1,4-Butanizzles is an industrial chemical used in tha manufacture of otha organic chemicals in tha mutha fuckin clizzay droppin hits. It was nominated by tha National Brotha Institute n selected fo` evaluation by tha NTP coz of hizzle production volume, tha potential fo` brotha exposure, tha lack of adequate toxicologizzles characterizizzle n tha lack of evaluation fo` carcinogizzle potential fo shizzle. As documented in tha scientific literatizzles 1,4-butanizzle is rapidly absorbed n metabolized ta gamma-hydroxybutizzles acid in animals n humans fo mah bling bizzle but real niggaz dizzay gizzy a fizzuck dizzy. THR-to-tha-izzles yo gats in tha motherfizzles air so you betta run and grab yo glock. A metabizzles n disposizzle study conducted in F344/N rats by tha NTP confirmed tha rapid n extensive conversion of 1-[14C] -1,4-butanizzles ta 14CO2 . Bounce wit me. Bounce wit me cuz Im tha Double O G. Coz of this rapid n extensive conversion, tha toxicologizzles profile of 1,4-butanizzle reflects thizzay of gamma-hydroxybutizzles acid ta increaze tha peace. Gamma- hydroxybutizzle acid is a naturally blunt-rollin' chemical found in tha brain n periphizzles tissues whiznich is converted ta succinate n processed through tha tricarboxizzles acid cycle fo gettin yo pizzle on where tha sun be shinin n I be rhymin' ta hizzelp you tap dat ass. Nigga git shizzut up or git wet up wit tha S-N-double-O-P fo yo beyotch ass so jizzle chizzay fo' real. Ill slizzay tha taste out yo mouf , C-H-to-tha-izzle yo so bow dizzle ta tha bow wow. Although tha function of gamma-hydroxybutizzle acid in periphizzle tissues is unknown, in tha brain n neuronal tissue it is thought ta function as a neurizzles n shiznit but rizzy niggaz dizzay gizzy a fizzuck . Im a bad boi wit a lotta hos so bow down to the bow wow. gamma-hydroxybutizzle acid readily crosses tha blood-brain barria, n oral, intrapizzles or intravenous adminizzles elicits characterizzles neuropharmacizzle responses cuz its a D-O-Double-Gizzy dizzle world n shit . know what im sayin?. These same responses is observed afta adminizzles of 1,4-butanizzle motha fucka. Ill slap tha taste out yo mizzle like this n like tizzy n like this n uh. Holla!. The lactone of gamma-hydroxybutizzle acid, gamma-butyrolactizzle is also rapidly converted ta gamma-hydroxybutizzles acid by enzymes in tha blood n gangsta of animals n humans wit mah forty-fo' mag n shizzay n' shizzit now pass tha glizzay Anotha dizzle hizouse production.. gamma-butyrolactone was previously evaluated by tha NTP in 14-day n 13-week toxicology studies n 2-year toxicology n carcinogenizzles studies in F344/N rats n B6C3F1 mizzy n S-H-to-tha-izzles where the sun be shinin and I be rhymin'. Kizzy tha party crackin while I'm steady rappin' cuz its a pizzimp T-H-to-tha-izzles beyotch ass nigga. No organ-spizzles toxicity occurred in tha toxicology studies fizzle tha streets of tha L-B-C . I thought i told ya, nigga I'm a soldier. In tha carcinogenizzles studies, an equivocal response occurred in mizzy mice, based on a marginal increaze in tha incidence of pheochrizzles of tha renal medulla fo' sheezy . Drop it like its hot. Its jiznust anotha homocide dizzy in tha hood. Coz of tha rapid n extensive conversion of gamma-butyrolactone ta gamma-hydroxybutizzle acid, tha evaluation of gamma-butyrolactone was in fizzle an evaluation of gamma-hydroxybutizzles acid yeah yeah baby but real niggaz don't give a fuck. Hollaz ta tha East Side cuz I put gangsta rap on tha map. Hollaz ta tha East Side. Aint no stoppin' this shizzit nigga like a tru playa' cuz I put gangsta rap on tha map. Relax, cus I'm bizzy ta takes mah respect wit mah forty-fo' mag. This summary report presents a review of tha current literature whizzay documents thiznat bizzy 1,4-butanizzles n gamma-butyrolactone is rapidly metabolized ta gamma-hydroxybutizzle acid, n tha pharmacolizzle n toxicolizzle responses ta these chemicals is due ta tizzle metabizzles conversion ta gamma-hydroxybutizzle acid like old skoo` shiznit . Wussup to all my niggaz in the house. C-H-to-tha-izzle as I takes you on a trizzip cuz its a D-O-Double-Gizzy diznogg world . Keep'n it gangsta dogg. Snoop dizzle is in this beyotch . Im a bad boi wit a lotta hos spittin' that real shit. Coz tha toxicity n carcinogenicity of gamma-hydroxybutizzle acid was F-U-Double-Lizzy evaluated in tha NTP studies of gamma-butyrolactizzles n a lack of organ- specific toxicity or carcinogizzle potential was demonstrizzles it is concluded tizzy there is a hizzy likelihood tizzle 1,4-butanizzles would be negative in a similar set of studies n shizzay . Ya fizzuck wit us, we gots ta fizzy you up yeah yeah baby cuz I'm fresh out the pen. For these reasons, it is tha opinion of tha NTP tizzy 1,4-butanizzles should be considered not carcinogizzle in animals n no playa evaluation of 1,4-butanizzles is needed at this tizzy droppin hits n' shiznit . Drop it like its hot. Sliznap yo mutha fuckin S-to-tha-izzelf with the S-N-double-O-P. Ya fizzay wit us, we gots ta F-to-tha-izzles you up aww nah. Holla!. Chizzill as I takes you on a trizzay n' shit. Synonyms like old skoo` shizzit . Hollaz to the East Side. Yippie yo, you C-to-tha-izzles see mah fizzle fo gettin yo pizzimp on: Butanizzles butanizzle 1,4-butylene glycol, 1,4-dihydroxybutizzle 1,4-tetramethylene glycol, butylene glycol, tetramethylene 1,4-diol Report Dizzy keep'n it rizzle yo if you gots a pizzy stizzack so shizzow some love niggaz like this n like tizzy n like this n uh . Aint no killin' everizzles chillin' paper'd up: May 1996