Eytan Abraham, Ph.D.
Background: Dr. Abraham received his Ph.D. in neuroendocrinology and brain development from the University of Maryland..

Research Interests: Focus is on vascular cell-based therapy and tissue engineering. Related areas of interest include cell-substrate interactions, cell differentiation, and drug delivery.

Natalie Artzi, Ph.D.
Background: Dr. Dr. Artzi is a chemical engineer who comes to us from the Technion (Israel Institute of Technology) after completion of her Ph.D. majoring in polymer science.

Research Interests: Polymer adhesives for medical applications. mechanical models of soft tissue.ascular biology

Selected Publications:

Artzi N, Shazly T, Crespo C, Bon Ramos A, chenault K, Edelman ER. Characterization of star adhesive sealant based on PEG:dextran hydrogels. Macromolecular Bioscience 2009 Aug; 9(8): 754-65. [PDF]

Artzi N*, Shazly T*, Baker A, Bon A, Edelman ER. Aldehyde-amine chemistry enables modulated biosealants with tissue specific adhesion. Advanced Materials 2009; 21:3339-3403. *Indicates equal author contribution [PDF]

Shazly TM, Artzi N, Boehning F, Edelman ER. Viscoelastic adhesive mechanics of aldehyde-mediated soft tissue sealants. Biomaterials 2008 Dec; 29(35): 4584-91. [PDF]

Aaron Baker, Ph.D.
Background: Dr. Baker received his Ph.D. from MIT in the HST medical engineering and medical physics program.

Research Interests: Vascular biology

Selected Publications:

Mobine H, Baker A, Wang L, Wakimoto H, Jacobsen K, Seidman C, Seidman J, Edelman ER. Pheochromocytoma-Induced Cardiomyopathy is Modulated by the Synergistic Effects of Cell-Secreted Factors. Circ Heart Fail 2009:1-16. [PDF]

Artzi N*, Shazly T*, Baker A, Bon A, Edelman ER. Aldehyde-amine chemistry enables modulated biosealants with tissue specific adhesion. Advanced Materials 2009; 21: 3399-3403.* Indicates equal author contribution. [PDF]

Chatzizisis YS, Jonas M, Beigel R, Coskun AU, Baker AB, Stone BV, Maynard C, Gerrity RG, Daley W, Edelman ER, Feldman CL, Stone PH. Attenuation of inflammation and expansive remodeling by Valsartan alone or in combination with Simvastatin in high-risk coronary atherosclerotic plaques. Atherosclerosis 2009; 203:387-394. [PDF].

Baker AB, Groothuis A, Jonas M, Ettenson DS, Shazly T, Zcharia E, Vlodavsky I, Seifert P, Edelman ER. Heparanase alters arterial structure, mechanics, and repair following endovascular stenting in mice. Cir Res 2009 Feb; 104(3); 380-387.[PDF]

Baker A, Ettenson D, Jonas M, Nugent M, Iozzo R, Edelman ER. Endothelial cells provide feedback control for vascular remodeling through a mechanosensitive autocrine TGF2-beta signaling pathway. Cir Res 2008 Aug; 103(3); 289-297.[PDF]

Jonas M, Edelman ER, Groothuis A, Baker A, Seifert P, Rogers C. Vascular neointimal formation and signaling pathway activation in response to stent injury in insulin-resistant and diabetic animals. Circ Res 2005; Sep 30;97(7):725-733.[PDF]

Mercedes Balcells, Ph.D.
Background: Dr. Balcells is a Research Scientist in the Harvard-MIT Division of Health Sciences and Technology and a Professor in bioengineering at Institut Quimic de Sarria (Universitat Ramon Llull, Barcelona). She is founder of the MIT-Spain Program within the MIT International Science and Technology Initiatives. MISTI 's mission is to build fruitful international scientific and technological relations [ MISTI Program web site].

As a La Caixa-German Academic Exchange Service fellow, Dr. Balcells recieved her Ph.D. in macromolecular chemistry from RWTH Aachen (Germany) in 1999 and was awarded the Borchers Plakette. She received a Masters in Science in chemical engineering from Institut Quimic de Sarria in 1995.

Research Interests: Dr. Balcells' research focuses on the study of the combined effects of complex flow alterations and local molecular interventions on endothelium injury and repair. Computational and in vitro models of arterial flow augment in vivo studies and enable examination of intracellular signaling pathways common to proliferation and migration of endothelial and smooth muscle cells and expression of markers of thrombosis and inflammation.

