Publications

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112. Schmidt, D. J., Cebeci, F., Kalcioglu, I., Wyman, S. G., Ortiz, C. Van Vliet, K. J., and Hammond, P. T., "Electrochemically-Controlled Swelling and Mechanical Properties of a Polymer Nanocomposite," in revision, 2009.

111. Lee, B., Han, L., Frank, E. H., Chubinskya, S., Ortiz, C., and A. J. Grodzinsky, “Dynamic Mechanical Properties of the Tissue-Engineered Matrix Associated with Individual Chondrocytes,” in review, 2009.

110. Yao, H., Dao, M., Carnelli, D., Tai, K., Suresh, S., and C. Ortiz, “Characteristics of Size-Dependent Nanoscale Heterogeneity for Mechanical Performance of Bone,” Submitted, 2009.

109. Yao, H., Dao, M., Imholt, T., Huang, J., Wheeler, K., Suresh, S., and C. Ortiz, “Protection Mechanisms Informed by the Unique Iron-Plated Armor of a Deep Sea Hydrothermal Vent Gastropod,” in review, 2009.

108. Wang, L., Song, J., Ortiz, C., and M. C. Boyce, “Anistropic Design of a Multilayered Biological Exoskeleton,” in review, 2009.

107. Carnelli, D., Yao, H., Dao, M., Vena, P., Contro, R. and C. Ortiz, “Mechanical Anistropy of Individual Osteons in Bone Tissue at High Spatial Resolutions,” Proceedings of the American Society of Mechanical Engineers Summer Bioengineering Conference (SBC2009), June 17-21, Squaw Creek, Lake Tahoe, CA, 2009.

106. Lee, H.-Y., Kopesky, P. W., Plaas, A. H. K., Diaz, M. A., Sandy, J. D., Kisiday, J. D., Frisbie, D. D., Ortiz, C. and A. J. Grodzinsky, “Adult Equine MSCs Synthesize Aggrecan having Nanomechanical Compressibility and Biochemical Composition Characteristic of Young Growth Cartilage,” Podium Presentation, Transactions of the 55th Annual Orthopaedic Research Society, Las Vegas, NV, 2009, 34, Paper no. 2732.

105. Lee, H.-Y., Roughley, P. J., Grodzinsky, A. J., and C. Ortiz, “Variations in Single Molecule Human Aggrecan Molecular Structure and Conformation after Removal of Chondroitin Sulfate and Keratan Sulfate,” Transactions of the 55th Annual Orthopaedic Research Society, Las Vegas, NV, 2009, 34, Paper no. 2767.

104. Lee, B., Hung, H.-H., Kopesky, P. W., Vanderploeg, E. J., Kurz, B., Frank, E., Grodzinsky, A. J., and C. Ortiz, “Mechanical Properties of Stem Cells and their PCM During Chondrogenesis in 3D-Gel Culture,” Transactions of the 55th Annual Orthopaedic Research Society, Las Vegas, NV, 2009, 34, Paper no. 2810.

103. Han, L., Plaas, A. H. K., Sandy, J. D., Frank, E. H., Hung, H. K., Anemaet, W. K., Ortiz, C. and A. J. Grodzinsky, “Nanomechanics of Murine Knee Joints Reveals Effects of Maturation and Inflammation,” Transactions of the 55th Annual Orthopaedic Research Society, Las Vegas, NV, 2009, 34, Paper no. 2835.

102. Choi, Jae, “Nanomechanical Properties of Hydrated Organic Thin Films,” Ph.D. Thesis, Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, May 2008 (Ortiz Supervisor).

101. Ye, Miao, “Molecular Design and Nanomechanical Testing of Biomimetic Stimulus-Responsive Macromolecular Architectures,” Ph.D. Thesis, Department of Materials Science and Engineering, Massachusetts Institute of Technology, January 2008 (Ortiz Supervisor).

100. Bruet, Benjamin, “Multiscale Structural and Mechanical Design of Mineralized Biocomposites,” Ph.D. Thesis, Department of Materials Science and Engineering, Massachusetts Institute of Technology, January 2008 (Ortiz Supervisor).

99. Wheeler, Kevin, “The Brittle-Compliant Junction and Fracture of the Shell from a Deep-sea Hydrothermal Vent Gastropod,” Bachelor’s Thesis, Department of Materials Science and Engineering, Massachusetts Institute of Technology, May 2008 (Ortiz Supervisor).

