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Polymeric Nanocarriers For Controlled Delivery
Polymeric micelles are attractive delivery carriers for a variety of
payloads, such as cancer therapeutics and imaging agents. These micelles
are expected to increase the accumulation of guest molecules in tumor
tissues through either passive targeting or active targeting. To
effectively target the tumor tissues, the micelles must retain their
integrity during in vivo circulation in order to accumulate at targeted
sites. However, most of the current systems, such as Pluronic, PEG-PCL
and PEG-PLGA, lack kinetic stability and dissociate rapidly after
intravenous injection. My research focus is to use chemical and
supramolecular approaches to enhance the stability of micelles based on
poly(ethylene glycol)-b-poly(amino acid)s and achieve tunable and
sustained drug release profile. |
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