Publications
2010
Nakatsu F.; Perera R. M.; Lucast L.; Zoncu R.; Domin J.; Gertler F. B.; Toomre D.; De Camilli P., The inositol 5-phosphatase SHIP2 regulates endocytic clathrin-coated pit dynamics. J Cell Biol 2010, 190 (3), 307-15.
Hao J. C.; Adler C. E.; Mebane L.; Gertler F. B.; Bargmann C. I.; Tessier-Lavigne M., The tripartite motif protein MADD-2 functions with the receptor UNC-40 (DCC) in Netrin-mediated axon attraction and branching. Dev Cell 2010, 18(6), 950-60.
Gupton S. L.; Gertler F. B., Integrin signaling switches the cytoskeletal and exocytic machinery that drives neuritogenesis. Dev Cell 2010, 18(5), 725-36. (DOI)
Worth D. C.; Hodivala-Dilke K.; Robinson S. D.; King S. J.; Morton P. E.; Gertler F. B.; Humphries M. J.; Parsons M., Alpha v beta3 integrin spatially regulates VASP and RIAM to control adhesion dynamics and migration. J Cell Biol 2010, 189 (2), 369-83.
2009
Meacham C. E.; Ho E. E.; Dubrovsky E.; Gertler F. B.; Hemann M. T., In vivo RNAi screening identifies regulators of actin dynamics as key determinants of lymphoma progression. Nat Genet 2009, 41 (10), 1133-7.
Sartoretto J. L.; Jin B. Y.; Bauer M.; Gertler F. B.; Liao R.; Michel T., Regulation of VASP phosphorylation in cardiac myocytes: differential regulation by cyclic nucleotides and modulation of protein expression in diabetic and hypertrophic heart. Am J Physiol Heart Circ Physiol 2009, 297 (5), H1697-710.
Menna E.; Disanza A.; Cagnoli C.; Schenk U.; Gelsomino G.; Frittoli E.; Hertzog M.; Offenhauser N.; Sawallisch C.; Kreienkamp H. J.; Gertler F. B.; Di Fiore P. P.; Scita G.; Matteoli M., Eps8 regulates axonal filopodia in hippocampal neurons in response to brain-derived neurotrophic factor (BDNF). PLoS Biol 2009, 7 (6), e1000138.
Bear J. E.; Gertler F.B., Ena/VASP: towards resolving a pointed controversy at the barbed end. J Cell Sci 2009, 122 (Pt 12), 1947-53. (DOI)
Neel N. F.; Barzik M.; Raman D.; Sobolik-Delmaire T.; Sai J.; Ham A. J.; Mernaugh R. L.; Gertler F. B.; Richmond A., VASP is a CXCR2-interacting protein that regulates CXCR2-mediated polarization and chemotaxis. J Cell Sci 2009, 122 (Pt 11), 1882-94.
Kwiatkowski A. V.; Garner C. C.; Nelson W. J.; Gertler F. B., Cell autonomous defects in cortical development revealed by two-color chimera analysis. Mol Cell Neurosci 2009, 41 (1), 44-50. (DOI)
Robinson, B. D.; Sica, G. L.; Liu Y. F.; Rohan T. E.; Gertler F. B.; Condeelis J. S.; Jones J. G., Tumor microenvironment of metastasis in human breast carcinoma: a potential prognostic marker linked to hematogeneous dissemination. Clin Cancer Res 2009, 15 (7), 2433-41.
Goswami, S.; Philippar, U.; Sun, D.; Patsialou, A.; Avraham, J.; Wang, W.; Di Modugno, F.; Nistico, P.; Gertler, F. B.; Condeelis, J. S., Identification of invasion specific splice variants of the cytoskeletal protein Mena present in mammary tumor cells during invasion in vivo. Clin Exp Metastasis 2009, 26 (2), 153-9.
