Hilary Finucane

I am no longer maintaining this website. Please visit my new website: www.finucanelab.org.

Email: firstname lastinitial@mit.edu

I am a Broad Fellow at the Broad Institute. My research group develops and applies new statistical and computational methods for analyzing biological data. Our main focus is on integrating genetic data about disease with molecular data about cell types and biological processes to learn about the causes of disease. Our new website is coming soon.

In June 2017, I completed my PhD in applied math at Department of Mathematics at MIT. My research was in statistical genetics, and I was advised by Alkes Price at the Harvard School of Public Health. I was supported by a Hertz Foundation Fellowship. I also hold a MSc in theoretical computer science from the Weizmann Institute of Science and a BA in math from Harvard.


Statistical Genetics and Computational Biology
Mathematics and Computer Science

Statistical Genetics and Computational Biology

Selected publications and preprints

Hilary Finucane, Yakir Reshef, Verneri Anttila, Kamil Slowkowski, Alexander Gusev, et al.
Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types
bioRxiv, 2017.

Hilary Finucane*, Brendan Bulik-Sullivan*, Alexander Gusev, Gosia Trynka, Yakir Reshef, et al. (* = co-first)
Partitioning heritability by functional category using GWAS summary statistics
Nature Genetics, 2015.

Brendan Bulik-Sullivan*, Hilary Finucane*, Verneri Anttila, Alexander Gusev, Felix Day, et al. (* = co-first)
An atlas of genetic correlations across human diseases and traits
Nature Genetics, 2015.

Other preprints

Steven Gazal, Hilary Finucane, Nicholas Furlotte, Po-Ru Loh, Pier Palamara, et al.
Linkage disequilibrium dependent architecture of human complex traits reveals action of negative selection.
bioRxiv, 2017.

Luke O'Connor, Alexander Gusev, Xuanyao Liu, Po-Ru Loh, Hilary Finucane, Alkes Price
Estimating the proportion of disease heritability mediated by gene expression levels.
bioRxiv, 2017.

Gaurav Bhatia, Nicholas A Furlotte, Po-Ru Loh, Xuanyao Liu, Hilary Finucane, et al.
Correcting subtle stratification in summary association statistics.
bioRxiv, 2016.

Alexander Gusev, Nick Mancuso, Hilary Finucane, Yakir Reshef, Lingyun Song, et al.
Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights.
bioRxiv, 2016.

Verneri Anttila, Brendan Bulik-Sullivan, Hilary Finucane, Jose Bras, Laramie Duncan, et al.
Analysis of shared heritability in common disorders of the brain.
bioRxiv, 2016.

Gaurav Bhatia, Alexander Gusev, Po-Ru Loh, Hilary Finucane, Bjarni J Vilhjalmsson, et al.
Subtle stratification confounds estimates of heritability from rare variants.
bioRxiv, 2016.

Other publications

Felix Day, Deborah Thompson, Hannes Helgason, Daniel Chasman, Hilary Finucane, et al.
Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk.
Nature Genetics, 2017.

Xuanyao Liu, Hilary Finucane, Alexander Gusev, Gaurav Bhatia, Steven Gazal, et al.
Functional Architectures of Local and Distal Regulation of Gene Expression in Multiple Human Tissues.
American Journal of Human Genetics, 2017.

Jie Zheng, A. Mesut Erzurumluoglu, Benjamin Elsworth, ..., Hilary Finucane, et al.
LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis.
Bioinformatics, 2017.

Po-Ru Loh, Petr Danecek, Pier Francesco Palamara, Christian Fuchsberger, Yakir A Reshef, Hilary Finucane, et al.
Reference-based phasing using the Haplotype Reference Consortium panel.
Nature Genetics, 2016.

Jennie Pouget, Vanessa Goncalves, Schizophrenia Working Group of the Pyschiatric Genomics Consortium, Sarah Spain, Hilary Finucane, et al.
Genome-Wide Association Studies Suggest Limited Immune Gene Enrichment in Schizophrenia Compared to 5 Autoimmune Diseases.
Schizophrenia Bulletin, 2016.

