Here are the most frequent email tasks, and shortcuts for navigating your mailbox with the keyboard instead of the mouse:
Press F9, click the Send/Receive button in the toolbar, or choose Actions->Send/Receive.
Press N to jump to the next unread message. P goes to the previous unread message. Use the arrow keys to move up and down along the list of all message.
Press the space bar to go a page down. Press Backspace to go a page up.
To reply to the sender of the message only: click Reply in the toolbar, or press Ctrl+R
To reply to the sender and all the other visible recipients of the message, click Reply to All or select the message and press Shift+Ctrl+R
Select the message or messages you want to forward, and click Forward in the toolbar, or press Ctrl+F
Double-click the message you want to view, or select it and press Ctrl+O
Right-click on a message and select Create Rule From Message. You can also create filters and virtual folders in the Tools menu.
Right-click on a message and select Add Sender to Address Book. You can also right-click on any email address to add it to your address book.