2008
Philippar, U.; Roussos, E. T.; Oser, M.; Yamaguchi, H.; Kim, H. D.; Giampieri, S.; Wang, Y.; Goswami, S.; Wyckoff, J. B.; Lauffenburger, D. A.; Sahai, E.; Condeelis, J. S.; Gertler, F. B., A Mena invasion isoform potentiates EGF-induced carcinoma cell invasion and metastasis. Dev Cell 2008, 15 (6), 813-28. (DOI)
Pino, M. S.; Balsamo, M.; Di Modugno, F.; Mottolese, M.; Alessio, M.; Melucci, E.; Milella, M.; McConkey, D. J.; Philippar, U.; Gertler, F. B.; Natali, P. G.; Nistico, P., Human Mena+11a isoform serves as a marker of epithelial phenotype and sensitivity to epidermal growth factor receptor inhibition in human pancreatic cancer cell lines. Clin Cancer Res 2008, 14 (15), 4943-50.
Kim, H. D.; Guo, T. W.; Wu, A. P.; Wells, A.; Gertler, F. B.; Lauffenburger, D. A., Epidermal growth factor-induced enhancement of glioblastoma cell migration in 3D arises from an intrinsic increase in speed but an extrinsic matrix- and proteolysis-dependent increase in persistence. Mol Biol Cell 2008, 19 (10), 4249-59.
Drees, F.; Gertler, F. B., Ena/VASP: proteins at the tip of the nervous system. Curr Opin Neurobiol 2008, 18 (1), 53-9. (DOI)
2007
Dent, E. W.; Kwiatkowski, A. V.; Mebane, L. M.; Philippar, U.; Barzik, M.; Rubinson, D. A.; Gupton, S.; Van Veen, J. E.; Furman, C.; Zhang, J.; Alberts, A. S.; Mori, S.; Gertler, F. B., Filopodia are required for cortical neurite initiation. Nat Cell Biol 2007, 9 (12), 1347-59. (DOI)
Furman, C.; Sieminski, A. L.; Kwiatkowski, A. V.; Rubinson, D. A.; Vasile, E.; Bronson, R. T.; Fassler, R.; Gertler, F. B., Ena/VASP is required for endothelial barrier function in vivo. J Cell Biol 2007, 179 (4), 761-75. (DOI)
Kwiatkowski, A. V.; Rubinson, D. A.; Dent, E. W.; Edward van Veen, J.; Leslie, J. D.; Zhang, J.; Mebane, L. M.; Philippar, U.; Pinheiro, E. M.; Burds, A. A.; Bronson, R. T.; Mori, S.; Fassler, R.; Gertler, F. B., Ena/VASP Is Required for neuritogenesis in the developing cortex. Neuron 2007, 56 (3), 441-55. (DOI)
Lacayo, C. I.; Pincus, Z.; VanDuijn, M. M.; Wilson, C. A.; Fletcher, D. A.; Gertler, F. B.; Mogilner, A.; Theriot, J. A., Emergence of large-scale cell morphology and movement from local actin filament growth dynamics. PLoS Biol 2007, 5 (9), e233.
Gupton, S. L.; Gertler, F. B., Filopodia: the fingers that do the walking. Sci STKE 2007, 2007 (400), re5.
Dwivedy, A.; Gertler, F. B.; Miller, J.; Holt, C. E.; Lebrand, C., Ena/VASP function in retinal axons is required for terminal arborization but not pathway navigation. Development 2007, 134 (11), 2137-46. (DOI)
Gates, J.; Mahaffey, J. P.; Rogers, S. L.; Emerson, M.; Rogers, E. M.; Sottile, S. L.; Van Vactor, D.; Gertler, F. B.; Peifer, M., Enabled plays key roles in embryonic epithelial morphogenesis in Drosophila. Development 2007, 134 (11), 2027-39.
Applewhite, D. A.; Barzik, M.; Kojima, S.; Svitkina, T. M.; Gertler, F. B.; Borisy, G. G., Ena/VASP proteins have an anti-capping independent function in filopodia formation. Mol Biol Cell 2007, 18 (7), 2579-91.
