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1979-1977-Prior to 1976
2012
Anderson, C., Zhou, S., Sawin, E., Horvitz, H.R., Hurwitz M.E. (2012)
SLI-1 Cbl inhibits the engulfment of apoptotic cells in C. elegans through a ligase-independent function PLoS Genet. 8(12):e1003115.
Emtage, L., Aziz-Zaman, S., Padovan-Merhar, O., Horvitz, H.R., Fang-Yen, C. and Ringstad, N. (2012)
IRK-1 potassium channels mediate peptidergic inhibition of Caenorhabditis elegans serotonin neurons via a dedicated Go signaling pathway J. Neuroscience 32, 16285-16295.
Gurel, G., Gustafson, M., Pepper, J., Horvitz, H.R. and Koelle, M. (2012)
Receptors and other signaling proteins required for serotonin control of locomotion in C. elegans. Genetics, Sept. 28, 112.142125
Klees, E. and Horvitz, H.R. (2012)
Biomedical Consulting Agreements – The Good, the Bad and the Ugly. Science Careers, Oct. 12, 10.1126/science.caredit.a1200114.
Klees, E. and Horvitz, H.R. (2012)
Biomedical Consulting Agreements: A Guide for Academics. The MIT Press.
Ma, L., Gau, X., Luo, J., Huang, L., Teng, Y. and Horvitz, H.R. (2012)
Caenorhabditis elegans gene mfap-1 encodes a nuclear protein that affects alternative splicing. PLoS Genetics, 8(7):e1002827.
Denning, D., Hatch, V. and Horvitz, H.R. (2012)
Programmed elimination of cells by caspase-independent cell extrusion in C. elegans. Nature 488, 226-230.
Omura, D., Clark, D., Samuel, A. and Horvitz, H.R. (2012)
Dopamine signalling is essential for precise rates of locomotion by C. elegans. PLoS One 7(6):e38649.
Boulias K and Horvitz H.R. (2012)
The C. elegans MicroRNA mir-71 Acts in Neurons to Promote Germline-Mediated Longevity through Regulation of DAF-16/FOXO. Cell Metab. 15, 439-50.
Ma, D.K., Vozdek, R., Bhatla, N. and Horvitz, H.R. (2012)
CYSL-1 Interacts with the O2-sensing Hydroxylase EGL-9 to Promote H2S-modulated Hypoxia-induced Behavioral Plasticity in C. elegans. Neuron 73, 925-40.
2011
Hallem, E., Spencer, W.C., McWhirter, R., Zeller, G., Henz, S., Ratsch, G., Miller, D., Horvitz, H.R., Sternberg, P. and Ringstad, N. (2011)
A receptor-type guanylate cyclase is required for carbon dioxide sensation by C. elegans. PNAS 108, 254-259.
Galvin, B., Denning, D. and Horvitz, H.R. (2011)
SPK-1, an SR protein kinase, inhibits programmed cell death in C. elegans. PNAS 108, 1998-2003.
Korzelius, J., The, I., Ruijtenberg, S., Portegijs, V., Xu, H., Horvitz, H.R. and S. van den Heuvel. (2011)
C. elegans MCM-4 is a general replication and checkpoint component with an epidermis-specific requirement for growth and viability. Devel. Biol. 350, 358-369.
Davison, E., Saffer, A., Huang, L., DeModena, J., Sternberg, P., and Horvitz, H.R. (2011)
The LIN-15A and LIN-56 transcriptional regulators interact to negatively regulate EGF/Ras signaling in Caenorhabditis elegans vulval cell-fate determination. Genetics 187, 803-815.
Tabuchi, T., Deplancke, B., Osato, N., Zhu, L., Barrasa, I., Harrison, M., Horvitz, H.R., Walhout, A. and Hagstrom, K. (2011)
Chromosome-biased binding and gene regulation by the Caenorhabditis elegans DRM complex. PLoS Genet. 7, e1002074.
Harris, D. and Horvitz, H.R. (2011)
MAB-10/NAB acts with LIN-29/EGR to regulate terminal differentiation and the transition from larva to adult in C. elegans. Development 138, 4051-4062.
Ma, L., Tan, Z., Teng, Y., Hoersch, S. and Horvitz, H.R. (2011)
In vivo effects on intron retention and exon skipping by the U2AF large subunit and SF1/BBP in the nematode Canenorhabditis elegans. RNA 17, 2201-11.
Saffer, A., Kim, D.H., van Oudenaarden, A., and Horvitz, H.R. (2011)
The C. elegans synthetic multivulva genes prevent Ras activation by tightly repressing global ectopic expression of lin-3 EGF. PLoS Genet. 7, e1002418.
Nakano, S., Stillman, B. and Horvitz, H.R. (2011)
Replication-coupled chromatin assembly generates a bilateral asymmetry. Cell 147, 1525-36.