98. Lee, B., Han, L., Frank, E. H., Chubinskaya, S., Ortiz, C. and A. J. Grodzinsky, “Dynamic Mechanical Properties of Growth Factor-stimulated Chondrocytes After 3D-Gel Culture,” Transactions of the 54th Annual Orthopaedic Research Society, San Francisco, CA, 2008, 33, Paper no. 0151.

97. Han, L., Greene, J. J., Frank, E. H., Hung, H. K., Grodzinsky, A. J. and C. Ortiz, “Effect of Length Scale on Frequency-dependent Cartilage Oscillatory Nanomechanics,” Transactions of the 54th Annual Orthopaedic Research Society, San Francisco, CA, 2008, 33, Paper no. 0448. Selected as a finalist for the Orthopaedic Research Society’s New Investigator Recognition Awards (NIRA).

96. Lee, H.-S., Kopesky, P., Daher, L., Mosquera, A., Frisbie, D., Kisiday, J., Grodzinsky, A. J. and C. Ortiz, “Morphology of Aggrecan Produced by Adult Equine Mesenchymal Stem Cells and Chondrocytes in Self-assembling Peptide Hydrogels,” Transactions of the 54th Annual Orthopaedic Research Society, San Francisco, CA, 2008, 33, Paper no. 0553.

95. Lee, H.-S., Han, L., Daher, L., Bonaparte, R., Roughley, P., Ortiz, C. and A. J. Grodzinsky,  “Age-Related Changes in Human Aggrecan Molecular Structure and its Nanomechanical Properties,” Transactions of the 54th Annual Orthopaedic Research Society, San Francisco, CA, 2008, 33, Paper no. 0064.

94. Tai, K., Pelled, G., Sheyn, D., Bershteyn, A., Han, L., Kallai, I., Zilberman, Y., Ortiz, C. and D. Gazit, “Nanobiomechanics of Repair Bone Regenerated by Genetically Modified Mesenchymal Stem Cells,” Tissue Engineering : Part A 14(10), 1709-1720, 2008. PDF

93. Han, L., Dean, D., Daher, L. A., Grodzinsky, A. J. and C. Ortiz, “Cartilage Aggrecan Can Undergo Self-Adhesion,” Biophysical Journal 95(10), 4862-4870, 2008. PDF

92. Bruet, B. J. F.; Song, J.; Boyce, M. C.; Ortiz, C., “Materials Design Principles of Ancient Fish Armor,” Nature Materials, 7(9), 748-756, 2008 (Cover of Issue) PDF  (Featured in: K.D. Jandt, “Fishing for Compliance,” Nature Materials, 7(9), 692-693, 2008). PDF

91. Arslan, M., Boyce, M.C, Qi, H. J. and C. Ortiz, “Constitutive Modeling of the Stress-Stretch Behavior of Two-Dimensional Triangulated Macromolecular Networks Containing Folded Domains,” Journal of Applied Mechanics 75(1), 011020, 2008. PDF

90. Ortiz, C. and M. C. Boyce, “Bioinspired Structural Materials,” Science 319(5866), 1053-1054, 2008. PDF

89. Han, Lin, “Nanomechanics of Cartilage Extracellular Matrix Macromolecules,” Ph.D. Thesis, Department of Materials Science and Engineering, Massachusetts Institute of Technology, September 2007 (Ortiz co-Supervisor, Grodzinsky co-Supervisor).

88. Tai, Kuangshin, "’Nanomechanics and Ultrastructural Studies of Cortical Bone: Fundamental Insights Regarding Structure-function, Mineral-organic Force Mechanics Interactions, and Heterogeneity,” Ph.D. Thesis, Department of Materials Science and Engineering, Massachusetts Institute of Technology, March 2007 (Ortiz Supervisor).

87. Lee, B., Han, L., Frank, E., Ortiz, C. and A. J. Grodzinsky, “Temporal Evolution of Viscoelastic Properties of Individual Cartilage Chondrocytes and Their Pericellular Matrix In Vitro,” Transactions of the 53rd Orthopaedic Research Society San Diego, CA, 2007, 32, Paper no. 0149.

86. Tai, K., Pelled, G., Bershteyn, A., Sheyn, D., Kallai, I., Zilberman, Y., Ortiz, C. and D. Gazit, “Nanobiomechanical Analyisis of Stem Cell-Based Non-Union Fracture Repair,” Transactions of the 53rd Orthopaedic Research Society, San Diego, CA, 2007, 32, Paper no. 0128.

