suture Interfaces of
Arbitrary Geometry,” Journal of the
Mechanics and Physics of Solids 61(4), p. 1144-1167, 2013.
42. Nia, H.T.,
Han, L., Bozchalooi, I., Youcef-Toumi, K., Grodzinsky, A.J., and C. Ortiz,
"Frequency Dependent Nanomechanical Behavior of Aggrecan Demonstrates that
Aggrecan is the Dominant Constituent Responsible for the Frequency Dependence
of Cartilage Poroelasticity,” The Annual Transactions of the 59th Annual
Orthopaedic Research Society, San Antonio, Texas, Vol. 38, Poster Presentation
0558, 2013.
43. Araya, S., E. Zolotovsky, F. Veliz, J. Song, S. Reichert,
M. Boyce, and C. Ortiz, "Bioinformed Performative Composite Structures:
From Biological Micro-Structures to Material Composites and Articulated
Assemblies." eCAADe. 2013: Computation and
Performance–Proceedings of the 31st International Conference on Education and
Research in Computer Aided Architectural Design in Europe, Delft, The
Netherlands, September 18-20, 2013. Faculty of Architecture, Delft University
of Technology; eCAADe (Education and Research in Computer Aided Architectural
Design in Europe), 2013.
45. Batista, M., Nia, H.T., Cox, K., Grodzinsky, A. J., Ortiz,
C., Heinegård, D., and L. Han, "Role of Chondroadherin in Nanoscale Tissue
Assembly and Biomechanics of Murine Articular Cartilage,” The Annual
Transactions of the 59th Annual Orthopaedic Research Society, San Antonio,
Texas, Vol, 38, Paper 0111, Podium Presentation, 2013.
46. Li, L. and C. Ortiz, “Biological Design for Simultaneous Optical Transparency and
Mechanical Robustness in the Shell of Placuna placenta,” Advanced Materials 25(16), p. 2344-2350, 2013.
47. Nia, H.T., Y. Li, Y. Wang, I. Soltani, S. Chubinskaya, K.
Youcef-Toumi, C. Ortiz, and A. Grodzinsky, “Depth-Dependent Self-Stiffening,
Energy Dissipation and Poroelastic Properties of Normal Human Cartilage via
Broad-Spectrum Dynamic Nanoindentation," The Annual Transactions of the
59th Annual Orthopaedic Research Society, San Antonio, Texas, Vol. 38, p. 0309,
2013, Podium Presentation.
48. Nia, H.T., "Nanomechanics of Cartilage at the Matrix
and Molecular Levels," Ph.D Thesis,
Department of Mechanical Engineering, Massachusetts Institute of
Technology, June 2013.
49. Nia, H.T., I.S. Bozchalooi, K. Youcef-Toumi, C. Ortiz, A.J.
Grodzinsky, and E. Frank, “High-Frequency Rheology System,” US Patent 8,516,610, August,
20th 2013.
50. Nia, H.T., I.S. Bozchalooi, Y. Li, L. Han, H.-H. Hung, E.
Frank, K. Youcef-Toumi, C. Ortiz, and A. Grodzinsky, “High Bandwidth AFM-Based
Rheology Reveals that Cartilage is Most Sensitive to High Loading Rates at
Early Stages of Impairment,” Biophysical journal 104(7), p. 1529-1537, 2013.
51. Batista, M.,
A. Grodzinsky, C. Ortiz, D. Heinegård, and L. Han, “Nanomechanics of Murine
Articular Cartilage Reveals the Effects of Chondroadherin Knockouts,”
Transactions of the 58th Annual Orthopaedic Research Society, San Francisco,
CA, 37, Paper No. 0013, 2012. (Podium Presentation).
52. Li, Y., C.
Ortiz, and M.C. Boyce, “Bioinspired, Mechanical, Deterministic Fractal Model for
Hierarchical Suture Joints,” Physical Review E 85, (3), p. 031901, 2012.
53. Connors, M.J.,
H. Ehrlich, M. Hog, C. Godeffroy, S. Araya, I. Kallai, D. Gazit, M. Boyce, and
C. Ortiz, “Three-Dimensional Structure of the Shell Plate Assembly of the
Chiton Tonicella marmorea and its Biomechanical Consequences,”
Journal of Structural Biology 177(2), p. 314-328, 2012.
54. Wong, S.Y., L.
Han, K. Timachova, J. Veselinovic, M.N. Hyder, C. Ortiz, A.M. Klibanov, and
P.T. Hammond, “Drastically Lowered
Protein Adsorption on Microbicidal Hydrophobic/Hydrophilic Polyelectrolyte
Multilayers,” Biomacromolecules 13(3), p. 719-726, 2012.
55. Rojas, F.P.,
Lindburg, C. A., Dean, D., Grodzinsky, A. J., Ortiz, C., and L. Han, “Molecular
Adhesion between Cartilage Extracellular Matrix Constituents,” Transactions of
the 58th Annual Orthopaedic Research Society, San Francisco, California, 37,
Paper No. 0692, 2012.
56. Nia, H.T.,
Soltani, I., Li, Y., Frank, E., Yousef-Toumi, K., Grodzinsky, A. J., and C.
Ortiz, “The Effect of GAG Depletion on Cartilage Nanoscale Hydraulic
Permeability,” Transactions of the 2012 Annual Orthopaedic Research Society,
San Francisco, CA, 37, Paper No. 0282, 2012. (Podium Presentation).
57. Han, L.,
Pazin, D., Rosen, V., Batista, M., Ortiz, C., and A. J. Grodzinsky,
"Biomechanical Properties of Murine Meniscus via Nanoindentation,” Transactions of the 58th Annual Orthopaedic
Research Society, San Francisco, CA, 37, Paper
No. 0770, 2012.
58. Browning, A.,
"Mechanics and Design of Flexible Composite Fish Armor," M. S. Thesis, Department of Mechanical
Engineering, Massachusetts Institute of Technology, June 2012.
59. Zhang, Y., H.
Yao, C. Ortiz, J. Xu, and M. Dao, “Bio-inspired Interfacial Strengthening Strategy Through
Geometrically Interlocking Designs,” Journal of the Mechanical Behavior of
Biomedical Materials 15, p. 70-77, 2012.