2010
Alvarez-Saavedra, E. and Horvitz, H.R. (2010)
Many families of Caenorhabditis elegans microRNAs are not essential for development and viability. Current Biology 20, 367-373
Hirose, T., Galvin, B. and Horvitz, H.R. (2010)
Six and Eya promote apoptosis through direct transcriptional activation of the pro-apoptotic BH3-only gene egl-1 in C. elegans. PNAS 107, 15479-15484.
Berdichevsky, A., Nedelcu, S., Boulias, K., Bishop, N., Guarente, L. and Horvitz, H.R. (2010)
3-ketoacyl thiolase delays aging in C. elegans and is required for metabolic changes and longevity mediated by sir-2.1. PNAS 107, 18927-18932.
Nakano, S., Ellis, R. and Horvitz, H.R. (2010)
Otx-dependent expression of proneural bHLH genes establishes a nervous system bilateral asymmetry. Develop. 137, 4017-4027.
2009
Kwiatkowski T., Jr., Bosco, D., LeClerc, A., Tamrazian, E.,Van den Berg, C., Russ, C., Davis, A., Gilchrist, J., Kasarskis, E., Munsat, T., Rouleau, G., Hosler, B., Cortelli, P., de Jong, P., Yoshinaga, Haines, J., Pericak-Vance, M., Yan, J., Siddique, T., McKenna-Yasek, D., Sapp, P., Horvitz, H.R., Landers, J. and Brown, R., Jr.(2009)
Mutations in the FUS/TLS gene on chromosome cause familial amyotrophic lateral sclerosis. Science 323, 1205-1208
Simpson, C., Lemmens, R., Broom, W., Hansen, V., Landers, J., Sapp, P., Van Den Bosch, L., Knight, J., Neale, B., Tripathi, V., Shah, M., Turner, M., Proitsi, P., Van Hoecke, A., Carmeliet, P., Horvitz, H.R., Leigh, N., Shaw, C., Sham, P., Powell, J., Brown, R., Robberecht, W., and Al-Chalabi, A. (2009)
Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration. Human Molec. Genetics 18, 472-481.
Landers, J., Melki, J., Meininger, V., Glass, H., Van den Berg, L., van Es, M., Sapp, P., van Vught, P., McKenna-Yasek, D., Blauw, H., Cho, T.-J., Polak, M., Shi, L., Wills, A.-M., Broom, W., Ticozzi, N., Ozoguz, A., Rodriquez, I., Veldink, J., Ivinson, A., Saris, C., Hosler, B., Barnes-Nessa, A., Couture, N., Wokke, J., Kwiatkowski, T., Ophoff, R., Cronin, S., Hardiman, O., Diekstra, F., Leigh, P., Shaw, C., Simpson, C., Hansen, V., Powell, J., Corcia, P., Salachas, F., Heath, S., Galen, P., Georges, F., Horvitz, H.R., Lathrop, M., Purcell, S., Al-Chalabi, Al and Brown, R. (2009)
Reduced expression of the kinesin-associated protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis. PNAS 106, 9004-9009.
Jospin, M., Qi, Y., Stawicki, T., Boulin, T., Schuske, K., Horvitz, H.R., Bessereau, J.-L., Jorgensen, E. and Jin, Y. (2009)
A neuronal acetylcholine receptor regulates the balance of muscle excitation and inhibition in Caenorhabditis elegans. PLoS Biology 7, e1000265.
Ma, L., Horvitz H.R. (2009) Mutations in the Caenorhabditis elegans U2AF large subunit UAF-1 alter the choice of a 3' splice site in vivo. PLoS Genet. 2009 Nov;5(11).
Ringstad N., Abe N., Horvitz H.R. (2009) Ligand-gated chloride channels are receptors for biogenic amines in C. elegans. Science. 2009 Jul 3;325(5936):96-100.
Hurwitz M.E., Vanderzalm P.J., Bloom L., Goldman J., Garriga G., Horvitz H.R. (2009) Abl kinase inhibits the engulfment of apoptotic cells in Caenorhabditis elegans. PLoS Biol. 2009 Apr 28;7(4).
Vanderzalm P.J., Pandey A., Hurwitz M.E., Bloom L., Horvitz H.R., Garriga G. (2009) C. elegans CARMIL negatively regulates UNC-73/Trio function during neuronal development. Development. 2009 Apr;136(7):1201-10.
Yu H., Seah A., Herman M.A., Ferguson E.L., Horvitz H.R., Sternberg P.W. (2009) Wnt and EGF pathways act together to induce C. elegans male hook development. Dev Biol. 2009 Mar 15;327(2):419-32.
2008
Choi, P., Zakhary, L., Choi, W.-Y., Caron, S., Alvarez-Saavedra, E., Miska, E., McManus, M., Harfe, B., Giraldez, A., Horvitz, H.R., Schier, A. and Dulac, C. (2008)
Members of the miRNA-200 family regulate olfactory neurogenesis. Neuron. 57, 41-55.
Ringstad, N and Horvitz, H.R. (2008) FMRFamide neuropeptides and acetylcholine synergistically inhibit egg-laying by C. elegans. Nat. Neurosci. 11(10): 1168-76.
