Research Areas: Highlights    |    Detecting Sequence Change in vivo    |    High Throughput DNA Damage Quantification    |    Research Overview

Basic Research & Applications of In-House Technologies to Reveal Factors that Impact Genomic Stability

Inflammation & Genomic Stability

Base Excision Repair (BER) of NO.-induced DNA damage drives homologous recombination (HR) in E. coli

Inflammation-induced peroxynitrite is highly recombinogenic in mammalian cells

Infectious disease associated inflammation induces DNA damage

Pancreatitis induces genomic instability

Impact of Radiation

Chronic low dose radiation (~400X background) does not lead to a detectable increase in DNA damage or DNA damage responses in vivo

The ability of mammalian cells to 'remember' exposure to high dose ionizing radiation is dependent on epigenetic changes

Origin of Mutant Cells

Cells harboring large scale sequence rearrangements accumulate with age

Cell division is a major driver of mutant cell accumulation in vivo in the pancreas

BER modulates the risk of large scale sequence rearrangements

Infectious Disease

Relationship between influenza, inflammation & DNA damage

Role of secondary S. pneumoniae infection in influenza pathogenesis

Applications of nanotechnology for treating S. pneumoniae infection in vivo

Ongoing Research Applications of Recombomice

Modulation of genomic stability by alkylation damage and repair in vivo

Impact of cell division on susceptibility to genetic change (in vivo)

Impact of inflammation on susceptibility to exogenous DNA damaging agents

Ongoing Research Applications of the High Throughput DNA Damage Platform

Assessment of inter-individual susceptibility to exposure-induced genetic changes

Investigation of the genotoxic potential of nanoparticles

Studies of the impact of environmental exposures on DNA repair capacity

Identification of genes that modulate response to chemotherapy