Pier Palamara, Laurent Francioli, Peter Wilton, Giulio Genovese, Alexander Gusev, Hilary Finucane, et al.
Leveraging Distant Relatedness to Quantify Human Mutation and Gene-Conversion Rates.
American Journal of Human Genetics, 2015.

Felix Day, Brendan Bulik-Sullivan, David Hinds, Hilary Finucane*, Joanne Murabito, et al.
Shared genetic aetiology of puberty timing between sexes and with health-related outcomes.
Nature Communications, 2015.

Po-Ru Loh, Gaurav Bhatia, Alexander Gusev, Hilary Finucane, Brendan Bulik-Sullivan, et al.
Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance-components analysis
Nature Genetics, 2015.

Brendan Bulik-Sullivan, Po-Ru Loh, Hilary Finucane, Stephan Ripke, Jian Yang, et al.
LD Score Regression Distinguishes Confounding from Polygenicity in Genome-Wide Association Studies
Nature Genetics, 2015.

Po-Ru Loh, George Tucker, Brendan Bulik-Sullivan, Bjarni Vilhjálmsson, Hilary Finucane, et al.
Efficient Bayesian mixed model analysis increases association power in large cohorts
Nature Genetics, 2015.

F Day, KS Ruth, DJ Thompson, KL Lunetta, N Pervjakova, ..., Hilary Finucane, et al.
Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair
Nature Genetics, 2015.

Felix Day, Brendan Bulik-Sullivan, D Hinds, Hilary Finucane, J Murabito et al.
Shared genetic aetiology of puberty timing between sexes and with health-related outcomes
Nature Communications, 2015.

Bjarni Vilhjálmsson, Jian Yang, Hilary Finucane, Alexander Gusev, Sara Lindström, et al.
Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores
American Journal of Human Genetics, 2015.

Pier Francesco Palamara, Laurent Francioli, Giulio Genovese, Peter Wilton, Alexander Gusev, Hilary Finucane, et al.
Leveraging distant relatedness to quantify human mutation and gene conversion rates
American Journal of Human Genetics, 2015.

Alexander Gusev, S. Hong Lee, Gosia Trynka, Hilary Finucane, Bjarni Vilhjálmsson, et al.
Partitioning Heritability of Regulatory and Cell-Type-Specific Variants across 11 Common Diseases
American Journal of Human Genetics 2014.

Bonnie Kirkpatrick, Yakir Reshef, Hilary Finucane, Haitao Jiang, Binhai Zhu, and Richard Karp
Comparing pedigree graphs
Journal of Computational Biology, September 2012.

David Reshef*, Yakir Reshef*, Hilary Finucane, Sharon Grossman, Gilean McVean, et al. (* = co-first)
Detecting novel associations in large datasets
Science, December 2011

Mathematics and theoretical computer science

(Note: all author lists are alphabetical by last name in these fields.)

[[Itai Benjamini, Hilary Finucane, and Romain Tessera]]
On the scaling limit of finite vertex transitive graphs with large diameter
Combinatorica, 2017.

[[Hilary Finucane, Omer Tamuz, and Yariv Yaari]]
Scenery reconstruction on finite abelian groups
Stochastic Processes and their Applications, 2014.

[[Hilary Finucane, Ron Peled, and Yariv Yaari]]
A recursive construction of t-wise uniform permutations
Random Structures and Algorithms, 2013.

[[Itai Benjamini, Hilary Finucane, and Romain Tessera]]
Algebraically recurrent random walks on groups
Electronic Communications in Probability 18, 2013.

Hilary Finucane
Finite Voronoi decompositions of infinite vertex transitive graphs
Journal of Topology and Analysis 5(02), 2013.

[[Hilary Finucane and Michael Mitzenmacher]]
An improved analysis of the lossy difference aggregator
SIGCOMM Computer Communication Review, April 2010.

[[Flavio Chierichetti, Hilary Finucane, Zhenming Liu, and Michael Mitzenmacher]]
Designing floating codes for expected performance
IEEE Transactions on Information Theory, March 2010.

[[Hilary Finucane and Michael Mitzenmacher ]]
Worst-case and average-case floating codes for flash memory
My undergraduate thesis, completed in April 2009.