60. Zolotovsky,
K., "BioConstructs–Methods for Bio-Inspired and Bio-Fabricated Design,” M.
S. Thesis, Department of Architecture, Massachusetts of Technology, August
2012.
61. Han, L., J.
Yin, L. Wang, K.-K. Chia, R.E. Cohen, M.F. Rubner, C. Ortiz, and M.C. Boyce, “Tunable Stimulus-Responsive Friction
Mechanisms of Polyelectrolyte Films and Tube Forests,” Soft Matter 8,
(33), p. 8642-8650, 2012.
62. Wang, L., C.
Ortiz, and M.C. Boyce, “Mechanics of Indentation into Micro- and Nanoscale Forests of
Tubes, Rods or Pillars,” Journal of Engineering Materials and Technology
133(1), 011014, 1-9, 2011.
63. Song, J., C.
Ortiz, and M.C. Boyce, “Threat-Protection Mechanics of an Armored Fish,” Journal of the Mechanical Behavior of
Biomedical Materials 4(5), p. 699-712, 2011.
65. Tavakoli Nia,
H., L. Han, Y. Li, C. Ortiz, and A. Grodzinsky, “Poroelasticity of Cartilage at the Nanoscale,” Biophysical
Journal 10(9), 2304-2313, 2011.
66. Han, L., E.H.
Frank, J.J. Greene, H.-Y. Lee, H.-H.K. Hung, A.J. Grodzinsky, and C. Ortiz, “Time Dependent Nanomechanics of
Cartilage,” Biophysical Journal 100(7), p.
1846-1854, 2011.
67. Han, L., A.J.
Grodzinsky, and C. Ortiz, “Nanomechanics of the Cartilage Extracellular Matrix: A Review,” Annual Review
of Materials Research 41, p. 133-168, 2011.
68. Han, L., L.
Wang, K.K. Chia, R.E. Cohen, M.F. Rubner, M.C. Boyce, and C. Ortiz,
“Geometrically-Controlled Mechanically Responsive Polyelectrolyte Tube Arrays,”
Advanced Materials 23(40), p. 4667-4673,
2011.
69. Han, L., L.
Wang, J. Song, M.C. Boyce, and C. Ortiz, “Direct Quantification of the Mechanical Anisotropy and Fracture of an
Individual Exoskeleton Layer via Uniaxial Compression of Micropillars,” Nano
letters 11(9),
p. 3868-3874, 2011.
70. Rojas, F.P., “Molecular Interactions between Collagen
and Aggrecan from the Cartilage Extracellular Matrix," B.S. Thesis, Department of
Materials Science and Engineering, Massachusetts Institute of Technology, June
2011.
71. Liang, F., “Molecular Studies of Aggrecan:
Experiments and Simulations,” M.S. Thesis, Department of Chemical Engineering, Massachusetts
Institute of Technology, June 2011.
72. Chen, T.-T., “Microstructure and Micromechanics of
the Sea Urchin, Colobocentrotus
Atratus,” M. S. Thesis, Department of Mechanical Engineering,
Massachusetts Institute of Technology, June 2011.
73. Song, J., “Multiscale Materials Design of Natural
Exoskeletons: Fish Armor,” Ph.D. Thesis, Department of Materials Science and
Engineering, Massachusetts Institute of Technology, June 2011.
74. Li, Y., C.
Ortiz, and M.C. Boyce, “Stiffness and Strength of Suture Joints in Nature,” Physical
Review E 84, 062904, 2011.
75. Yao, H., M.
Dao, D. Carnelli, K. Tai, and C. Ortiz, “Size-Dependent Heterogeneity Benefits the Mechanical Performance
of Bone,” Journal of the Mechanics and Physics of Solids 59(1), p. 64-74, 2011.
76. Yao, H., M.
Dao, T. Imholt, J. Huang, K. Wheeler, A. Bonilla, S. Suresh, and C. Ortiz, “Protection Mechanisms Informed by the
Unique Iron-Plated Armor of a Deep Sea Hydrothermal Vent Gastropod,” Proceedings
of the National Academy of Sciences 107(3), 987-992, 2010. (Featured in: “Biomaterials: Super
Snail Shells” Nature Research Highlights 463, 404, 2010.
77. Cranford, S.,
H. Yao, C. Ortiz, and M.J. Buehler, “A Single Degree of Freedom “Lollipop” Model for Carbon Nanotube
Bundle Formation,” Journal of the Mechanics and Physics of Solids
58(3), 409-427, 2010.
78. Lee, H.-Y.,
P.W. Kopesky, A. Plaas, J. Sandy, J. Kisiday, D. Frisbie, A.J. Grodzinsky, and
C. Ortiz, “Adult Bone Marrow Stromal Cell-Based Tissue-Engineered Aggrecan
Exhibits Ultrastructure and Nanomechanical Properties Superior to Native
Cartilage,” Osteoarthritis and Cartilage 18(11), 1477-1486, 2010.
79. Cheng, H., “Technology Assessment and Feasibility
Study of High-Throughput Single Cell Force Spectroscopy,” Masters of
Engineering Thesis, Department of Materials Science and Engineering, Massachusetts
Institute of Technology, September 2010.
80. Lai, C., “Potential Applications of the Natural
Design of Internal Explosion Chambers in the Bombardier Beetle (Carabidae,
Brachinus),” Masters of Engineering
Thesis, Department of Materials Science and Engineering, Massachusetts
Institute of Technology, September, 2010.
81. Song, J., S.
Reichert, I. Kallai, D. Gazit, M. Wund, M.C. Boyce, and C. Ortiz, “Quantitative Microstructural Studies
of the Armor of the Marine Threespine Stickleback (Gasterosteus aculeatus),” Journal of Structural Biology 171(3), 318-331,
2010.
82. Kisiday, J.D.,
D.D. Frisbie, A. Plaas, P.W. Kopesky, S.B. Leeb, E.J. Vanderploeg, C. Ortiz,
and A.J. Grodzinsky, "Adult Equine Bone-Marrow Stromal Cells Produce a
Cartilage-Like ECM Mechanically Superior to Animal-Matched Adult Chondrocytes,
" Matrix Biology 29(5),
427-438, 2010.