Selected Publications:

Balcells M, Wallins J, Edelman ER. Amyloid beta toxicity dependent upon endotheial cell state. Neuroscience Letters 2008 Aug; 441(3):319-322.[PDF]

Methe H, Balcells M, Alegret MD, Santacana M, Molins B, Hamik A, Jain M, Edelman ER. Vascular bed origin dictates flow pattern regulation of endothelial adhesion molecule expression. Am J Physiol Heart Circ Physiol 2007 May; 292(5):H2167-75.[PDF]

Hamik A, Lin Z, Kumar A, Balcells M, Sinha S, Katz J, Feinberg M, Gerzsten R, Edelman ER, Jain M. Kruppel-like factor 4 regulates endothelial inflammation. J Biol Chem 2007 May; 28(18):13769-79. [PDF]

Laura Indolfi, Ph.D.
Background: Dr. Indolfi is a materials engineer who comes to us from the Interdisciplinary Research Center on Biomaterials, Naples, Italy. She completed her Ph.D. in biomaterials at the University Federico II, Naples, Italy.

Research Interests: Polymeric drug delivery systems for medical devices and tissue engineering applications.

Vijaya Kolachalama, Ph.D.
Background: Dr. Kolachalama is a Postdoctoral Associate in the Edelman laboratory and an ORISE fellow at the Division of Cardiovascular Devices, Center for Devices and Radiological Health, US Food and Drug Administration.

He obtained a PhD degree in Mechanical Engineering from the University of Southampton, U.K. after completing his undergraduate studies from the Department of Aerospace Engineering at the Indian Institute of Technology, Kharagpur, India.

Research Interests: Dr. Kolachalama is particularly interested to combine principles of fluid mechanics, vascular biology and applied mathematics to understand the physiological mechanisms governing cardiovascular diseases and their therapeutic outcomes.

New Computer Model Could Lead to Safer Stents. [MIT News Headline]

Model Predicts How To Build A Better Stent. [MIT News Headline]

Selected Publications:

Kolachalama VB, Levine EG, Edelman ER. Luminal flow amplifies stent-based drug deposition in arterial bifurcations. PLoS ONE 2009 Dec; 4(12): e8105.[PDF]

Kolachalama VB, Tzafriri AR, Arifin DY, Edelman ER. Luminal flow patterns dictate arterial drug deposition in stent-based delivery. J Control Release 2009 Jan; 133(1):24-30. [PDF] [COVER]

Kumaran Kolandaivelu, Ph.D.
Background: Dr. Kolandaivelu is a medical engineer who comes to us from Illinois.

Research Interests: Thrombosis of coronary prosthetics.

Selected Publications:

Maron B, Kolandaivelu K, Rhee D, Bukhman A, Edelman ER. Echocardiographic capture of right ventricular wall rupture during inferior wall acute myocardial infarction. American Journal of Cardiology 2009 May;103(10):1478-1480. [PDF]

Kolandaivelu K, Edelman ER. Environmental influences on endovascular stent platelet reactivity: An in vitro comparison of stainless steel and gold surfaces. Journal of Biomedical Materials Research. 2004 Aug 1;70A(2):186-93. [PDF]

Kolandaivelu K, Edelman ER. Low background, pulsatile, in vitro flow circuit for modeling coronary implant thombosis. Journal of Biomechanical Engineering. 2002 Dec;124(6):662-8. [PDF]

Li Yuan Mi (Luanne), Ph.D.
Background: Dr. Mi is a Biomedical Engineer from China via New York City.

Research Interests: Intercellular Signaling.

Selected Publications:

Mi LY, Ettenson D, Edelman ER. Phospholipase C-delta extends intercellular signalling range and responses to injury-released growth factors in non-excitable cells. Cell Proliferation 2008 Aug; 41(4):671-690. [PDF]

Tarek Shazly, Ph.D.
Background: Dr. Shazly is a Materials Science Engineer.

Research Interests: Development of biomaterials.

