The focus of research in the White lab is the quantitative analysis of protein phosphorylation events regulating signal transduction cascades associated with cancer and other biological processes. With our mass spectrometry-based technology, analysis of protein phosphorylation occurs on a global scale, allowing for quantitative mapping of complex signal transduction cascades in a variety of biological samples. Currently, we are applying this technology to understand signaling processes regulating biological response to exogenous stimuli in a variety of cancer models systems. Although a significant amount of work will be done in human cell lines, we will also analyze signaling networks in tumors derived from mouse cancer models, with the eventual goal of analyzing staged human clinical samples. Elucidation of signal transduction cascades involved in oncogenesis, cancer progression, and metastasis will generate both novel drug targets and a host of biological markers, allowing for early diagnosis and tracking of cancer progression. A variety of other applications will be pursued, including mapping the phosphorylation events associated with development of Type I and Type II diabetes.

Recent Publications

Johnson H, Lescarbeau RS, Gutierrez JA, White FM. Phosphotyrosine Profiling of
NSCLC cells in Response to EGF and HGF Reveals Network Specific Mediators of
Invasion. J Proteome Res. 2013 Feb 26. PMID: 23438512.

Winter GE, Rix U, Carlson SM, Gleixner KV, Grebien F, Gridling M, Müller AC,
Breitwieser FP, Bilban M, Colinge J, Valent P, Bennett KL, White FM,
Superti-Furga G. Systems-pharmacology dissection of a drug synergy in
imatinib-resistant CML. Nat Chem Biol. 2012 Nov;8(11):905-12. PMID: 23023260.

Johnson H, Del Rosario AM, Bryson BD, Schroeder MA, Sarkaria JN, White FM.
Molecular characterization of EGFR and EGFRvIII signaling networks in human
glioblastoma tumor xenografts. Mol Cell Proteomics. 2012 Dec;11(12):1724-40. PMID: 22964225

Naegle KM, White FM, Lauffenburger DA, Yaffe MB. Robust co-regulation of
tyrosine phosphorylation sites on proteins reveals novel protein interactions.
Mol Biosyst. 2012 Oct;8(10):2771-82. PMID: 22851037

Bryson BD, White FM. Signaling for death: tyrosine phosphorylation in the
response to glucose deprivation. Mol Syst Biol. 2012 Jun 26;8:591. PMID: 22735337