Background:
Increasingly, mechanical interventions are being used to deal with atherosclerotic vascular disease. Unfortunately, the intervention themselves are beset by an accelerated atherosclerosis. We are using polymer-based drug delivery systems, image analysis, molecular and cell biology, and histo- and immunochemistry to more fully appreciate the role of locally expressed growth mediators in the pathobiology of the blood vessel wall. These studies have enabled us to characterize the tissue response to implanted devices such as endovascular stents and to determine how design influences biology.

Keywords:
Atherosclerosis, stents, devices

 

 

 
       

Key References:

  • Rogers C, Edelman ER. Pushing drug-eluting stents into uncharted territory. Simpler than you think -- More complex than you imagine. Circulation 2006 May 16; 113:2262-2265.[PDF]
  • Jonas M, Fang JC, Wang JC, Giri S, Elian D, Har-Zahav Y, Ly H, Seifert PA, Popma JJ, Rogers C. In-stent restenosis and remote coronary lesion progression are coupled in cardiac transplant vasculopathy but not in native coronary artery disease. J of the American College of Cariology 2006 July 26; 48(3):453-461. [PDF}
  • Jonas M, Edelman ER, Groothuis A, Baker AB, Seifert P, Rogers C. Vascular neointimal formation and signaling pathway activation in response to stent injury in insulin-resistant and diabetic animals. Circulation Research 2005 Sept 30;97(7):725-33. Epub 2005 Aug 25 [PDF]
  • Levin AD, Jonas M, Hwang CW, Edelman ER. Local and systematic drug competition in drug-eluting stent tissue deposition properties. J Controlled Release. 2005 Aug 15;109:236-243. [PDF]
  • Schwartz RS, Edelman ER, Carter A, Chronos NA, Rogers C, Robinson KA, Waksman R, Machan L, Weinberger J, Wilensky RL, Goode JL, Hottenstein OD, Zuckerman BD, Virmani R. Preclinical evaluation of drug-eluting stents for peripheral applications: recommendations from an expert consensus group. Circulation 2004 Oct. 19; 110(16): 2498-2505. [PDF]
  • Kolandaivelu K, Edelman ER. Environmental influences on endovascular stent platelet reactivity: An in vitro comparison of stainless steel and gold surfaces. Journal of Biomedical Materials Research 2004 Aug 1; 70A(2):186-193. [PDF]
  • Danenberg HD, Golomb G, Groothuis A, Gao J, Epstein H, Swaminathan RV, Seifert P, Edelman ER. Liposomal alendronate inhibit systmic innate immunity and reduces in-stent neointimal hyperplasia in rabbits. Circulation. 2003 Dec 2; 108(22):2798-2804.[PDF] [Cover]
  • Danenberg HD, Szalai AJ, Swaminathan RV, Peng L, Chen Z, Seifert P, Fay WP, Simon DI, Edelman ER. Increased thrombosis after arterial injury in human C-reactive protein-transgenic mice. Circulation. 2003 Aug 5; 108(5):512-5.[PDF]
  • Hwang CW, Wu D, Edelman ER. Impact of transport and drug properties on the local pharmacology of drug-eluting stents. International Journal of Cardiovascular Interventions. 2003; 5(1):7-12.[PDF]
  • Danenberg HD, Welt FG, Walker M 3rd, Seifert P, Toegel GS, Edelman ER. Systematic inflammation induced by lipopolysaccharide increases neointimal formation after balloon and stent injury in rabbits. Circulation. 2002 Jun 18. 105(24):2917-22.[PDF]
  • Welt FG, Rogers C. Inflammation and restenosis in the stent era. Arteriosclerosis, Thrombosis and Vascular Biology. 2002 Nov 1; 22(11):1769-76.[PDF]
  • Schwartz RS, Edelman ER, Carter A, Chronos N, Rogers C, Robinson KA, Waksman R, Weinberger J, Wilensky RL, Jensen DN, Zuckerman BD, Virmani R. Drug-eluting stents in preclinical studies: recommended evaluation from a consensus group. Circulation 2002 Oct 1; 106(14): 1867-73.[PDF]
  • Hwang CW, Wu D, Edelman ER. Physiological transport forces govern drug distribution for stent-based delivery. Circulation. 2001 Jul 31. 104(5): 600-605. [PDF] [Cover]
  • Edelman ER, Seifert P, Groothuis A, Morss A, Bornstein D, Rogers C. Gold-coated NIR stents in porcine coronary arteries. Circulation. 2001 Jan 23.103(3):429-434.[PDF]
  • Drachman DE, Edelman ER, Seifert P, Groothuis AR, Bornstein DA, Kamath KR, Palasis M, Yang D, Nott SH, Rogers C. Neointimal thickening after stent delivery of paclitaxel: change in composition and arrest of growth over six months. Journal of the American College of Cardiology. 2000 Dec. 36(7): 2325-2332.[PDF]
  • Garasic JM, Edelman ER, Squire JC, Seifert P, Williams MS, Rogers C. Stent and artery geometry determine intimal thickening independent of arterial injury. Circulation. 2000 Feb 22. 101(7):812-8.[PDF]
  • Rogers C, Tseng D, Squire JC, Edelman ER. Balloon-Artery Interactions During Stent Placement: A Finite Element Analysis Approach to Pressure, Compliance, and Stent Design as Contributors to Vascular Injury. Circulation Research. 1999. 84(4), 378-383. [PDF]
  • Tseng DY and Edelman ER. Effects of Amide and Amine Plasma Reacted ePTFE Vascular Grafts on Endothelial Cell Lining in an Artificial Circulatory System. Journal of Biomedical Materials Research. 1998. 42: 188-198. [PDF]
  • Rogers C, Parikh S, Seifert P, Edelman ER. Endogenous Cell Seeding: Remnant endothelium after stenting enhances vascular repair. Circulation. 1996. 94: 2909-2914.[PDF]
  • Edelman E and Rogers C. Hoop Dreams: Stents without Restenosis. Circulation. 1996. 94(6): 1199-1202. [PDF]
  • Rogers C, Parikh S, Edelman ER. A unified model of vascular repair after mechanical injury. Circulation. 1995. 92: I-300.[PDF]\\
  • Rogers C and Edelman ER. Endovascular stent design dictates experimental restenosis and thrombosis. Circulation. 1995. 91(12): 2995-3001.[PDF]
The PDF and files associated with the papers on this page are intended solely for the academic use of persons directly affiliated with the Edelman Laboratory. If you are not affiliated with the Laboratory, you are hereby notified that any downloading, copying, distribution or use of any of the PDF and files associated with the papers on this page is strictly PROHIBITED.
Research Fellows:
  • Natalie Artzi
  • Vijaya Kolachalama
  • Kumaran Kolandaivelu
  • Michael Jonas
  • Alisa Morss

Graduates:

  • Brinda Balakrishnan
  • Michael Feldstein
  • Sylaja Murikipudi
  • Tarek Shazly

Undergraduates:

  • Cristina Crespo Roman

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