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Layer-by-layer Nanoparticle
Combination Therapies Targeted to Ovarian Tumors
Multiple Drug Delivery LbL techniques allow for the design of nanoparticles capable of scheduled multiple-drug delivery. The layered architecture of our nanoparticles allows for each payload to be localized within a specific layer, allowing for a spatial segregation of drug within the delivery vehicle. This spatial segregation translates to temporally distinct release of the individual payloads at the target site, allowing us to effectively schedule the delivery of multiple drugs to improve their efficacy. Control of Surface Properties The terminal layer of our nanoparticles can bestow specific properties to aid in tumor targeting and biocompatibility. Nanoparticles can be made to have a hydrophilic stealth layer that sheds in the tumor microenvironment, thereby preventing drug release except in the vicinity of a tumor. Additionally, surface layers can present ligands or receptors that could target membrane proteins known to characterize ovarian cancer cells.
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