Evans, I. R.; Renne, T.; Gertler, F. B.; Nobes, C. D., Ena/VASP proteins mediate repulsion from ephrin ligands. J Cell Sci 2007, 120 (Pt 2), 289-98.
2006
Pinheiro, E. M.; Gertler, F. B., Nervous Rac: DOCK7 regulation of axon formation. Neuron 2006, 51 (6), 674-6. (DOI)
Kovacs, E. M.; Makar, R. S.; Gertler, F. B., Tuba stimulates intracellular N-WASP-dependent actin assembly. J Cell Sci 2006, 119 (Pt 13), 2715-26. (DOI)
Chang, C.; Adler, C. E.; Krause, M.; Clark, S. G.; Gertler, F. B.; Tessier-Lavigne, M.; Bargmann, C. I., MIG-10/lamellipodin and AGE-1/PI3K promote axon guidance and outgrowth in response to slit and netrin. Curr Biol 2006, 16 (9), 854-62.
Scott, J. A.; Shewan, A. M.; den Elzen, N. R.; Loureiro, J. J.; Gertler, F. B.; Yap, A. S., Ena/VASP proteins can regulate distinct modes of actin organization at cadherin-adhesive contacts. Mol Biol Cell 2006, 17 (3), 1085-95.
2005
Barzik, M.; Kotova, T. I.; Higgs, H. N.; Hazelwood, L.; Hanein, D.; Gertler, F. B.; Schafer, D. A., Ena/VASP proteins enhance actin polymerization in the presence of barbed end capping proteins. J Biol Chem 2005, 280 (31), 28653-62.
Bierne, H.; Miki, H.; Innocenti, M.; Scita, G.; Gertler, F. B.; Takenawa, T.; Cossart, P., WASP-related proteins, Abi1 and Ena/VASP are required for Listeria invasion induced by the Met receptor. J Cell Sci 2005, 118 (Pt 7), 1537-47.
2004
Lafuente, E. M.; van Puijenbroek, A. A.; Krause, M.; Carman, C. V.; Freeman, G. J.; Berezovskaya, A.; Constantine, E.; Springer, T. A.; Gertler, F. B.; Boussiotis, V. A., RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion. Dev Cell 2004, 7 (4), 585-95.
Krause, M.; Leslie, J. D.; Stewart, M.; Lafuente, E. M.; Valderrama, F.; Jagannathan, R.; Strasser, G. A.; Rubinson, D. A.; Liu, H.; Way, M.; Yaffe, M. B.; Boussiotis, V. A.; Gertler, F. B., Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics. Dev Cell 2004, 7 (4), 571-83. (DOI)
Menzies, A. S.; Aszodi, A.; Williams, S. E.; Pfeifer, A.; Wehman, A. M.; Goh, K. L.; Mason, C. A.; Fassler, R.; Gertler, F. B., Mena and vasodilator-stimulated phosphoprotein are required for multiple actin-dependent processes that shape the vertebrate nervous system. J Neurosci 2004, 24 (37), 8029-38. (DOI)
Mejillano, M. R.; Kojima, S.; Applewhite, D. A.; Gertler, F. B.; Svitkina, T. M.; Borisy, G. G., Lamellipodial versus filopodial mode of the actin nanomachinery: pivotal role of the filament barbed end. Cell 2004, 118 (3), 363-73.
Strasser, G. A.; Rahim, N. A.; VanderWaal, K. E.; Gertler, F. B.; Lanier, L. M., Arp2/3 is a negative regulator of growth cone translocation. Neuron 2004, 43 (1), 81-94.