Andersen, E.C., Saffer, A.M. and Horvitz, H.R. (2008) Multiple levels of redundant processes inhibit Caenorhabditis elegans vulval cell fates. Genetics 179(4): 2001-12.
Galvin, B.D., Kim S., and Horvitz H.R. (2008) Caenorhabditis elegans genes required for the engulfment of apoptotic corpses function in the cytotoxic cell deaths induced by mutations in lin-24 and lin-33. Genetics 179(1):403-17.
2007
Miska, E., Alvarez-Saavedra, E., Abbott, A., Lau, N., Hellman, A., McGonagle, S., Bartel, D. Ambros, V and Horvitz, H.R. (2007) Most Caenorhabditis elegans microRNAs are individually not essential for development or viability. PLoS Genetics 3(12), e215.
Schwartz, H. and Horvitz, H.R. (2007) The C. elegans protein CEH-30 protects male-specific CEM neurons from apoptosis independently of the Bcl-2 homolog CED-9. Genes & Develop. 21, 3181-3194.
Eimar, S., Gottschalk, A., Hengartner, M., Horvitz, H.R., Richmond, J., Schafer, W., and Bessereau, J.-L. (2007) Regulation of nicotinic receptor trafficking by the transmembrane Golgi protein UNC-50. EMBO J., 26, 4313-4323.
Andersen, E. and Horvitz, H.R.(2007) Two C. elegans histone methyltransferases repress lin-3 EGF to inhibit vulval development. Development 134, 2991-2999.
Harrison, M., Lu, X. and Horvitz, H.R. (2007) LIN-61, one of two Caenorhabditis elegans MBT-repeat-containing proteins, acts with the DRM and NuRD-like protein complexes in vulval development but not in certain other biological processes. Genetics 176, 255-271.
Reddien, P., Andersen, E. and Horvitz, H.R. (2007) DPL-1 DP, LIN-35 Rb and EFL-1 E2F act with the MCD-1 Zn finger protein to promote programmed cell death in Caenorhabditis elegans. Genetics 175, 1719-1733.
2006
Harrison, M., Ceol, C., Lu, X. and Horvitz (2006) Some C. elegans class B synthetic multivulva proteins encode a conserved LIN-35 Rb-containing protein complex distinct from a NuRD-like complex. Proc. Natl. Acad. Sci. U.S.A. 103, 16782-16787.
Su, C.-W., Tharin, S., Jin, Y., Wightman, B., Spector, M., Meili, D., Tsung, N., Rhiner, C., Bourikas, D., Stoeckli, E., Garriga, G., Horvitz, H.R., and Hengartner, M. (2006) The short coiled-coil domain-containing protein UNC-69 cooperates with UNC-76 to regulate axonal outgrowth and normal presynaptic organization in Caenorhabditis elegans. J. Biol. 5, 9.1-9.26.
Andersen, E., Lu, X. and Horvitz, H.R. (2006) C. elegans ISW1 and NURF301 antagonize an Rb-like pathway in the determination of multiple cell fates. (2006) Development 133, 2695-2704
Berdichevsky, A., Viswanathan, M., Horvitz, H.R. and Guarente, L. (2006) C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span. Cell 125, 1165-1177
Ceol, C., Stegmeier, F., Harrison, M., and Horvitz, H.R. (2006) Identification and classification of genes that act antagonistically to let-60 Ras signaling in C. elegans vulval development. Genetics 173, 709-726
Shah, P., Ahmad-Annuar, A., Ahmadi, K., Russ, C., Sapp, P., Horvitz, H.R., Brown, R., Goldstein, D. and Fisher, E. (2006) No association of DYNC1H1 with sporadic ALS in a case-control study of a northern European derived population: a tagging SNP approach. Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders 7, 46-56
Morita, M., Al-Chalabi, A., Andersen, P., Hosler, B., Sapp, P., Englund, E., Mitchell, J, Habgood, J., de Belleroche, J., Xi, J., Jongjaroenprasert, W., Horvitz, H.R., Gunnarsson, L.-G. and Brown, R. (2006) A locus on chromosomem 9p confers susceptibility to ALS and frontotemporal dementia. Neurology 66, 839-844
2005
Davison, E., Harrison, M., Walhout, A., Vidal, M and Horvitz, H.R. (2005) lin-8, which antagonizes Caenorhabditis elegans Ras-mediated vulval induction, encodes a novel nuclear protein that interacts with the LIN-35 Rb protein. Genetics 171, 1017-1031
Frank, C.A., Hawkins, N., Guenther, C., Horvitz, H.R., and Garriga, G. (2005) C. elegans HAM-1 positions the cleavage plane of certain asymmetric neuroblast divisions. Develop. Biol. 284, 301-310
Abbott, Al., Alvarez-Saavedra, E., Miska, E., Lau, N. Bertell, D., Horvitz, H.R., and Ambros, V. (2005) The let-7 microRNA family members mir-48, mir-84, and mir-241 function together to regulate developmental timing in Caenorhabditis elegans. Develop. Cell 9, 403-414
Wienholds, E., Kloosterman, W., Miska, E., Alvarez-Saavedra, E., Berezikov, E., de Bruijn, E., Tolstrup, N., Horvitz, H.R., Kauppinen, S., and Plasterk, R. (2005) MicroRNA expression in zebrafish embryonic development. Science 309, 310-311.
