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2007 Spring |
20.213 DNA Damage and Genomic Instability |
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Recent progress has resulted in the identification of dozens of genes that, when mutated, promote tumorigenesis. However, it is not yet clear what causes these mutations. Subject analyzes the chemistry of DNA damaging agents, and continues with analysis of the mutagenic and toxic consequences of modifications to DNA structure. The contrasting perspective that normal DNA processing leads to mutations is also presented. The biochemistry and molecular mechanisms of DNA replication, DNA repair, and recombination form the foundation of the subject. B. P. Engelward , J. M. Essigmann, P. C. Dedon |
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2007 Summer |
Chulabhorn Graduate Institute: Applied Biological Sciences
Program |
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Research progress depends on applying the right technology and experimental approaches to the problem at hand. This course focuses on building up the experimental repertoire of students so that they are poised to maximally benefit from existing and emerging technologies. Students will learn in detail how cutting edge experiments are performed and how data is analyzed, with particular emphasis on controls and statistics. A broad range of techniques will be covered in the areas of molecular biology, biochemistry and genetics. Students will be empowered to independently create research plans that draw upon reliable sources of information to assure that the proposed approaches are appropriate, well described, and include foresight into potential problems and pitfalls. P. C. Dedon, B. P. Engelward, J. M. Essigmann, P. Mavasumrit. P. Ploypradith, R. Sasisekharan |
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2008 Spring |
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Introduces experimental biochemical and molecular techniques from a quantitative engineering perspective. Experimental design, rigorous data analysis, and scientific communication form the underpinnings of this subject. Discovery-based experimental modules focus on (1) DNA Engineering in which students design, construct, and use genetic material. (2) Parts Engineering which emphasizes protein design and quantitative assessment of protein performance. (3) System Engineering in which students consider genome-wide consequences of genetic perturbations. (4) Biomaterial Engineering in which students use biologically-encoded devices to design and build materials. Limited enrollment. Priority given to BE majors. B. P. Engelward, A, Jasanoff, N. Kuldell, A. Stachowiak |
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Copyright © 2006 The Engelward Lab All rights reserved. Website design Yoon Sung Nam |
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