Lebrand, C.; Dent, E. W.; Strasser, G. A.; Lanier, L. M.; Krause, M.; Svitkina, T. M.; Borisy, G. G.; Gertler, F. B., Critical role of Ena/VASP proteins for filopodia formation in neurons and in function downstream of netrin-1. Neuron 2004, 42 (1), 37-49. (DOI)
Ally, S.; Sauer, N. J.; Loureiro, J. J.; Snapper, S. B.; Gertler, F. B.; Goldberg, M. B., Shigella interactions with the actin cytoskeleton in the absence of Ena/VASP family proteins. Cell Microbiol 2004, 6 (4), 355-66.
Boukhelifa, M.; Parast, M. M.; Bear, J. E.; Gertler, F. B.; Otey, C. A., Palladin is a novel binding partner for Ena/VASP family members. Cell Motil Cytoskeleton 2004, 58 (1), 17-29.
2003
Krause, M.; Dent, E. W.; Bear, J. E.; Loureiro, J. J.; Gertler, F. B., Ena/VASP proteins: regulators of the actin cytoskeleton and cell migration. Annu Rev Cell Dev Biol 2003, 19, 541-64. (DOI)
Dent, E. W.; Gertler, F. B., Cytoskeletal dynamics and transport in growth cone motility and axon guidance. Neuron 2003, 40 (2), 209-27. (DOI)
Salazar, M. A.; Kwiatkowski, A. V.; Pellegrini, L.; Cestra, G.; Butler, M. H.; Rossman, K. L.; Serna, D. M.; Sondek, J.; Gertler, F. B.; De Camilli, P., Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton. J Biol Chem 2003, 278 (49), 49031-43.
Auerbuch, V.; Loureiro, J. J.; Gertler, F. B.; Theriot, J. A.; Portnoy, D. A., Ena/VASP proteins contribute to Listeria monocytogenes pathogenesis by controlling temporal and spatial persistence of bacterial actin-based motility. Mol Microbiol 2003, 49 (5), 1361-75.
Kwiatkowski, A. V.; Gertler, F. B.; Loureiro, J. J., Function and regulation of Ena/VASP proteins. Trends Cell Biol 2003, 13 (7), 386-92.
Bladt, F.; Aippersbach, E.; Gelkop, S.; Strasser, G. A.; Nash, P.; Tafuri, A.; Gertler, F. B.; Pawson, T., The murine Nck SH2/SH3 adaptors are important for the development of mesoderm-derived embryonic structures and for regulating the cellular actin network. Mol Cell Biol 2003, 23 (13), 4586-97.
Apostol, B. L.; Kazantsev, A.; Raffioni, S.; Illes, K.; Pallos, J.; Bodai, L.; Slepko, N.; Bear, J. E.; Gertler, F. B.; Hersch, S.; Housman, D. E.; Marsh, J. L.; Thompson, L. M., A cell-based assay for aggregation inhibitors as therapeutics of polyglutamine-repeat disease and validation in Drosophila. Proc Natl Acad Sci U S A 2003, 100 (10), 5950-5.
Rubinson, D. A.; Dillon, C. P.; Kwiatkowski, A. V.; Sievers, C.; Yang, L.; Kopinja, J.; Rooney, D. L.; Zhang, M.; Ihrig, M. M.; McManus, M. T.; Gertler, F. B.; Scott, M. L.; Van Parijs, L., A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference. Nat Genet 2003, 33 (3), 401-6.
Hoffman, L. M.; Nix, D. A.; Benson, B.; Boot-Hanford, R.; Gustafsson, E.; Jamora, C.; Menzies, A. S.; Goh, K. L.; Jensen, C. C.; Gertler, F. B.; Fuchs, E.; Fassler, R.; Beckerle, M. C., Targeted disruption of the murine zyxin gene. Mol Cell Biol 2003, 23 (1), 70-9.
