 Luiz C. Godoy, Ph.D.
Postdoctoral Associate
Massachusetts Institute of Technology
Department of Biological Engineering
77 Massachusetts Avenue
Room 56-654
Cambridge, MA 02139
Phone: 617-253-9619
Fax: 617-258-8676
E-mail: lcgodoy@mit.edu
Dr. Godoy earned his bachelor's degree in Biological Sciences from the Federal University of São Carlos, Brazil, in 1997. In 2003, he obtained his PhD in Microbiology and Immunology at the Federal University of São Paulo. Since then, Dr. Godoy has held postdoctoral appointments in the University of São Paulo Medical School (2003-2005) and the University of Massachusetts Medical School (2005-2008). He joined Dr. Wogan's research group as a postdoctoral associate in March 2008.
Research Interests and Goals
Dr. Luiz Godoy has a strong background in immunology, having worked extensively on a murine model of immune response to a tropical systemic mycosis during his PhD thesis research . While presently working in the USA, Dr. Godoy still collaborates with Brazilian researchers in the investigation of physiopathological aspects of B-1 cells in immunity and other biological systems. During his postdoctoral experience, he has studied the involvement of nitric oxide in cell signaling in several contexts. At the University of Sao Paulo, he characterized the S-nitrosation-mediated regulatory property of nitric oxide in signaling initiated by the molecule CD40, with important implications for the fate of inflammation in pathological conditions such as sepsis. The peroxynitrite-dependent effects of nitric oxide were the object of his research at the University of Massachusetts, leading to the finding of a mechanism of resistance to oxidative stress in which the nuclear translocation of cytochrome c plays an important role. Currently, Luiz Godoy is investigating regulatory properties of nitric oxide in mechanisms controlling growth and resistance to chemotherapeutic agents in human melanoma cells.
Selected Publications
Godoy LC, Muñoz-Pinedo C, Castro L, Cardaci S, Schonhoff CM, King M, Tórtora V, Marín M, Miao Q, Jiang JF, Kapralov A, Jemmerson R, Silkstone GG, Patel JN, Evans JE, Wilson MT, Green DR, Kagan VE, Radi R, Mannick JB. Disruption of the M80-Fe ligation stimulates the translocation of cytochrome c to the cytoplasm and nucleus in nonapoptotic cells. Proc Natl Acad Sci USA, 106(8): 2653-2658, 2009.
Popi, AF, Godoy, LC, Xander, P, Lopes, JD, Mariano, M. B-1 cells facilitate Paracoccidioides brasiliensis infection in mice via IL-10 secretion. Microbes and Infection, v. 10, p. 817-824, 2008.
Lorenzo, BHP, Brito, RRN, Godoy, LC, Lopes, JD, Mariano, M. Tolerogenic property of B-1b cells in a model of allergic reaction.. Immunology Letters, 114(2): 110-118, 2007.
Brito, RRN, Lorenzo, BHP, Xander, P, Godoy, LC, Lopes, JD, Silva, NP, Sampaio, SC, Mariano, M. Role of distinct immune components in the radiation-induced abrogation of systemic lupus erythematosus development in mice.. Lupus (Basingstoke), v. 16, p. 947-954, 2007.
Godoy, LC, Mariano, M, Lopes, JD. Immunity and hypersensitivity to gp43 in susceptible and resistant mice infected with Paracoccidioides brasiliensis. Medical Mycology, v. 41, n. 5, p. 427-436, 2003.
Vigna, AFG, Godoy, LC, Almeida, SR, Mariano, M, Lopes, JD. Characterization of B1-b cells as antigen presenting cells in the immune response to gp43 from Paracoccidioides brasiliensis in vitro. Immunology Letters, v. 83, p. 61-66, 2002.
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