Massachusetts Institute of Technology Massachusetts Institute of Technology
Department of Chemical Engineering

The Hatton Group

Jie Wu
Post-doctoral Associate

Chemical Engineering, MIT
77 Massachusetts Avenue, 66-325
Cambridge, MA 02139-4703


Ph.D. in Organic Chemistry, Boston University, 2012
Thesis title: “Total Synthesis of (−)-Virginiamycin M2 and Chiral Organosilane Based Sequential Transformations to Access Polycyclic Scaffolds”
Thesis Advisor: Prof. James S. Panek

B.S. in Chemistry, Beijing Normal University, P.R. China, 2006
Advisor: Prof. Zhanbin Zhang and Prof. Ying Cheng

Research Summary:
Carbon dioxide capture and conversion using catalytic methods


1. Wu, J.; Yang, X.-Q.; He, Z.; Mao, X. -W.; Hatton, T. A.; Jamison, T. F. “Continuous Flow Synthesis of Ketones from Carbon Dioxide and Organolithium or Grignard Reagents” Angew. Chem. Int. Ed. 2014, 53, in press, DOI: 10.1002/anie.201405014.

2. Yang, X.-Q.; Wu, J.; Jamison, T. F.; Hatton, T. A. “Microwave Assisted Synthesis of Cyclocarbonates from Olefins with Sodium Bicarbonates as the C1 Source” Chem. Commun. 2014, 50, 3245-3248.

3. Wu, J.; Kozak, J. A.; Simeon, F.; Hatton, T. A.; Jamison, T. F. “Mechanism-Guided Design of Flow Systems for Multicomponent Reactions: Conversion of CO2 and Olefins to Cyclic Carbonates” Chem. Sci. 2014, 5, 1227-1231.

4. Kozak, J. A.*; Wu, J.*; Su, X.; Simeon, F.; Hatton, T. A.; Jamison, T. F. “Bromine-Catalyzed Conversion of CO2 and Epoxides to Cyclic Carbonates under Continuous Flow Conditions” J. Am. Chem. Soc. 2013, 135, 18497-18501. (*Co-first author)

5. Wu, J.; Pu, Y.; Panek, J. S. “Divergent Synthesis of Functionalized Carbocycles through Organosilane-Directed Asymmetric Alkyne-Alkene Reductive Coupling and Annulation Sequence” J. Am. Chem. Soc. 2012, 134, 18440-18446.

6. Wu, J.; Zhu, K.; Yuan, P.; Panek, J. S. “Bifunctional Homoallylic Carbamates from Chiral Silane Additions to in Situ Generated N-Acyl Iminium Ions” Org. Lett. 2012, 14, 3624-3627.

7. Wu, J.; Panek, J. S. “Total Synthesis of (-)-Virginiamycin M2: Application of Crotylsilanes Accessed by Enantioselective Rh(II) or Cu(I) Promoted Carbenoid Si-H Insertion” J. Org. Chem. 2011, 76, 9900-9918.

8. Wu, J.; Becerril, J.; Lian, Y.; Davies, H. M. L.; Porco, J. A. Jr.; Panek, J. S. “Sequential Transformations to Access Polycyclic Chemotypes: Asymmetric Crotylation and Metal Carbenoid Reactions” Angew. Chem. Int. Ed. 2011, 50, 5938-5942.

9. Wu, J.; Panek, J. S. “Total Synthesis of (-)-Virginiamycin M2” Angew. Chem. Int. Ed. 2010, 49, 6165-6168.

10. Wu, J.; Chen, Y.; Panek, J. S. “Vinylogous Aldol Products from Chiral Crotylsilanes Obtained by Enantioselective Rh(II) and Cu(I) Carbenoid Si-H Insertion” Org. Lett. 2010, 12, 2112-2115.





The Hatton Group, 77 Mass. Ave, Rm 66-309, Cambridge, MA 02139 | Phone: 617.253.4588 | Updated: July 10, 2014