2002
Krause, M.; Bear, J. E.; Loureiro, J. J.; Gertler, F. B., The Ena/VASP enigma. J Cell Sci 2002, 115 (Pt 24), 4721-6. (DOI)
Loureiro, J. J.; Rubinson, D. A.; Bear, J. E.; Baltus, G. A.; Kwiatkowski, A. V.; Gertler, F. B., Critical roles of phosphorylation and actin binding motifs, but not the central proline-rich region, for Ena/vasodilator-stimulated phosphoprotein (VASP) function during cell migration. Mol Biol Cell 2002, 13 (7), 2533-46. (DOI)
Geese, M.; Loureiro, J. J.; Bear, J. E.; Wehland, J.; Gertler, F. B.; Sechi, A. S., Contribution of Ena/VASP proteins to intracellular motility of listeria requires phosphorylation and proline-rich core but not F-actin binding or multimerization. Mol Biol Cell 2002, 13 (7), 2383-96.
Bear, J. E.; Svitkina, T. M.; Krause, M.; Schafer, D. A.; Loureiro, J. J.; Strasser, G. A.; Maly, I. V.; Chaga, O. Y.; Cooper, J. A.; Borisy, G. G.; Gertler, F. B., Antagonism between Ena/VASP proteins and actin filament capping regulates fibroblast motility. Cell 2002, 109 (4), 509-21. (DOI)
Goh, K. L.; Cai, L.; Cepko, C. L.; Gertler, F. B., Ena/VASP proteins regulate cortical neuronal positioning. Curr Biol 2002, 12 (7), 565-9. (DOI)
Kazantsev, A.; Walker, H. A.; Slepko, N.; Bear, J. E.; Preisinger, E.; Steffan, J. S.; Zhu, Y. Z.; Gertler, F. B.; Housman, D. E.; Marsh, J. L.; Thompson, L. M., A bivalent Huntingtin binding peptide suppresses polyglutamine aggregation and pathogenesis in Drosophila. Nat Genet 2002, 30 (4), 367-76.
2001
Nash, P.; Tang, X.; Orlicky, S.; Chen, Q.; Gertler, F. B.; Mendenhall, M. D.; Sicheri, F.; Pawson, T.; Tyers, M., Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication. Nature 2001, 414 (6863), 514-21.
Bear, J. E.; Krause, M.; Gertler, F. B., Regulating cellular actin assembly. Curr Opin Cell Biol 2001, 13 (2), 158-66. (DOI)
2000
Lanier, L. M.; Gertler, F. B., Actin cytoskeleton: thinking globally, actin' locally. Curr Biol 2000, 10 (18), R655-7. (DOI)
Lambrechts, A.; Kwiatkowski, A. V.; Lanier, L. M.; Bear, J. E.; Vandekerckhove, J.; Ampe, C.; Gertler, F. B., cAMP-dependent protein kinase phosphorylation of EVL, a Mena/VASP relative, regulates its interaction with actin and SH3 domains. J Biol Chem 2000, 275 (46), 36143-51. (DOI)
Zukerberg, L. R.; Patrick, G. N.; Nikolic, M.; Humbert, S.; Wu, C. L.; Lanier, L. M.; Gertler, F. B.; Vidal, M.; Van Etten, R. A.; Tsai, L. H., Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth. Neuron 2000, 26 (3), 633-46.
Bear, J. E.; Loureiro, J. J.; Libova, I.; Fassler, R.; Wehland, J.; Gertler, F. B., Negative regulation of fibroblast motility by Ena/VASP proteins. Cell 2000, 101 (7), 717-28. (DOI)
Krause, M.; Sechi, A. S.; Konradt, M.; Monner, D.; Gertler, F. B.; Wehland, J., Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton. J Cell Biol 2000, 149 (1), 181-94.
Lanier, L. M.; Gertler, F. B., From Abl to actin: Abl tyrosine kinase and associated proteins in growth cone motility. Curr Opin Neurobiol 2000, 10 (1), 80-7. (DOI)
1990 - 1999
Howell, B. W.; Lanier, L. M.; Frank, R.; Gertler, F. B.; Cooper, J. A., The disabled 1 phosphotyrosine-binding domain binds to the internalization signals of transmembrane glycoproteins and to phospholipids. Mol Cell Biol 1999, 19 (7), 5179-88.
