ORTIZ LABORATORY @ MIT : PUBLICATIONS

Publications

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161. Li, L. and C. Ortiz “Pervasive nanoscale deformation twinning as a catalyst for efficient energy dissipation in a bioceramic armour,” Nature Materials, 2014, Vol. 13, doi:10.1038/nmat3920. PDF, Supplementary Information, MIT News Article

160. Nia, H.T, Gauci, S., Hung, H.-H., Azadi, N., Frank, E., Fosang, A., Ortiz, C. and A. Grodzinsky, “High-bandwidth AFM-based rheology is a sensitive differentiator of GAG-depletion in mouse cartilage,” The Annual Transactions of the 60th Annual Orthopaedic Research Society, New Orleans, Louisiana, 2014, Vol. 39, Poster Presentation.

159. Lee, H.-Y., Han L., Roughley, P.J., Grodzinsky, A.J. and C. Ortiz, “Age-related nanostructural and nanomechanical changes of individual human cartilage aggrecan monomers and their glycosaminoglycan side chains,” Journal of Structural Biology, 2013, 181 (3), 264–273. PDF

158. Rubin, D.J., Nia, H. T., Desire T., Nguyen, P.Q., Gevelber, M., Ortiz, C. and N. S. Joshi, “Mechanical Reinforcement of Polymeric Fibers through Peptide Nanotube Incorporation,” Biomacromolecules, 2013, 14 (10), 3370–3375. PDF

157. Nia, H.T., "Nanomechanics of Cartilage at the Matrix and Molecular Levels," Ph.D. Thesis, Department of Mechanical Engineering, Massachusetts Institute of Technology, June 2013 (Ortiz co-Supervisor, Grodzinsky co-Supervisor).

156. Nia, H.T., Li, Y., Wang, Y., Soltani, I., Chubinskaya, S., Youcef-Toumi, K.., Ortiz, C., and A.J. Grodzinsky, “High Bandwidth AFM-Based Rheology Reveals that Cartilage is Most Sensitive to High Loading Rates at Early Stages of Impairment,” Biophysical Journal, 2013;104(7):1529-37. PDF

155. Li, L., and Ortiz, C., “Biological Design for Simultaneous Optical Transparency and Mechanical Robustness in the Shell of Placuna placenta,” Advanced Materials, 25: 16, 2344–2350, 2013. PDF

154. Browning, A., Ortiz, C., Boyce, M.,“Mechanics of Composite Elasmoid Fish Scale Assemblies and their Bioinspired Analogues,” Journal of the Mechanical Behavior of Biomedical Materials 2013;19:75-86. PDF

153. Batista, M., Nia, H.T., Cox, K., Grodzinsky, A. J., Ortiz, C., Heinegård, D., and L. Han, “Role of Chondroadherin in Nanoscale Tissue Assembly and Biomechanics of Murine Articular Cartilage,” The Annual Transactions of the 59th Annual Orthopaedic Research Society, San Antonio, Texas, 2013, Vol. 38, Paper 0111, Podium Presentation.

152. Nia, H.T., Han, L., Bozchalooi, I., Youcef-Toumi, K., Grodzinsky, A.J., and C. Ortiz, “Frequency-dependent Nanomechanical Behavior of Aggrecan Demonstrates that Aggrecan is the Dominant Constituent Responsible for the Frequency Dependence of Cartilage Poroelasticity,” The Annual Transactions of the 59th Annual Orthopaedic Research Society, San Antonio, Texas, 2013, Vol. 38, Poster Presentation 0558.

151. Nia, H.T., Li, Y., Wang, Y., Soltani, I., Chubinskaya, S., Youcef-Toumi, K., Ortiz, C., and A.J. Grodzinsky, “Depth-Dependent Self-Stiffening, Energy Dissipation and Poroelastic Properties of Normal Human Cartilage via Broad-Spectrum Dynamic Nanoindentation,” The Annual Transactions of the 59th Annual Orthopaedic Research Society, San Antonio, Texas, 2013, Vol. 38, Paper 0309, Podium Presentation.

150. Han, L., Yin, J., Wang, L., Chia, K.K., Cohen, R. E., Rubner, M. F., Ortiz, C., and M.C. Boyce, “Tunable stimulus-responsive friction mechanisms of polyelectrolyte films and tube forests," Soft Matter 8, Pages 8642-8650, 2012. PDF

149. Li, Y., Ortiz, C., and M.C. Boyce, “A Generalized Mechanical Model for Suture Interfaces of Arbitrary Geometry,” Journal of the Mechanics and Physics of Solids, 61: 4, 2013, 1144-1167. PDF

148. Zhang, Y., Yao, H., Ortiz, C., Xu, J., and M. Dao, “Bio-inspired Interfacial Strengthening Strategy through Geometrically Interlocking Designs,” Journal of the Mechanical Behavior of Biomedical Materials 15, Pages 70-77, 2012. PDF

147. Zolotovsky, K. “BioConstructs–Methods for Bio-Inspired and Bio-Fabricated Design,” M. S. Thesis, Department of Architecture, Massachusetts Institute of Technology, August 2012 (Ortiz co-Supervisor, Oxman co-Supervisor).

146. Browning, A. "Mechanics and Design of Flexible Composite Fish Armor," M. S. Thesis, Department of Mechanical Engineering, Massachusetts Institute of Technology, June 2012 (Ortiz co-Supervisor, Boyce co-Supervisor).

145. Wong, S., Han, L., Timachova, K., Veselinovic, J., Hyder, Md. N., Ortiz, C., Klibanov, A. and Paula T. Hammond, “Drastically Lowered Protein Adsorption on Microbicidal Hydrophobic/Hydrophilic Polyelectrolyte Multilayers,” Biomacromolecules, 13, 3, 1525-7797 (2012). PDF

144. Li, Y., Ortiz, C. and M. C. Boyce “Bioinspired, Mechanical, Deterministic Fractal Model for Hierarchical Suture Joints,” Physical Review E 85, 031901 (2012). PDF

143. Connors, M., Ehrlich, H., Hog, M., Godeffroy, C., Araya, S., Kallai, I., Gazit, D., Boyce, M.C., and C. Ortiz, “Three-dimensional Structure of the Shell Plate Assembly of the Chiton Tonicella marmorea and its Biomechanical Consequences,” Journal of Structural Biology 177 (2012), pp. 314-328 2012. PDF,Supplement.