85. Tai, K., Ulm, F. and C. Ortiz, “Cohesive-Frictional Plasticity Arising From The Nanogranular Nature in Bone,” Transactions of the 53rd Orthopaedic Research Society, San Diego, CA, 2007, 32, Paper no. 0314.

84. Tai, K., Dao, M., Suresh, S., and C. Ortiz, “Nanomechanical Heterogeneity As A Toughening Mechanism In Bone,” Transactions of the 53rd Orthopaedic Research Society, San Diego, CA, 2007, 32, Paper no. 1358.

83. Han, L., Greene, J., Frank, E., Hung, H.-H.., Grodzinsky, A. J. and C. Ortiz, “Nanostructure and Time-Dependent Nanomechanics of Bovine Cartilage and Its Type II Collagen Network,”  Transactions of the 53rd Orthopaedic Research Society, San Diego, CA, 2007, 32, Paper no. 0099.

82. Han, L., Dean, D., Ortiz, C. and A. J. Grodzinsky, “Lateral Nanomechanics of Cartilage Aggrecan Macromolecules,” Biophysical Journal 92(4), 1384-1398, 2007. PDF

81. Ng, L., Hung, H, Sprunt, A., Chubinskaya, S., Ortiz, C. and A. J. Grodzinsky, “Nanomechanical Properties of Individual Chondrocytes and Their Developing Growth Factor-Stimulated Pericellular Matrix,” Journal of Biomechanics 40(5), 1011-1023, 2007.  PDF Supplementary Material PDF

80. Tai, K., Dao, M., Palazoglu, A., Suresh, S. and C. Ortiz. “Nanoscale Heterogeneity Promotes Energy Dissipation in Bone,” Nature Materials 6(6), 454-462, 2007. PDF Supplementary Materials PDF

79. Pelled, G., Tai, K., Sheyn, D., Zilberman, Y., Kumbar, S., Nair, L. S., Laurencin, C. T., Gazit, D. and C. Ortiz, “Structural and Nanoindentation Studies of Stem Cell-based Tissue Engineered Bone,” Journal of Biomechanics 40(2), 399-411, 2007. PDF

78. Han, L., Dean, D., Mao, P., Ortiz, C. and A. J. Grodzinsky, “Nanoscale Shear Deformation Mechanisms of Opposing Cartilage Aggrecan Macromolecules,” Biophysical Journal 93(5), L23-L25, 2007. PDF

77. Ulm, F.-J., Vandamme, M., Bobko, C., Ortega, J. A., Tai, K. and C. Ortiz, “Statistical Indentation Techniques for Hydrated Nanocomposites: Concrete, Bone and Shale,” Invited review article, Journal of the American Ceramic Society 90(9), 2677-2692, 2007. PDF

76. Vandiver, Jennifer, “Molecular Origins of Bioactivity in Synthetic Hydroxyapatite-based Bone Impant Materials,” Master’s Thesis, Department of Materials Science and Engineering, Massachusetts Institute of Technology, May 2006 (Ortiz Supervisor).

75. Kearney, Cathal “Anisotropic Nanoscale Plasticity of Aragonite,” Master’s Thesis, Department of Mechanical Engineering, Massachusetts Institute of Technology, May 2006 (Ortiz co-Supervisor, Boyce co-supervisor).

74. Negussie, Hailemariam, “Molecular Origins of the Protein Resistance of Oligo(ethylene oxide) Self-Assembling Monolayers,” Bachelor’s Thesis, Department of Biomedical Engineering, College of Engineering, Boston University, May 2006 (Ortiz Supervisor).

73. Villareal, Julian, “Mapping of the Elastic Modulus and Hardness in Trochus niloticus Seashell Nacre by Nanoindentation,” Bachelor’s Thesis, Department of Materials Science and Engineering, Massachusetts Institute of Technology, May 2006 (Ortiz Supervisor).

72. Han, L., Dean, D., Daher, L. A., Grodzinsky, A. J., and C. Ortiz, “Shear Nanomechanics of Opposing Cartilage Aggrecan via Lateral Force Microscopy,” Transactions of the 52nd Orthopaedic Research Society, Chicago, IL, 2006, 31, Paper no. 1011.