Lu, J., Getz, G., Miska, E., Alvarez-Saavedra, E., Lamb, J., Peck, D., Sweet-Cordero, A., Ferrando, A., Downing, J., Jacks, T., Horvitz, H.R., and Golub, T. (2005) MicroRNA expression profiles classify human cancers.
Nature 435, 834-848
Horvitz, H.R. (2005) Stanley J. Korsmeyer (1950-2005).
Nature 435, 161.
Alkema, M., Hunter-Ensor, M., Ringstad, N., and Horvitz, H.R. (2005) Tyramine functions independently of octopamine in the Caenorhabditis elegans nervous system.
Neuron 46, 247-260
2004
Miska, E., Alvarez-Saavedra, E., Yoshii, A., Townsend, M., Sestan, N., Rakic, P., Constantine-Paton, M., and Horvitz, H.R. (2004) Microarray analysis of microRNA expression in the developing mammalian brain.
Genome Biology 5, R68. 1-13
Reddien, P. and Horvitz, H.R. (2004) The engulfment process of programmed cell deaths in Caenorhabditis elegans. Ann. Rev. Cell & Develop. Bio. 20, 193-221
Jaeger, S. Schwartz, H., Horvitz, H.R., and Conradt, B. (2004) The Caenorhabditis elegans F-box protein SEL-10 promotes female development and may target FEM-1 and FEM-3 for degradation by the proteasome. Proc. Natl. Acad. Sci. U.S.A. 101, 12549-12554
Ceol, C. and Horvitz, H.R. (2004) A new class of C. elegans synMuv genes implicates a Tip60/NuA4-like HAT complex as a negative regulator of Ras signaling. Developmental Cell 6, 563-576
Yuan, J. and Horvitz, H.R. (2004) A first insight into the molecular mechanisms of apoptosis. Cell S116, S53-S56
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2003
Horvitz, H.R. (2003)
Worms, Life and Death: Nobel Lecture, December 8, 2002. In Les Prix Nobel; The Nobel Prizes 2002. Frangsmyr, T., ed. Edita Norstedts Tryckeri AB, Stockholm, pp. 320-351.
Horvitz, H.R. (2003)
H. Robert Horvitz -- Autobiography. In Les Prix Nobel; The Nobel Prizes 2002. Frangsmyr, T., ed. Edita Norstedts Tryckeri AB, Stockholm, pp. 284-319.
de la Cruz IP, Levin JZ, Cummins C, Anderson P, Horvitz H.R. (2003)
sup-9, sup-10, and unc-93 may encode components of a two-pore K+ channel that coordinates muscle contraction in Caenorhabditis elegans. J Neurosci. 2003 Oct 8;23(27):9133-45.
Horvitz, H.R. (2003)
Worms, Life, and Death (Nobel Lecture) Chembiochem. 4(8),
697-711
Sapp, P., Hosler, B., McKenna-Yasek, D.,
Chin, W., Gann, A., Genise, H., Gorenstein, J., Huang, M., Sailer,
W., Scheffler, M., Valesky, M., Haines, J., Pericak-Vance, M., Siddique,
T., Horvitz, H.R., and Brown, Jr., R.H. (2003)
Identification of two novel loci for dominantly inherited familial
amyotrophic lateral sclerosis. Amer. J. Human Genetics
73, 397-403.
Thomas, J.H., Ceol, C., Schwartz, H. and
Horvitz, H.R. (2003)
New genes that interact with lin-35 Rb to negatively regulate the let-60 Ras pathway in Caenorhabditis elegans.
Genetics 164, 135-151.
Hwang, H.-Y., Olson, S., Esko, J. and Horvitz, H.R. (2003)
Caenorhabditis elegans early embryogenesis and vulval morphogenesis require chondroitin biosynthesis. Nature 423, 439-443.
Hwang, H.-Y., Olson, S., Brown, J., Esko, J and Horvitz, H.R. (2003)
The Caenorhabditis elegans genes sqv-2 and sqv-6, which are required for vulval morphogenesis, encode glycosaminoglycan galactosyltransferase II and xylosyltransferase. J. Biol. Chem. 278, 11735-11738.
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2002
Hwang, H.-Y. and Horvitz, H.R. (2002)
The C. elegans vulval morphogenesis gene sqv-4 encodes a UDP-glucose dehydrogenase that is temporally and spatially regulated.
Proc. Natl. Acad. Sci. U.S.A. 99, 14224-14229.
