Background:
Standard means of drug administration are unacceptable for newer classes of drugs and many experimental compounds. We are investigating how polymer-based controlled drug delivery can be used to obtain sustained and modulated drug delivery. We are focusing on the design and development of such systems, mathematical modeling of transport from these systems and the in vivo use of these devices in understanding their impact and potential use in a variety of disease states.

Keywords:
Drug delivery, controlled release, transport

 

 

 
       

Key References:

  • Levin AD, Jonas M, Hwang CW, Edelman ER. Local and systematic drug competition in drug-eluting stent tissue deposition properties. J. Controlled Release. 2005 Aug 15;109:236-243.[PDF]
  • Balakrishnan B, Tzafriri AR, Seifert P, Groothuis A, Rogers C, Edelman ER. Strut position, blood flow, and drug deposition: implications for single and overlapping drug-eluting stents. Circulation 2005 Jun 7;111(22):2958-65.[PDF]
  • Hwang CW, Levin AD, Jonas M, Li PH, Edelman ER. Thrombosis modulates arterial drug distribution for drug-eluting stents. Circulation 2005 Apr 5;111(13):1619-26. [PDF]
  • Levin AD, Vukmirovic N, Hwang CW, Edelman ER. Specific binding to intracellular proteins determines arterial transport properties for rapamycin and paclitaxel. Proceedings for the National Academy of Sciences USA. 2004 Jun 22;101(25):9463-7.[PDF]
  • Wu D, Edelman ER. Resonance energy transfer for assessing the molecular integrity of proteins for local delivery. Biotechnology and Bioengineering 2004 Feb 20; 85(4): 406-412. [PDF]
  • Janicki C, Hwang CW, Edelman ER. Dose model for stent-based delivery of a radioactive compound for the treatment of restenosi in coronary arteries. Medical Physics. 2003 Oct; 30(10):2622-2628.[PDF]
  • Hwang CW, Wu D, Edelman ER. Impact of transport and drug properties on the local pharmacology of drug-eluting stents. International Journal of Cardiovascular Interventions. 2003; 5(1):7-12.[PDF]
  • Hwang CW, Edelman ER. Arterial ultrastructure influences transport of locally delivered drugs. Circulation Research. 2002 Apr 19. 90(7): 826-832. [PDF]
  • Lovich MA, Creel CJ, Hong K, Hwang CW, Edelman ER. Carrier proteins determine local pharmacokinetics and arterial distribution of paclitaxel. Journal of Pharmaceutical Sciences. 2001 Sep. 90(9): 1324-1335. [PDF]
  • Hwang CW, Wu D, Edelman ER. Physiological transport forces govern drug distribution for stent-based delivery. Circulation. 2001 Jul 31. 104(5): 600-605. [PDF] [Cover]
  • Elmalak O, Lovich MA, Edelman ER. Correlation of transarterial transport of various dextrans with their physicochemical properties. Biomaterials. 2000 Nov. 21(22):2263-2272. [PDF]
  • Noh I, Lovich MA, Edelman ER. Mechanisms of heparin transport through expanded poly(tetrafluoroethylene) vascular grafts. Journal of Biomedical Materials Research. 2000 Jan. 49(1):112-9.[PDF]
  • Creel CJ, Lovich MA, Edelman ER. Arterial paclitaxel distribution and deposition. Circulation Research. 2000 Apr 28. 86(8): 879-884. [PDF] [Methods]
  • Wan WK, Lovich MA, Hwang CW, Edelman ER. Measurement of drug distribution in vascular tissue using quantitative fluorescence microscopy. Journal of Pharmaceutical Sciences. 1999 Aug. 88(8): 822-829. [PDF]
  • Lovich MA, Brown L, Edelman ER. Drug clearance and arterial uptake following local perivascular delivery to the Rat Carotid Artery. Journal of the American College of Cardiology. 1997. 29: 1645-1650. [PDF]
  • Lovich MA and Edelman ER. Tissue average binding and equilibrium distribution: An example with heparin in arterial issues. Biophysical Journal. 1996. 70: 1553-1559. [PDF]
  • Brown L, Edelman ER, Fischel-Ghodsian, Langer R. Characterization of Glucose-Mediated Insulin Release from Implantable Polymers. Journal of Pharmaceutical Sciences. 1996. 85(12): 1341-1345. [PDF]
  • Lovich MA and Edelman ER. Mechanisms of transmural heparin transport in the rat abdominal aorta after local vascular delivery. Circulation Research. 1995. 77(6): 1143-1150. [PDF]
The PDF and files associated with the papers on this page are intended solely for the academic use of persons directly affiliated with the Edelman Laboratory. If you are not affiliated with the Laboratory, you are hereby notified that any downloading, copying, distribution or use of any of the PDF and files associated with the papers on this page is strictly PROHIBITED.
Research Fellows:
  • David Ettenson
  • Vijaya Kolachalama
  • Andrew Levin
  • Rami Tzafriri

Graduates:

  • Brinda Balakrishnan
  • Kha Le
  • Neda Vukmirovic
  • Peter Wu

Undergraduates:

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