142. Han, L., Pazin, D., Rosen, V., Batista, M., Ortiz, C., and A. J. Grodzinsky, “Biomechanical Properties of Murine Meniscus via Nanoindentation,” Transactions of the 58th Annual Orthopaedic Research Society, San Francisco, CA, 37, 2012, Paper No. 0770.

141. Nia, H. T., Soltani, I., Li, Y., Frank, E., Yousef-Toumi, K., Grodzinsky, A. J., and C. Ortiz, “The Effect of GAG Depletion on Cartilage Nanoscale Hydraulic Permeability,” Transactions of the 2012 Annual Orthopaedic Research Society, San Francisco, CA, 37, 2012, Paper No. 0282 (Podium Presentation)

140. Batista, M., Grodzinsky, A. J., Ortiz, C., Heinegård, D., and L. Han, “Nanomechanics of Murine Articular Cartilage Reveals the Effects of Chondroadherin Knockouts,” Transactions of the 58th Annual Orthopaedic Research Society, San Francisco, CA, 37, 2012, Paper No. 0013 (Podium Presentation).

139. Rojas, F. P., Lindburg, C. A., Dean, D., Grodzinsky, A. J., Ortiz, C., and L. Han, “Molecular Adhesion between Cartilage Extracellular Matrix Constituents,” Transactions of the 58th Annual Orthopaedic Research Society, San Francisco, CA, 37, 2012, Paper No. 0692.

138. Li, Y., Ortiz, C., and M. C. Boyce, “Stiffness and Strength of Suture Joints in Nature,” Physical Review E, 84, 062904, 2011. PDF

137. Nia, H. T., Han, L., Li, Y., Ortiz, C. and A.J. Grodzinsky, “Poroelasticity of Cartilage at the Nanoscale,” Biophysical Journal, 101(9), 2304-2313, 2011. PDF

136. Han, L., Wang, L., Khek-Khiang, C., Cohen, R. E., Rubner, M. F., Boyce, M. C., and C. Ortiz, “Geometrically-Controlled Mechanically Responsive Polyelectrolyte Tube Arrays,” Advanced Materials, 23, 4667-4673, 2011. PDF

135. Song, Juha, “Multiscale Materials Design of Natural Exoskeletons: Fish Armor,” Ph.D. Thesis, Department of Materials Science and Engineering, Massachusetts Institute of Technology, June 2011 (Ortiz co-Supervisor, Boyce co-Supervisor).

134. Han, L., Wang, L, Boyce, M.S. and C. Ortiz, “Direct Quantification of the Mechanical Anisotropy and Fracture of an Individual Exoskeleton Layer via Uniaxial Compression of Micropillars,” Nano Letters, 11(9), 3868-3874 2011. PDF

133. Rojas, Fredrick, "Molecular Interactions between Collagen and Aggrecan from the Cartilage Extracellular Matrix," B.S. Thesis, Department of Materials Science and Engineering, Massachusetts Institute of Technology, June 2011 (Ortiz co-Supervisor, Grodzinsky co-Supervisor).

132. Chen, Ting-Ting, “Microstructure and Micromechanics of the Sea Urchin, Colobocentrotus atratus,” M. S. Thesis, Department of Mechanical Engineering, Massachusetts Institute of Technology, June 2011 (Ortiz co-Supervisor, Boyce co-Supervisor).

131. Liang, Fei, “Molecular Studies of Aggrecan: Experiments and Simulations,” M.S. Thesis, Department of Chemical Engineering, Massachusetts Institute of Technology, June 2011 (Ortiz co-Supervisor, Grodzinsky co-Supervisor).

130. Han, L., Grodzinsky, A. J., and C. Ortiz, "Nanomechanics of the Cartilage Extracellular Matrix: A Review," Annual Review of Materials Research, 41, 133-168, 2011. PDF

129. Han, L., Frank, E. H., Greene, J. J., Lee, H.-S., Hung, H.-H. K., Grodzinsky, A. J., and C. Ortiz, "Time-Dependent Nanomechanics of Cartilage," Biophysical Journal, 100(7), 1846-1854, 2011. PDF

128. Song, J., Ortiz, C., and M. C. Boyce, "Threat-protection Mechanics of an Armored Fish," Journal of the Mechanical Behavior of Biomedical Materials, 4(5), 699-712, 2011. PDF

127. Nia, H. T., Han, L., Li, Y., Ortiz, C., and A. J. Grodzinsky, “Poroelasticity is the Dominant Energy Dissipation Mechanism in Cartilage at the Nano-scale," accepted for publication, Transactions of the 57th Annual Orthopaedic Research Society Podium Presentation Spotlight Session, Long Beach, California, 36, 2011.

126. Yao, H., Dao, M., Carnelli, D., Tai, K., and C. Ortiz, "Size-Dependent Heterogeneity Benefits the Mechanical
Performance of Bone," Journal of the Mechanics and Physics of Solids, 59(1), 64-74, 2011. PDF

125. Wang, L., Ortiz, C., and M. C. Boyce, "Mechanics of Indentation into Micro- and Nanoscale Forests of
Tubes, Rods or Pillars," Journal of Engineering Materials and Technology, 133(1), 011014, 2011. PDF

124. Ortiz, C., Boyce, M. C., Song, J. and S. H. Reichert, “Articulating Protective System for Resisting Mechanical Loads,” US Patent application, US 2012/0137864 A1, June 7th 2012.

123. Lee, H.-Y., Kopesky, P. W., Plaas, A., Sandy, J., Kisiday, J., Frisbie, D., Grodzinsky, A. J., and C. Ortiz, "Adult Bone Marrow Stromal Cell-Based Tissue-Engineered Aggrecan Exhibits Ultrastructure and Nanomechanical Properties Superior to Native Cartilage," Osteoarthritis and Cartilage, 18(11), 1477-1486, 2010. PDF

122. Cranford, S., Ortiz, C., and M. Buehler, “Mechanomutable Properties of a PAA/PAH Polyelectrolyte Complex: Rate Dependence and Ionization Effects on Tunable Adhesion Strength,” Soft Matter, 6, 4175-4188, 2010. PDF

121. Carnelli, D., Contro, R., Ortiz, C., and P. Vena, “Orientation and Length-scale Dependent Mechanical Properties in Lamellar Bone at the Micro and Nanostructural Hierarchical Levels,” Secondo Congresso Nazionale di Bioingegneria, Torino, Italy, 2010.

