Department of Biology
Massachusetts Institute of Technology
Howard Hughes Medical Institute
McGovern Institute for Brain Research


Publications of H. R. Horvitz

Choose the topic:

Cell Lineage and Cell Fate Behavior
Programmed Cell Death Micro RNAs
Neural Development Splicing
Morphogenesis Human Disease
Aging Other
Signal Transduction and Epigenetics  

Cell Lineage and Cell Fate

Denning, D., Hatch, V. and Horvitz, H.R. (2012) Programmed elimination of cells by caspase-independent cell extrusion in C. elegans. Nature 488, 226-230.

Saffer, A., Kim, D.H., van Oudenaarden, A., and Horvitz, H.R. (2011) The C. elegans synthetic multivulva genes prevent Ras activation by tightly repressing global ectopic expression of lin-3 EGF. PLoS Genet. 7, e1002418.

Nakano, S., Stillman, B. and Horvitz, H.R. (2011) Replication-coupled chromatin assembly generates a bilateral asymmetry. Cell 147, 1525-36.

Harris, D. and Horvitz, H.R. (2011) MAB-10/NAB acts with LIN-29/EGR to regulate terminal differentiation and the transition from larva to adult in C. elegans. Development 138, 4051-4062.

Tabuchi, T., Deplancke, B., Osato, N., Zhu, L., Barrasa, I., Harrison, M., Horvitz, H.R., Walhout, A. and Hagstrom, K. (2011) Chromosome-biased binding and gene regulation by the Caenorhabditis elegans DRM complex. PLoS Genetics 7, e1002074.

Davison, E., Saffer, A., Huang, L., DeModena, J., Sternberg, P., and Horvitz, H.R. (2011) The LIN-15A and LIN-56 transcriptional regulators interact to negatively regulate EGF/Ras signaling in Caenorhabditis elegans vulval cell-fate determination. Genetics 187, 803-815.

Korzelius, J., The, I., Ruijtenberg, S., Portegijs, V., Xu, H., Horvitz, H.R. and S. van den Heuvel. (2011) C. elegans MCM-4 is a general replication and checkpoint component with an epidermis-specific requirement for growth and viability. Devel. Biol. 350, 358-369.

Nakano, S., Ellis, R. and Horvitz, H.R. (2010) Otx-dependent expression of proneural bHLH genes establishes a nervous system bilateral asymmetry. Develop. 137, 4017-4027.

Andersen, E.C., Saffer, A.M. and Horvitz, H.R. (2008) Multiple levels of redundant processes inhibit Caenorhabditis elegans vulval cell fates. Genetics 179(4): 2001-12.

Andersen, E. and Horvitz, H.R.(2007) Two C. elegans histone methyltransferases repress lin-3 EGF to inhibit vulval development. Development 134, 2991-2999.

Harrison, M., Lu, X. and Horvitz, H.R. (2007) LIN-61, one of two Caenorhabditis elegans MBT-repeat-containing proteins, acts with the DRM and NuRD-like protein complexes in vulval development but not in certain other biological processes. (2006) Genetics 176, 255-271.

Harrison, M., Ceol, C., Lu, X. and Horvitz (2006) Some C. elegans class B synthetic multivulva proteins encode a conserved LIN-35 Rb-containing protein complex distinct from a NuRD-like complex. Proc. Natl. Acad. Sci. U.S.A. 103, 16782-16787.

Andersen, E., Lu, X. and Horvitz, H.R. (2006) C. elegans ISW1 and NURF301 antagonize an Rb-like pathway in the determination of multiple cell fates. (2006) Development 133, 2695-2704

Jaeger, S. Schwartz, H., Horvitz, H.R., and Conradt, B. (2004) The Caenorhabditis elegans F-box protein SEL-10 promotes female development and may target FEM-1 and FEM-3 for degradation by the proteasome. Proc. Natl. Acad. Sci. U.S.A. 101, 12549-12554

Horvitz, H.R. (2003) Worms, Life, and Death (Nobel Lecture) Chembiochem. 4(8), 697-711

Cameron, S., Clark S., McDermott, J., Aamodt, E. and Horvitz, H.R. (2002) PAG-3, a Zn finger transcription factor, determines neuroblast identity in C. elegans. Development 129, 1763-1774.

Slack, F.J., Basson, M., Liu, Z., Ambros, V., Horvitz, H.R. and Ruvkun, G. (2000) The lin-41 RBCC Gene Acts in the C. elegans Heterochronic Pathway between the let-7 Regulatory RNA and the LIN-29 Transcription Factor. Molec. Cell 5, 659-669.

Reinhart, B.J., Slack, F.J., Basson, M., Pasquinelli, A.E., Bettinger, J.C., Rougvie, A.E., Horvitz, H.R. and Ruvkun, G. (2000) The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature 403, 901-906.

Lorson, M.A., Horvitz, H.R., van den Heuvel, S. (2000) LIN-5 is a novel component of the spindle apparatus required for chromosome segregation and cleavage plane specification in Caenorhabditis elegans. J. Cell Biol. 148, 73-86.

Newman, A.P., Acton, G. Z., Hartwieg, E., Horvitz, H.R. and Sternberg, P.W. (1999) The lin-11 LIM domain transcription factor is necessary for morphogenesis of C. elegans uterine cells. Development 126, 5319-5326.

Tax, F.E., Thomas, J.H., Ferguson, E.L. and Horvitz, H.R. (1997) Identification and characterization of genes that interact with lin-12 in Caenorhabditis elegans. Genetics 147, 1675-1695.

Labouesse, M., Hartwieg, E. and Horvitz, H.R. (1996) The Caenorhabditis elegans LIN-26 protein is required to specify and/or maintain all non-neuronal ectodermal cell fates. Development 122, 2579-2588.

Sawa, H., Lobel, L. and Horvitz, H.R. (1996) The Caenorhabditis elegans gene lin-17, which is required for certain asymmetric cell divisions, encodes a putative seven-transmembrane protein similar to the Drosophila Frizzled protein. Genes & Develop. 10, 2189-2197.

Basson, M. and Horvitz, H.R. (1996) The Caenorhabditis elegans gene sem-4 controls neuronal and mesodermal cell development and encodes a zinc-finger protein. Genes & Develop. 10, 1953-1965.

Herman, M., Vassilieva, L., Horvitz, H.R., Shaw, J. and Herman, R. (1995) The Caenorhabditis elegans gene lin-44, which controls the polarity of certain asymmetric cell divisions, encodes a Wnt protein and acts cell nonautonomously. Cell 83, 101-110.

Chisholm, A. and Horvitz, H.R. (1995) Patterning of the Caenorhabditis elegans head region by the Pax-6 family member vab-3. Nature 377, 52-55.

Labouesse, M., Sookhareea, S. and Horvitz, H.R. (1994) The Caenorhabditis elegans gene lin-26 is required to specify the fates of hypodermal cells and encodes a presumptive zinc-finger transcription factor. Development 120, 2359-2368.

Clark, S., Chisholm, A. and Horvitz, H.R. (1993) Control of cell fates in the central body region of C. elegans by the homeobox gene lin-39. Cell 74, 43-55.

Horvitz, H.R. and Herskowitz, I. (1992) Mechanisms of asymmetric cell division: two Bs or not two Bs, that is the question. Cell 68, 237-255.

Li, M., Reichert, J., Freyd, G., Horvitz, H.R. and Walsh, C. (1991) The LIM region of a presumptive C. elegans transcription factor is an iron-sulfur and zinc-containing metallodomain. Proc. Natl. Acad. Sci. U.S.A. 88, 9210- 9213.

Beitel, G., Clark, S. and Horvitz, H.R. (1990) The Caenorhabditis elegans ras gene let-60 acts as a switch in the pathway of vulval induction. Nature 348, 503-509.

Thomas, J., Stern, M. and Horvitz, H.R. (1990) Cell interactions coordinate the development of the C. elegans egg-laying system. Cell 62, 1041-1052.

Horvitz, H.R. (1990) Genetic control of Caenorhabditis elegans cell lineage. The Harvey Lectures, Series 84, pp. 65-77 (Wiley-Liss, Inc.)

Freyd, G., Kim, S. and Horvitz, H.R. (1990) Novel cysteine-rich motif and homeodomain in the product of Caenorhabditis elegans cell lineage gene lin-11. Nature 344, 876-879.

Kim, S. and Horvitz, H.R. (1990) The Caenorhabditis elegans gene lin-10 is broadly expressed while required specifically for the determination of vulval cell fates. Genes & Develop. 4, 357-371.

Ferguson, E. and Horvitz, H.R. (1989) The multivulva phenotype of certain Caenorhabditis elegans mutants results from defects in two functionally- redundant pathways. Genetics 123, 109-121.

Sternberg, P. and Horvitz, H.R. (1989) The combined action of two intercellular signaling pathways specifies three cell fates during vulval induction in C. elegans. Cell 58, 679-693.

Ruvkun, G., Ambros, V., Coulson, A., Sulston, J., Waterston, R., and Horvitz, H.R. (1989) Molecular genetics of the Caenorhabditis elegans heterochronic gene lin-14. Genetics 121, 501-516.

Herr, W., Sturm, R., Clerc, R., Corcoran, L., Baltimore, D., Sharp, P., Ingraham, H., Rosenfeld, M., Finney, M., Ruvkun, G., and Horvitz, H.R. (1988) The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2 and Caenorhabditis elegans unc-86 gene products. Genes & Develop., 2, 1513-1516.