83. Cranford,
S.W., C. Ortiz, and M.J. Buehler, “Mechanomutable Properties of a PAA/PAH Polyelectrolyte
Complex: Rate Dependence and Ionization Effects on Tunable Adhesion Strength,”
Soft Matter 6(17), 4175-4188, 2010.
84. Carnelli, D.,
D. Gastaldi, V. Sassi, R. Contro, C. Ortiz, and P. Vena, “A Finite Element
Model for Direction Dependent Mechanical Response to Nanoindentation of
Cortical Bone Allowing for Anisotropic Post-yield Behaviour of the Tissue,”
Journal of Biomechanical Engineering 132(8), 081008, 1-10, 2010.
85. Kopesky, P.W.,
Lee, H.-Y., Vanderploeg, E. J., Kisiday, J. D., Frisbie, D. D., Plaas, A. H.
K., Ortiz, C., and A. J. Grodzinsky, "Adult Equine Bone-marrow Stromal
Cells Produce a Cartilage-like ECM Mechanically Superior to Animal-Matched
Adult Chondrocytes," Matrix Biology 29(5), 427-438, 2010.
86. Carnelli, D.,
P. Vena, C. Ortiz, and R. Contro. “Orientation and Length-Scale Dependent Mechanical Properties in
Lamellar Bone at the Micro and Nanostructural Hierarchical Levels,” Secondo
Congresso Nazionale di Bioingegneria, Torino, Italy, 2010.
87. Lee, H.-Y.,
Sandy, J., Plaas, A., Ortiz, C., and A. Grodzinsky, “Ultrastructure of
Reconstituted Cartilage Proteoglycan Aggregates Studied by Atomic Force
Microscopy,” Transactions of the 56th Annual Orthopaedic Research Society, New
Orleans, LA, 35, Paper no. 0872, 2010.
88. Lee, B., L.
Han, E.H. Frank, S. Chubinskaya, C. Ortiz, and A.J. Grodzinsky, “Dynamic
Mechanical Properties of the Tissue-Engineered Matrix Associated with
Individual Chondrocytes,” Journal of Biomechanics 43(3), 469-476, 2010.
89. Liang, F.,
Grodzinsky, A., Roughley, P., and C. Ortiz, “Ultrastructure of Individual
Aggrecan Molecules from Human Intervertebral Disc,” Transactions of the 56th
Annual Orthopaedic Research Society, New Orleans, LA, 35, Paper no. 1414, 2010.
90. Carnelli, D.,
H. Yao, M. Dao, P. Vena, R. Contro, and C. Ortiz. “Mechanical Anisotropy of Individual
Osteons in Bone Tissue at High Spatial Resolutions,” Proceedings of the
American Society of Mechanical Engineers Summer Bioengineering Conference (SBC2009), Squaw Creek, Lake Tahoe, CA, June
17-21, 2009.
91. Wang, L., S. Juha, C. Ortiz, and M.C. Boyce, “Anisotropic Design of a Multilayered
Biological Exoskeleton,” Journal of Materials Research 24(12), 3477-3494,
2009.
92. Schmidt, D.J., F.C. Cebeci, Z.I. Kalcioglu, S.G. Wyman, C.
Ortiz, K.J. Van Vliet, and P.T. Hammond, “Electrochemically Controlled Swelling and Mechanical Properties
of a Polymer Nanocomposite,” ACS Nano 3(8), 2207-2216, 2009.
93. Lee, H.-Y., Roughley, P. J., Grodzinsky, A. J., and C.
Ortiz, “Variations in Single Molecule
Human Aggrecan Molecular Structure and Conformation after Removal of
Chondroitin Sulfate and Keratan Sulfate,” Transactions of the 55th Annual Orthopaedic Research Society, Las
Vegas, NV, 34, Paper no. 1042, 2009.
94. Lee, B., Hung, H.-H., Kopesky, P. W., Vanderploeg, E. J.,
Kurz, B., Frank, E., Grodzinsky, A. J., and C. Ortiz, "Mechanical Properties of Stem Cells and their PCM During
Chondrogenesis in 3D-Gel Culture,”
Transactions of the 55th Annual Orthopaedic Research Society, Las Vegas, NV,
34, Paper no. 0300, 2009.
95. Han, L., Plaas, A. H. K., Sandy, J. D., Frank, E. H., Hung,
H. K., Anemaet, W. K., Ortiz, C. and A. J. Grodzinsky, “Nanomechanics of Murine
Knee Joints Reveals Effects of Maturation and Inflammation,” Transactions of
the 55th Annual Orthopaedic Research Society, Las Vegas, NV, 34, Paper no.
0324, 2009.
96. Lee, H., P. Kopesky, A. Plaas, M. Diaz, J. Sandy, D.
Frisbie, J. Kisiday, C. Ortiz, and A. Grodzinsky, “Adult Equine MSCs Synthesize
Aggrecan having Nanomechanical Compressibility and Biochemical Composition
Characteristic of Young Growth Cartilage,” Podium Presentation, Transactions of
the 55th Annual Orthopaedic Research Society, Las Vegas, NV, 34, Paper no.
0172, 2009.
97. Lee, H.-Y., P. Kopesky, L. Daher, A. Mosquera, D. Frisbie,
J. Kisiday, A. Grodzinsky, and C. Ortiz. “Morphology of Aggrecan Produced by
Adult Equine Mesenchymal Stem Cells and Chondrocytes in Selfassembling Peptide
Hydrogels,” Transactions of the 54th Annual Orthopaedic Research Society, San
Francisco, CA, 33, Paper no. 0553, Submitted to the Orthopaedic Research
Society Meeting, San Francisco, CA, 2008.
98. Han, L., J.J. Greene, E.H. Frank, H.-H.K. Hung, A.
Grodzinsky, and C. Ortiz, “Effect of Length Scale on Frequency-Dependent Cartilage Oscillatory
Nanomechanics,” Transactions of the 54th Annual Orthopaedic Research Society,
San Francisco, CA, 33, Paper no. 0448, 2008.
Selected as a finalist for the Orthopaedic Research
Society’s New Investigator Recognition Awards (NIRA).