Laurent, V.; Loisel, T. P.; Harbeck, B.; Wehman, A.; Grobe, L.; Jockusch, B. M.; Wehland, J.; Gertler, F. B.; Carlier, M. F., Role of proteins of the Ena/VASP family in actin-based motility of Listeria monocytogenes. J Cell Biol 1999, 144 (6), 1245-58.
Lanier, L. M.; Gates, M. A.; Witke, W.; Menzies, A. S.; Wehman, A. M.; Macklis, J. D.; Kwiatkowski, D.; Soriano, P.; Gertler, F. B., Mena is required for neurulation and commissure formation. Neuron 1999, 22 (2), 313-25.
Niebuhr, K.; Ebel, F.; Frank, R.; Reinhard, M.; Domann, E.; Carl, U. D.; Walter, U.; Gertler, F. B.; Wehland, J.; Chakraborty, T., A novel proline-rich motif present in ActA of Listeria monocytogenes and cytoskeletal proteins is the ligand for the EVH1 domain, a protein module present in the Ena/VASP family. EMBO J 1997, 16 (17), 5433-44.
Howell, B. W.; Gertler, F. B.; Cooper, J. A., Mouse disabled (mDab1): a Src binding protein implicated in neuronal development. EMBO J 1997, 16 (1), 121-32.
Gertler, F. B.; Niebuhr, K.; Reinhard, M.; Wehland, J.; Soriano, P., Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics. Cell 1996, 87 (2), 227-39.
Gertler, F. B.; Comer, A. R.; Juang, J. L.; Ahern, S. M.; Clark, M. J.; Liebl, E. C.; Hoffmann, F. M., enabled, a dosage-sensitive suppressor of mutations in the Drosophila Abl tyrosine kinase, encodes an Abl substrate with SH3 domain-binding properties. Genes Dev 1995, 9 (5), 521-33.
Gertler, F. B.; Hill, K. K.; Clark, M. J.; Hoffmann, F. M., Dosage-sensitive modifiers of Drosophila abl tyrosine kinase function: prospero, a regulator of axonal outgrowth, and disabled, a novel tyrosine kinase substrate. Genes Dev 1993, 7 (3), 441-53.
Henkemeyer, M.; West, S. R.; Gertler, F. B.; Hoffmann, F. M., A novel tyrosine kinase-independent function of Drosophila abl correlates with proper subcellular localization. Cell 1990, 63 (5), 949-60.
Gertler, F. B.; Doctor, J. S.; Hoffmann, F. M., Genetic suppression of mutations in the Drosophila abl proto-oncogene homolog. Science 1990, 248 (4957), 857-60.
1987 - 1989
Gertler, F. B.; Bennett, R. L.; Clark, M. J.; Hoffmann, F. M., Drosophila abl tyrosine kinase in embryonic CNS axons: a role in axonogenesis is revealed through dosage-sensitive interactions with disabled. Cell 1989, 58 (1), 103-13.
Gertler, F. B.; Chiu, C. Y.; Richter-Mann, L.; Chin, D. J., Developmental and metabolic regulation of the Drosophila melanogaster 3-hydroxy-3-methylglutaryl coenzyme A reductase. Mol Cell Biol 1988, 8 (7), 2713-21.
Henkemeyer, M. J.; Bennett, R. L.; Gertler, F. B.; Hoffmann, F. M., DNA sequence, structure, and tyrosine kinase activity of the Drosophila melanogaster Abelson proto-oncogene homolog. Mol Cell Biol 1988, 8 (2), 843-53.
Henkemeyer, M. J.; Gertler, F. B.; Goodman, W.; Hoffmann, F. M., The Drosophila Abelson proto-oncogene homolog: identification of mutant alleles that have pleiotropic effects late in development. Cell 1987, 51 (5), 821-8.