Finney, M., Ruvkun, G. and Horvitz, H.R. (1988) The C. elegans cell lineage and differentiation gene unc-86 encodes a protein with a homeodomain and extended similarity to transcription factors. Cell 55, 757-769.

Sternberg, P. and Horvitz, H.R. (1988) lin-17 mutations of C. elegans disrupt certain asymmetric cell divisions. Develop. Biol. 130, 67-73.

Horvitz, H.R. (1988) Genetics of cell lineage. In The Nematode Caenorhabditis elegans, ed. W. Wood. Cold Spring Harbor Laboratory Monograph, pp. 157-190.

Ambros, V. and Horvitz, H.R. (1987) The lin-14 locus of Caenorhabditis elegans controls the time of expression of specific postembryonic developmental events. Genes & Development 1, 398-414.

Ferguson, E., Sternberg, P. and Horvitz, H.R. (1987) A genetic pathway for the specification of the vulval cell lineages of Caenorhabditis elegans. Nature 326, 259-267.

Sternberg, P. and Horvitz, H.R. (1986) Pattern formation during vulval development in C. elegans. Cell 44, 761-772.

Fixsen, W., Sternberg, P., Ellis, H. and Horvitz, H.R. (1985) Genes that affect cell fates during the development of Caenorhabditis elegans. Cold Spring Harbor Symp. Quant. Biol. 50, 99-104.

Ferguson, E. and Horvitz, H.R. (1985) Identification and characterization of 22 genes that affect the vulval cell lineages of the nematode Caenorhabditis elegans. Genetics 110, 17-72.

Sternberg, P. and Horvitz, H.R. (1984) Genetic control of cell lineage during nematode development. Ann. Rev. Genetics 18, 489-524.

Ambros, V. and Horvitz, H.R. (1984) Heterochronic mutants of the nematode Caenorhabditis elegans. Science 226, 409-416.

Horvitz, H.R., Sternberg, P., Greenwald, I., Fixsen, W. and Ellis, H. (1983) Mutations that affect neural cell lineages and cell fates during the development of the nematode Caenorhabditis elegans. Cold Spring Harbor Symp. Quant. Biol. 48, 453-463.

Sternberg, P. and Horvitz, H.R. (1982) Postembryonic nongonadal cell lineages of the nematode Panagrellus redivivus: description and comparison with those of Caenorhabditis elegans. Develop. Biol. 93, 181-205.

Horvitz, H.R. and Sternberg P. (1982) Nematode postembryonic cell lineages. J. Nematology 14, 240-248.

Sternberg, P. and Horvitz, H.R. (1981) Gonadal cell lineages of the nematode Panagrellus redivivus and implications for evolution by the modification of cell lineage. Develop. Biol. 88, 147-166.

Chalfie, M., Horvitz, H.R. and Sulston, J. (1981) Mutations that lead to reiterations in the cell lineages of Caenorhabditis elegans. Cell 24, 59-69.

Horvitz, H.R. (1981) Neuronal cell lineages in the nematode Caenorhabditis elegans. In Development of the Nervous System. D. Garrod and J. Feldman, eds., Cambridge University Press, pp. 331-345.

Sulston, J. and Horvitz, H.R. (1981) Abnormal cell lineages in mutants of the nematode Caenorhabditis elegans. Develop. Biol. 82, 41-55.

Horvitz, H.R. and Sulston, J. (1980) Isolation and genetic characterization of cell lineage mutants of the nematode Caenorhabditis elegans. Genetics 96, 435-454.

Sulston, J. and Horvitz, H.R. (1977) Postembryonic cell lineages of the nematode Caenorhabditis elegans. Develop. Biol. 56, 110-156.

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Programmed Cell Death

Hirose, T. and Horvitz, H.R. (2013) An Sp1 transcription factor coordinates caspase-dependent and –independent apoptotic pathways. Nature 500, 354-358.

Suzuki, J., Denning, D., Imanishi, E., Horvitz, H.R. and Nagata, S. (2013) Xk-related protein 8 and CED-8 promote phosphatidylserine exposure in apoptotic cells. Science 341, 403-406.

Denning, D., Hatch, V., Horvitz (2013) Both the caspase CSP-1 and a caspase-independent pathway promote programmed cell death in parallel to the canonical pathway for apoptosis in C. elegans. PLoS Genet. 9(3):e1003341.

Anderson, C., Zhou, S., Sawin, E., Horvitz, H.R., Hurwitz M.E. (2012) SLI-1 Cbl inhibits the engulfment of apoptotic cells in C. elegans through a ligase-independent function PLoS Genet. 8(12):e1003115.

Denning, D., Hatch, V. and Horvitz, H.R. (2012) Programmed elimination of cells by caspase-independent cell extrusion in C. elegans. Nature 488, 226-230.

Galvin, B., Denning, D. and Horvitz, H.R. (2011) SPK-1, an SR protein kinase, inhibits programmed cell death in C. elegans. PNAS 108, 1998-2003.

Hirose, T., Galvin, B. and Horvitz, H.R. (2010) Six and Eya promote apoptosis through direct transcriptional activation of the pro-apoptotic BH3-only gene egl-1 in C. elegans. PNAS 107, 15479-15484.

Hurwitz M.E., Vanderzalm P.J., Bloom L., Goldman J., Garriga G., Horvitz H.R. (2009) Abl kinase inhibits the engulfment of apoptotic cells in Caenorhabditis elegans. PLoS Biol. 2009 Apr 28;7(4).

Galvin, B.D., Kim S., and Horvitz H.R. (2008) Caenorhabditis elegans genes required for the engulfment of apoptotic corpses function in the cytotoxic cell deaths induced by mutations in lin-24 and lin-33. Genetics 179(1):403-17.

Schwartz, H. and Horvitz, H.R. (2007) The C. elegans protein CEH-30 protects male-specific CEM neurons from apoptosis independently of the Bcl-2 homolog CED-9. Genes & Develop. 21, 3181-3194.

Reddien, P., Andersen, E. and Horvitz, H.R. (2007) DPL-1 DP, LIN-35 Rb and EFL-1 E2F act with the MCD-1 Zn finger protein to promote programmed cell death in Caenorhabditis elegans. Genetics 175, 1719-1733.

Reddien, P. and Horvitz, H.R. (2004) The engulfment process of programmed cell deaths in Caenorhabditis elegans. Ann. Rev. Cell & Develop. Bio. 20, 193-221

Yuan, J. and Horvitz, H.R. (2004) A first insight into the molecular mechanisms of apoptosis. Cell S116, S53-S56

Horvitz, H.R. (2003) Worms, Life, and Death (Nobel Lecture) Chembiochem. 4(8), 697-711

Tzur, Y., Hersh, B., Horvitz, H.R. and Gruenbaum. Y. (2002) Fate of the nuclear lamina during Caenorhabditis elegans apoptosis. J. Struct. Biol. 137, 146-153.

Hersh, B., Hartwieg, E. and Horvitz, H.R. (2002) The Caenorhabditis elegans mucolipin-like gene cup-5 is essential for viability and regulates lysosomes in multiple cell types. Proc. Natl. Acad. Sci. U.S.A., 99, 4355-4360.

Zhou, Z., Caron, E., Hartwieg, E., Hall, A. and Horvitz, H.R. (2001) The C. elegans PH domain protein CED-12 regulates cytoskeletal reorganization via a Rho/Rac GTPase signaling pathway. Develop. Cell, 1, 477-489.

Reddien, P., Cameron, S. and Horvitz, H.R. (2001) Phagocytosis promotes programmed cell death in C. elegans. Nature 412, 198-202.

Zhou, Z., Hartwieg, E. and Horvitz, H.R. (2001) CED-1 is a transmembrane receptor that mediates cell-corpse engulfment in C. elegans. Cell 104, 43-56.

Stanfield, G. and Horvitz, H.R. (2000) The ced-8 gene controls the timing of programmed cell deaths in C. elegans. Molec. Cell 5, 423-433.

Wu, Y.-C., Stanfield, G. and Horvitz, H.R. (2000) NUC-1, a Caenorhabditis elegans DNase II homolog, functions in an intermediate step of DNA degradation during apoptosis. Genes & Develop. 14, 536-548.

Reddien, P.W. and Horvitz, H.R. (2000) CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans. Nature Cell Biology 2, 131-136.

Chen, F., Hersh, B., Conradt, B., Zhou, Z., Riemer, D., Gruenbaum, Y. and Horvitz, H.R. (2000) Translocation of C. elegans CED-4 to nuclear membranes during programmed cell death. Science 287, 1485-1489.

Shaham, S., Reddien, P., Davies, B. and Horvitz, H.R. (1999) Mutational analysis of the C. elegans cell-death gene ced-3. Genetics 153, 1655-1671.

Metzstein, M.M. and Horvitz, H.R. (1999) The Caenorhabditis elegans cell-death specification gene ces-1 encodes a Snail-family zinc-finger protein. Molecular Cell 4, 309-319.

Conradt, B. and Horvitz, H.R. (1999) The TRA-1A sex determination protein of C. elegans regulates sexually dimorphic cell deaths by repressing the egl-1 cell death activator gene. Cell 98, 317-327.

Gumienny, T.L., Lambie, E., Hartwieg, E., Horvitz, H.R. and Hengartner, M.O. (1999) Genetic control of programmed cell death in the Caenorhabditis elegans hermaphrodite germline. Development 126, 1011-1022.

Horvitz, H.R. (1999) Genetic control of programmed cell death in the nematode Caenorhabditis elegans. Cancer Research (Suppl.) 59, 1701s-1706s.

Metzstein, M.M., Stanfield, G.M. and Horvitz, H.R. (1998) Genetics of programmed cell death in C. elegans: Past, present and future. Trends in Genetics 14, 410-416.