Selected Publications:

Artzi N, Shazly T, Crespo C, Bon Ramos A, chenault K, Edelman ER. Characterization of star adhesive sealants based on PEG:dextran hydrogels. Macromolecular Bioscience 2009 Aug; 9(8): 754-65. [PDF]

Baker AB, Groothuis A, Jonas M, Ettenson DS, Shazly T, Zcharia E, Vlodavsky I, Seifert P, Edelman ER. Heparanase alters arterial structure, mechanics, and repair following endovascular stenting in mice. Cir Res 2009 Feb; 104(3);
380-387.[PDF]

Artzi N*, Shazly T*, Baker A, Bon A, Edelman ER. Aldehyde-amine chemistry enables modulated biosealants with tissue-specific adhesion. Advanced Materials 2009;21:3399-3403.* Indicates equal author contribution. [PDF]

Shazly TM, Artzi N, Boehning F, Edelman ER. Viscoelastic adhesive mechanics of aldehyde-mediated soft tissue sealants. Biomaterials 2008 Dec; 29(35): 4584-91. [PDF]

Rami Tzafriri, Ph.D.
Background: Dr. Tzafriri is an applied mathematician and biophysicist who comes to us from The Hebrew University of Jerusalem, Israel [CV].

Research Interests: Mathematical modeling of drug delivery problems with special emphasis on therapeutic angiogenesis and intratumoral chemotherapy. Related interests include modeling controlled release devices, biodegradation of polymers and proteins and analysis of enzyme and receptor kinetics.

Model Predicts How To Build A Better Stent. [MIT News Headline]

Selected Publications:

Tzafriri AR, Levin AD, Edelman ER. Diffusion-limited binding explains binary dose response for local arterial and tumor drug delivery. Cell Proliferation 2009 Jun; 42(3):348-363. [PDF]

Kolachalama VB, Tzafriri AR, Arifin DY, Edelman ER. Luminal flow patterns dictate arterial drug deposition in stent-based delivery. J Control Release 2009 Jan; 133(1):24-30. [PDF] [COVER]

Gomez-Uribe CA, Verghese GC, Tzafriri AR. Enhanced identification and exploitation of time scales for model reduction in stochastic chemical kinetics. J Chem Phys 2008 Dec; 129(24):244112. [PDF]

Tzafriri AR, Edelman ER. Quasi-steady state kinetics at enzyme and substrate concentrations in excess of the Michaelis-Menten constant. J of Theoretical Biology 2007 Apr; 245(4): 737-48. [PDF]

Tzafriri AR, Edelman ER. Endosomal receptor kinetics determine the stability of intracellular growth factor signaling complexes. Biochem J. 2007, Mar 15;402(3):537-549. [PDF]

Balakrishnan B, Tzafriri AR, Seifert P, Groothuis A, Rogers C, Edelman ER. Strut position, blood flow, and drug deposition: implications for single and overlapping drug-eluting stents. Circulation 2005 Jun 7;111(22):2958-65. [PDF]

Tzafriri AR et al. Mathematical modeling and optimization of drug delivery from intratumorally injected microspheres Clinical Cancer Research. 2005 11: 826-834. [PDF] [Supplement A] [Supplement B][Supplement C]

Tzafriri AR, Edelman ER. On the Validity of the Quasi-Steady State Approximation of Bimolecular Reactions in Solution . Journal of Theoretical Biology. 2005 233: 343-350. [PDF]

Tzafriri AR, Wu D, Edelman ER. Analysis of compartmental models of ligand-induced endocytosis . Journal of Theoretical Biology. 2004 229: 127-138. [PDF]

Tzafriri, AR, Edelman ER. The Total Quasi-Steady State Approximation is Valid for Reversible Enzyme Kinetics . Journal of Theoretical Biology. 2004 226: 301-311. [PDF]

Tzafriri, A. R. Michaelis-Menten Kinetics at High Enzyme Concentrations . Bulletin of Mathematical Biology. 2003 65: 1111-1129. [PDF]

Brett Zani, Ph.D.
Background: Dr. Zani is a cellular/molecular biologist and physiologist from Indiana via New York.

Research Interests: Vascular biology/nitric oxide, tissue engineering and regeneration

Zani BG., Kojima K., Vacanti CA., and Edelman ER. Tissue engineered endothelial and epithelial implants differentially and synergistically regulate airway repair. Proc Natl Acad Sci U S A. 2008 May 13; 105(19): 7046-7051. Epub 2008 May 5. [PDF][Supplement]

The PDF and files associated with the papers on this page are intended solely for the academic use of persons directly affiliated with the Edelman Laboratory. If you are not affiliated with the Laboratory, you are hereby notified that any downloading, copying, distribution or use of any of the PDF and files associated with the papers on this page is strictly PROHIBITED.