Hwang, H.-Y. and Horvitz, H.R. (2002)
The SQV-1 UDP-glucoronic acid decarboxylase and the SQV-7 nucleotide-sugar transporter may act in the Golgi apparatus to affect C. elegans vulval morphogenesis and embryonic development.
Proc. Natl. Acad. Sci. U.S.A. 99, 14218-14223.
Tzur, Y., Hersh, B.,
Horvitz, H.R. and Gruenbaum. Y. (2002)
Fate of the nuclear lamina during Caenorhabditis elegans apoptosis.
J. Struct. Biol. 137, 146-153.
Cameron, S., Clark
S., McDermott, J., Aamodt, E. and Horvitz, H.R. (2002)
PAG-3, a Zn finger transcription factor, determines neuroblast identity
in C. elegans. Development 129, 1763-1774.
Hersh, B., Hartwieg,
E. and Horvitz, H.R. (2002)
The Caenorhabditis elegans mucolipin-like gene cup-5
is essential for viability and regulates lysosomes in multiple cell
types. Proc. Natl. Acad. Sci. U.S.A., 99, 4355-4360.
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2001
Starr, D., Hermann,
G., Malone, C., Fixsen, W., Priess, J., Horvitz, H.R. and Han, M.
(2001)
UNC-83 encodes a novel component of the nuclear envelope and is essential
for proper nuclear migration. Development 128, 5039-5050.
Zhou, Z., Caron, E.,
Hartwieg, E., Hall, A. and Horvitz, H.R. (2001)
The C. elegans PH domain protein CED-12 regulates cytoskeletal
reorganization via a Rho/Rac GTPase signaling pathway.
Develop. Cell, 1, 477-489.
Lundquist, E., Reddien,
P., Hartwieg, E., Horvitz, H.R. and Bargmann, C. (2001) Three
C. elegans Rac proteins and several alternative Rac regulators
control axon guidance, cell migration and apoptotic cell phagocytosis.
Development 128, 4475-4488.
Ranganathan, R., Sawin,
E., Trent, C. and Horvitz, H.R. (2001)
Mutations in the Caenorhabditis elegans serotonin reuptake
transporter MOD-5 reveal serotonin-dependent and -independent activities
of fluoxetine. J. Neurosci. 21, 5871-5884.
Reddien, P., Cameron,
S. and Horvitz, H.R. (2001) Phagocytosis
promotes programmed cell death in C. elegans. Nature
412, 198-202.
Ceol, C. and Horvitz,
H.R. (2001)
dpl-1 DP and efl-1 E2F act with lin-35 Rb to antagonize
Ras signaling in C. elegans vulval development.
Molec. Cell 7, 461-473.
Berninsone, P., Hwang,
H.-Y., Zemtesava, I., Horvitz, H.R. and Hirschberg, C. (2001)
SQV-7, a protein involved in C. elegans epithelial invagination
and early embryogenesis, transports UDP-glucoronic acid, UDP-N-acetylgalactosamine
and UDP-galactose. Proc. Natl. Acad. Sci. U.S.A. 98, 3738-3743.
Zhou, Z., Hartwieg,
E. and Horvitz, H.R. (2001)
CED-1 is a transmembrane receptor that mediates cell-corpse engulfment
in C. elegans. Cell 104, 43-56.
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2000
Ranganathan, R., Cannon,
S. and Horvitz, H.R. (2000)
MOD-1 is a serotonin-gated chloride channel that modulates locomotory
behaviour in C. elegans. Nature 408, 470-475.
Hosler, B.A., Siddique,
T., Sapp, P.C., Sailor, W., Huang, M.C., Hossain, A., Daube, J.R.,
Nance, M., Fan, C., Kaplan, J., Hung, W-Y., McKenna-Yasek, D., Haines,
J.L., Pericak-Vance, M.A., Horvitz, H.R. and Brown, Jr., R.H. (2000)
Linkage
of familial amyotrophic lateral sclerosis with frontotemporal dementia
to chromosome 9q21-q22. J. Amer. Med. Assoc. 284, 1664-1669.
Beitel, G., Lambie,
E.J. and Horvitz, H.R. (2000) The
C. elegans gene lin-9, which acts in an Rb-related pathway,
is required for gonadal sheath cell development and encodes a novel
protein. Gene 254, 253-263.
Speliotes, E., Uren,
A., Vaux, D. and Horvitz, H.R. (2000)
The survivin-like C. elegans BIR-1 protein acts with the Aurora-like
kinase AIR-2 to affect chromosomes and the spindle midzone.
Molec. Cell, 6, 211-223.
Harris, T., Hartwieg,
E., Horvitz, H.R. and Jorgensen, E. (2000)
Mutations in synaptojanin disrupt synaptic vesicle recycling.
J. Cell Biol. 150, 589-599.
Sawin, E.R., Ranganathan,
R. and Horvitz, H.R. (2000)
C. elegans locomotory rate is modulated by the environment through
a dopaminergic pathway and by experience through a serotonergic pathway.
Neuron 26, 619-631.