Wu, Y-C. and Horvitz, H.R. (1998) The C. elegans cell corpse engulfment gene ced-7 encodes a protein similar to ABC transporters. Cell 93, 951-960.

Conradt, B. and Horvitz, H.R. (1998) The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9. Cell 93, 519-529.

Wu, Y.-C. and Horvitz, H.R. (1998) C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180. Nature 392, 501-504.

Xue, D. and Horvitz, H.R. (1997) Caenorhabditis elegans CED-9 protein is a bifunctional cell-death inhibitor. Nature 390, 305-308.

Barkett, M., Xue, D., Horvitz, H.R. and Gilmore, T.D. (1997) Phosphorylation of IkB-a inhibits its cleavage by caspase CPP32 in vitro. J. Biol. Chem. 272, 29419-29422.

Metzstein, M.M., Hengartner, M.O., Tsung, N., Ellis, R.E. and Horvitz, H.R. (1996) Transcriptional regulator of programmed cell death encoded by Caenorhabditis elegans gene ces-2. Nature 382, 545-547.

Shaham, S. and Horvitz, H.R. (1996) An alternatively spliced C. elegans ced-4 RNA encodes a novel cell-death inhibitor. Cell 86, 201-208.

Xue, D., Shaham, S. and Horvitz, H.R. (1996) The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease. Genes & Develop. 10, 1073-1083.

Shaham, S. and Horvitz, H.R. (1996) Developing Caenorhabditis elegans neurons may contain both cell-death protective and killer activities. Genes & Develop. 10, 578-591.

Horvitz, H.R. (1996) The biology of cell death in the nematode Caenorhabditis elegans and implications for the understanding and treatment of human brain injury after cardiac surgery. In Brain Injury and Pediatric Cardiac Surgery. R.A. Jonas, J.W. Newburger and J.J. Volpe, eds. Butterworth-Heinemann, pp. 75-83.

Xue, D. and Horvitz, H.R. (1995) Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein. Nature 377, 248-251.

Horvitz, H.R., Shaham, S. and Hengartner, M. (1994) The genetics of programmed cell death in the nematode Caenorhabditis elegans. Cold Spring Harbor Symp. Quant. Biol. 59, 377-385.

Hengartner, M. and Horvitz, H.R. (1994) The ins and outs of programmed cell death during C. elegans development. In Death from Inside Out: The Role of Apoptosis in Development, Tissue Homeostasis and Malignancy. T.M. Dexter, M.C. Raff and A. H. Wyllie, eds., Phil. Trans. R. Soc. Lond. 345, 243-246.

Hengartner, M. and Horvitz, H.R. (1994) Programmed cell death in Caenorhabditis elegans. Curr. Opin. Gen. & Develop. 4, 581-586.

Horvitz, H.R. (1994) Genetic control of programmed cell death in the nematode Caenorhabditis elegans. In Apoptosis. Pezcoller Foundation Symposia, Vol. 5. E. Mihich and R. Schimke, eds. New York: Plenum Press, pp. 1-13.

Hengartner, M.O. and Horvitz, H.R. (1994) Activation of C. elegans cell death protein CED-9 by an amino-acid substitution in a domain conserved in Bcl-2. Nature 369, 318-323.

Hengartner, M.O. and Horvitz, H.R. (1994) C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2. Cell 76, 665-676.

Hengartner, M. and Horvitz, H.R. (1993) Programmed cell death in the nematode Caenorhabditis elegans (in Japanese). Experimental Medicine 11, 2255-2261.

Yuan, J., Shaham, S., Ledoux, S., Ellis, H. and Horvitz, H.R. (1993) The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1ß-converting enzyme. Cell 75, 641-652.

Yuan, J. and Horvitz, H.R. (1992) The C. elegans cell death gene ced-4 encodes a novel protein and is expressed during the period of extensive programmed cell death. Development 116, 309-320.

Hengartner, M., Ellis, R. and Horvitz, H.R. (1992) Caenorhabditis elegans gene ced-9 protects cells from programmed cell death. Nature 356, 494-499.

Choi, D., Barde, Y., Chalfie, M., Heinemann, U., Horvitz, H.R., Kosik, K., Muller, H., Schwarcz, R., Schwarz, M., Shooter, E., Siesjo, B. and Unsicker, K. (1991) Neuronal death and survival. In Neurodegenerative Disorders: Mechanisms and Prospects for Therapy. D. Price, H. Thoenen and A. Aguayo, eds. Dahlem Konferenzen, Berlin, John Wiley & Sons Ltd., pp. 233-248.

Horvitz, H.R. and Chalfie, M. (1991) Implications of nematode neuronal cell death for human neurological disorders. In Neurodegenerative Disorders: Mechanisms and Prospects for Therapy. D. Price, H. Thoenen and A. Aguayo, eds. Dahlem Konferenzen, Berlin, John Wiley & Sons Ltd., pp. 5-19.

Ellis, R., Jacobson, D. and Horvitz, H.R. (1991) Genes required for the engulfment of cell corpses during programmed cell death in C. elegans. Genetics 129, 79-94.

Ellis, R., Yuan, J. and Horvitz, H.R. (1991) Mechanisms and functions of cell death. Ann. Rev. Cell Biol. 7, 663-698.

Ellis, R. and Horvitz, H.R. (1991) Two C. elegans genes control the programmed deaths of specific cells in the pharynx. Development 112, 591-603.

Yuan, J. and Horvitz, H.R. (1990) The Caenorhabditis elegans genes ced-3 and ced-4 act cell autonomously to cause programmed cell death. Develop. Biol. 138, 33-41.

Avery, L. and Horvitz, H.R. (1987) A cell that dies during wild-type C. elegans development can function as a neuron in a ced-3 mutant. Cell 51, 1071-1078.

Ellis, H. and Horvitz, H.R. (1986) Genetic control of programmed cell death in the nematode C. elegans. Cell 44, 817-829.

Horvitz, H.R., Ellis, H. and Sternberg, P. (1982) Programmed cell death in nematode development. Neuroscience Commentaries 1, 56-65.

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Neural Development

Nakano, S., Stillman, B. and Horvitz, H.R. (2011) Replication-coupled chromatin assembly generates a bilateral asymmetry. Cell 147, 1525-36.

Vanderzalm P.J., Pandey A., Hurwitz M.E., Bloom L., Horvitz H.R., Garriga G. (2009) C. elegans CARMIL negatively regulates UNC-73/Trio function during neuronal development. Development. 2009 Apr;136(7):1201-10.

Choi, P., Zakhary, L., Choi, W.-Y., Caron, S., Alvarez-Saavedra, E., Miska, E., McManus, M., Harfe, B., Giraldez, A., Horvitz, H.R., Schier, A. and Dulac, C. (2008) Members of the miRNA-200 family regulate olfactory neurogenesis. Neuron. 57, 41-55.

Eimar, S., Gottschalk, A., Hengartner, M., Horvitz, H.R., Richmond, J., Schafer, W., and Bessereau, J.-L. (2007) Regulation of nicotinic receptor trafficking by the transmembrane Golgi protein UNC-50. EMBO J., 26, 4313-4323.

Su, C.-W., Tharin, S., Jin, Y., Wightman, B., Spector, M., Meili, D., Tsung, N., Rhiner, C., Bourikas, D., Stoeckli, E., Garriga, G., Horvitz, H.R., and Hengartner, M. (2006) The short coiled-coil domain-containing protein UNC-69 cooperates with UNC-76 to regulate axonal outgrowth and normal presynaptic organization in Caenorhabditis elegans. J. Biol. 5, 9.1-9.26.

Miska, E., Alvarez-Saavedra, E., Yoshii, A., Townsend, M., Sestan, N., Rakic, P., Constantine-Paton, M., and Horvitz, H.R. (2004) Microarray analysis of microRNA expression in the developing mammalian brain. Genome Biology 5, R68. 1-13

Cameron, S., Clark S., McDermott, J., Aamodt, E. and Horvitz, H.R. (2002) PAG-3, a Zn finger transcription factor, determines neuroblast identity in C. elegans. Development 129, 1763-1774.

Lundquist, E., Reddien, P., Hartwieg, E., Horvitz, H.R. and Bargmann, C. (2001) Three C. elegans Rac proteins and several alternative Rac regulators control axon guidance, cell migration and apoptotic cell phagocytosis. Development 128, 4475-4488.

Eastman, C., Horvitz, H.R. and Jin, Y. (1999) Coordinated transcriptional regulation of the unc-25 glutamic acid decarboxylase and the unc-47 GABA vesicular transporter by the Caenorhabditis elegans UNC-30 homeodomain protein. J. Neuroscience 19, 6225-6234.

Bloom, L. and Horvitz, H.R. (1997) The unc-76 gene of Caenorhabditis elegans and its human homologs define a new family of genes involved in axonal outgrowth and fasciculation. Proc. Natl. Acad. Sci. U.S.A. 94, 3414-3419.

Labouesse, M., Hartwieg, E. and Horvitz, H.R. (1996) The Caenorhabditis elegans LIN-26 protein is required to specify and/or maintain all non-neuronal ectodermal cell fates. Development 122, 2579-2588.

Basson, M. and Horvitz, H.R. (1996) The Caenorhabditis elegans gene sem-4 controls neuronal and mesodermal cell development and encodes a zinc-finger protein. Genes & Develop. 10, 1953-1965.

Jin, Y., Hoskins, R. and Horvitz, H.R. (1994) Control of type-D GABAergic neuron differentiation by C. elegans UNC-30 homeodomain protein. Nature 372, 780-783.