99. Tai, K., G. Pelled, D. Sheyn, A. Bershteyn, L. Han, I.
Kallai, Y. Zilberman, C. Ortiz, and D. Gazit, “Nanobiomechanics of Repair Bone
Regenerated by Genetically Modified Mesenchymal Stem Cells,” Tissue
Engineering: Part A, 14(10), p. 1709-1720, 2008.
100. Han, L., D.
Dean, L.A. Daher, A.J. Grodzinsky, and C. Ortiz, “Cartilage Aggrecan Can Undergo Self-Adhesion,” Biophysical
Journal, 95(10), p. 4862-4870, 2008.
101. Choi, J.H., “Nanomechanical Properties of Hydrated Organic Thin
Films,” Ph.D. Thesis, Department of Civil and Environmental Engineering,
Massachusetts Institute of Technology, May 2008.
102. Ye, M., “Molecular Design and Nanomechanical Testing
of Biomimetic Stimulus-Responsive Macromolecular Architectures,” Ph D. Department of
Materials Science and Engineering, Massachusetts Institute of Technology,
January 2008.
103. Arslan, M., M.
Boyce, H.J. Qi, and C. Ortiz, “Constitutive Modeling of the Stress-Stretch
Behavior of Two-Dimensional Triangulated Macromolecular Networks Containing
Folded Domains,” Journal of Applied Mechanics, 75(1), 0110220, 1-7, 2008.
104. Lee, H.-Y., L.
Han, L. Daher, R. Bonaparte, P.J. Roughley, C. Ortiz, and A. Grodzinsky,
“Age-Related Changes in Human Aggrecan Molecular Structure and its
Nanomechanical Properties,” Transactions of the 54th Annual Orthopaedic
Research Society, San Francisco, CA, 33, Paper no. 0064, 2008.
105. Wheeler, K., “The Brittle-Compliant Junction and
Fracture of the Shell from a Deep-Sea Hydrothermal Vent Gastropod,” Bachelor’s Thesis, Department of Materials Science and Engineering,
Massachusetts Institute of Technology, May 2008.
106. Ortiz, C. and
M.C. Boyce, “Bioinspired
Structural Materials,” Science, 319(5866), p. 1053-1054, 2008.
107. Bruet, B.J., J. Song, M.C. Boyce, and C. Ortiz,
“Materials Design Principles of Ancient Fish Armor,” Nature materials, 7(9), p.
748-756, 2008. (Cover of Issue) (Featured in: K.D. Jandt, “Fishing
for Compliance,” Nature Materials, 7(9), 692-693, 2008).
108. Lee, B., L. Han, E. Frank, S. Chubinskaya,
C. Ortiz, and A. Grodzinsky. “Dynamic Mechanical Properties of Growth
Factor-stimulated Chondrocytes After 3D-Gel Culture,” Transactions of the 54th
Annual Orthopaedic Research Society, San Francisco,
CA, 33, Paper no. 0151, 2008.
109. Bruet, B.J.F., “Multiscale Structural and Mechanical
Design of Mineralized Biocomposites,” Ph.D. Thesis, Department of Materials
Science and Engineering, Massachusetts Institute of Technology, January 2008.
110. Han, L., J.
Greene, E. Frank, H. Hung, A. Grodzinsky, and C. Ortiz, “Nanostructure and
TimeDependent Nanomechanics of Bovine Cartilage and Its Type II Collagen
Network,” Transactions of the 53rd Orthopaedic Research Society, San Diego, CA,
32, Paper no 0099, 2007.
111. Ng, L., H.-H.
Hung, A. Sprunt, S. Chubinskaya, C. Ortiz, and A. Grodzinsky, “Nanomechanical Properties of
Individual Chondrocytes and Their Developing Growth Factor-Stimulated
Pericellular Matrix,” Journal of biomechanics, 40(5), p. 1011-1023, 2007.
112. Pelled, G., K.
Tai, D. Sheyn, Y. Zilberman, S. Kumbar, L.S. Nair, C.T. Laurencin, D. Gazit,
and C. Ortiz, “Structural and
Nanoindentation Studies of Stem Cell-based Tissue Engineered Bone,” Journal of
Biomechanics, 40(2), p. 399-411, 2007.
113. Tai, K., M.
Dao, S. Suresh, A. Palazoglu, and C. Ortiz, “Nanoscale Heterogeneity Promotes Energy Dissipation in
Bone,” Nature materials, 6(6), p. 454-462, 2007.
114. Ulm, F.J., M.
Vandamme, C. Bobko, J. Alberto Ortega, K. Tai, and C. Ortiz, “Statistical Indentation Techniques for
Hydrated Nanocomposites: Concrete, Bone and Shale,” Invited review article, Journal of the
American Ceramic Society, 90(9), p.
2677-2692, 2007.
115. Han, L., “Nanomechanics of Cartilage
Extracellular Matrix Macromolecules,” Ph D. Thesis, Department of
Materials Science and Engineering,
Massachusetts Institute of Technology, September 2007.
116. Han, L., D.
Dean, P. Mao, C. Ortiz, and A.J. Grodzinsky, “Nanoscale Shear Deformation Mechanisms of Opposing
Cartilage Aggrecan Macromolecules,” Biophysical journal, 93(5), p. L23-L25, 2007.
117. Tai, K., "’Nanomechanics and
Ultrastructural Studies of Cortical Bone: Fundamental Insights Regarding
Structure-Function, Mineral-organic Force Mechanics Interactions, and
Heterogeneity,” Ph.D. Thesis, Department of Materials Science and Engineering, Massachusetts
Institute of Technology, March 2007.
118. Lee, B., Han,
L., Frank, E., Ortiz, C. and A. J. Grodzinsky,, “Temporal Evolution of Viscoelastic Properties of Individual
Cartilage Chondrocytes and Their Pericellular Matrix In Vitro,” Transactions of
the 53rd Orthopaedic Research Society San Diego, CA, 32, Paper no. 0149, 2007.
119. Han, L., D.
Dean, C. Ortiz, and A.J. Grodzinsky, “Lateral Nanomechanics of Cartilage Aggrecan Macromolecules,” Biophysical Journal, 92(4), p. 1384-1398, 2007.