120. Song, J., Reichert, S. Kallai, I., Gazit, D., Wund, M., Boyce, M. C., and C. Ortiz, “Quantitative Microstructural Studies of the Armor of the Marine Threespine Stickleback (Gasterosteus aculeatus),” Journal of Structural Biology, 171(3), 318-331, 2010. PDF

119. Carnelli, D., Gastaldi, D., Sassi, V., Contro, R., Ortiz, C., and P. Vena, “A Finite Element Model for Direction Dependent Mechanical Response to Nanoindentation of Cortical Bone Allowing for Anisotropic Post-yield Behaviour of the Tissue,” Journal of Biomechanical Engineering, 132(8), 081008, 2010. PDF

118. Kopesky, P. W., Lee, H.-Y., Vanderploeg, E. J., Kisiday, J. D., Frisbie, D. D., Plaas, A. H. K., Ortiz, C., and A. J. Grodzinsky, “Adult Equine Bone-marrow Stromal Cells Produce a Cartilage-like ECM Mechanically Superior to Animal-Matched Adult Chondrocytes,” Matrix Biology, 29(5), 427-438, 2010. PDF

117. Lee, B., Han, L., Frank, E. H., Chubinskya, S., Ortiz, C., and A. J. Grodzinsky, “Dynamic Mechanical Properties of the Tissue-Engineered Matrix Associated with Individual Chondrocytes,” Journal of Biomechanics, 43(3), 469-476, 2010. PDF Supplementary Material PDF

116. Yao, H., Dao, M., Imholt, T., Huang, J., Wheeler, K., Suresh, S., and C. Ortiz, “Protection Mechanisms Informed by the Unique Iron-Plated Armor of a Deep Sea Hydrothermal Vent Gastropod,” PNAS, 107(3), 987-992, 2010. PDF (Featured in:Biomaterials: Super Snail ShellsNature Research Highlights, 463, 404, 2010 PDF).

115. Lai, Changquan, “Potential Applications of the Natural Design of Internal Explosion Chambers in the Bombardier Beetle (Carabidae, Brachinus),” M.Eng. Thesis, Department of Materials Science and Engineering, Massachusetts Institute of Technology, September 2010 (Ortiz Supervisor).

114. Cheng, He, “Technology Assessment and Feasibility Study of High-Throughput Single Cell Force Spectroscopy,” M.Eng. Thesis, Department of Materials Science and Engineering, Massachusetts Institute of Technology, September 2010 (Ortiz Supervisor).

113. Lee, H.-Y., Sandy, J., Plaas, A., Ortiz, C., and A. Grodzinsky, “Ultrastructure of Reconstituted Cartilage Proteoglycan Aggregates Studied by Atomic Force Microscopy,” Transactions of the 56th Annual Orthopaedic Research Society, New Orleans, LA, 2010, 35, Paper no. 2184.

112. Liang, F., Grodzinsky, A., Roughley, P., and C. Ortiz, “Ultrastructure of Individual Aggrecan Molecules from Human Intervertebral Disc,” Transactions of the 56th Annual Orthopaedic Research Society, New Orleans, LA, 2010, 35, Paper no. 2701.

111. Yao, H. and C. Ortiz, “Protective Articles for Resisting Mechanical Loads and Related Methods,” U.S. Patent 8,365,315, Feb. 5th 2013.

110. Cranford, S., Yao, H., Ortiz, C., and M. J. Buehler, "A Single Degree of Freedom "Lollipop" Model for Carbon Nanotube Bundle Formation," The Journal of the Mechanics and Physics of Solids, 58(3), 409-427, 2010. PDF

109. Wang, L., Song, J., Ortiz, C., and M. C. Boyce, “Anisotropic Design of a Multilayered Biological Exoskeleton,” The Journal of Materials Research, 24(12), 3477-3494, 2009. PDF

108. Schmidt, D. J., Cebeci, F., Kalcioglu, I., Wyman, S. G., Ortiz, C. Van Vliet, K. J., and Hammond, P. T., "Electrochemically Controlled Swelling and Mechanical Properties of a Polymer Nanocomposite," ACS-Nano, 3(8), 2207-2216, 2009. PDF

107. Carnelli, D., Yao, H., Dao, M., Vena, P., Contro, R. and C. Ortiz, “Mechanical Anisotropy of Individual Osteons in Bone Tissue at High Spatial Resolutions,” Proceedings of the American Society of Mechanical Engineers Summer Bioengineering Conference (SBC2009), June 17-21, Squaw Creek, Lake Tahoe, CA, 2009.

106. Lee, H.-Y., Kopesky, P. W., Plaas, A. H. K., Diaz, M. A., Sandy, J. D., Kisiday, J. D., Frisbie, D. D., Ortiz, C. and A. J. Grodzinsky, “Adult Equine MSCs Synthesize Aggrecan having Nanomechanical Compressibility and Biochemical Composition Characteristic of Young Growth Cartilage,” Podium Presentation, Transactions of the 55th Annual Orthopaedic Research Society, Las Vegas, NV, 2009, 34, Paper no. 2732.

105. Lee, H.-Y., Roughley, P. J., Grodzinsky, A. J., and C. Ortiz, “Variations in Single Molecule Human Aggrecan Molecular Structure and Conformation after Removal of Chondroitin Sulfate and Keratan Sulfate,” Transactions of the 55th Annual Orthopaedic Research Society, Las Vegas, NV, 2009, 34, Paper no. 2767.

104. Lee, B., Hung, H.-H., Kopesky, P. W., Vanderploeg, E. J., Kurz, B., Frank, E., Grodzinsky, A. J., and C. Ortiz, “Mechanical Properties of Stem Cells and their PCM During Chondrogenesis in 3D-Gel Culture,” Transactions of the 55th Annual Orthopaedic Research Society, Las Vegas, NV, 2009, 34, Paper no. 2810.

103. Han, L., Plaas, A. H. K., Sandy, J. D., Frank, E. H., Hung, H. K., Anemaet, W. K., Ortiz, C. and A. J. Grodzinsky, “Nanomechanics of Murine Knee Joints Reveals Effects of Maturation and Inflammation,” Transactions of the 55th Annual Orthopaedic Research Society, Las Vegas, NV, 2009, 34, Paper no. 2835.

