"BIO" - BIOTECHNOLOGY AND BIOMEDICAL INNOVATIONS
		INFO BIO NANO MACRO ENVIRO Biotechnology at MIT Artificial Intelligence Laboratory Bio-Instrumentation Laboratory Biological Engineering Division Biotechnology Process Engineering Center Center for Biological and Computational Learning Center for Biomedical Engineering Harvard-MIT Division of Health Science and Technology McGovern Institute for Brain Research Whitehead Institute			A NEW TOOL FOR NON-INVASIVE TISSUE BIOPSY Peter So Department of Mechanical Engineering A traditional endoscope is well suited for detection and intervention of disease. However, using it for diagnosis is an invasive and time-consuming procedure involving the removal of bodily tissue. A new endoscope that could perform diagnoses non-invasively would revolutionize endoscopic procedures and create a profitable new market in medicine. This project’s goal is to develop a new kind of endoscope by integrating two-photon imaging. The new endoscope would allow 3D imaging of opaque tissue specimens with sub-cellular resolution and would permit rapid, noninvasive diagnosis of tissue pathology. While there are formidable technical challenges to incorporating a two-photon microscope module into an endoscope, they can be adequately met by the project team’s combined expertise in tissue optics, two-photon microscopy, meso-scale actuation, micro-optics assembly, and photonic bandgap fiber fabrication.
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