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Rajdeep ChowduryRajdeep Chowdury, Ph.D.

Postdoctoral Associate

Massachusetts Institute of Technology
Department of Biological Engineering
77 Massachusetts Avenue
Room 56-654
Cambridge, MA 02139

Phone: 617-253-6752
Fax: 617-324-5698
E-mail: rajdeep2@mit.edu

Dr. Chowdhury earned his bachelor’s degree in Zoology with Molecular Biology as allied subject from Calcutta University, India, in 1999. In 2001, he completed his master’s degree from Calcutta University in Zoology with specialization in Endocrinology. Then in 2003, he qualified the National Eligibility Test (CSIR, Govt. of India) to be eligible for government scholarship to pursue his doctoral research. He received his Ph.D. in 2009, under the guidance of Dr. Keya Chaudhuri, from the Molecular & Human Genetics Department, Indian Institute of Chemical Biology, Kolkata, with significant contributions in the field of Molecular Biology and Toxicology. He joined Dr. Wogan's research group as a postdoctoral associate in June, 2009.

Research Interests

In his Ph.D. research, Dr. Chowdhury formulated an effective protective regimen to arsenic toxicity; the research findings were of considerable public health impact considering the millions exposed in India & Bangladesh to groundwater arsenic contamination. The antidote attenuated arsenic toxicity by chelating it from biological systems. The spectrum of his research also included demonstration of carcinogenic potential of arsenic by analysis of gene expression profiles in arsenic-exposed human subjects by microarray analysis; a novel bio-marker for arsenic toxicity was identified. He also made significant contributions in understanding the paradoxical role of arsenic in cancer therapeutics. Following his expertise in toxicology and cancer molecular biology, Dr. Chowdhury presently is working on analyzing the pleiotropic effects of nitric oxide (NO) in diverse cellular tumor micro-environments. He is in the process of characterization of NO-induced molecular events and post-translational protein modifications that can lead tumor cells to become refractory to chemotherapy facilitating cancer progression.

Selected Publications

Arsenic Induced Cell Proliferation is Associated with Enhanced ROS Generation, Erk Signaling and CyclinA Expression. Chowdhury R, Chatterjee R, Giri KA and Chaudhuri K. Toxicology Letters. 2010 Oct; Vol 198(2):263-71.

Arsenic Toxicity Amelioration: A Review. Chowdhury R, Das B and Chaudhuri K. Symposium proceedings book, "Proceedings of 14th All India Congress of Cytology and Genetics (AICCG)" (to be published in Dec. 2010).

Expression of metallothionein-1 (MT-1) mRNA in the rat testes and liver after cadmium injection. Mukhopadhyay D, Mitra A, Nandi P, Chowdhury R, Chaudhuri K and Bhattacharya A. Sys Bio Reprod Med, 2009; Dec. Vol 55(5-6): pp188-92.

Garlic, a Promising Antidote to Heavy Metal Toxicity. Chowdhury R and Chaudhuri K. Book Chapter in Nova Science, USA (2009) https://www.novapublishers.com/catalog/product_info.php?products_id=10118.

Arsenic induced apoptosis in malignant melanoma cells is enhanced by menadione through ROS generation, p38 signaling and p53 activation. Chowdhury R, Chowdhury S, Mandal C and Chaudhuri K. Apoptosis, 2009; 14(1): pp 108-23.

Isolation and Characterization of an arsenic resistant bacterium from a bore-well in West Bengal, India. Chowdhury R, Sen KA, Karak P, Giri KA and Chaudhuri K. Annals of Microbiology, 2009; Vol 59 (2): pp 1-6.

In vitro and in vivo reduction of sodium arsenite induced toxicity by aqueous garlic extract. Chowdhury R, Dutta A, Giri  AK and Chaudhuri K. Food and Chemical Toxicology, 2008; Vol 46(2): pp 740-51.

Chronic exposure to arsenic at low concentration has toxic effect in human but short term exposure in vitro induces apoptosis. Chowdhury R, Roychoudhury P and Chaudhuri K. Icfai Journal of Biotech, 2008; Vol II (3): pp 7-23.

Genetic landscape of the people of India: a canvas for disease gene exploration. Journal of Genetics, 2008; Vol 87: pp 3-20. – One of the authors in the manuscript & project with contributions in SNP discovery, validation and analysis.

Comparison of health effects between individuals with and without skin lesions in the population exposed to arsenic through drinking water in West Bengal, India; Ghosh P, Banerjee M, De Chaudhuri S, Chowdhury R and Giri AK. Journal of Exposure Science and Environmental Epidemiology, 2007; Vol 17: pp 215–223.

Novel glycoconjugates of diospyrin, a quinonoid plant product: synthesis and evaluation of cytotoxicity against human malignant melanoma (A375) and laryngeal carcinoma (Hep2). Das Sarma M,Ghosh R, Chowdhury R,Chaudhuri Kand Hazra B. Organic & Biomolecular Chemistry, 2007; Vol 5: pp 3115-3125.

HnRNPE2 is downregulated in human oral cancer cells and the overexpression of hnRNPE2 induces apoptosis. Roychoudhury P, Paul R, Chowdhury R and Chaudhuri K. Molecular Carcinogenesis, 2006; Vol 46: pp 198-207.

The Indian Genome Variation database (IGVdb): a project overview. Human Genetics, 2005; Vol 118: pp 1-11. One of the authors in the manuscript & project with contributions in SNP discovery, validation and analysis
 

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