102. Choi, Jae, “Nanomechanical Properties of Hydrated Organic Thin Films,” Ph.D. Thesis, Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, May 2008 (Ortiz Supervisor).

101. Ye, Miao, “Molecular Design and Nanomechanical Testing of Biomimetic Stimulus-Responsive Macromolecular Architectures,” Ph.D. Thesis, Department of Materials Science and Engineering, Massachusetts Institute of Technology, January 2008 (Ortiz Supervisor).

100. Bruet, Benjamin, “Multiscale Structural and Mechanical Design of Mineralized Biocomposites,” Ph.D. Thesis, Department of Materials Science and Engineering, Massachusetts Institute of Technology, January 2008 (Ortiz Supervisor).

99. Wheeler, Kevin, “The Brittle-Compliant Junction and Fracture of the Shell from a Deep-sea Hydrothermal Vent Gastropod,” Bachelor’s Thesis, Department of Materials Science and Engineering, Massachusetts Institute of Technology, May 2008 (Ortiz Supervisor).

98. Lee, B., Han, L., Frank, E. H., Chubinskaya, S., Ortiz, C. and A. J. Grodzinsky, “Dynamic Mechanical Properties of Growth Factor-stimulated Chondrocytes After 3D-Gel Culture,” Transactions of the 54th Annual Orthopaedic Research Society, San Francisco, CA, 2008, 33, Paper no. 0151.

97. Han, L., Greene, J. J., Frank, E. H., Hung, H. K., Grodzinsky, A. J. and C. Ortiz, “Effect of Length Scale on Frequency-dependent Cartilage Oscillatory Nanomechanics,” Transactions of the 54th Annual Orthopaedic Research Society, San Francisco, CA, 2008, 33, Paper no. 0448. Selected as a finalist for the Orthopaedic Research Society’s New Investigator Recognition Awards (NIRA).

96. Lee, H.-S., Kopesky, P., Daher, L., Mosquera, A., Frisbie, D., Kisiday, J., Grodzinsky, A. J. and C. Ortiz, “Morphology of Aggrecan Produced by Adult Equine Mesenchymal Stem Cells and Chondrocytes in Self-assembling Peptide Hydrogels,” Transactions of the 54th Annual Orthopaedic Research Society, San Francisco, CA, 2008, 33, Paper no. 0553.

95. Lee, H.-S., Han, L., Daher, L., Bonaparte, R., Roughley, P., Ortiz, C. and A. J. Grodzinsky,  “Age-Related Changes in Human Aggrecan Molecular Structure and its Nanomechanical Properties,” Transactions of the 54th Annual Orthopaedic Research Society, San Francisco, CA, 2008, 33, Paper no. 0064.

94. Tai, K., Pelled, G., Sheyn, D., Bershteyn, A., Han, L., Kallai, I., Zilberman, Y., Ortiz, C. and D. Gazit, “Nanobiomechanics of Repair Bone Regenerated by Genetically Modified Mesenchymal Stem Cells,” Tissue Engineering : Part A 14(10), 1709-1720, 2008. PDF

93. Han, L., Dean, D., Daher, L. A., Grodzinsky, A. J. and C. Ortiz, “Cartilage Aggrecan Can Undergo Self-Adhesion,” Biophysical Journal 95(10), 4862-4870, 2008. PDF

92. Bruet, B. J. F.; Song, J.; Boyce, M. C.; Ortiz, C., “Materials Design Principles of Ancient Fish Armor,” Nature Materials, 7(9), 748-756, 2008 (Cover of Issue) PDF  (Featured in: K.D. Jandt, “Fishing for Compliance,” Nature Materials, 7(9), 692-693, 2008). PDF

Nature Materials Cover

91. Arslan, M., Boyce, M.C, Qi, H. J. and C. Ortiz, “Constitutive Modeling of the Stress-Stretch Behavior of Two-Dimensional Triangulated Macromolecular Networks Containing Folded Domains,” Journal of Applied Mechanics 75(1), 011020, 2008. PDF

90. Ortiz, C. and M. C. Boyce, “Bioinspired Structural Materials,” Science 319(5866), 1053-1054, 2008. PDF

89. Han, Lin, “Nanomechanics of Cartilage Extracellular Matrix Macromolecules,” Ph.D. Thesis, Department of Materials Science and Engineering, Massachusetts Institute of Technology, September 2007 (Ortiz co-Supervisor, Grodzinsky co-Supervisor).

88. Tai, Kuangshin, "’Nanomechanics and Ultrastructural Studies of Cortical Bone: Fundamental Insights Regarding Structure-function, Mineral-organic Force Mechanics Interactions, and Heterogeneity,” Ph.D. Thesis, Department of Materials Science and Engineering, Massachusetts Institute of Technology, March 2007 (Ortiz Supervisor).

87. Lee, B., Han, L., Frank, E., Ortiz, C. and A. J. Grodzinsky, “Temporal Evolution of Viscoelastic Properties of Individual Cartilage Chondrocytes and Their Pericellular Matrix In Vitro,” Transactions of the 53rd Orthopaedic Research Society San Diego, CA, 2007, 32, Paper no. 0149.

86. Tai, K., Pelled, G., Bershteyn, A., Sheyn, D., Kallai, I., Zilberman, Y., Ortiz, C. and D. Gazit, “Nanobiomechanical Analyisis of Stem Cell-Based Non-Union Fracture Repair,” Transactions of the 53rd Orthopaedic Research Society, San Diego, CA, 2007, 32, Paper no. 0128.

85. Tai, K., Ulm, F. and C. Ortiz, “Cohesive-Frictional Plasticity Arising From The Nanogranular Nature in Bone,” Transactions of the 53rd Orthopaedic Research Society, San Diego, CA, 2007, 32, Paper no. 0314.

84. Tai, K., Dao, M., Suresh, S., and C. Ortiz, “Nanomechanical Heterogeneity As A Toughening Mechanism In Bone,” Transactions of the 53rd Orthopaedic Research Society, San Diego, CA, 2007, 32, Paper no. 1358.

83. Han, L., Greene, J., Frank, E., Hung, H.-H.., Grodzinsky, A. J. and C. Ortiz, “Nanostructure and Time-Dependent Nanomechanics of Bovine Cartilage and Its Type II Collagen Network,”  Transactions of the 53rd Orthopaedic Research Society, San Diego, CA, 2007, 32, Paper no. 0099.