120. Tai, K., Dao,
M., Suresh, S., and C. Ortiz, , “Nanomechanical
Heterogeneity As A Toughening Mechanism In Bone,” Transactions of the 53rd Orthopaedic
Research Society, San Diego, CA, 32, Paper no. 1358, 2007.
121. Tai, K., Ulm,
F. and C. Ortiz, , "Cohesive-Frictional
Plasticity Arising From The Nanogranular Nature in Bone,” Transactions of the 53rd Orthopaedic
Research Society, San Diego, CA, 32, Paper no. 0314, 2007.
122. Tai, K.,
Pelled, G., Bershteyn, A., Sheyn, D., Kallai, I., Zilberman, Y., Ortiz, C. and
D. Gazit, , "Nanobiomechanical Analyisis of Stem Cell-Based Non-Union
Fracture Repair,” Transactions of the
53rd Orthopaedic Research Society, San Diego, CA, 32, Paper no. 0128, 2007.
123. Ye, M., D.
Zhang, L. Han, J. Tejada, and C. Ortiz, "Synthesis, Preparation, and
Conformation of Stimulus-Responsive End-Grafted Polymer Layers of
Poly(methacrylic acid-g-ethylene glycol)" Polymer Preprints (American Chemical Society, Division of
Polymer Chemistry) 46 (2), p.
120-121, Washington, DC, 2005.
124. Ng, L.J.,
Chubinskaya, S., Grodzinsky, A. J., and C. Ortiz,, “Nanomechanical Properties of Individual Chondrocytes and Their
Developing Pericellular Matrix: Effect of
IGF-1 and OP-1,”. Transactions of the 52nd Orthopaedic Research Society, Chicago,
IL, 31, Paper no. 0391, 2006.
125. Villareal,
J.E., "Mapping of Elastic Modulus and Hardness in Trochus Niloticus
Seashell Nacre by Nanoindentation," Bachelor's Thesis, Department of
Materials Science and Engineering,
Massachusetts Institute of Technology, May 2006.
126. Kearney, C.,
Z. Zhao, B. Bruet, R. Radovitzky, M. Boyce, and C. Ortiz, "Nanoscale Anisotropic Plastic Deformation in Single Crystal
Aragonite," Physical review
letters, 96(25), p. 255505,
1-4, 2006.
127. Han, L., Dean,
D., Daher, L. A., Grodzinsky, A. J., and C. Ortiz, “Shear Nanomechanics of Opposing Cartilage Aggrecan via Lateral
Force Microscopy,” Transactions of the 52nd Orthopaedic
Research Society, Chicago, IL, 31, Paper no. 1011, 2006.
129. Jerry Qi, H.,
C. Ortiz, and M.C. Boyce, “Mechanics of Biomacromolecular Networks Containing Folded
Domains,” Journal of Engineering Materials and Technology 128(4), 509-518, 2006.
130. Oyen, M.L.,
A.J. Bushby, A. Mann, and C. Ortiz, “Mechanics of Biological and Biomimetic Materials at Small Length
Scales,” Journal of Materials Research, 21(8), p. 1869-1870, 2006.
131. Qi, H., B.
Bruet, J. Palmer, C. Ortiz, and M. Boyce, "Micromechanics and
Macromechanics of the Tensile Deformation of Nacre, in Mechanics of Biological
Tissue," Mechanics of Biological
Tissue, Springer Link. p. 189-203, 2006.
132. Dean, D., L.
Han, A.J. Grodzinsky, and C. Ortiz, “Compressive Nanomechanics of Opposing Aggrecan Macromolecules,” Journal of
biomechanics, 39(14), p. 2555-2565, 2006.
133. Negussie, H.,
"Molecular Origins of the Protein Resistance of Oligo(ethylene oxide)
SelfAssembling Monolayers,"
Bachelor's Thesis, Department of Biomedical Engineering, College of Engineering, Boston University, May
2006.
134. Vandiver, J.,
D. Dean, N. Patel, C. Botelho, S. Best, J.D. Santos, M.A. Lopes, W. Bonfield,
and C. Ortiz, “Silicon Addition to
Hydroxyapatite Increases Nanoscale Electrostatic, Van der Waals, and Adhesive
Interactions,” Journal of Biomedical Materials
Research Part A: An Official Journal of The Society for Biomaterials, The
Japanese Society for Biomaterials, and The Australian Society for Biomaterials
and the Korean Society for Biomaterials, 78(2), p. 352-363, 2006.
135. Han, L., Dean,
D., Daher, L. A.., Grodzinsky, A. J., and C. Ortiz, , “Biomolecular Adhesive Interactions
between Cartilage Aggrecan Macromolecules,”
Transactions of the 52nd Orthopaedic
Research Society, Chicago, IL, 31, Paper no. 0361, 2006.
136. Dean, D., Han,
L., Daher, L., Plaas, A. H. K., Grodzinsky, A. J., and C. Ortiz,, "Nanomechanical Properties of
Aggrecan from Bovine Fetal Epiphyseal and Mature Nasal Cartilage,” Transactions
of the 52nd Orthopaedic Research Society, Chicago, IL, 31, Paper no. 1012, 2006.
137. Tai, K., F.-J.
Ulm, and C. Ortiz, "Nanogranular origins of the strength of bone,"
Nano letters, 6(11), p. 2520-2525, 2006.
(Featured in: J. Thomas, “Biomaterials: Close to the Bone,” Nature
Nanotechnology News and Views 1(2), 99, 2006. Commentary in: D. Fyhrie, “Rocks in a Bag,” Journal
of the American Academy of Orthopaedic Surgeons 14(4), 257, 2007).
138. Tai, K.a.C.O.,
"Positionally Specific
Nanoindentation of Adult Bovine Tibial Cortical Bone of Varying Mineral
Contents at the Length Scale of Individual Collagen Fibrils,” Transactions of the 52nd
Orthopaedic Research Society, Chicago, IL, 31, Paper no. 1773, 2006.
139. Tai, K.,
Pelled, G., Sheyn, D., Zilberman, Y., Gazit, D. and C. Ortiz,, “Nanomechanics of Stem-Cell Based Tissue
Engineered Bone,” Transactions of the 52nd Orthopaedic
Research Society, Chicago, IL, 31, Paper no. 0103, 2006.
