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RNAi
Microsponges RNA interference (RNAi) is powerful way for suppressing gene expression. In the gene silencing process by RNAi, double-stranded RNA (dsRNA) is processed to small interfering RNAs (siRNAs), which can mediate the cleavage of complementary target mRNA. Although siRNA mediated-gene silencing has been developed significantly, safe and effective intracellular delivery must be addressed to realize the full potential of siRNA therapeutics. Nucleic acids (DNA and RNA) have emerged as versatile
polymers that can be utilized
as a building block to build precisely controlled
structures. With their
biologically relevant functionality, self-assembled DNA
or RNA structures are
able to function as therapeutic agents for cancer
treatment, viral infection
and genetic diseases. Therefore, RNA particles encoding
the sequences of small
interfering RNAs (siRNAs) or micro RNAs (miRNAs) have
great potential for RNA interference with precise
control over the shape, size
and composition. In the same passion of RNA particle,
DNA particles can also be
employed for gene or oligodeoxynucleotide (ODN)
delivery. These rationally
designed platforms make use of the particles for
efficient drug delivery.
References
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