82. Han, L., Dean, D., Ortiz, C. and A. J. Grodzinsky, “Lateral Nanomechanics of Cartilage Aggrecan Macromolecules,” Biophysical Journal 92(4), 1384-1398, 2007. PDF

81. Ng, L., Hung, H, Sprunt, A., Chubinskaya, S., Ortiz, C. and A. J. Grodzinsky, “Nanomechanical Properties of Individual Chondrocytes and Their Developing Growth Factor-Stimulated Pericellular Matrix,” Journal of Biomechanics 40(5), 1011-1023, 2007.  PDF Supplementary Material PDF

80. Tai, K., Dao, M., Palazoglu, A., Suresh, S. and C. Ortiz. “Nanoscale Heterogeneity Promotes Energy Dissipation in Bone,” Nature Materials 6(6), 454-462, 2007. PDF Supplementary Materials PDF

79. Pelled, G., Tai, K., Sheyn, D., Zilberman, Y., Kumbar, S., Nair, L. S., Laurencin, C. T., Gazit, D. and C. Ortiz, “Structural and Nanoindentation Studies of Stem Cell-based Tissue Engineered Bone,” Journal of Biomechanics 40(2), 399-411, 2007. PDF

78. Han, L., Dean, D., Mao, P., Ortiz, C. and A. J. Grodzinsky, “Nanoscale Shear Deformation Mechanisms of Opposing Cartilage Aggrecan Macromolecules,” Biophysical Journal 93(5), L23-L25, 2007. PDF

77. Ulm, F.-J., Vandamme, M., Bobko, C., Ortega, J. A., Tai, K. and C. Ortiz, “Statistical Indentation Techniques for Hydrated Nanocomposites: Concrete, Bone and Shale,” Invited review article, Journal of the American Ceramic Society 90(9), 2677-2692, 2007. PDF

76. Vandiver, Jennifer, “Molecular Origins of Bioactivity in Synthetic Hydroxyapatite-based Bone Impant Materials,” Master’s Thesis, Department of Materials Science and Engineering, Massachusetts Institute of Technology, May 2006 (Ortiz Supervisor).

75. Kearney, Cathal “Anisotropic Nanoscale Plasticity of Aragonite,” Master’s Thesis, Department of Mechanical Engineering, Massachusetts Institute of Technology, May 2006 (Ortiz co-Supervisor, Boyce co-supervisor).

74. Negussie, Hailemariam, “Molecular Origins of the Protein Resistance of Oligo(ethylene oxide) Self-Assembling Monolayers,” Bachelor’s Thesis, Department of Biomedical Engineering, College of Engineering, Boston University, May 2006 (Ortiz Supervisor).

73. Villareal, Julian, “Mapping of the Elastic Modulus and Hardness in Trochus niloticus Seashell Nacre by Nanoindentation,” Bachelor’s Thesis, Department of Materials Science and Engineering, Massachusetts Institute of Technology, May 2006 (Ortiz Supervisor).

72. Han, L., Dean, D., Daher, L. A., Grodzinsky, A. J., and C. Ortiz, “Shear Nanomechanics of Opposing Cartilage Aggrecan via Lateral Force Microscopy,” Transactions of the 52nd Orthopaedic Research Society, Chicago, IL, 2006, 31, Paper no. 1011.

71. Ng, L. J., Chubinskaya, S., Grodzinsky, A. J., and C. Ortiz, “Nanomechanical Properties of Individual Chondrocytes and Their Developing Pericellular Matrix: Effect of IGF-1 and OP-1,” Transactions of the 52nd Orthopaedic Research Society, Chicago, IL, 2006, 31, Paper no. 0391.

70. Tai, K. and C. Ortiz, “Nanoscale Intermolecular Forces of Bovine Tibial Cortical Bone of Varying Mineral Content,” Transactions of the 52nd Orthopaedic Research Society, Chicago, IL, 2006, 31, Paper no. 1585.

69. Tai, K., Pelled, G., Sheyn, D., Zilberman, Y., Gazit, D. and C. Ortiz, “Nanomechanics of Stem-Cell Based Tissue Engineered Bone,” Transactions of the 52nd Orthopaedic Research Society, Chicago, IL, 2006, 31, Paper no. 0103.

68. Tai, K. and C. Ortiz, “Positionally Specific Nanoindentation of Adult Bovine Tibial Cortical Bone of Varying Mineral Contents at the Length Scale of Individual Collagen Fibrils,” Transactions of the 52nd Orthopaedic Research Society, Chicago, IL, 2006, 31, Paper no. 1773.

67. Dean, D., Han, L., Daher, L., Plaas, A. H. K., Grodzinsky, A. J., and C. Ortiz, “Nanomechanical Properties of Aggrecan from Bovine Fetal Epiphyseal and Mature Nasal Cartilage,” Transactions of the 52nd Orthopaedic Research Society, Chicago, IL, 2006, 31, Paper no. 1012.

66. Han, L., Dean, D., Daher, L. A.., Grodzinsky, A. J., and C. Ortiz, “Biomolecular Adhesive Interactions between Cartilage Aggrecan Macromolecules,” Transactions of the 52nd Orthopaedic Research Society, Chicago, IL, 2006, 31, Paper no. 0361.

65. Tai, K., Ulm, F.J. and C. Ortiz, “Nanogranular Origins of the Strength of Bone,” Nano Letters 6(11), 2520-2525, 2006 PDF (Featured in: J. Thomas, “Biomaterials: Close to the Bone,” Nature Nanotechnology News and Views 1(2), 99, 2006. PDF Commentary in: D. Fyhrie, “Rocks in a Bag,” Journal of the American Academy of Orthopaedic Surgeons 14(4), 257, 2007 PDF).