140. Tai, K. and C.
Ortiz, “Nanoscale Intermolecular
Forces of Bovine Tibial Cortical Bone of Varying Mineral Content,”
Transactions of the 52nd
Orthopaedic Research Society, Chicago, IL, 31, Paper no. 1585, 2006.
141. Vandiver, J., "Molecular Origins of Bioactivity in Synthetic
Hydroxyapatite-Based Bone Impant Materials,”
Master’s Thesis, Department of
Materials Science and Engineering, Massachusetts Institute of Technology, May
2006.
142. Kearney, C.,
"Anisotropic Nanoscale Plasticity of Aragonite," Master's Thesis,
Department of Mechanical Engineering, Massachusetts
Institute of Technology, May 2006.
143. Zhang, D., C.
Macias, and C. Ortiz, “Synthesis and Solubility of (Mono)End-Functionalized
Poly(2hydroxyethyl methacrylate-g-ethylene glycol) Graft Copolymers with
Varying Macromolecular Architecture,” Macromolecules, 38(6), p. 2530-2534,
2005.
144. Zhang, D. and
C. Ortiz, “Single Macromolecule
Nanomechanical Design: Poly(2-hydroxyethyl methacrylate-g-ethylene glycol)
Graft Copolymers of Varying Architecture,” Macromolecules, 38(6), p.
2535-2539, 2005.
145. Tai, K., H.J.
Qi, and C. Ortiz, “Effect of Mineral
Content on the Nanoindentation Properties and Nanoscale Deformation Mechanisms
of Bovine Tibial Cortical Bone,” Journal of Materials Science: Materials in
Medicine, 16(10), p. 947-959, 2005.
146. Ngai, S.,
Domike, R., Sio, R., Ortiz, C. and C. Cooney,, “Multi-Scale Analysis of Pharmaceutical Powder – Linking
Microscopic Interparticle Interaction to Macroscopic Blending Performance,” Conference Proceedings of the 7th World
Congress of Chemical Engineering, Glasgow, Scotland, July 10-14, 2005.
147. Ng, L., Bathe,
M., Ortiz, C., Tidor, B. and A. J. Grodzinsky, , “Aggrecan Conformation Depends on GAG-GAG Interactions: The Effects
of Aggrecan Concentration, GAG Molecular Weight, And Bath Ionic Strength,” Transactions of the 51st Orthopaedic Research Society, Washington
DC, 30, Paper no. 0047, 2005.
148. Ng, L.,
Grodzinsky, A. J. and C. Ortiz, , “Visualization
and Nanomechanical Properties of Individual Chondrocytes with an Increasingly
Thick Pericellular Matrix,” Transactions of the 51st Orthopaedic
Research Society, Washington DC, 30, Paper no. 0182, 2005.
149. Han, L., Dean,
D., Plaas, A. H. K., Ortiz, C. and A. J. Grodzinsky,, "Lateral Deformability and Nanomechancial Behavior of
Cartilage Aggrecan via Lateral Force Microscopy Imaging and Micro-Contact
Printing,”
Transactions of the 51st Orthopaedic Research Society, Washington DC,
30, Paper no. 0179, 2005.
150. Dean, D., Han,
L., Ortiz, C. and A. J. Grodzinsky, “Aggrecan-Aggrecan
Interaction Forces Assessed via High Resolution Force Spectroscopy of
End-Grafted Macromolecules Compressed between a Planar Substrate and Probe Tip,” Transactions of the 51st Orthopaedic
Research Society, Washington DC, 30, Paper no. 0050, 2005.
151. Ye, M., Zhang,
D., Han, L. and C. Ortiz,, “Synthesis, Preparation, and Conformation of
Stimulus Responsive End-Grafted Polymer Layers of Poly(methacrylic
acid-g-ethylene glycol),” Soft Matter
2(3), 243-256, 2005.
152. Ng, L.,
"Structure, Conformation, and Self-Assembly of Cartilage Polyelectrolyte
Macromolecules Studied via Atomic Force Microscopy," Ph.D. Thesis,
Department of Materials Science and Engineering, Massachusetts Institute of
Technology, September 2005.
153. Qi, H.J., C.
Ortiz, and M.C. Boyce, "Protein Forced Unfolding and its Effects on the
Finite Deformation Stress-Strain Behavior of Biomacromolecular Solids," Materials Research Society Symposium Proceedings (Structure
and Mechanical Behavior of Biological Materials), San Francisco, CA, 874(1): p.
15-20, 2005.
154. Seog, J., D.
Dean, B. Rolauffs, T. Wu, J. Genzer, A.H. Plaas, A.J. Grodzinsky, and C. Ortiz,
"Nanomechanics of Opposing
Glycosaminoglycan Macromolecules," Journal of Biomechanics, 38(9), p.
1789-1797, 2005.
155. Dean, D., L.
Han, C. Ortiz, and A.J. Grodzinsky, "Nanoscale Conformation and
Compressibility of Cartilage Aaggrecan using Microcontact Printing and Atomic
Force Microscopy,"
Macromolecules, 38(10), p. 4047-4049, 2005.
156. Ng, S.,
"Molecular Origins of Nanomechanical Properties of Supported Lipid
Blayers," Bachelor’s Thesis, in Department of Materials Science and
Engineering, Massachusetts Institute of Technology, May 2005.
157. Vandiver, J.,
N. Patel, W. Bonfield, and C. Ortiz. "Nanoscale Morphology of Apatite
Precipitated onto Synthetic Hydroxyapatite from Simulated Body Fluid," in
Key Engineering Materials 284-286, 497-500, 2005.
158. Dean, D.M.D.,
"Modeling and Measurement of Intermolecular Interaction Forces between
Cartilage ECM Macromolecules," Ph.D. Thesis, Department of Materials Science and Engineering, Massachusetts
Institute of Technology, February 2005.
159. Bruet, B., H.
Qi, M. Boyce, R. Panas, K. Tai, L. Frick, and C. Ortiz, "Nanoscale
Morphology and Indentation of Individual Nacre Tablets from the Gastropod
Mollusc Trochus Niloticus,"
Journal of Materials Research, 20(9), p. 2400-2419, 2005.