71. Ng, L. J., Chubinskaya, S., Grodzinsky, A. J., and C. Ortiz, “Nanomechanical Properties of Individual Chondrocytes and Their Developing Pericellular Matrix: Effect of IGF-1 and OP-1,” Transactions of the 52nd Orthopaedic Research Society, Chicago, IL, 2006, 31, Paper no. 0391.

70. Tai, K. and C. Ortiz, “Nanoscale Intermolecular Forces of Bovine Tibial Cortical Bone of Varying Mineral Content,” Transactions of the 52nd Orthopaedic Research Society, Chicago, IL, 2006, 31, Paper no. 1585.

69. Tai, K., Pelled, G., Sheyn, D., Zilberman, Y., Gazit, D. and C. Ortiz, “Nanomechanics of Stem-Cell Based Tissue Engineered Bone,” Transactions of the 52nd Orthopaedic Research Society, Chicago, IL, 2006, 31, Paper no. 0103.

68. Tai, K. and C. Ortiz, “Positionally Specific Nanoindentation of Adult Bovine Tibial Cortical Bone of Varying Mineral Contents at the Length Scale of Individual Collagen Fibrils,” Transactions of the 52nd Orthopaedic Research Society, Chicago, IL, 2006, 31, Paper no. 1773.

67. Dean, D., Han, L., Daher, L., Plaas, A. H. K., Grodzinsky, A. J., and C. Ortiz, “Nanomechanical Properties of Aggrecan from Bovine Fetal Epiphyseal and Mature Nasal Cartilage,” Transactions of the 52nd Orthopaedic Research Society, Chicago, IL, 2006, 31, Paper no. 1012.

66. Han, L., Dean, D., Daher, L. A.., Grodzinsky, A. J., and C. Ortiz, “Biomolecular Adhesive Interactions between Cartilage Aggrecan Macromolecules,” Transactions of the 52nd Orthopaedic Research Society, Chicago, IL, 2006, 31, Paper no. 0361.

65. Tai, K., Ulm, F.J. and C. Ortiz, “Nanogranular Origins of the Strength of Bone,” Nano Letters 6(11), 2520-2525, 2006 PDF (Featured in: J. Thomas, “Biomaterials: Close to the Bone,” Nature Nanotechnology News and Views 1(2), 99, 2006. PDF Commentary in: D. Fyhrie, “Rocks in a Bag,” Journal of the American Academy of Orthopaedic Surgeons 14(4), 257, 2007 PDF).

64. Dean, D., Han, L., Grodzinsky, A. J. and C. Ortiz, “Compressive Nanomechanics of Opposing Aggrecan Macromolecules,” Journal of Biomechanics 39(14), 2555-2565, 2006. PDF

63. Vandiver, J., Dean, D., Patel, N., Botelho, C., Best, S., Santos, J. D., Lopes, M. A., Bonfield, W. and C. Ortiz, “Silicon Addition to Hydroxyapatite Increases Nanoscale Electrostatic, Van der Waals, and Adhesive Interactions,” Journal of Biomedical Research A 78A(2), 352-363, 2006. PDF

62. Qi, J.H., Ortiz, C. and M. C. Boyce, “Mechanics of Biomacromolecular Networks Containing Folded Domains,” Journal of Engineering Materials and Technology 128(4), 509-518, 2006. PDF

61. Kearney, C., Zhao, Z., Bruet, B.J.F., Radovitzky, R., Boyce, M.C. and C. Ortiz, “Nanoscale Anisotropic Plastic Deformation in Single Crystal Aragonite,” Physical Review Letters 96(25), 255505 1-4, 2006. PDF

60. Oyen, M. L., Bushby, A. J., Mann, A. and C. Ortiz, “Mechanics of Biological and Biomimetic Materials at Small Length Scales,” Journal of Material Research 21(8), 1869-1870, 2006. PDF

59. Ng, Laurel, “Structure, Conformation, and Self-Assembly of Cartilage Polyelectrolyte Macromolecules Studied via Atomic Force Microscopy,” Ph.D. Thesis, Department of Materials Science and Engineering, Massachusetts Institute of Technology, September 2005 (Ortiz co-Supervisor, Grodzinsky co-Supervisor).

58. Ng, Sarah, “Molecular Origins of Nanomechanical Properties of Supported Lipid Blayers,” Bachelor’s Thesis, Department of Materials Science and Engineering, Massachusetts Institute of Technology, May 2005 (Ortiz Supervisor).