64. Dean, D., Han, L., Grodzinsky, A. J. and C. Ortiz, “Compressive Nanomechanics of Opposing Aggrecan Macromolecules,” Journal of Biomechanics 39(14), 2555-2565, 2006. PDF

63. Vandiver, J., Dean, D., Patel, N., Botelho, C., Best, S., Santos, J. D., Lopes, M. A., Bonfield, W. and C. Ortiz, “Silicon Addition to Hydroxyapatite Increases Nanoscale Electrostatic, Van der Waals, and Adhesive Interactions,” Journal of Biomedical Research A 78A(2), 352-363, 2006. PDF

62. Qi, J.H., Ortiz, C. and M. C. Boyce, “Mechanics of Biomacromolecular Networks Containing Folded Domains,” Journal of Engineering Materials and Technology 128(4), 509-518, 2006. PDF

61. Kearney, C., Zhao, Z., Bruet, B.J.F., Radovitzky, R., Boyce, M.C. and C. Ortiz, “Nanoscale Anisotropic Plastic Deformation in Single Crystal Aragonite,” Physical Review Letters 96(25), 255505 1-4, 2006. PDF

60. Oyen, M. L., Bushby, A. J., Mann, A. and C. Ortiz, “Mechanics of Biological and Biomimetic Materials at Small Length Scales,” Journal of Material Research 21(8), 1869-1870, 2006. PDF

59. Ng, Laurel, “Structure, Conformation, and Self-Assembly of Cartilage Polyelectrolyte Macromolecules Studied via Atomic Force Microscopy,” Ph.D. Thesis, Department of Materials Science and Engineering, Massachusetts Institute of Technology, September 2005 (Ortiz co-Supervisor, Grodzinsky co-Supervisor).

58. Ng, Sarah, “Molecular Origins of Nanomechanical Properties of Supported Lipid Blayers,” Bachelor’s Thesis, Department of Materials Science and Engineering, Massachusetts Institute of Technology, May 2005 (Ortiz Supervisor).

57. Dean, Delphine, “Modeling and Measurement of Intermolecular Interaction Forces between Cartilage Extracellular Matrix Macromolecules,” Ph.D. Thesis, Department of Materials Science and Engineering, Massachusetts Institute of Technology, February 2005 (Ortiz co-Supervisor, Grodzinsky co-supervisor).

56. Ye, M., Zhang, D., Han, L. and C. Ortiz, “Synthesis, Preparation, and Conformation of Stimulus-Responsive End-Grafted Polymer Layers of Poly(methacrylic acid-g-ethylene glycol),” Polymer Preprints (American Chemical Society, Division of Polymer Chemistry) 46(2),  120-121, Washington, DC, 2005.

55. Arslan, M., Qi, H., Ortiz, C. and M. C. Boyce, “Constitutive Modeling of the Stress-Stretch Behavior of Biological Membranes Containing Folded Domains,” Fall Materials Research Society Symposium L (Structure and Mechanical Behavior of Biological Materials), Boston, MA, 2005.

54. Dean, D., Han, L., Ortiz, C. and A. J. Grodzinsky, “Aggrecan-Aggrecan Interaction Forces Assessed via High Resolution Force Spectroscopy of End-Grafted Macromolecules Compressed between a Planar Substrate and Probe Tip,” Transactions of the 51st Orthopaedic Research Society, Washington DC, 2005, 30, Paper no. 0050.

53. Han, L., Dean, D., Plaas, A. H. K.,  Ortiz, C. and A. J. Grodzinsky, “Lateral Deformability and Nanomechancial Behavior of Cartilage Aggrecan via Lateral Force Microscopy Imaging and Micro-Contact Printing,” Transactions of the 51st Orthopaedic Research Society, Washington DC, 2005, 30, Paper no. 0179.

52. Ng, L., Grodzinsky, A. J. and C. Ortiz, “Visualization and Nanomechanical Properties of Individual Chondrocytes with an Increasingly Thick Pericellular Matrix,” Transactions of the 51st Orthopaedic Research Society, Washington DC, 2005, 30, Paper no. 0182.

51. Ng, L., Bathe, M., Ortiz, C., Tidor, B. and A. J. Grodzinsky, “Aggrecan Conformation Depends on GAG-GAG Interactions: The Effects of Aggrecan Concentration, GAG Molecular Weight, And Bath Ionic Strength,” Transactions of the 51st Orthopaedic Research Society, Washington DC, 2005, 30, Paper no. 0047.

50. Ngai, S., Domike, R., Sio, R., Ortiz, C. and C. Cooney, “Multi-Scale Analysis of Pharmaceutical Powder – Linking Microscopic Interparticle Interaction to Macroscopic Blending Performance,” Conference Proceedings of the 7th World Congress of Chemical Engineering, Glasgow, Scotland, July 10-14, 2005.

49. Qi, H.-J., Ortiz, C. and M. C. Boyce, “Protein Forced Unfolding and Its Effects on the Finite Deformation Stress-Strain Behavior of Biomacromolecular Solids,” Materials Research Society Symposium Proceedings (Structure and Mechanical Behavior of Biological Materials), San Francisco, CA, 2005, 874, pp 15-20.

48. Vandiver, J., Patel, N., Bonfield, W. and C. Ortiz, “Nanoscale Morphology of Apatite Precipitated onto Synthetic Hydroxyapatite from Simulated Body Fluid,” Key Engineering Materials 284-286, 497-500, 2005. PDF

47. Tai, K., Qi, H. J. and C. Ortiz, “Effect of Mineral Content on the Nanoindentation Properties and Nanoscale Deformation Mechanisms of Bovine Tibial Cortical Bone,” Journal of Materials Science: Materials in Medicine 16(10), 947 – 959, 2005. PDF

46. Dean, D, Han, L, Ortiz, C. and A. J. Grodzinsky, “Nanoscale Conformation and Compressibility of Cartilage Aggrecan using Micro-Contact Printing and Atomic Force Microscopy,” Macromolecules 38(10), 4047-4049, 2005. PDF

45. Bruet, B. J. F., Qi, H. J., Panas, R., Tai, K., Frick, L., Boyce, M. C. and C. Ortiz, “Nanoscale Morphology and Indentation of Individual Nacre Tablets from The Gastropod Mollusc Trochus niloticus,” Journal of Materials Research 20(9), 2400-2419, 2005. PDF

44. Ye, M., Han, L. and C. Ortiz, “Synthesis, Preparation, and Conformation of Stimulus-Responsive End-Grafted Polymer Layers of Poly(methacrylic acid-g-ethylene glycol),” Soft Matter 2(3), 243-256, 2005. PDF

43. Vandiver, J., Dean, D., Patel, N., Bonfield, W. and C. Ortiz, “Nanoscale Variation in Surface Charge of Synthetic Hydroxyapatite Detected by Chemically and Spatially Specific High-Resolution Force Spectroscopy,” Biomaterials 26(3), 271-283, 2005. PDF