160. Arslan, M.,
M.C. Boyce, H.J. Qi, and C. Ortiz, “Constitutive Modeling of the Stress-Stretch
Behavior of Biological Membranes Containing Folded Domains,” Fall Materials
Research Society Symposium L (Structure and Mechanical Behavior of Biological
Materials), Boston, MA, MRS Online Proceedings Library, 898(1), p. 1-7, 2005.
161. Vandiver, J.,
D. Dean, N. Patel, W. Bonfield, and C. Ortiz, "Nanoscale Variation in
Surface Charge of Synthetic Hydroxyapatite Detected by Chemically and Spatially
Specific High-Resolution Force Spectroscopy,"
Biomaterials, 26(3), p. 271-283, 2005.
162. Qi, H.J.,
Bruet, B. F. J., Palmer, J. S., Ortiz, C. and M. C. Boyce, , “Micromechanics and Macromechanics of
the Tensile Deformation of Nacre,” Chapter in Mechanics of Biological
Tissues, edited by G. Holzapfel, R.W. Ogden; Springer Verlag, 175, 2005.
163. Ng, L., A.J.
Grodzinsky, J. Sandy, A. Plaas, and C. Ortiz. "Persistence Length of
Cartilage Aggrecan Macromolecules Measured via Atomic Force Microscopy,"
Macromolecular Symposia, 214, 1-4, 2004.
164. Dean, D., L.
Ng, J. Seog, C. Ortiz, and A. Grodzinsky, “Measurement of Nanomechanical and Electrical Interaction Force within
Intact Aggrecan Molecules using High Resolution Force Spectroscopy,” Transactions of the 50th Orthopaedic Research
Society, San Francisco, CA, 29, Paper no. 0335, 2004.
165. Brodie, K., “Visualization, Characterization, and the Consequences of Plasticizer on the
Surface of Poly(vinyl chloride)," Master’s Thesis, Department of Materials Science and Engineering, Massachusetts
Institute of Technology, September, 2004.
166. Seog, J., D.M.
Dean, E.H. Frank, C. Ortiz, and A.J. Grodzinsky, “Preparation of End-Grafted Polyelectrolytes on Nanoscale
Probe Tips Using an Electric Field,” Macromolecules, 37(3), p. 1156-1158, 2004.
167. Zhang, D. and
C. Ortiz, "Synthesis and Single Molecule Force Spectroscopy of Graft
Copolymers of Poly (2-hydroxyethyl methacrylate-g-ethylene glycol)," Macromolecules, 37(11), p.
4271-4282, 2004.
168. Ferreira, M., “Technological Properties of Latex and
Natural Rubber of Hevea brasiliensis Clones,” Ph.D. Thesis, International Visiting Graduate Student (Embrapa Instrumentação
Agropecuária, Brazil) for one year at MIT, 2004.
169. Rixman, M.A.,
“Investigating the
Molecular Origins of Biocompatibility: Intermolecular Interactions between
Human Serum Albumin and Various Chemically Modified Surfaces via High
Resolution Force Spectroscopy,” Ph D.
Thesis, Department of Materials Science and Engineering, Massachusetts
Institute of Technology, February 2004.
170. Bruet, B.J.F.,
"Multiscale Mechanical Study of
Nacre from Gastropod Mollusk Trochus Nilocitus," Master’s Thesis, Department of
Materials Science and Engineering, Massachusetts Institute of Technology, 2004.
171. Macias, C.E.,
"Nanoscale Properties of poly (ethylene terephthalate) Vascular Grafts," Bachelor’s Thesis, Department of Materials Science and
Engineering,2004, Massachusetts Institute of Technology, May 2004.
172. Rixman, M.,
Macias, C. and C. Ortiz, , “Effect of
Solution Conditions on The Nanoscale Interaction Between Human Serum Albumin
and Poly(ethylene oxide)," Polymer Preprints (American Chemical Society, Division of Polymer
Chemistry) 45(1), 70-71, Anaheim, CA, 2004.
173. C. Ortiz,
“Challenges for Nanomechanics of Biological Systems,” Workshop Proceedings NNI Interagency
Workshop: Instrumentation and Metrology for Nanotechnology Grand Challenge
Workshop, National Institute of Standards and Technology, Gaithersburg, MD Jan
27-29, 2004.
174. Ng, L.J.,
Patwari, P., Sandy, J. S., Plaas, A., Ortiz, C. and A. J. Grodzinsky,, “Aggrecan Conformation, Persistence
Length, and Stiffness Depend on The Nanomolecular Properties of its Constituent
GAG Chain,”. Transactions of the 50th Orthopaedic
Research Society, San Francisco, CA, 29, Paper no. 0051, 2004.
175. Tai, K.a.C.O.,
“Ultrastructural and Nanomechanical
Properties of Bovine Cortical Bone,”
Transactions of the 50th Orthopaedic Research Society, San Francisco,
CA, 29, Paper no. 0496, 2004.
176. Rixman, M., D.
Dean, C. Macias, and C. Ortiz, “Nanoscale Intermolecular Interactions Between Human Serum
Albumin and Alkanethiol Self-Assembled Monolayers,” Langmuir,
19(15), p. 6202-6218, 2003.
177. Dean, D., J.
Seog, C. Ortiz, and A.J. Grodzinsky, “Molecular Level Theoretical Model for
Electrostatic Interactions within Polyelectrolyte Brushes: Applications to
Charged Glycosaminoglycans,” Langmuir,
19(13), p. 5526-5539, 2003.
178. Ng, L., K.
Tai, A. Plaas, A. Grodzinsky, and C. Ortiz, “Ultrastructure and Nanomechanics of Biological Tissues:
Cartilage and Bone,” American Chemical Society Division of Polymeric Materials:
Science and Engineering, Polymer Preprints 88, 526-527, 2003.
179. Ng, L., A.J. Grodzinsky, P. Patwari, J. Sandy, A. Plaas, and
C. Ortiz, “Individual Cartilage
Aggrecan Macromolecules and Their
Constituent Glycosaminoglycans Visualized via Atomic Force Microscopy,” Journal of Structural Biology, 143(3), p.