57. Dean, Delphine, “Modeling and Measurement of Intermolecular Interaction Forces between Cartilage Extracellular Matrix Macromolecules,” Ph.D. Thesis, Department of Materials Science and Engineering, Massachusetts Institute of Technology, February 2005 (Ortiz co-Supervisor, Grodzinsky co-supervisor).

56. Ye, M., Zhang, D., Han, L. and C. Ortiz, “Synthesis, Preparation, and Conformation of Stimulus-Responsive End-Grafted Polymer Layers of Poly(methacrylic acid-g-ethylene glycol),” Polymer Preprints (American Chemical Society, Division of Polymer Chemistry) 46(2),  120-121, Washington, DC, 2005.

55. Arslan, M., Qi, H., Ortiz, C. and M. C. Boyce, “Constitutive Modeling of the Stress-Stretch Behavior of Biological Membranes Containing Folded Domains,” Fall Materials Research Society Symposium L (Structure and Mechanical Behavior of Biological Materials), Boston, MA, 2005.

54. Dean, D., Han, L., Ortiz, C. and A. J. Grodzinsky, “Aggrecan-Aggrecan Interaction Forces Assessed via High Resolution Force Spectroscopy of End-Grafted Macromolecules Compressed between a Planar Substrate and Probe Tip,” Transactions of the 51st Orthopaedic Research Society, Washington DC, 2005, 30, Paper no. 0050.

53. Han, L., Dean, D., Plaas, A. H. K.,  Ortiz, C. and A. J. Grodzinsky, “Lateral Deformability and Nanomechancial Behavior of Cartilage Aggrecan via Lateral Force Microscopy Imaging and Micro-Contact Printing,” Transactions of the 51st Orthopaedic Research Society, Washington DC, 2005, 30, Paper no. 0179.

52. Ng, L., Grodzinsky, A. J. and C. Ortiz, “Visualization and Nanomechanical Properties of Individual Chondrocytes with an Increasingly Thick Pericellular Matrix,” Transactions of the 51st Orthopaedic Research Society, Washington DC, 2005, 30, Paper no. 0182.

51. Ng, L., Bathe, M., Ortiz, C., Tidor, B. and A. J. Grodzinsky, “Aggrecan Conformation Depends on GAG-GAG Interactions: The Effects of Aggrecan Concentration, GAG Molecular Weight, And Bath Ionic Strength,” Transactions of the 51st Orthopaedic Research Society, Washington DC, 2005, 30, Paper no. 0047.

50. Ngai, S., Domike, R., Sio, R., Ortiz, C. and C. Cooney, “Multi-Scale Analysis of Pharmaceutical Powder – Linking Microscopic Interparticle Interaction to Macroscopic Blending Performance,” Conference Proceedings of the 7th World Congress of Chemical Engineering, Glasgow, Scotland, July 10-14, 2005.

49. Qi, H.-J., Ortiz, C. and M. C. Boyce, “Protein Forced Unfolding and Its Effects on the Finite Deformation Stress-Strain Behavior of Biomacromolecular Solids,” Materials Research Society Symposium Proceedings (Structure and Mechanical Behavior of Biological Materials), San Francisco, CA, 2005, 874, pp 15-20.

48. Vandiver, J., Patel, N., Bonfield, W. and C. Ortiz, “Nanoscale Morphology of Apatite Precipitated onto Synthetic Hydroxyapatite from Simulated Body Fluid,” Key Engineering Materials 284-286, 497-500, 2005. PDF

47. Tai, K., Qi, H. J. and C. Ortiz, “Effect of Mineral Content on the Nanoindentation Properties and Nanoscale Deformation Mechanisms of Bovine Tibial Cortical Bone,” Journal of Materials Science: Materials in Medicine 16(10), 947 – 959, 2005. PDF

46. Dean, D, Han, L, Ortiz, C. and A. J. Grodzinsky, “Nanoscale Conformation and Compressibility of Cartilage Aggrecan using Micro-Contact Printing and Atomic Force Microscopy,” Macromolecules 38(10), 4047-4049, 2005. PDF

45. Bruet, B. J. F., Qi, H. J., Panas, R., Tai, K., Frick, L., Boyce, M. C. and C. Ortiz, “Nanoscale Morphology and Indentation of Individual Nacre Tablets from The Gastropod Mollusc Trochus niloticus,” Journal of Materials Research 20(9), 2400-2419, 2005. PDF

