Ming-Wei Chao, Ph.D.
Massachusetts Institute of Technology
Department of Biological Engineering
77 Massachusetts Avenue
Cambridge, MA 02139
Dr. Chao earned his Bachelor of Science degree in Department of Agricultural Chemistry at National Taiwan University, Taiwan, in 2002. In 2009, he received his PhD from Dr. Marion Gordon’s lab at the Joint Graduate Program of Toxicology, Rutgers University. He joined Dr. Wogan's research group as a postdoctoral associate in October 2009.
Dr. Chao was appointed as a scientist with the necessary background in molecular biology and genetics that also demonstrated interests in applying research to important human health problems. In his PhD thesis research he sought to identify possible mechanisms through which nanoparticles in diesel exhaust penetrate into the lumen of capillaries and activate the generation of atherogenesis. His findings identified the mechanisms underlying increased re-distribution of adherent junctional proteins and secretion of endothelial cytokines caused by acute diesel exhaust exposure, which represent significant potential risk factors for cardiovascular disorders. His pre-doctoral training and experience was in an outstanding laboratory, in which he employed experimental approaches of direct relevance to his current work.
The specific projects on which Dr. Chao is currently working concern genetic and cellular damage caused by exposure to monocyclic aromatic amines, namely several dimethylanilines (DMA) and their metabolites in Chinese hamster ovary (CHO) cells. Although aromatic amines such as 4-aminobiphenyl are well-documented risk factors for bladder cancer, little is known about the genotoxicity and potential carcinogenic risk created by DMA exposure. Dr. Chao is currently investigating mechanisms responsible for the induction of cytotoxicity and APRT mutagenicity in nuclear excision repair (NER) proficient and NER deficient CHO cells. To date he has extensively characterized DNA damage, mutagenesis, and the production of reactive oxygen species (ROS) in this system.
Chao M-W, Po IP, Laumbach R, Kozlosky J, Cooper K, Gordon MK. DEP Induction of ROS in Capillary-like EndothelialTubes Leads to VEGF-A Expression. Toxicology (Submitted, In Revision).
Chao M-W, Kozlosky J, Po IP, Ohman-Strickland P, Svoboda K, Cooper K, Laumbach R, Gordon MK. Diesel Exhaust Particle Exposure Causes Redistribution of Endothelial Tube VE-Cadherin. Toxicology, 279: 73-84, 2011.
Chao M-W, Kozlosky J, Po IP, Gerecke DR, Svoboda K, Laumbach R, Gordon MK. In Vitro Capillary Endothelial Tubes as A Model System To Study Cytotoxicity of Diesel Particles. FASEB J., 23: 639.1, 2009.
Chao M-W, Po IP, Kozlosky J, Gerecke DR, Laumbach R, Svoboda K, Gordon, MK. Capillary Endothelial Tubes Lose Cell Junctional Integrity snd Apoptose In Response To Diesel Exhaust Particles. FASEB J. 22: 524.8, 2008.
Deng W-P, Chao M-W, Lai W-F, Sun C, Chung C-Y, Wu C-C, Lin I-H, Hwang J-J, Wu C-H, Chiu W-T, Chen C-Y and Redpath J-L. Correction Of Malignant Behavior Of Tumor Cells By Traditional Chinese Herb Medicine Through A Restoration of p53. Cancer Lett. 233(2): 315-327, 2006.
Lin C-P, Chen Y-J, Lee Y-L, Wang J-S, Chang M-C, Lan W-H, Chang H-H, Chao W M-W, Tai T-F, Lee M-Y, Lin B-R and Jeng J-H. Effects Of Root-end Filling Materials And Eugenol On Mitochondrial Dehydrogenase Activity And Cytotoxicity To Human Periodontal Ligament Fibroblasts. J Biomed Mater Res B Appl Biomater, 71(2): 429-440, 2004.