242-257, 2003.
180. Rixman, M., D. Dean, and C. Ortiz, “Nanoscale Intermolecular Interactions
between Human Serum Albumin and Low Grafting Density Surfaces of Poly(ethylene
oxide),” Langmuir, 19(22), p. 9357-9372, 2003.
181. Brodie, K. and C. Ortiz,
“Studies of Poly(vinyl
chloride)-Based Endotracheal Tubes from the Nano- to Macroscopic Scale,”
Bachelor’s Thesis, Department of Materials Science and Engineering,
Massachusetts Institute of Technology, May 2003.
182. Seog, J., “Molecular Mechanics of Cartilage: Quantification of
Glycosaminoglycan Electrostatic Interactions via High-Resolution Force
Spectroscopy,” Ph.D. Thesis, Department of Materials Science and Engineering, Massachusetts Institute of Technology,
June 2003.
183. Wilkinson, D.A., "Regulation of Single Integrin-laminin
Bond Force by Divalent Cations,"
Bachelor’s Thesis, Department of Materials Science and Engineering,
Massachusetts Institute of Technology, June 2003.
184. Heersink, S., “Molecular
Unfolding Patterns Exhibited by the
Laminin G4-5 Dystroglycan Binding Domain,” Bachelor’s Thesis, Department
of Materials Science and Engineering, Massachusetts Institute of Technology,
June 2003,
185. Ng, L., Plaas, A., Ortiz, C. and A. J. Grodzinsky, , "AFM
Imaging of the Conformation And Interactions of Aggrecan, Hyaluronan, and Their
Constituents,” Transactions of the 49th Orthopaedic Research Society, New
Orleans, LA Feb 2-4, 28, Paper no. 0569, 2003.
186. Dean, D., J. Seog, C. Ortiz, and A. Grodzinsky,
“Nanomechanical Modeling of Electrostatic Forces Between Glycosaminoglycan
Molecules,” Transactions of the 48th Orthopaedic Research Society, Dallas, TX,
Feb 10-13, 27, Paper no. 0080, 2002.
187. Jiang, X., C. Ortiz, and P.T. Hammond, “Exploring the Rules for Selective
Deposition: Interactions Between Model Polyamines on Acid and Oligoethylene
oxide Surfaces,” Langmuir, 18(4), p. 1131-1143,
2002.
188. Ng, L., A. Plaas, A. Grodzinsky, and C. Ortiz, “Structure, Conformation, and
Self-Assembly of Cartilage Polyelectrolyte Macromolecules Studied via Atomic
Force Microscopy,” Polymer Preprints
(American Chemical Society, Division of Polymer Chemistry) 43(2), 388-389,
Boston, MA, 2002.
189. Robbins, E.M., “Design and Nanomechanical Testing of Molecular Springs using
Biomimetic Modular Macromolecular Architectures," Bachelor’s Thesis,
Department of Materials Science and Engineering, Massachusetts Institute of
Technology, June 2002.
190. Seog, J., E. Frank, D. Dean, S. Wong-Palms, A. Plaas, A.
Grodzinsky, and C. Ortiz. “Measurement of GAG-GAG Nano-Electromechanical
Interactions Using High Resolution Force Spectroscopy,” Transactions of the
48th Orthopaedic Research Society, Dallas, TX, Feb 10-13 2002, 27, Paper no.
0060, 2002.
191. Bras, R., A. Upadhyaya, A. Van Oudenaarden, and C. Ortiz,
"Imaging of the World's Fastest Biological Spring, Vorticella Convallaria
Via Atomic Force Micoscopy," Bachelor's Thesis, Department of Materials Science and
Engineering, Massachusetts Institute of Technology, June 2002..
192. Seog, J., D. Dean, A. Plaas, S. Wong-Palms, A. Grodzinsky, and
C. Ortiz, “Direct Measurement of Glycosaminoglycan Intermolecular Interactions
via High-Resolution Force Spectroscopy,” Macromolecules 35(14), p. 5601-5615,
2002.
193. Seog, J., Dean, D., Plaas, A., Wong-Palms, S., Lee, I.,
Laibinis, P., Grodzinsky, A. J. and C. Ortiz,, “Cartilage Molecular Mechanics: Detection of GAG Electrostatic
Interactions By High-Resolution Force Spectroscopy,” Transactions of the
47th Orthopaedic Research Society, San Francisco, CA, 26, Paper no. 0055, Feb
25-28, 2001.
194. Ortiz, C. and G. Hadziioannou, “Force-Displacement
Properties of Single Polymer Chains,”
(Review Article) Encyclopedia of
Materials: Science and Technology (EMSAT), 2001.
195. Ortiz, C., L. Belenky, C. Ober, and E. Kramer, “Microdeformation of a Polydomain,
Smectic Liquid Crystalline Thermoset,” Journal of Materials Science, 35(8), p. 2079-2086,
2000.
196. Ortiz, C. and G. Hadziioannou, “Entropic Elasticity of Single Polymer Chains of
Poly(methacrylic acid) Measured by Atomic Force Microscopy,” Macromolecules,
32(3), p. 780-787, 1999.
197. Ortiz, C., R. Kim, E. Rodighiero, C. Ober, and E. Kramer, “Deformation of a Polydomain, Liquid
Crystalline Epoxy-Based Thermoset,” Macromolecules, 31(13), p. 4074-4088, 1998.
198. Ortiz, C., C. Ober, and E. Kramer, “Stress Relaxation of a
Main-Chain, Smectic, Polydomain Liquid Crystalline Elastomer,” Polymer, 39(16), p. 3713-3718, 1998.
199. Ortiz, C., M. Wagner, N. Bhargava, C. Ober, and E. Kramer, “Deformation of a Polydomain, Smectic
Liquid Crystalline Elastomer,” Macromolecules, 31(24), p. 8531-8539, 1998.
200. Ortiz, C., Kim, R., Rodiguiero, E., Ober, C. K., and E. J.
Kramer, , “Fracture of a Liquid
Crystalline Epoxy Based Thermoset,” Proceedings of the Deformation, Fracture
and Rheology of Polymers Conference, Cambridge, UK, 1997.