44. Ye, M., Han, L. and C. Ortiz, “Synthesis, Preparation, and Conformation of Stimulus-Responsive End-Grafted Polymer Layers of Poly(methacrylic acid-g-ethylene glycol),” Soft Matter 2(3), 243-256, 2005. PDF

43. Vandiver, J., Dean, D., Patel, N., Bonfield, W. and C. Ortiz, “Nanoscale Variation in Surface Charge of Synthetic Hydroxyapatite Detected by Chemically and Spatially Specific High-Resolution Force Spectroscopy,” Biomaterials 26(3), 271-283, 2005. PDF

42. Zhang, D., Macias C. and C. Ortiz, “Synthesis and Solubility of (Mono)End-Functionalized Poly(2-hydroxyethyl methacrylate-g-ethylene glycol) Graft Copolymers with Varying Macromolecular Architecture,” Macromolecules 38(6), 2530-2534, 2005. PDF

41. Zhang, D. and C. Ortiz, “Single Macromolecule Nanomechanical Design: Poly(2-hydroxyethyl methacrylate-g-ethylene glycol) Graft Copolymers of Varying Architecture,” Macromolecules 38(6), 2535-2539, 2005. PDF

40. Seog, J., Dean, D., Rolauffs, B., Wu, T., Genzer, J., Plaas, A. H. K., Grodzinsky, A. J. and C. Ortiz, “Nanomechanics of Opposing Glycosaminoglycan Macromolecules,” Journal of Biomechanics 38(9), 1789-1797, 2005. PDF

39. Qi, H. J., Bruet, B. F. J., Palmer, J. S., Ortiz, C. and M. C. Boyce, “Micromechanics and Macromechanics of the Tensile Deformation of Nacre,” Chapter in Mechanics of Biological Tissues, edited by G. Holzapfel, R.W. Ogden; Springer Verlag, 175, 2005. PDF

38. Ferreira, Mariselma, “Technological Properties of Latex and Natural Rubber of Hevea brasiliensis Clones,” Ph.D. Thesis, international visiting graduate student (Embrapa Instrumentação Agropecuária, Brazil) for one year at MIT, 2004 (Ortiz Co-Supervisor).

37. Rixman, Monica, “Investigating the Molecular Origins of Biocompatibility: Intermolecular Interactions between Human Serum Albumin and Various Chemically Modified Surfaces via High Resolution Force Spectroscopy,” Ph.D. Thesis, Department of Materials Science and Engineering, Massachusetts Institute of Technology, February 2004 (Ortiz Supervisor).

36. Brodie, Kristin, “Visualization, Characterization, and the Consequences of Plasticizer on the Surface of Poly(vinyl chloride) Master’s Thesis, Department of Materials Science and Engineering, Massachusetts Institute of Technology, September 2004 (Ortiz Supervisor).

35. Bruet, Benjamin, “Multiscale Mechanical Study of Nacre from the Gastropod Mollusk Trochus niloticus,” Master’s Thesis, Department of Materials Science and Engineering, Massachusetts Institute of Technology, June 2004 (Ortiz Supervisor).

34. Macias, Celia, “Nanoscale Properties of Poly(ethylene terephthalate) Vascular Grafts,” Bachelor’s Thesis, Department of Materials Science and Engineering, Massachusetts Institute of Technology, May 2004 (Ortiz Supervisor).

33. Rixman, M., Macias, C. and C. Ortiz, “Effect of Solution Conditions on The Nanoscale Interaction Between Human Serum Albumin and Poly(ethylene oxide),” Polymer Preprints (American Chemical Society, Division of Polymer Chemistry) 45(1), 70-71, Anaheim, CA, 2004.

32. C. Ortiz, “Challenges for Nanomechanics of Biological Systems,” Workshop Proceedings NNI Interagency Workshop: Instrumentation and Metrology for Nanotechnology Grand Challenge Workshop, National Institute of Standards and Technology, Gaithersburg, MD Jan 27-29, 2004.

31. Ng, L. J., Patwari, P., Sandy, J. S., Plaas, A., Ortiz, C. and A. J. Grodzinsky, “Aggrecan Conformation, Persistence Length, and Stiffness Depend on The Nanomolecular Properties of its Constituent GAG Chain,” Transactions of the 50th Orthopaedic Research Society, San Francisco, CA, 2004, 29, Paper no. 0051.

30. Dean, D., Ng, L. J., Seog,  J., Ortiz, C. and A. J. Grodzinsky, “Measurement of Nanomechanical and Electrical Interaction Force within Intact Aggrecan Molecules using High Resolution Force Spectroscopy,” Transactions of the 50th Orthopaedic Research Society, San Francisco, CA, 2004, 29, Paper no. 0335.