Slack, F.J., Basson,
M., Liu, Z., Ambros, V., Horvitz, H.R. and Ruvkun, G. (2000) The
lin-41 RBCC Gene Acts in the C. elegans Heterochronic
Pathway between the let-7 Regulatory RNA and the LIN-29 Transcription
Factor. Molec. Cell 5, 659-669.
Stanfield, G. and
Horvitz, H.R. (2000) The
ced-8 gene controls the timing of programmed cell deaths in
C. elegans. Molec. Cell 5, 423-433.
Wu, Y.-C., Stanfield,
G. and Horvitz, H.R. (2000) NUC-1,
a Caenorhabditis elegans DNase II homolog, functions in an
intermediate step of DNA degradation during apoptosis.
Genes & Develop. 14, 536-548.
Reddien, P.W. and
Horvitz, H.R. (2000)
CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration
in Caenorhabditis elegans. Nature Cell Biology 2,
131-136.
Reinhart, B.J., Slack,
F.J., Basson, M., Pasquinelli, A.E., Bettinger, J.C., Rougvie, A.E.,
Horvitz, H.R. and Ruvkun, G. (2000) The
21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis
elegans. Nature 403, 901-906.
Chen, F., Hersh, B.,
Conradt, B., Zhou, Z., Riemer, D., Gruenbaum, Y. and Horvitz, H.R.
(2000) Translocation
of C. elegans CED-4 to nuclear membranes during programmed
cell death. Science 287, 1485-1489.
Lorson, M.A., Horvitz,
H.R., van den Heuvel, S. (2000) LIN-5
is a novel component of the spindle apparatus required for chromosome
segregation and cleavage plane specification in Caenorhabditis
elegans. J. Cell Biol. 148, 73-86.
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1999
Newman, A.P., Acton,
G. Z., Hartwieg, E., Horvitz, H.R. and Sternberg, P.W. (1999)
The lin-11 LIM domain transcription factor is necessary for
morphogenesis of C. elegans uterine cells. Development
126, 5319-5326.
Shaham, S., Reddien,
P., Davies, B. and Horvitz, H.R. (1999) Mutational
analysis of the C. elegans cell-death gene ced-3.
Genetics 153, 1655-1671.
Metzstein, M.M. and
Horvitz, H.R. (1999)
The Caenorhabditis elegans cell-death specification gene ces-1
encodes a Snail-family zinc-finger protein. Molecular Cell
4, 309-319.
Conradt, B. and Horvitz,
H.R. (1999)
The TRA-1A sex determination protein of C. elegans regulates
sexually dimorphic cell deaths by repressing the egl-1 cell
death activator gene. Cell 98, 317-327.
Eastman, C., Horvitz,
H.R. and Jin, Y. (1999) Coordinated
transcriptional regulation of the unc-25 glutamic acid decarboxylase
and the unc-47 GABA vesicular transporter by the Caenorhabditis
elegans UNC-30 homeodomain protein. J. Neuroscience
19, 6225-6234.
Thomas, J.H. and Horvitz,
H.R. (1999)
The C. elegans gene lin-36 acts cell autonomously in
the lin-35 Rb pathway. Development 126, 3449-3459.
Malone, C.J., Fixsen,
W.D., Horvitz, H.R. and Han, M. (1999) UNC-84
localizes to the nuclear envelope and is required for nuclear migration
and anchoring during Caenorhabditis elegans development.
Development 126, 3171-3181.
Gumienny, T.L., Lambie,
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gene lin-10 is broadly expressed while required specifically
for the determination of vulval cell fates. Genes & Develop.
4, 357-371.
Ruvkun, G., Gilbert,
W. and Horvitz, H.R. (1990) Detection
of mutations and DNA polymorphisms using whole genome Southern Cross
hybridizations. Nucleic Acids Res. 18, 809-815.
Yuan, J. and Horvitz,
H.R. (1990) The Caenorhabditis elegans
genes ced-3 and ced-4 act cell autonomously to cause
programmed cell death. Develop. Biol. 138, 33-41.
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1989
Avery, L. and Horvitz,
H.R. (1989) Pharyngeal pumping continues
after laser killing of the pharyngeal nervous system of C. elegans.
Neuron 3, 473-485.
Ferguson, E. and Horvitz,
H.R. (1989) The multivulva phenotype
of certain Caenorhabditis elegans mutants results from defects
in two functionally- redundant pathways. Genetics 123, 109-121.
Sternberg, P. and
Horvitz, H.R. (1989) The combined action
of two intercellular signaling pathways specifies three cell fates
during vulval induction in C. elegans. Cell 58, 679-693.
Desai, C. and Horvitz,
H.R. (1989) Caenorhabditis elegans
mutants defective in the functioning of the motor neurons responsible
for egg laying. Genetics 121, 703-721.
Ruvkun, G., Ambros,
V., Coulson, A., Sulston, J., Waterston, R., and Horvitz, H.R. (1989)
Molecular genetics of the Caenorhabditis elegans heterochronic
gene lin-14. Genetics 121, 501-516.
