Min-Young Kim, Ph.D.

Research Associate

Massachusetts Institute of Technology
Department of Biological Engineering
77 Massachusetts Avenue
Room 56-654
Cambridge, MA 02139

Phone: 617-253-6752
Fax: 617-258-8676
E-mail: jeffmkim@mit.edu

Dr. Kim earned a bachelor's degree in molecular biology from the Konkuk University (1996). He received an MS in environmental public health (1998) and a PhD in Toxicology (2002) from Seoul National University. He joined Dr. Wogan's research group as a postdoctoral associate in October 2002. He was promoted to the position of Research Associate in December, 2007.

Research Interests

Prior to joining Dr. Wogan's research group, Dr. Kim studied toxicity and pharmacological activities of newly-developed therapeutics and other chemicals by various in vivo or in vitro methods in The Republic of Korea. He also assessed potential toxicological interactions of mixtures administered by inhalation. In the Wogan lab, he has defined ONOO- induced mutation spectra in plasmids exposed instantaneously to large, bolus doses of ONOO-, and compared them with spectra induced by hydroxyl radical and singlet oxygen. Modulating effects of CO2 on ONOO-induced spectra were characterized and a high level of concordance between DNA damage sites and loci of mutations was defined. Current work is designed to characterized mutation spectra induced by exposure of plasmids and cultured human cells to ONOO- by slow perfusion and decomposition of SIN-1. Mutation spectra will be compared with DNA damage sites in collaboration with the Dedon and Tannenbaum groups, and the combined information will provide further guidance for investigations of chemical lesions responsible for specific mutations. Future work will involve studies of mutagenesis induced in vivo in transgenic gpt delta mice by chronic inflammation associated with development of colon cancer.

Selected Publications

Kim, M.Y, Zhou, Z., Delaney, J.C., Taghizadeh, K., Dedon, P.C., Essigmann, J.M., and Wogan, G.N. AlkB influences the chloroacetaldehyde-induced mutation spectra and toxicity in the pSP189 supF shuttle vector. Chem. Res. Toxicol. 20:1075-1083, 2007.

Kim, MY, N. Tretyakova and Wogan, G.N. Mutagenesis of the supF gene by stereoisomers of 1,2,3,4-diepoxybutane Chemical Res. Toxicol 20:790-797, 2007.

Kim, M.Y and G.N. Wogan. Mutagenesis of the supF Gene of pSP189 Replicating in AD293 Cells Co-cultivated with Activated Macrophages: Roles of Nitric Oxide and Reactive Oxygen Species. Chemical Res. Toxicol., 19: 1483-1491, 2006.

Kim, M.Y., Dong, M., Dedon, P.C. and G. N. Wogan. Effects of peroxynitrite dose and dose-rate onDNA damage and mutation in the supF shuttle vector. Chem. Res. Toxicol. 18(1): 76-86, 2005.

Kim, M.Y., Yoo, G.Y., Yoo, W.H., Choi, J.H., Bae, M.O., Kim, J.S., Kim, H.W., Moon, S.H., Kim, J.H., Han, K.T. Chae, C.H., Kim, M.S. and Cho, M.H. 4-Week inhalation toxicity, mutagenicity and immunotoxicity studies of Keum-Yeon-Cho (NosmoQ), tobacco substitute composition, in mice. Environmental Toxicology and Pharmacology, 13: 37-46, 2003.
 
Kim, M.Y., Kim, Y.C. and Cho, M.H. Combined treatment of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone and dibutyl phthalate enhanced ozone-induced genotoxic effects in B6C3F1 mice. Mutagenesis, 17(4): 331-336, 2002.
 
Kim, M.Y., Son, J.W., Choi, C.S., Chae, C., Lee, M.H. and Cho, M.H. Oviductural adenocarcinoma was observed in B6C3F1 female mice exposed to 0.5 ppm ozone. Veterinary and Human Toxicology, 43(6): 370-372, 2001.

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