29. Tai, K. and C. Ortiz, “Ultrastructural and Nanomechanical Properties of Bovine Cortical Bone,” Transactions of the 50th Orthopaedic Research Society, San Francisco, CA, 2004, 29, Paper no. 0496.

28. Ng, L., Grodzinsky, A. J., Sandy, J., Plaas, A. and C. Ortiz, “Persistence Length of Cartilage Aggrecan Macromolecules Measured via Atomic Force Microscopy,” Macromolecular Symposia 214, 1-4, 2004.

27. Zhang, D. and C. Ortiz, “Synthesis and Single Molecule Force Spectroscopy of Graft Copolymers of Poly(2-hydroxyethyl methacrylate-g-ethylene glycol),” Macromolecules 37(11), 4271-4282, 2004. PDF

26. Seog, J., Dean, D., Frank, E., Ortiz, C. and A. J. Grodzinsky, “Preparation of End-Grafted Polyelectrolytes on Nanoscale Probe Tips Using an Electric Field,” Macromolecules 37(3), 1156-1158, 2004. PDF

25. Seog, Joonil, “Molecular Mechanics of Cartilage: Quantification of Glycosaminoglycan Electrostatic Interactions via High-Resolution Force Spectroscopy,” Ph.D. Thesis, Department of Materials Science and Engineering, Massachusetts Institute of Technology, June 2003 (Ortiz co-supervisor, Grodzinsky co-supervisor).

24. Wilkinson, D. Andrew, “Regulation of Single Integrin-Laminin Bond Force by Divalent Cations,” Bachelor’s Thesis, Department of Materials Science and Engineering, Massachusetts Institute of Technology, June 2003 (Ortiz co-supervisor, Gilbert co-supervisor).

23. Heersink, Sebastian, “Molecular Unfolding Patterns Exhibited by the Laminin G4-5 Dystroglycan-Binding Domain,” Bachelor’s Thesis, Department of Materials Science and Engineering, Massachusetts Institute of Technology, June 2003 (Ortiz co-supervisor, Gilbert co-supervisor).

22. Brodie, Kristin, “Studies of Poly(vinyl chloride)-Based Endotracheal Tubes from the Nano- to Macroscopic Scale,” Bachelor’s Thesis, Department of Materials Science and Engineering, Massachusetts Institute of Technology, May 2003 (Ortiz Supervisor).

21. Ng, L., Tai, K., Plaas, A., Grodzinsky, A. J. and C. Ortiz, “Ultrastructure and Nanomechanics of Biological Tissues: Cartilage and Bone,” American Chemical Society Division of Polymeric Materials: Science and Engineering, Polymer Preprints 88, 526-527, 2003.

20. Ng, L., Plaas, A., Ortiz, C. and A. J. Grodzinsky, “AFM Imaging of the Conformation And Interactions of Aggrecan, Hyaluronan, and Their Constituents,” Transactions of the 49th Orthopaedic Research Society, New Orleans, LA Feb 2-4, 2003, 28, Paper no. 0569.

19. Ng, L. J., Grodzinsky, A. J., Plaas, A., Sandy, J. and C. Ortiz, “Individual Cartilage Aggrecan Macromolecules and Their Constituent Glycosaminoglycans visualized via atomic force microscopy,” Journal of Structural Biology 143(3), 242-257, 2003 [Cover of Issue]. PDF Journal Cover PDF

18. Rixman, M. A., Dean, D. and C. Ortiz, “Nanoscale Intermolecular Interactions between Human Serum Albumin and Low Grafting Density Surfaces of Poly(ethylene oxide),” Langmuir 19(22), 9357-9372, 2003. PDF

17. Dean, D., Seog, J., Ortiz, C. and A. J. Grodzinsky, “Molecular Level Theoretical Model for Electrostatic Interactions within Polyelectrolyte Brushes: Applications to Charged Glycosaminoglycans,” Langmuir 19(13), 5526-5539, 2003. PDF

16. Rixman, M. A., Dean, D., Macias, C. and C. Ortiz, “Nanoscale Intermolecular Interactions Between Human Serum Albumin and Alkanethiol Self-Assembled Monolayers,” Langmuir 19(15), 6202-6218, 2003. PDF

15. Bras, Rafael, “Imaging of the World’s Fastest Biological Spring, Vorticella convallaria, via Atomic Force Microscopy,” Bachelor’s Thesis, Department of Materials Science and Engineering, Massachusetts Institute of Technology, June 2002 (Ortiz Supervisor).