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1988
Desai, C., Garriga,
G., McIntire, S. and Horvitz, H.R. (1988)
A genetic pathway for the development of the Caenorhabditis elegans
HSN motor neurons. Nature 336, 638-646.
Herr, W., Sturm, R.,
Clerc, R., Corcoran, L., Baltimore, D., Sharp, P., Ingraham, H., Rosenfeld,
M., Finney, M., Ruvkun, G., and Horvitz, H.R. (1988)
The POU domain: a large conserved region in the mammalian pit-1,
oct-1, oct-2 and Caenorhabditis elegans unc-86 gene
products. Genes & Develop., 2, 1513-1516.
Finney, M., Ruvkun,
G. and Horvitz, H.R. (1988) The C.
elegans cell lineage and differentiation gene unc-86 encodes
a protein with a homeodomain and extended similarity to transcription
factors. Cell 55, 757-769.
Sternberg, P. and
Horvitz, H.R. (1988) lin-17 mutations
of C. elegans disrupt certain asymmetric cell divisions. Develop.
Biol. 130, 67-73.
Trent, C., Wood, W.,
and Horvitz, H.R. (1988) A novel dominant
transformer allele of the sex-determining gene her-1 of Caenorhabditis
elegans. Genetics 120, 145-157.
Horvitz, H.R. (1988)
Genetics of cell lineage. In The Nematode Caenorhabditis elegans,
ed. W. Wood. Cold Spring Harbor Laboratory Monograph, pp. 157-190.
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1987
Avery, L. and Horvitz,
H.R. (1987) A cell that dies during wild-type
C. elegans development can function as a neuron in a ced-3
mutant. Cell 51, 1071-1078.
Edgar, R., Horvitz,
H.R. and Wood, W. (1987) The nematode
Caenorhabditis elegans: Toward the complete understanding of
an animal. Chinese J. Cell Biology (in Chinese), Suppl. 2,
1-20.
Ambros, V. and Horvitz,
H.R. (1987) The lin-14 locus of
Caenorhabditis elegans controls the time of expression of specific
postembryonic developmental events. Genes & Development
1, 398-414.
Ferguson, E., Sternberg,
P. and Horvitz, H.R. (1987) A genetic
pathway for the specification of the vulval cell lineages of Caenorhabditis
elegans. Nature 326, 259-267.
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1986
Park, E. and Horvitz,
H.R. (1986) C. elegans unc-105
mutations affect muscle and are suppressed by other mutations that
affect muscle. Genetics 113, 853-867.
Park, E. and Horvitz,
H.R. (1986) Mutations with dominant effects
on the behavior and morphology of the nematode Caenorhabditis elegans.
Genetics 113, 821-852.
Greenwald, I. and
Horvitz, H.R. (1986) A visible allele
of the muscle gene sup-10 X of C. elegans. Genetics
113, 63-72.
Ellis, H. and Horvitz,
H.R. (1986) Genetic control of programmed
cell death in the nematode C. elegans. Cell 44, 817-829.
Sternberg, P. and
Horvitz, H.R. (1986) Pattern formation
during vulval development in C. elegans. Cell 44, 761-772.
top
1985
Fixsen, W., Sternberg,
P., Ellis, H. and Horvitz, H.R. (1985)
Genes that affect cell fates during the development of Caenorhabditis
elegans. Cold Spring Harbor Symp. Quant. Biol. 50, 99-104.
Ferguson, E. and Horvitz,
H.R. (1985) Identification and characterization
of 22 genes that affect the vulval cell lineages of the nematode Caenorhabditis
elegans. Genetics 110, 17-72.
top
1984
Sternberg, P. and Horvitz,
H.R. (1984) Genetic control of cell lineage
during nematode development. Ann. Rev. Genetics 18, 489-524.
Ambros, V. and Horvitz,
H.R. (1984) Heterochronic mutants of
the nematode Caenorhabditis elegans. Science 226, 409-416.
top
1983
Horvitz, H.R., Sternberg,
P., Greenwald, I., Fixsen, W. and Ellis, H. (1983)
Mutations that affect neural cell lineages and cell fates during the
development of the nematode Caenorhabditis elegans. Cold
Spring Harbor Symp. Quant. Biol. 48, 453-463.
Greenwald, I., Sternberg,
P. and Horvitz, H.R. (1983) The lin-12
locus specifies cell fates in Caenorhabditis elegans.
Cell 34, 435-444.
Trent, C., Tsung,
N. and Horvitz, H.R. (1983) Egg-laying
defective mutants of the nematode Caenorhabditis elegans.
Genetics 104, 619-647.
top
1982
Horvitz, H.R., Ellis,
H. and Sternberg, P. (1982) Programmed
cell death in nematode development. Neuroscience Commentaries
1, 56-65.
Sternberg, P. and
Horvitz, H.R. (1982) Postembryonic nongonadal
cell lineages of the nematode Panagrellus redivivus: description
and comparison with those of Caenorhabditis elegans.
Develop. Biol. 93, 181-205.