42. Zhang, D., Macias C. and C. Ortiz, “Synthesis and Solubility of (Mono)End-Functionalized Poly(2-hydroxyethyl methacrylate-g-ethylene glycol) Graft Copolymers with Varying Macromolecular Architecture,” Macromolecules 38(6), 2530-2534, 2005. PDF

41. Zhang, D. and C. Ortiz, “Single Macromolecule Nanomechanical Design: Poly(2-hydroxyethyl methacrylate-g-ethylene glycol) Graft Copolymers of Varying Architecture,” Macromolecules 38(6), 2535-2539, 2005. PDF

40. Seog, J., Dean, D., Rolauffs, B., Wu, T., Genzer, J., Plaas, A. H. K., Grodzinsky, A. J. and C. Ortiz, “Nanomechanics of Opposing Glycosaminoglycan Macromolecules,” Journal of Biomechanics 38(9), 1789-1797, 2005. PDF

39. Qi, H. J., Bruet, B. F. J., Palmer, J. S., Ortiz, C. and M. C. Boyce, “Micromechanics and Macromechanics of the Tensile Deformation of Nacre,” Chapter in Mechanics of Biological Tissues, edited by G. Holzapfel, R.W. Ogden; Springer Verlag, 175, 2005. PDF

38. Ferreira, Mariselma, “Technological Properties of Latex and Natural Rubber of Hevea brasiliensis Clones,” Ph.D. Thesis, international visiting graduate student (Embrapa Instrumentação Agropecuária, Brazil) for one year at MIT, 2004 (Ortiz Co-Supervisor).

37. Rixman, Monica, “LinkInvestigating the Molecular Origins of Biocompatibility: Intermolecular Interactions between Human Serum Albumin and Various Chemically Modified Surfaces via High Resolution Force Spectroscopy,” Ph.D. Thesis, Department of Materials Science and Engineering, Massachusetts Institute of Technology, February 2004 (Ortiz Supervisor).

36. Brodie, Kristin, “Visualization, Characterization, and the Consequences of Plasticizer on the Surface of Poly(vinyl chloride) Master’s Thesis, Department of Materials Science and Engineering, Massachusetts Institute of Technology, September 2004 (Ortiz Supervisor).

35. Bruet, Benjamin, “LinkMultiscale Mechanical Study of Nacre from the Gastropod Mollusk Trochus niloticus,” Master’s Thesis, Department of Materials Science and Engineering, Massachusetts Institute of Technology, June 2004 (Ortiz Supervisor).

34. Macias, Celia, “Nanoscale Properties of Poly(ethylene terephthalate) Vascular Grafts,” Bachelor’s Thesis, Department of Materials Science and Engineering, Massachusetts Institute of Technology, May 2004 (Ortiz Supervisor).

33. Rixman, M., Macias, C. and C. Ortiz, “Effect of Solution Conditions on The Nanoscale Interaction Between Human Serum Albumin and Poly(ethylene oxide),” Polymer Preprints (American Chemical Society, Division of Polymer Chemistry) 45(1), 70-71, Anaheim, CA, 2004.

32. C. Ortiz, “Challenges for Nanomechanics of Biological Systems,” Workshop Proceedings NNI Interagency Workshop: Instrumentation and Metrology for Nanotechnology Grand Challenge Workshop, National Institute of Standards and Technology, Gaithersburg, MD Jan 27-29, 2004.

31. Ng, L. J., Patwari, P., Sandy, J. S., Plaas, A., Ortiz, C. and A. J. Grodzinsky, “Aggrecan Conformation, Persistence Length, and Stiffness Depend on The Nanomolecular Properties of its Constituent GAG Chain,” Transactions of the 50th Orthopaedic Research Society, San Francisco, CA, 2004, 29, Paper no. 0051.

30. Dean, D., Ng, L. J., Seog,  J., Ortiz, C. and A. J. Grodzinsky, “Measurement of Nanomechanical and Electrical Interaction Force within Intact Aggrecan Molecules using High Resolution Force Spectroscopy,” Transactions of the 50th Orthopaedic Research Society, San Francisco, CA, 2004, 29, Paper no. 0335.

29. Tai, K. and C. Ortiz, “Ultrastructural and Nanomechanical Properties of Bovine Cortical Bone,” Transactions of the 50th Orthopaedic Research Society, San Francisco, CA, 2004, 29, Paper no. 0496.

28. Ng, L., Grodzinsky, A. J., Sandy, J., Plaas, A. and C. Ortiz, “Persistence Length of Cartilage Aggrecan Macromolecules Measured via Atomic Force Microscopy,” Macromolecular Symposia 214, 1-4, 2004.

27. Zhang, D. and C. Ortiz, “Synthesis and Single Molecule Force Spectroscopy of Graft Copolymers of Poly(2-hydroxyethyl methacrylate-g-ethylene glycol),” Macromolecules 37(11), 4271-4282, 2004. PDF

26. Seog, J., Dean, D., Frank, E., Ortiz, C. and A. J. Grodzinsky, “Preparation of End-Grafted Polyelectrolytes on Nanoscale Probe Tips Using an Electric Field,” Macromolecules 37(3), 1156-1158, 2004. PDF

25. Seog, Joonil, “Molecular Mechanics of Cartilage: Quantification of Glycosaminoglycan Electrostatic Interactions via High-Resolution Force Spectroscopy,” Ph.D. Thesis, Department of Materials Science and Engineering, Massachusetts Institute of Technology, June 2003 (Ortiz co-supervisor, Grodzinsky co-supervisor).

24. Wilkinson, D. Andrew, “Regulation of Single Integrin-Laminin Bond Force by Divalent Cations,” Bachelor’s Thesis, Department of Materials Science and Engineering, Massachusetts Institute of Technology, June 2003 (Ortiz co-supervisor, Gilbert co-supervisor).

23. Heersink, Sebastian, “Molecular Unfolding Patterns Exhibited by the Laminin G4-5 Dystroglycan-Binding Domain,” Bachelor’s Thesis, Department of Materials Science and Engineering, Massachusetts Institute of Technology, June 2003 (Ortiz co-supervisor, Gilbert co-supervisor).

22. Brodie, Kristin, “LinkStudies of Poly(vinyl chloride)-Based Endotracheal Tubes from the Nano- to Macroscopic Scale,” Bachelor’s Thesis, Department of Materials Science and Engineering, Massachusetts Institute of Technology, May 2003 (Ortiz Supervisor).