14. Robbins, Elissa, “Design and Nanomechanical Testing of Molecular Springs using Biomimetic Modular Macromolecular Architectures Bachelor’s Thesis, Department of Materials Science and Engineering, Massachusetts Institute of Technology, June 2002 (Ortiz Supervisor).

13. Ng, L. J., Plaas, A., Grodzinsky, A. J. and C. Ortiz, “Structure, Conformation, and Self-Assembly of Cartilage Polyelectrolyte Macromolecules Studied via Atomic Force Microscopy,” Polymer Preprints (American Chemical Society, Division of Polymer Chemistry) 43(2), 388-389, Boston, MA, 2002.

12. Seog, J., Frank, E., Dean, D., Wong-Palms, S., Plaas, A.., Grodzinsky, A. J. and C. Ortiz,  “Measurement of  GAG-GAG Nano-Electromechanical Interactions Using High Resolution Force Spectroscopy,” Transactions of the 48th Orthopaedic Research Society, Dallas, TX, Feb 10-13 2002, 27, Paper no. 0060.

11. Dean, D., Seog, J., Ortiz, C. and A. J. Grodzinsky, “Nanomechanical Modeling of Electrostatic Forces Between Glycosaminoglycan Molecules,” Transactions of the 48th Orthopaedic Research Society, Dallas, TX, Feb 10-13, 2002, 27, Paper no. 0080.

10. Seog, J., Dean, D., Plaas, A., Wong-Palms, S., Grodzinsky, A. J. and C. Ortiz, “Direct Measurement of Glycosaminoglycan Intermolecular Interactions via High-Resolution Force Spectroscopy,” Macromolecules 35(14), 5601-5615, 2002. PDF

9. Jiang, X.-P., Ortiz, C. and P. Hammond, “Exploring the Rules for Selective Deposition: Interactions Between Model Polyamines on Acid and Oligoethylene oxide Surfaces,” Langmuir 18(4), 1131-1143, 2002. PDF

8. Ortiz, C. and G. Hadziioannou, “Force-Displacement Properties of Single Polymer Chains,” (Review Article) Encyclopedia of Materials: Science and Technology (EMSAT), 2001.

7. Seog, J., Dean, D., Plaas, A., Wong-Palms, S., Lee, I., Laibinis, P., Grodzinsky, A. J. and C. Ortiz, “Cartilage Molecular Mechanics: Detection of GAG Electrostatic Interactions By High-Resolution Force Spectroscopy,” Transactions of the 47th Orthopaedic Research Society, San Francisco, CA, Feb 25-28, 2001, 26, Paper no. 0055.

6. Ortiz, C., Belenky, L. Ober, C. K and E. J. Kramer, “Microdeformation of a Polydomain, Smectic Liquid Crystalline Thermoset,” Journal of Materials Science 35(8), 2079-2086, 2000. [Cover of Issue] PDF

5. Ortiz, C. and G. Hadziioannou, “Entropic Elasticity of Single Polymer Chains of Poly(methacrylic acid) Measured by Atomic Force Microscopy,” Macromolecules 32(3), 780-787, 1999. PDF

4. Ortiz, C., Kim, R., Rodiguiero, E., Ober, C. K., and E. J. Kramer, “Deformation of a Polydomain, Liquid Crystalline Epoxy-Based Thermoset,” Macromolecules 31(13), 4074-4088, 1998. PDF

3. Ortiz, C., Wagner, M.., Bhargava, N., Ober, C. K. and E. J. Kramer, “Deformation of a Polydomain, Smectic Liquid Crystalline Elastomer,” Macromolecules 31(24), 8531-8539, 1998. PDF

2. Ortiz, C., Ober, C. K. and E. J. Kramer, “Stress Relaxation of a Main-Chain, Smectic, Polydomain Liquid Crystalline Elastomer,” Polymer 39(16), 3713-3718, 1998. PDF

1. Ortiz, C., Kim, R., Rodiguiero, E., Ober, C. K., and E. J. Kramer, “Fracture of a Liquid Crystalline Epoxy-Based Thermoset,” Proceedings of the Deformation, Fracture and Rheology of Polymers Conference, Cambridge, UK, 1997.