Engineered tissues could be potentially useful in treating diseased tissues and organs, and are often used as models to test drug candidates. Native tissues have complex architectures, containing various cell types with different spatial arrangements and hence, replicating such complexity requires the knowledge and application of various engineering principles. Tissue engineering holds an important role to create biomimetic tissue constructs by using different methods. In my PhD studies, I developed first generation of dynamic microstructures in tissue engineering by microengineering stimuli-responsive polymers and utilized these tools to spatially and geometrically control multicellular organizations for replicating in vivo conditions.
It has been challenging to study human
genetics of wide range of human neurological diseases in vitro due to
lack of in vitro tissue models. It still remains a challenge to produce
in vitro neural circuits which can closely mimic the 3D cellular and
molecular complexity of the brain. In my postdoctoral studies I
focus on utilizing tissue engineering techniques to develop biomimetic
human neuronal tissues and merge CRISPR/Cas9 tools to study human
neurological disease mechanisms.