Garriga, G., Guenther, C. and Horvitz, H.R. (1993) Migrations of the Caenorhabditis elegans HSNs are regulated by egl-43, a gene encoding two zinc-finger proteins. Genes & Develop. 7, 2097-2109.

Garriga, G., Desai, C. and Horvitz, H.R. (1993) Cell interactions control the direction of outgrowth, branching and fasciculation of the HSN axons of Caenorhabditis elegans. Development 117, 1071-1087.

McIntire, S., Garriga, G., Jacobson, D., White, J. and Horvitz, H.R. (1992) Genes necessary for directed axonal elongation and fasciculation in Caenorhabditis elegans. Neuron 8, 307-322.

Bargmann, C. and Horvitz, H.R. (1991) Control of larval development by chemosensory neurons in Caenorhabditis elegans. Science 251, 1243-1246.

Desai, C. and Horvitz, H.R. (1989) Caenorhabditis elegans mutants defective in the functioning of the motor neurons responsible for egg laying. Genetics 121, 703-721.

Desai, C., Garriga, G., McIntire, S. and Horvitz, H.R. (1988) A genetic pathway for the development of the Caenorhabditis elegans HSN motor neurons. Nature 336, 638-646.

Shatz, C., Bate, M., Bonhoeffer, F., Cowan, M., Easter, S., Herschkowitz, N., Horvitz, H.R., McKhann, G., Rathjen, F., Schachner, M. and Sears, T. (1982) Neural development: implications for recovery from injury. In Repair and Regeneration of the Nervous System. J. G. Nicholls, ed. Dahlem Konferenzen, Berlin, Springer-Verlag, pp. 289-311.

Horvitz, H.R. (1982) Factors that influence neural development in nematodes. In Repair and Regeneration of the Nervous System. J. G. Nicholls, ed. Dahlem Konferenzen, Berlin, Springer-Verlag, pp. 41-55.

White, J., Horvitz, H.R. and Sulston, J. (1982) Neurone differentiation in cell lineage mutants of Caenorhabditis elegans. Nature 297, 584-587.

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Morphogenesis

Yu H., Seah A., Herman M.A., Ferguson E.L., Horvitz H.R., Sternberg P.W. (2009) Wnt and EGF pathways act together to induce C. elegans male hook development. Dev Biol. 2009 Mar 15;327(2):419-32.

Frank, C.A., Hawkins, N., Guenther, C., Horvitz, H.R., and Garriga, G. (2005) C. elegans HAM-1 positions the cleavage plane of certain asymmetric neuroblast divisions. Develop. Biol. 284, 301-310

Jaeger, S. Schwartz, H., Horvitz, H.R., and Conradt, B. (2004) The Caenorhabditis elegans F-box protein SEL-10 promotes female development and may target FEM-1 and FEM-3 for degradation by the proteasome. Proc. Natl. Acad. Sci. U.S.A. 101, 12549-12554

Hwang, H.-Y., Olson, S., Esko, J. and Horvitz, H.R. (2003) Caenorhabditis elegans early embryogenesis and vulval morphogenesis require chondroitin biosynthesis. Nature 423, 439-443.

Hwang, H.-Y., Olson, S., Brown, J., Esko, J and Horvitz, H.R. (2003) The Caenorhabditis elegans genes sqv-2 and sqv-6, which are required for vulval morphogenesis, encode glycosaminoglycan galactosyltransferase II and xylosyltransferase. J. Biol. Chem. 278, 11735-11738.

Hwang, H.-Y. and Horvitz, H.R. (2002) The C. elegans vulval morphogenesis gene sqv-4 encodes a UDP-glucose dehydrogenase that is temporally and spatially regulated. Proc. Natl. Acad. Sci. U.S.A. 99, 14224-14229.

Hwang, H.-Y. and Horvitz, H.R. (2002) The SQV-1 UDP-glucoronic acid decarboxylase and the SQV-7 nucleotide-sugar transporter may act in the Golgi apparatus to affect C. elegans vulval morphogenesis and embryonic development. Proc. Natl. Acad. Sci. U.S.A. 99, 14218-14223.

Berninsone, P., Hwang, H.-Y., Zemtesava, I., Horvitz, H.R. and Hirschberg, C. (2001) SQV-7, a protein involved in C. elegans epithelial invagination and early embryogenesis, transports UDP-glucoronic acid, UDP-N-acetylgalactosamine and UDP-galactose. Proc. Natl. Acad. Sci. U.S.A. 98, 3738-3743.

Newman, A.P., Acton, G. Z., Hartwieg, E., Horvitz, H.R. and Sternberg, P.W. (1999) The lin-11 LIM domain transcription factor is necessary for morphogenesis of C. elegans uterine cells. Development 126, 5319-5326.

Herman, T. and Horvitz, H.R. (1999) Three proteins involved in Caenorhabditis elegans vulva invagination are similar to components of a glycosylation pathway. Proc. Natl. Acad. Sci. U.S.A. 96, 974-979.

Herman, T., Hartwieg, E. and Horvitz, H.R. (1999) sqv mutants of Caenorhabditis elegans are defective in vulval epithelial invagination. Proc. Natl. Acad. Sci. U.S.A. 96, 968-973

Herman, T. and Horvitz, H.R. (1997) Mutations that perturb vulval invagination in C. elegans. Cold Spring Harbor Symp. Quant. Biol. 62, 353-360.

Park, E. and Horvitz, H.R. (1986) Mutations with dominant effects on the behavior and morphology of the nematode Caenorhabditis elegans. Genetics 113, 821-852.

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Aging

Boulias K and Horvitz H.R. (2012) The C. elegans MicroRNA mir-71 Acts in Neurons to Promote Germline-Mediated Longevity through Regulation of DAF-16/FOXO. Cell Metab. 15, 439-50.

Berdichevsky, A., Nedelcu, S., Boulias, K., Bishop, N., Guarente, L. and Horvitz, H.R. (2010) 3-ketoacyl thiolase delays aging in C. elegans and is required for metabolic changes and longevity mediated by sir-2.1. PNAS 107, 18927-18932.

Berdichevsky, A., Viswanathan, M., Horvitz, H.R. and Guarente, L. (2006) C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span. Cell 125, 1165-1177

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Signal Transduction and Epigenetics

Ma, D.K., Vozdek, R., Bhatla, N. and Horvitz, H.R. (2012) CYSL-1 Interacts with the O2-sensing Hydroxylase EGL-9 to Promote H2S-modulated Hypoxia-induced Behavioral Plasticity in C. elegans. Neuron 73, 925-40.

Nakano, S., Stillman, B. and Horvitz, H.R. (2011) Replication-coupled chromatin assembly generates a bilateral asymmetry. Cell 147, 1525-36.

Saffer, A., Kim, D.H., van Oudenaarden, A., and Horvitz, H.R. (2011) The C. elegans synthetic multivulva genes prevent Ras activation by tightly repressing global ectopic expression of lin-3 EGF. PLoS Genet. 7, e1002418.

Davison, E., Saffer, A., Huang, L., DeModena, J., Sternberg, P., and Horvitz, H.R. (2011) The LIN-15A and LIN-56 transcriptional regulators interact to negatively regulate EGF/Ras signaling in Caenorhabditis elegans vulval cell-fate determination. Genetics 187, 803-815.

Yu H., Seah A., Herman M.A., Ferguson E.L., Horvitz H.R., Sternberg P.W. (2009) Wnt and EGF pathways act together to induce C. elegans male hook development. Dev Biol. 2009 Mar 15;327(2):419-32.

Andersen, E. and Horvitz, H.R.(2007) Two C. elegans histone methyltransferases repress lin-3 EGF to inhibit vulval development. Development 134, 2991-2999.

Harrison, M., Lu, X. and Horvitz, H.R. (2007) LIN-61, one of two Caenorhabditis elegans MBT-repeat-containing proteins, acts with the DRM and NuRD-like protein complexes in vulval development but not in certain other biological processes. Genetics 176, 255-271.

Reddien, P., Andersen, E. and Horvitz, H.R. (2007) DPL-1 DP, LIN-35 Rb and EFL-1 E2F act with the MCD-1 Zn finger protein to promote programmed cell death in Caenorhabditis elegans. Genetics 175, 1719-1733.

Harrison, M., Ceol, C., Lu, X. and Horvitz (2006) Some C. elegans class B synthetic multivulva proteins encode a conserved LIN-35 Rb-containing protein complex distinct from a NuRD-like complex. Proc. Natl. Acad. Sci. U.S.A. 103, 16782-16787.

Ceol, C., Stegmeier, F., Harrison, M., and Horvitz, H.R. (2006) Identification and classification of genes that act antagonistically to let-60 Ras signaling in C. elegans vulval development. Genetics 173, 709-726

Andersen, E., Lu, X. and Horvitz, H.R. (2006) C. elegans ISW1 and NURF301 antagonize an Rb-like pathway in the determination of multiple cell fates. (2006) Development 133, 2695-2704

Davison, E., Harrison, M., Walhout, A., Vidal, M and Horvitz, H.R. (2005) lin-8, which antagonizes Caenorhabditis elegans Ras-mediated vulval induction, encodes a novel nuclear protein that interacts with the LIN-35 Rb protein. Genetics 171, 1017-1031

Ceol, C. and Horvitz, H.R. (2004) A new class of C. elegans synMuv genes implicates a Tip60/NuA4-like HAT complex as a negative regulator of Ras signaling. Developmental Cell 6, 563-576

Horvitz, H.R. (2003) Worms, Life, and Death (Nobel Lecture) Chembiochem. 4(8), 697-711

Thomas, J.H., Ceol, C., Schwartz, H. and Horvitz, H.R. (2003) New genes that interact with lin-35 Rb to negatively regulate the let-60 Ras pathway in Caenorhabditis elegans. Genetics 164, 135-151.