Greenwald, I. and
Horvitz, H.R. (1982) Dominant suppressors
of a muscle mutant define an essential gene of C. elegans.
Genetics 101, 211-225.
Shatz, C., Bate, M.,
Bonhoeffer, F., Cowan, M., Easter, S., Herschkowitz, N., Horvitz,
H.R., McKhann, G., Rathjen, F., Schachner, M. and Sears, T. (1982)
Neural development: implications for recovery from injury. In
Repair and Regeneration of the Nervous System. J. G. Nicholls, ed.
Dahlem Konferenzen, Berlin, Springer-Verlag, pp. 289-311.
Horvitz, H.R. (1982)
Factors that influence neural development in nematodes. In
Repair and Regeneration of the Nervous System. J. G. Nicholls, ed.
Dahlem Konferenzen, Berlin, Springer-Verlag, pp. 41-55.
White, J., Horvitz,
H.R. and Sulston, J. (1982) Neurone differentiation
in cell lineage mutants of Caenorhabditis elegans. Nature
297, 584-587.
Horvitz, H.R., Chalfie,
M., Trent, C., Sulston, J. and Evans, P. (1982)
Serotonin and octopamine in the nematode Caenorhabditis elegans.
Science 216, 1012-1014.
Horvitz, H.R. and
Sternberg P. (1982) Nematode postembryonic
cell lineages. J. Nematology 14, 240-248.
top
1981
Sternberg, P. and Horvitz,
H.R. (1981) Gonadal cell lineages of
the nematode Panagrellus redivivus and implications for evolution
by the modification of cell lineage. Develop. Biol. 88, 147-166.
Chalfie, M., Horvitz,
H.R. and Sulston, J. (1981) Mutations
that lead to reiterations in the cell lineages of Caenorhabditis
elegans. Cell 24, 59-69.
Horvitz, H.R. (1981)
Neuronal cell lineages in the nematode Caenorhabditis elegans.
In Development of the Nervous System. D. Garrod and J. Feldman,
eds., Cambridge University Press, pp. 331-345.
Sulston, J. and Horvitz,
H.R. (1981) Abnormal cell lineages in
mutants of the nematode Caenorhabditis elegans. Develop.
Biol. 82, 41-55.
top
1980
Horvitz, H.R. and Sulston,
J. (1980) Isolation and genetic characterization
of cell lineage mutants of the nematode Caenorhabditis elegans.
Genetics 96, 435-454.
Herman, H.R. and Horvitz,
R. (1980) Genetic analysis of Caenorhabditis
elegans. In Nematodes as Biological Models. B. Zuckerman,
ed., Academic Press, New York, pp. 227-261.
Greenwald, I. and
Horvitz, H.R. (1980) unc-93(e1500):
a behavioral mutant of Caenorhabditis elegans that defines
a gene with a wild-type null phenotype. Genetics 96, 147-164.
Herman, R., Horvitz,
H.R. and Riddle, D. (1980) Caenorhabditis
elegans. In Genetic Maps, Vol. 1, S. O'Brien, ed., N.I.H.,
Bethesda, MD, pp. 183-193.
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1979
Brockes, J., Aguayo,
A., Black, I., Horvitz, H.R., Raff, M., Vacquier, V., Warner, A.,
Wiesel, T. and Wolpert, L. (1979) Consequences
of signal reception. In The Role of Intercellular Signals:
Navigation, Encounter, Outcome. J. Nicholls, ed. Dahlem Konferenzen,
Verlag Chemie, Berlin, pp. 285-300.
Horvitz, H.R., Brenner,
S., Hodgkin, J. and Herman, R. (1979)
A uniform genetic nomenclature for the nematode Caenorhabditis
elegans. Molec. gen. Genet. 175, 129-133.
White, J. and Horvitz,
H.R. (1979) Laser microbeam techniques
in biological research. Electro-Optical Systems Design, August,
pp. 23-24.
Hodgkin, J., Horvitz,
H.R. and Brenner, S. (1979) Nondisjunction
mutants of the nematode Caenorhabditis elegans. Genetics
91, 67-94.
top
1977
Sulston, J. and Horvitz,
H.R. (1977) Postembryonic cell lineages
of the nematode Caenorhabditis elegans. Develop. Biol.
56, 110-156.
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Prior
to 1976
Horvitz, H.R. (1975)
Studies of mutations in T4 control genes 33 and 55. Genetics
79, 349-360.
Horvitz, H.R. (1974)
Bacteriophage T4 mutants deficient in alteration and modification
of the Escherichia coli RNA polymerase. J. Mol. Biol.
90, 739-750.
Horvitz, H.R. (1974)
Control by bacteriophage T4 of two sequential phosphorylations of
the alpha subunit of the Escherichia coli RNA polymerase. J.
Mol. Biol. 90, 727-738.
Horvitz, H.R. (1973)
Polypeptide bound to the host RNA polymerase is specified by T4 control
gene 33. Nature New Biology, 244, 137-140.
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