Massachusetts Institute of Technology Massachusetts Institute of Technology
Department of Chemical Engineering

The Hatton Group

Jie Wu
Post-doctoral Associate

Chemical Engineering, MIT
77 Massachusetts Avenue, 66-325
Cambridge, MA 02139-4703


Ph.D. in Organic Chemistry, Boston University, 2012
Thesis title: “Total Synthesis of (−)-Virginiamycin M2 and Chiral Organosilane Based Sequential Transformations to Access Polycyclic Scaffolds”
Thesis Advisor: Prof. James S. Panek

B.S. in Chemistry, Beijing Normal University, P.R. China, 2006
Advisor: Prof. Zhanbin Zhang and Prof. Ying Cheng

Research Summary:
Carbon dioxide capture and conversion using catalytic methods


1. “Vinylogous Aldol Products from Chiral Crotylsilanes Obtained by Enantioselective Rh(II) and Cu(I) Carbenoid Si-H Insertion” Wu, J.; Chen, Y.; Panek, J. S. Org. Lett. (2010), 12, 2112-2115.

2. “Total Synthesis of (-)-Virginiamycin M2” Wu, J.; Panek, J. S. Angew. Chem. 2010, 122, 6301-6304; Angew. Chem. Int. Ed. (2010), 49, 6165-6168.

3. “Sequential Transformations to Access Polycyclic Chemotypes: Asymmetric Crotylation and Metal Carbenoid Reactions” Wu, J.; Becerril, J.; Lian, Y.; Davies, H. M. L.; Porco, J. A. Jr.; Panek, J. S. Angew. Chem. Int. Ed. (2011), 50, 5938-5942.

4. “Total Synthesis of (-)-Virginiamycin M2: Application of Crotylsilanes Accessed by Enantioselective Rh(II) or Cu(I) Promoted Carbenoid Si-H Insertion” Wu, J.; Panek, J. S. J. Org. Chem. (2011), 76, 9900-9918 (Featured Article).

5. “Bifunctional Homoallylic Carbamates from Chiral Silane Additions to in Situ Generated N-Acyl Iminium Ions” Wu, J.; Zhu, K.; Yuan, P.; Panek, J. S. Org. Lett. (2012), 14, 3624-3627.

6. “Divergent Synthesis of Functionalized Carbocycles through Organosilane-Directed Asymmetric Alkyne-Alkene Reductive Coupling and Annulation Sequence” Wu, J.; Pu, Y.; Panek, J. S. J. Am. Chem. Soc. (2012), 134, 18440-18446.




The Hatton Group, 77 Mass. Ave, Rm 66-309, Cambridge, MA 02139 | Phone: 617.253.4588 | Updated: September 23, 2013