Ceol, C. and Horvitz, H.R. (2001) dpl-1 DP and efl-1 E2F act with lin-35 Rb to antagonize Ras signaling in C. elegans vulval development. Molec. Cell 7, 461-473.

Beitel, G., Lambie, E.J. and Horvitz, H.R. (2000) The C. elegans gene lin-9, which acts in an Rb-related pathway, is required for gonadal sheath cell development and encodes a novel protein. Gene 254, 253-263.

Thomas, J.H. and Horvitz, H.R. (1999) The C. elegans gene lin-36 acts cell autonomously in the lin-35 Rb pathway. Development 126, 3449-3459.

Lu, X. and Horvitz H.R. (1998) lin-35 and lin-53, two genes that antagonize a C. elegans Ras pathway, encode proteins similar to Rb and its binding protein RbAp48. Cell 95, 981-991.

Jacobs, D., Beitel, G.J., Clark, S.G., Horvitz, H.R. and Kornfeld, K. (1998) Gain-of-function mutations in the Caenorhabditis elegans lin-1 ETS gene identify a C-terminal regulatory domain phosphorylated by ERK MAP kinase. Genetics 149, 1809-1822.

Kokel, M., DeLong, L., Horvitz, H.R. and Stern, M.J. (1998) clr-1 encodes a receptor tyrosine phosphatase that negatively regulates an FGF receptor signaling pathway in Caenorhabditis elegans. Genes & Develop. 12, 1425-1437.

Tax, F.E., Thomas, J.H., Ferguson, E.L. and Horvitz, H.R. (1997) Identification and characterization of genes that interact with lin-12 in Caenorhabditis elegans. Genetics 147, 1675-1695.

Sawa, H., Lobel, L. and Horvitz, H.R. (1996) The Caenorhabditis elegans gene lin-17, which is required for certain asymmetric cell divisions, encodes a putative seven-transmembrane protein similar to the Drosophila Frizzled protein. Genes & Develop. 10, 2189-2197.

Koelle, M. and Horvitz, H.R. (1996) EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins. Cell 84, 115-125.

Beitel, G.J., Tuck, S., Greenwald, I. and Horvitz, H.R. (1995) The Caenorhabditis elegans gene lin-1 encodes an ETS-domain protein and defines a branch in the vulval signaling pathway. Genes & Develop. 9, 3149-3162.

Kornfeld, K., Hom, D.B. and Horvitz, H.R. (1995) The ksr-1 gene encodes a novel protein kinase involved in ras-mediated signaling in Caenorhabditis elegans. Cell 83, 903-913.

DeVore, D.L., Horvitz, H.R. and Stern, M.J. (1995) An FGF receptor signaling pathway is required for the normal cell migrations of the sex myoblasts in C. elegans hermaphrodites. Cell 83, 611-620.

Herman, M., Vassilieva, L., Horvitz, H.R., Shaw, J. and Herman, R. (1995) The Caenorhabditis elegans gene lin-44, which controls the polarity of certain asymmetric cell divisions, encodes a Wnt protein and acts cell nonautonomously. Cell 83, 101-110.

Kornfeld, K., Guan, K-L. and Horvitz, H.R. (1995) The Caenorhabditis elegans gene mek-2 is required for vulval induction and encodes a protein similar to the protein kinase MEK. Genes & Develop. 9, 756-768.

Clark, S., Lu, X. and Horvitz, H.R. (1994) The C. elegans locus lin-15, a negative regulator of a tyrosine kinase signaling pathway, encodes two different proteins. Genetics 137, 987-997.

Herman, M. and Horvitz, H.R. (1994) The Caenorhabditis elegans gene lin-44 controls the polarity of certain asymmetric cell divisions. Development 120, 1035-1047.

Lackner, M., Kornfeld, K., Miller, L., Horvitz, H.R. and Kim, S. (1994) A MAP kinase homolog, mpk-1, is involved in ras-mediated induction of vulval cell fates in Caenorhabditis elegans. Genes & Develop. 8, 160-173.

Clark, S., Stern, M. and Horvitz, H.R. (1992) Genes involved in two C. elegans cell-signaling pathways. Cold Spring Harb. Symp. Quant. Biol. 57, 363-373.

Clark, S., Stern, M. and Horvitz, H.R. (1992) C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains. Nature 356, 340-344.

Stern, M. and Horvitz, H.R. (1991) A normally attractive cell interaction is repulsive in two C. elegans mesodermal cell migration mutants. Development 113, 797-803.

Sternberg, P. and Horvitz, H.R. (1991) Signal transduction during C. elegans vulval induction. Trends in Genetics 7, 366-371.

Horvitz, H.R. and Sternberg, P. (1991) Multiple intercellular signalling systems control the development of the Caenorhabditis elegans vulva. Nature 351, 535-541.

Beitel, G., Clark, S. and Horvitz, H.R. (1990) The Caenorhabditis elegans ras gene let-60 acts as a switch in the pathway of vulval induction. Nature 348, 503-509.

Thomas, J., Stern, M. and Horvitz, H.R. (1990) Cell interactions coordinate the development of the C. elegans egg-laying system. Cell 62, 1041-1052.

Freyd, G., Kim, S. and Horvitz, H.R. (1990) Novel cysteine-rich motif and homeodomain in the product of Caenorhabditis elegans cell lineage gene lin-11. Nature 344, 876-879.

Kim, S. and Horvitz, H.R. (1990) The Caenorhabditis elegans gene lin-10 is broadly expressed while required specifically for the determination of vulval cell fates. Genes & Develop. 4, 357-371.

Ferguson, E. and Horvitz, H.R. (1989) The multivulva phenotype of certain Caenorhabditis elegans mutants results from defects in two functionally- redundant pathways. Genetics 123, 109-121.

Sternberg, P. and Horvitz, H.R. (1989) The combined action of two intercellular signaling pathways specifies three cell fates during vulval induction in C. elegans. Cell 58, 679-693.

Ferguson, E., Sternberg, P. and Horvitz, H.R. (1987) A genetic pathway for the specification of the vulval cell lineages of Caenorhabditis elegans. Nature 326, 259-267.

Sternberg, P. and Horvitz, H.R. (1986) Pattern formation during vulval development in C. elegans. Cell 44, 761-772.

Ferguson, E. and Horvitz, H.R. (1985) Identification and characterization of 22 genes that affect the vulval cell lineages of the nematode Caenorhabditis elegans. Genetics 110, 17-72.

Brockes, J., Aguayo, A., Black, I., Horvitz, H.R., Raff, M., Vacquier, V., Warner, A., Wiesel, T. and Wolpert, L. (1979) Consequences of signal reception. In The Role of Intercellular Signals: Navigation, Encounter, Outcome. J. Nicholls, ed. Dahlem Konferenzen, Verlag Chemie, Berlin, pp. 285-300.

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Behavior

Ma, D.K., Rothe, M., Zheng, S., Bhatla, N., Pender, C., Menzel, R. and Horvitz, H.R. (2013) Cytochrome P450 drives a HIF-regulated behavioral response to reoxygenation by C. elegans. Science 341, 554-558.

Emtage, L., Aziz-Zaman, S., Padovan-Merhar, O., Horvitz, H.R., Fang-Yen, C. and Ringstad, N. (2012) IRK-1 potassium channels mediate peptidergic inhibition of Caenorhabditis elegans serotonin neurons via a dedicated Go signaling pathway. J. Neuroscience 32, 16285-16295.

Gurel, G., Gustafson, M., Pepper, J., Horvitz, H.R. and Koelle, M. (2012) Receptors and other signaling proteins required for serotonin control of locomotion in C. elegans. Genetics, Sept. 28, 112.142125

Ma, L., Gau, X., Luo, J., Huang, L., Teng, Y. and Horvitz, H.R. (2012) Caenorhabditis elegans gene mfap-1 encodes a nuclear protein that affects alternative splicing. PLoS Genetics, 8(7):e1002827.

Omura, D., Clark, D., Samuel, A. and Horvitz, H.R. (2012) Dopamine signalling is essential for precise rates of locomotion by C. elegans. PLoS One 7(6):e38649.

Ma, D.K., Vozdek, R., Bhatla, N. and Horvitz, H.R. (2012) CYSL-1 Interacts with the O2-sensing Hydroxylase EGL-9 to Promote H2S-modulated Hypoxia-induced Behavioral Plasticity in C. elegans. Neuron 73, 925-40.

Hallem, E., Spencer, W.C., McWhirter, R., Zeller, G., Henz, S., Ratsch, G., Miller, D., Horvitz, H.R., Sternberg, P. and Ringstad, N. (2011) A receptor-type guanylate cyclase is required for carbon dioxide sensation by C. elegans. PNAS 108, 254-259.

Jospin, M., Qi, Y., Stawicki, T., Boulin, T., Schuske, K., Horvitz, H.R., Bessereau, J.-L., Jorgensen, E. and Jin, Y. (2009) A neuronal acetylcholine receptor regulates the balance of muscle excitation and inhibition in Caenorhabditis elegans. PLoS Biology 7, e1000265.

Ringstad N., Abe N., Horvitz H.R. (2009) Ligand-gated chloride channels are receptors for biogenic amines in C. elegans. Science. 2009 Jul 3;325(5936):96-100.

