 |
 |
||||||||
 |
  |
 |
 |
 |
 |
 |
 |
||
   |
      |
Microwell Arrays For High Resolution Assay of Rare Cells in a Complex Cell Mixture
Microfabrication tools have been widely used to create microenviroments
to culture and study a large variety of cell types. These
microenviroments are usually tiny wells built on an adherent substrate
where cells can be sorted and physically isolated from each other. Using
this technique one can study individual cell behavior, cell-cell
communication, migration and many other facets of cell biology. I work
in a multidisciplinary project co-advised by Prof. Paula Hammond and
Prof. Linda Griffith to create microenviroments that will allow us to
parse and study rare cells in complex populations, such as progenitor
cells from aspirated bone marrow. Another facet of our work is to study
human endometrial cells to understand the mechanism that leads to one of
the most painful and somewhat unknown women’s disease
called endometriosis, where cells from the peritoneal cavity migrate to
other tissues in the women’s body causing a lot of pain, and in some
cases infertility. By using our microfabrication tools, we aim to be
able to isolate and study endometrial cells in order to understand what
leads these cells to invade other tissues and develop lesions. |
 |
||||||