21. Ng, L., Tai, K., Plaas, A., Grodzinsky, A. J. and C. Ortiz, “Ultrastructure and Nanomechanics of Biological Tissues: Cartilage and Bone,” American Chemical Society Division of Polymeric Materials: Science and Engineering, Polymer Preprints 88, 526-527, 2003.

20. Ng, L., Plaas, A., Ortiz, C. and A. J. Grodzinsky, “AFM Imaging of the Conformation And Interactions of Aggrecan, Hyaluronan, and Their Constituents,” Transactions of the 49th Orthopaedic Research Society, New Orleans, LA Feb 2-4, 2003, 28, Paper no. 0569.

19. Ng, L. J., Grodzinsky, A. J., Plaas, A., Sandy, J. and C. Ortiz, “Individual Cartilage Aggrecan Macromolecules and Their Constituent Glycosaminoglycans visualized via atomic force microscopy,” Journal of Structural Biology 143(3), 242-257, 2003 [Cover of Issue]. PDF Journal Cover PDF

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18. Rixman, M. A., Dean, D. and C. Ortiz, “Nanoscale Intermolecular Interactions between Human Serum Albumin and Low Grafting Density Surfaces of Poly(ethylene oxide),” Langmuir 19(22), 9357-9372, 2003. PDF

17. Dean, D., Seog, J., Ortiz, C. and A. J. Grodzinsky, “Molecular Level Theoretical Model for Electrostatic Interactions within Polyelectrolyte Brushes: Applications to Charged Glycosaminoglycans,” Langmuir 19(13), 5526-5539, 2003. PDF

16. Rixman, M. A., Dean, D., Macias, C. and C. Ortiz, “Nanoscale Intermolecular Interactions Between Human Serum Albumin and Alkanethiol Self-Assembled Monolayers,” Langmuir 19(15), 6202-6218, 2003. PDF

15. Bras, Rafael, “LinkImaging of the World’s Fastest Biological Spring, Vorticella convallaria, via Atomic Force Microscopy,” Bachelor’s Thesis, Department of Materials Science and Engineering, Massachusetts Institute of Technology, June 2002 (Ortiz Supervisor).

14. Robbins, Elissa, “LinkDesign and Nanomechanical Testing of Molecular Springs using Biomimetic Modular Macromolecular Architectures Bachelor’s Thesis, Department of Materials Science and Engineering, Massachusetts Institute of Technology, June 2002 (Ortiz Supervisor).

13. Ng, L. J., Plaas, A., Grodzinsky, A. J. and C. Ortiz, “Structure, Conformation, and Self-Assembly of Cartilage Polyelectrolyte Macromolecules Studied via Atomic Force Microscopy,” Polymer Preprints (American Chemical Society, Division of Polymer Chemistry) 43(2), 388-389, Boston, MA, 2002.

12. Seog, J., Frank, E., Dean, D., Wong-Palms, S., Plaas, A.., Grodzinsky, A. J. and C. Ortiz,  “Measurement of  GAG-GAG Nano-Electromechanical Interactions Using High Resolution Force Spectroscopy,” Transactions of the 48th Orthopaedic Research Society, Dallas, TX, Feb 10-13 2002, 27, Paper no. 0060.

11. Dean, D., Seog, J., Ortiz, C. and A. J. Grodzinsky, “Nanomechanical Modeling of Electrostatic Forces Between Glycosaminoglycan Molecules,” Transactions of the 48th Orthopaedic Research Society, Dallas, TX, Feb 10-13, 2002, 27, Paper no. 0080.

10. Seog, J., Dean, D., Plaas, A., Wong-Palms, S., Grodzinsky, A. J. and C. Ortiz, “Direct Measurement of Glycosaminoglycan Intermolecular Interactions via High-Resolution Force Spectroscopy,” Macromolecules 35(14), 5601-5615, 2002. PDF

9. Jiang, X.-P., Ortiz, C. and P. Hammond, “Exploring the Rules for Selective Deposition: Interactions Between Model Polyamines on Acid and Oligoethylene oxide Surfaces,” Langmuir 18(4), 1131-1143, 2002. PDF

8. Ortiz, C. and G. Hadziioannou, “Force-Displacement Properties of Single Polymer Chains,” (Review Article) Encyclopedia of Materials: Science and Technology (EMSAT), 2001.

7. Seog, J., Dean, D., Plaas, A., Wong-Palms, S., Lee, I., Laibinis, P., Grodzinsky, A. J. and C. Ortiz, “Cartilage Molecular Mechanics: Detection of GAG Electrostatic Interactions By High-Resolution Force Spectroscopy,” Transactions of the 47th Orthopaedic Research Society, San Francisco, CA, Feb 25-28, 2001, 26, Paper no. 0055.

6. Ortiz, C., Belenky, L. Ober, C. K and E. J. Kramer, “Microdeformation of a Polydomain, Smectic Liquid Crystalline Thermoset,” Journal of Materials Science 35(8), 2079-2086, 2000. [Cover of Issue] PDF

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5. Ortiz, C. and G. Hadziioannou, “Entropic Elasticity of Single Polymer Chains of Poly(methacrylic acid) Measured by Atomic Force Microscopy,” Macromolecules 32(3), 780-787, 1999. PDF

4. Ortiz, C., Kim, R., Rodiguiero, E., Ober, C. K., and E. J. Kramer, “Deformation of a Polydomain, Liquid Crystalline Epoxy-Based Thermoset,” Macromolecules 31(13), 4074-4088, 1998. PDF

3. Ortiz, C., Wagner, M.., Bhargava, N., Ober, C. K. and E. J. Kramer, “Deformation of a Polydomain, Smectic Liquid Crystalline Elastomer,” Macromolecules 31(24), 8531-8539, 1998. PDF

2. Ortiz, C., Ober, C. K. and E. J. Kramer, “Stress Relaxation of a Main-Chain, Smectic, Polydomain Liquid Crystalline Elastomer,” Polymer 39(16), 3713-3718, 1998. PDF

1. Ortiz, C., Kim, R., Rodiguiero, E., Ober, C. K., and E. J. Kramer, “Fracture of a Liquid Crystalline Epoxy-Based Thermoset,” Proceedings of the Deformation, Fracture and Rheology of Polymers Conference, Cambridge, UK, 1997.