Ringstad, N and Horvitz, H.R. (2008) FMRFamide neuropeptides and acetylcholine synergistically inhibit egg-laying by C. elegans. Nat. Neurosci. 11(10): 1168-76.

Alkema, M., Hunter-Ensor, M., Ringstad, N., and Horvitz, H.R. (2005) Tyramine functions independently of octopamine in the Caenorhabditis elegans nervous system. Neuron 46, 247-260

de la Cruz IP, Levin JZ, Cummins C, Anderson P, Horvitz H.R. (2003) sup-9, sup-10, and unc-93 may encode components of a two-pore K+ channel that coordinates muscle contraction in Caenorhabditis elegans. J Neurosci. 2003 Oct 8;23(27):9133-45.

Ranganathan, R., Sawin, E., Trent, C. and Horvitz, H.R. (2001) Mutations in the Caenorhabditis elegans serotonin reuptake transporter MOD-5 reveal serotonin-dependent and -independent activities of fluoxetine. J. Neurosci. 21, 5871-5884.

Ranganathan, R., Cannon, S. and Horvitz, H.R. (2000) MOD-1 is a serotonin-gated chloride channel that modulates locomotory behaviour in C. elegans. Nature 408, 470-475.

Harris, T., Hartwieg, E., Horvitz, H.R. and Jorgensen, E. (2000) Mutations in synaptojanin disrupt synaptic vesicle recycling. J. Cell Biol. 150, 589-599.

Sawin, E.R., Ranganathan, R. and Horvitz, H.R. (2000) C. elegans locomotory rate is modulated by the environment through a dopaminergic pathway and by experience through a serotonergic pathway. Neuron 26, 619-631.

Jin, Y., Jorgensen, E., Hartwieg, E. and Horvitz, H.R. (1999) The C. elegans gene unc-25 encodes glutamic acid decarboxylase and is required for synaptic transmission but not synaptic development. J. Neuroscience 19, 539-548.

Lee, R.Y.N., Sawin, E.R., Chalfie, M., Horvitz, H.R. and Avery, L. (1999) EAT-4, a homolog of a mammalian sodium-dependent inorganic phosphate cotransporter, is necessary for glutamatergic neurotransmission in Caenorhabditis elegans. J. Neuroscience 19, 159-167.

Nonet, M.L., Staunton, J.E., Kilgard, M.P., Fergestad, T., Hartwieg, E., Horvitz, H.R., Jorgensen, E.M. and Meyer, B.J. (1997) C. elegans rab-3 mutant synapses exhibit impaired function and are partially depleted of vesicles. J. Neuroscience 17, 8061-8073.

Lee, R.Y.N., Lobel, L., Hengartner, M., Horvitz, H.R. and Avery, L. (1997) Mutations in the alpha1 subunit of an L-type voltage-activated Ca2+ channel cause myotonia in Caenorhabditis elegans. EMBO J. 16, 6066-6076.

Barnes, T.M., Jin, Y., Horvitz, H.R., Ruvkun, G. and Hekimi, S. (1996) The C. elegans behavioural gene unc-24 encodes a novel bipartite protein similar to both erythrocyte band 7.2 (stomatin) and non-specific lipid transfer protein (nsLTP). J. Neurochem. 67, 46-57.

Koelle, M. and Horvitz, H.R. (1996) EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins. Cell 84, 115-125.

Jorgensen, E.M., Hartwieg, E., Yook, K. and Horvitz, H.R. (1996) Genetic screens for synaptic function mutants in the nematode C. elegans. In Basic Neuroscience in Invertebrates. Tenth Tokyo Metropolitan Institute for Neuroscience International Symposium, Tokyo, Japan, pp. 217-226.

Jorgensen, E.M., Hartwieg, E., Schuske, K., Nonet, M.L., Jin, Y. and Horvitz, H.R. (1995) Defective recycling of synaptic vesicles in synaptotagmin mutants of Caenorhabditis elegans. Nature 378, 196-199.

Bargmann, C., Hartwieg, E. and Horvitz, H.R. (1993) Odorant-selective genes and neurons mediate olfaction in C. elegans. Cell 74, 515-527.

Levin, J. and Horvitz, H.R. (1993) Three new classes of mutations in the Caenorhabditis elegans muscle gene sup-9. Genetics 135, 53-70.

McIntire, S., Jorgensen, E., Kaplan, J. and Horvitz, H.R. (1993) The GABAergic nervous system of Caenorhabditis elegans. Nature 364, 337-341.

McIntire, S., Jorgensen, E. and Horvitz, H.R. (1993) Genes required for GABA function in Caenorhabditis elegans. Nature 364, 334-337.

Avery, L., Bargmann, C. and Horvitz, H.R. (1993) The Caenorhabditis elegans unc-31 gene affects multiple nervous system-controlled functions. Genetics 134, 455-464.

Kaplan, J. and Horvitz, H.R. (1993) A dual mechanosensory and chemosensory neuron in Caenorhabditis elegans. Proc. Natl. Acad. Sci. U.S.A. 90, 2227- 2231.

Levin, J. and Horvitz, H.R. (1992) The Caenorhabditis elegans unc-93 gene encodes a putative transmembrane protein that regulates muscle contraction. J. Cell Biology 117, 143-155.

Bargmann, C. and Horvitz, H.R. (1991) Chemosensory neurons with overlapping functions direct chemotaxis to multiple chemicals in C. elegans. Neuron 7, 729-742.

Bargmann, C. and Horvitz, H.R. (1991) Control of larval development by chemosensory neurons in Caenorhabditis elegans. Science 251, 1243-1246.

Bargmann, C., Thomas, J. and Horvitz, H.R. (1990) Chemosensory cell function in the behavior and development of Caenorhabditis elegans. Cold Spring Harbor Symp. Quant. Biol. 55, 529-538.

Avery, L. and Horvitz, H.R. (1990) Effects of starvation and neuroactive drugs on feeding in Caenorhabditis elegans. J. Exp. Zool. 253, 263-270.

Avery, L. and Horvitz, H.R. (1989) Pharyngeal pumping continues after laser killing of the pharyngeal nervous system of C. elegans. Neuron 3, 473-485.

Desai, C. and Horvitz, H.R. (1989) Caenorhabditis elegans mutants defective in the functioning of the motor neurons responsible for egg laying.Genetics 121, 703-721.

Desai, C., Garriga, G., McIntire, S. and Horvitz, H.R. (1988) A genetic pathway for the development of the Caenorhabditis elegans HSN motor neurons. Nature 336, 638-646.

Park, E. and Horvitz, H.R. (1986) C. elegans unc-105 mutations affect muscle and are suppressed by other mutations that affect muscle. Genetics 113, 853-867.

Park, E. and Horvitz, H.R. (1986) Mutations with dominant effects on the behavior and morphology of the nematode Caenorhabditis elegans. Genetics 113, 821-852.

Greenwald, I. and Horvitz, H.R. (1986) A visible allele of the muscle gene sup-10 X of C. elegans. Genetics 113, 63-72.

Greenwald, I., Sternberg, P. and Horvitz, H.R. (1983) The lin-12 locus specifies cell fates in Caenorhabditis elegans. Cell 34, 435-444.

Trent, C., Tsung, N. and Horvitz, H.R. (1983) Egg-laying defective mutants of the nematode Caenorhabditis elegans. Genetics 104, 619-647.

Greenwald, I. and Horvitz, H.R. (1982) Dominant suppressors of a muscle mutant define an essential gene of C. elegans. Genetics 101, 211-225.

Horvitz, H.R., Chalfie, M., Trent, C., Sulston, J. and Evans, P. (1982) Serotonin and octopamine in the nematode Caenorhabditis elegans. Science 216, 1012-1014.

Greenwald, I. and Horvitz, H.R. (1980) unc-93(e1500): a behavioral mutant of Caenorhabditis elegans that defines a gene with a wild-type null phenotype. Genetics 96, 147-164.

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Micro RNAs

Boulias K and Horvitz H.R. (2012) The C. elegans MicroRNA mir-71 Acts in Neurons to Promote Germline-Mediated Longevity through Regulation of DAF-16/FOXO. Cell Metab. 15, 439-50.

Alvarez-Saavedra, E. and Horvitz, H.R. (2010) Many families of Caenorhabditis elegans microRNAs are not essential for development and viability. Current Biology 20, 367-373

Choi, P., Zakhary, L., Choi, W.-Y., Caron, S., Alvarez-Saavedra, E., Miska, E., McManus, M., Harfe, B., Giraldez, A., Horvitz, H.R., Schier, A. and Dulac, C. (2008) Members of the miRNA-200 family regulate olfactory neurogenesis. Neuron. 57, 41-55.

Miska, E., Alvarez-Saavedra, E., Abbott, A., Lau, N., Hellman, A., McGonagle, S., Bartel, D. Ambros, V and Horvitz, H.R. (2007) Most Caenorhabditis elegans microRNAs are individually not essential for development or viability. PLoS Genetics 3(12), e215.

Abbott, Al., Alvarez-Saavedra, E., Miska, E., Lau, N. Bertell, D., Horvitz, H.R., and Ambros, V. (2005) The let-7 microRNA family members mir-48, mir-84, and mir-241 function together to regulate developmental timing in Caenorhabditis elegans. Develop. Cell 9, 403-414

Wienholds, E., Kloosterman, W., Miska, E., Alvarez-Saavedra, E., Berezikov, E., de Bruijn, E., Tolstrup, N., Horvitz, H.R., Kauppinen, S., and Plasterk, R. (2005) MicroRNA expression in zebrafish embryonic development. Science 309, 310-311.

