Interested applicants should contact Professor Hammond directly at hammond(at)mit.edu
Postdoctoral Openings – Microneedle Array Technologies for Vaccines
1) MIT-Singapore SMART Program: The P.T. Hammond research labs at MIT, in collaboration with the D.J. Irvine lab, have developed multilayer thin films that can release DNA from the surfaces of microneedles. Here we hope to expand the utility of this work to a new area of transdermal RNA and/or DNA vaccines against tropical disease. We seek to investigate these systems with the ultimate intent of developing promising systems that can be translated to meaningful clinical applications. A new program sponsored by the Singapore-MIT Alliance will involve the establishment of these approaches at the SMART Infectious Disease CREATE center in Singapore, and in collaboration with the Duke-NUS program and the Novartis Infectious and Tropical Disease Center located in Singapore. The research will involve new and potentially revolutionary approaches to the delivery of vaccines to address infectious disease using transdermal delivery of nucleic acids. Work will also include collaboration or interaction with collaborators to do animal studies in humanized mouse models. The position requires a highly motivated and independent researcher with strong biomaterials background, cell culture and biological laboratory know-how and the ability to work collaboratively and manage interactions with faculty and a broad range of senior and junior research collaborators. Interested parties must be willing to live and work in Singapore throughout the project period.
2) Ragon Institute Postdoctoral Position: As a part of our long-standing collaboration with the Irvine group at MIT, the Hammond and Irvine research groups are seeking to continue examination of a range of protein and DNA encapsulation methods in microneedles for their use in vaccines. Of particular interest are investigations of the application of these systems for AIDS, and as well as other key diseases, as part of the objectives of the MIT-Harvard-MGH RAGON Institute. The postdoctoral associate would be joint between the two research labs, and would focus on the use of a range of different polymers and assembly methods to achieve vaccines that are adaptable and yield results competitive with or better than those achieved using adenovirus or other viral vectors. Research work would be located at the Koch Institute in the research laboratories of the investigators. Applicants should have a strong background in biomaterials applications and some capability in cell culture and other standard biological assays and methods.