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Linda Griffith's laboratory (M.I.T.)
attempts to understand and control cell interactions with surfaces with
a focus on applications in tissue engineering and cell culture. Projects
encompass two complementary areas: synthesis and modification of polymeric
materials, and characterization of cell and tissue responses to materials. |
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Rick
Horwitz's laboratory (University of Virginia) is actively investigating
many aspects of the structure and function of integrin molecules and
the processes they mediate. Recent progress includes elucidation of the
roles of several different integrins during (muscle) differentiation. |
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Roger Kamm's research
(M.I.T.) includes biomedical fluid dynamics such as repiratory mechanics,
ocular fluid dynamics and transport, and cardiovascular fluid dynamics.
Models of normal and pathologic conditions are used to elucidate mechanical
phenomena. |
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Bruce Tidor |
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Peter Sorger |
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Alan Wells'
laboratory researches growth factor receptor-mediated cell locomotion and
its consequences in physiologic and pathologic situations. The laboratory
is investigating motility signaling from the
epidermal growth factor receptor (EGFR) as our model system. |
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Steve Wiley's
research interests have focused on understanding mechanisms of cell communication
and signaling using the epidermal growth factor receptor (EGFR) system
as a model. He pioneered methods for the quantitative analysis of receptor
dynamics in mammalian cells and published some of the first computer models
of receptor regulation. He has been a major contributor to the field of
receptor research, particularly with regard to the control of receptor
distribution within cells. |
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Dane Wittrup's lab develops
protein engineering technology and applies it to the discovery of new biopharmaceuticals.
In particular, yeast surface display is used for the directed evolution
of protein expression stability, affinity, and specificity. A particular
focus is on the development of anti-cancer drugs, with quantitative studies
of cellular-level pharmacokinetics and pharmacodynamics. |
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Michael
Yaffe |