Lu, J., Getz, G., Miska, E., Alvarez-Saavedra, E., Lamb, J., Peck, D., Sweet-Cordero, A., Ferrando, A., Downing, J., Jacks, T., Horvitz, H.R., and Golub, T. (2005) MicroRNA expression profiles classify human cancers. Nature 435, 834-848

Miska, E., Alvarez-Saavedra, E., Yoshii, A., Townsend, M., Sestan, N., Rakic, P., Constantine-Paton, M., and Horvitz, H.R. (2004) Microarray analysis of microRNA expression in the developing mammalian brain. Genome Biology 5, R68. 1-13

Slack, F.J., Basson, M., Liu, Z., Ambros, V., Horvitz, H.R. and Ruvkun, G. (2000) The lin-41 RBCC Gene Acts in the C. elegans Heterochronic Pathway between the let-7 Regulatory RNA and the LIN-29 Transcription Factor. Molec. Cell 5, 659-669.

Reinhart, B.J., Slack, F.J., Basson, M., Pasquinelli, A.E., Bettinger, J.C., Rougvie, A.E., Horvitz, H.R. and Ruvkun, G. (2000) The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature 403, 901-906.

Ruvkun, G., Ambros, V., Coulson, A., Sulston, J., Waterston, R., and Horvitz, H.R. (1989) Molecular genetics of the Caenorhabditis elegans heterochronic gene lin-14. Genetics 121, 501-516.

Ambros, V. and Horvitz, H.R. (1987) The lin-14 locus of Caenorhabditis elegans controls the time of expression of specific postembryonic developmental events. Genes & Development 1, 398-414.

Ambros, V. and Horvitz, H.R. (1984) Heterochronic mutants of the nematode Caenorhabditis elegans. Science 226, 409-416.

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Splicing

Ma, L., Gau, X., Luo, J., Huang, L., Teng, Y. and Horvitz, H.R. (2012) Caenorhabditis elegans gene mfap-1 encodes a nuclear protein that affects alternative splicing. PLoS Genetics, 8(7):e1002827.

Ma, L., Tan, Z., Teng, Y., Hoersch, S. and Horvitz, H.R. (2011) In vivo effects on intron retention and exon skipping by the U2AF large subunit and SF1/BBP in the nematode Canenorhabditis elegans. RNA 17, 2201-11.

Galvin, B., Denning, D. and Horvitz, H.R. (2011) SPK-1, an SR protein kinase, inhibits programmed cell death in C. elegans. PNAS 108, 1998-2003.

Ma, L., Horvitz H.R. (2009) Mutations in the Caenorhabditis elegans U2AF large subunit UAF-1 alter the choice of a 3' splice site in vivo. PLoS Genet. 2009 Nov;5(11).

Shaham, S. and Horvitz, H.R. (1996) An alternatively spliced C. elegans ced-4 RNA encodes a novel cell-death inhibitor. Cell 86, 201-208.

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Human Disease

Kwiatkowski T., Jr., Bosco, D., LeClerc, A., Tamrazian, E.,Van den Berg, C., Russ, C., Davis, A., Gilchrist, J., Kasarskis, E., Munsat, T., Rouleau, G., Hosler, B., Cortelli, P., de Jong, P., Yoshinaga, Haines, J., Pericak-Vance, M., Yan, J., Siddique, T., McKenna-Yasek, D., Sapp, P., Horvitz, H.R., Landers, J. and Brown, R., Jr.(2009) Mutations in the FUS/TLS gene on chromosome cause familial amyotrophic lateral sclerosis. Science 323, 1205-1208

Landers, J., Melki, J., Meininger, V., Glass, H., Van den Berg, L., van Es, M., Sapp, P., van Vught, P., McKenna-Yasek, D., Blauw, H., Cho, T.-J., Polak, M., Shi, L., Wills, A.-M., Broom, W., Ticozzi, N., Ozoguz, A., Rodriquez, I., Veldink, J., Ivinson, A., Saris, C., Hosler, B., Barnes-Nessa, A., Couture, N., Wokke, J., Kwiatkowski, T., Ophoff, R., Cronin, S., Hardiman, O., Diekstra, F., Leigh, P., Shaw, C., Simpson, C., Hansen, V., Powell, J., Corcia, P., Salachas, F., Heath, S., Galen, P., Georges, F., Horvitz, H.R., Lathrop, M., Purcell, S., Al-Chalabi, Al and Brown, R. (2009) Reduced expression of the kinesin-associated protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis. PNAS 106, 9004-9009.

Simpson, C., Lemmens, R., Broom, W., Hansen, V., Landers, J., Sapp, P., Van Den Bosch, L., Knight, J., Neale, B., Tripathi, V., Shah, M., Turner, M., Proitsi, P., Van Hoecke, A., Carmeliet, P., Horvitz, H.R., Leigh, N., Shaw, C., Sham, P., Powell, J., Brown, R., Robberecht, W., and Al-Chalabi, A. (2009) Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration. Human Molec. Genetics 18, 472-481.

Shah, P., Ahmad-Annuar, A., Ahmadi, K., Russ, C., Sapp, P., Horvitz, H.R., Brown, R., Goldstein, D. and Fisher, E. (2006) No association of DYNC1H1 with sporadic ALS in a case-control study of a northern European derived population: a tagging SNP approach. Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders 7, 46-56

Morita, M., Al-Chalabi, A., Andersen, P., Hosler, B., Sapp, P., Englund, E., Mitchell, J, Habgood, J., de Belleroche, J., Xi, J., Jongjaroenprasert, W., Horvitz, H.R., Gunnarsson, L.-G. and Brown, R. (2006) A locus on chromosomem 9p confers susceptibility to ALS and frontotemporal dementia. Neurology 66, 839-844

Lu, J., Getz, G., Miska, E., Alvarez-Saavedra, E., Lamb, J., Peck, D., Sweet-Cordero, A., Ferrando, A., Downing, J., Jacks, T., Horvitz, H.R., and Golub, T. (2005) MicroRNA expression profiles classify human cancers. Nature 435, 834-848

Sapp, P., Hosler, B., McKenna-Yasek, D., Chin, W., Gann, A., Genise, H., Gorenstein, J., Huang, M., Sailer, W., Scheffler, M., Valesky, M., Haines, J., Pericak-Vance, M., Siddique, T., Horvitz, H.R., and Brown, Jr., R.H. (2003) Identification of two novel loci for dominantly inherited familial amyotrophic lateral sclerosis. Amer. J. Human Genetics 73, 397-403.

Hersh, B., Hartwieg, E. and Horvitz, H.R. (2002) The Caenorhabditis elegans mucolipin-like gene cup-5 is essential for viability and regulates lysosomes in multiple cell types.Proc. Natl. Acad. Sci. U.S.A., 99, 4355-4360.

Hosler, B.A., Siddique, T., Sapp, P.C., Sailor, W., Huang, M.C., Hossain, A., Daube, J.R., Nance, M., Fan, C., Kaplan, J., Hung, W-Y., McKenna-Yasek, D., Haines, J.L., Pericak-Vance, M.A., Horvitz, H.R. and Brown, Jr., R.H. (2000) Linkage of familial amyotrophic lateral sclerosis with frontotemporal dementia to chromosome 9q21-q22. J. Amer. Med. Assoc. 284, 1664-1669.

Hosler, B.A., Sapp, P.C., Berger, R., O'Neill, G., Bejaoui, K., Hamida, M.B., Hentati, F., Chin, W., McKenna-Yasek, D., Haines, J., Patterson, D., Horvitz, H.R. and Brown, Jr., R.H. (1998) Refined mapping and characterization of the recessive familial amyotrophic lateral sclerosis locus (ALS2) on chromosome 2q33. Neurogenetics 2, 34-42.

Aoki, M., Chien-Liang, G.L., Rothstein, J.D., Geller, B.A., Hosler, B.A., Munsat, T.L., Horvitz, H.R. and Brown, Jr., R.H. (1998) Mutations in the glutamate transporter EAAT2 gene do not cause abnormal EAAT2 transcripts in amyotrophic lateral sclerosis. Annals of Neurology 43, 645-653.

Cudkowicz, M.E., McKenna-Yasek, D., Sapp, P.E., Chin, W., Geller, B., Hayden, D.L., Schoenfeld, D.A., Hosler, B.A., Horvitz, H.R. and Brown, R.H. (1997) Epidemi-ology of mutations in superoxide dismutase in amyotrophic lateral sclerosis. Annals of Neurology 41, 210-221.

Hosler, B.A., Nicholson, G.A., Sapp, P.C., Chin, W., Orrell, R.W., de Belleroche, J.S., Esteban, J., Hayward, L.J., McKenna-Yasek, D., Yeung, L., Cherryson, A.K., Dench, J.E., Wilton, S.D., Laing, N.G., Horvitz, H.R. and Brown, Jr., R.H. (1996) Three novel mutations and two variants in the gene for Cu/Zn superoxide dismutase in familial amyotrophic lateral sclerosis. Neuromuscular Disorders 6, 361-366.

Sapp, P., Rosen, D., Hosler, B., Esteban, J., McKenna-Yasek, D., O'Regan, J., Horvitz, H.R. and Brown, Jr., R.H. (1995) Identification of three novel mutations in the gene for Cu/Zn superoxide dismutase in patients with familial amyotrophic lateral sclerosis. Neuromuscular Disorders 5, 353-357.

Bowling, A.C., Barkowski, E.E., McKenna-Yasek, D., Sapp, P., Horvitz, H.R., Beal, M.F. and Brown, Jr., R.H. (1995) Superoxide dismutase concentration and activity in familial amyotrophic lateral sclerosis. J. Neurochem. 64, 2366-2369.

Esteban, J., Rosen, D., Bowling, A., Sapp, P., McKenna-Yasek, D., O'Regan, J., Beal, M., Horvitz, H.R. and Brown, Jr., R.H. (1994) Identification of two novel mutations and a new polymorphism in the gene for Cu/Zn superoxide dismutase in pa-tients with amyotrophic lateral sclerosis. Human Molecular Genetics 3, 997-998.

Gregor, P., Gaston, S., Yang, X., O'Regan, J., Rosen, D., Tanzi, R., Patterson, D., Haines, J., Horvitz, H.R., Uhl, G. and Brown, Jr., R.H. (1994) Genetic and physical mapping of the GLUR5 glutamate receptor gene on human chromosome 21. Human Genetics 94, 565-570.

Rosen, D., Bowling, A., Patterson, D., Usdin, T., Sapp, P., Mezey, E., McKenna-Yasek, D., O'Regan, J., Rahmani, Z., Ferrante, R., Brownstein, M., Kowall, N., Beal, M., Horvitz, H.R. and Brown, Jr., R.H. (1994) A frequent Ala 4 to Val superoxide dismutase-1 mutation is associated with rapidly progressive familial amyotrophic lateral sclerosis. Human Molecular Genetics 3, 981-987.

Robberecht, W., Sapp, P., Viaene, M., Rosen, D., McKenna-Yasek, D., Haines, J., Horvitz, H.R., Theys, P. and Brown, Jr., R.H. (1994) Cu/Zn superoxide dismutase activity in familial and sporadic amyotrophic lateral sclerosis. J. Neurochem. 62, 384-387.

Rosen, D., Sapp, P., O'Regan, J., McKenna-Yasek, D., Schlumpf, K., Haines, J., Gusella, J., Horvitz, H.R. and Brown, Jr., R.H. (1994) Genetic linkage analysis of familial amyotrophic lateral sclerosis using human chromosome 21 microsatellite DNA markers. Amer. J. Medical Genetics 51, 61-69.

Rosen, D., Siddique, T., Patterson, D., Figlewicz, D., Sapp, P., Hentati, A., Donaldson, D., Goto, J., O'Regan, J., Deng, H., Rahmani, Z., Krizus, A., McKenna-Yasek, D., Cayabyab, A., Gaston, S., Tanzi, R., Halperin, J., Herzfeldt, B., Van den Berg, R., Hung, W., Bird, T., Deng, G., Mulder, D., Smyth, C., Laing, N., Soriano, E., Pericak-Vance, M., Haines, J., Rouleau, G., Gusella, J., Horvitz, H.R. and Brown, Jr., R.H. (1993) Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 362, 59-62.

Brown, Jr., R.H. and Horvitz, H.R. (1992) Research directions in ALS: problems and prospects. In Handbook of Amyotrophic Lateral Sclerosis. R. Smith, ed. Marcel Dekker, Inc. pp. 739-753.

Choi, D., Barde, Y., Chalfie, M., Heinemann, U., Horvitz, H.R., Kosik, K., Muller, H., Schwarcz, R., Schwarz, M., Shooter, E., Siesjo, B. and Unsicker, K. (1991) Neuronal death and survival. In Neurodegenerative Disorders: Mechanisms and Prospects for Therapy. D. Price, H. Thoenen and A. Aguayo, eds. Dahlem Konferenzen, Berlin, John Wiley & Sons Ltd., pp. 233-248.

Horvitz, H.R. and Chalfie, M. (1991) Implications of nematode neuronal cell death for human neurological disorders. In Neurodegenerative Disorders: Mechanisms and Prospects for Therapy. D. Price, H. Thoenen and A. Aguayo, eds. Dahlem Konferenzen, Berlin, John Wiley & Sons Ltd., pp. 5-19.

Brown Jr., R., Horvitz, H.R., Rouleau, G., McKenna-Yasek, D., Beard, C., Sapp, P., Haines, J., Gusella, J. and Figlewicz, D. (1991) Gene linkage in familial amyotrophic lateral sclerosis: a progress report. In Advances in Neurology Vol. 56: Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases. L. P. Rowland, ed., Raven Press, N.Y., pp. 215-226.

Siddique, T., Figlewicz, D., Pericak-Vance, M., Haines, J., Rouleau, G., Jeffers, A., Sapp, P., Hung, W.-Y., Bebout, J., McKenna-Yasek, D., Deng, G., Horvitz, H.R., Gusella, J., Brown, R., Roses, A. and collaborators. (1991) Linkage of a gene causing familial amyotrophic lateral sclerosis to chromosome 21 and evidence for genetic heterogeneity. N. Engl. J. Med. 324, 1381-1384.

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Other

Klees, E. and Horvitz, H.R. (2012) Biomedical Consulting Agreements – The Good, the Bad and the Ugly. Science Careers, Oct. 12, 10.1126/science.caredit.a1200114.

Klees, E. and Horvitz, H.R. (2012) Biomedical Consulting Agreements: A Guide for Academics. The MIT Press.

Horvitz, H.R. (2005) Stanley J. Korsmeyer (1950-2005). Nature 435, 161.

Horvitz, H.R. (2003) Worms, Life and Death: Nobel Lecture, December 8, 2002. In Les Prix Nobel; The Nobel Prizes 2002. Frangsmyr, T., ed. Edita Norstedts Tryckeri AB, Stockholm, pp. 320-351.

Horvitz, H.R. (2003) H. Robert Horvitz -- Autobiography. In Les Prix Nobel; The Nobel Prizes 2002. Frangsmyr, T., ed. Edita Norstedts Tryckeri AB, Stockholm, pp. 284-319.

Horvitz, H.R. (2003) Worms, Life, and Death (Nobel Lecture) Chembiochem. 4(8), 697-711

Starr, D., Hermann, G., Malone, C., Fixsen, W., Priess, J., Horvitz, H.R. and Han, M. (2001) UNC-83 encodes a novel component of the nuclear envelope and is essential for proper nuclear migration. Development 128, 5039-5050.

Speliotes, E., Uren, A., Vaux, D. and Horvitz, H.R. (2000) The survivin-like C. elegans BIR-1 protein acts with the Aurora-like kinase AIR-2 to affect chromosomes and the spindle midzone. Molec. Cell, 6, 211-223.

Malone, C.J., Fixsen, W.D., Horvitz, H.R. and Han, M. (1999) UNC-84 localizes to the nuclear envelope and is required for nuclear migration and anchoring during Caenorhabditis elegans development. Development 126, 3171-3181.

Yuan, J. Y., Finney, M., Tsung, N. and Horvitz, H.R. (1991) Tc4, a C. elegans transposable element with novel foldback structure. Proc. Natl. Acad. Sci. U.S.A., 88, 3334-3338.

Horvitz, H.R. and Sulston, J. (1990) "Joy of the worm." Genetics 126, 287-292.

Ruvkun, G., Gilbert, W. and Horvitz, H.R. (1990) Detection of mutations and DNA polymorphisms using whole genome Southern Cross hybridizations. Nucleic Acids Res. 18, 809-815.

Herr, W., Sturm, R., Clerc, R., Corcoran, L., Baltimore, D., Sharp, P., Ingraham, H., Rosenfeld, M., Finney, M., Ruvkun, G., and Horvitz, H.R. (1988) The pou domain: a large conserved region in the mammalian pit-1, oct-1, oct-2 and Caenorhabditis elegans unc-86 gene products. Genes & Develop., 2, 1513-1516.

Trent, C., Wood, W., and Horvitz, H.R. (1988) A novel dominant transformer allele of the sex-determining gene her-1 of Caenorhabditis elegans. Genetics 120, 145-157.

Edgar, R., Horvitz, H.R. and Wood, W. (1987) The nematode Caenorhabditis elegans: Toward the complete understanding of an animal. Chinese J. Cell Biology (in Chinese), Suppl. 2, 1-20.

Herman, H.R. and Horvitz, R. (1980) Genetic analysis of Caenorhabditis elegans. In Nematodes as Biological Models. B. Zuckerman, ed., Academic Press, New York, pp. 227-261.

Herman, R., Horvitz, H.R. and Riddle, D. (1980) Caenorhabditis elegans. In Genetic Maps, Vol. 1, S. O'Brien, ed., N.I.H., Bethesda, MD, pp. 183-193.

Horvitz, H.R., Brenner, S., Hodgkin, J. and Herman, R. (1979) A uniform genetic nomenclature for the nematode Caenorhabditis elegans. Molec. gen. Genet. 175, 129-133.

White, J. and Horvitz, H.R. (1979) Laser microbeam techniques in biological research. Electro-Optical Systems Design, August, pp. 23-24.

Hodgkin, J., Horvitz, H.R. and Brenner, S. (1979) Nondisjunction mutants of the nematode Caenorhabditis elegans. Genetics 91, 67-94.

Horvitz, H.R. (1975) Studies of mutations in T4 control genes 33 and 55. Genetics 79, 349-360.

Horvitz, H.R. (1974) Bacteriophage T4 mutants deficient in alteration and modification of the Escherichia coli RNA polymerase. J. Mol. Biol. 90, 739-750.

Horvitz, H.R. (1974) Control by bacteriophage T4 of two sequential phosphorylations of the alpha subunit of the Escherichia coli RNA polymerase. J. Mol. Biol. 90, 727-738.

Horvitz, H.R. (1973) Polypeptide bound to the host RNA polymerase is specified by T4 control gene 33. Nature New Biology, 244, 137-140.

 

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