Background:
Polypeptide growth factors have been shown to play a primary role in the physiology of normal cells and tissues. In addition, it has become increasingly appreciated that these factors may play a significant role in the pathophysiology of many diseases. We are examining natural storage, binding, stabilization and release of these factors in hope of understanding (1) growth factor biology and (2) how different diseases are affected by these growth mediators.

Keywords:
Growth factor, vascular biology

 

 

 
       
  • Danenberg HD, Kantak N, Grad E, Swaminathan RV, Lotan C, Edelman ER. C-reactive protein promotes monocyte-platelet aggregation: an additional link to the inflammatory-thrombotic intricacy. Eur J Haematol 2007;78(3):246-252. [PDF]
  • Costa LF, Balcells M, Edelman ER, Nadler LM, Cardoso AA. Proangiogenic stimulation of bone marrow endothelium engages mTOR and is inhibited by simultaneious blockage of mTOR and NF-(kappa)B. Blood 2006; 107(1):285-292. [PDF]
  • Jonas M, Fang JC, Wang JC, Ciri S, Elian D, Har-Zahav Y, Ly H, Seifert PA, Popma JJ, Rogers C. In-stent restenosis and remote coronary lesion progression are coupled in cardiac transplant vasculopathy but not in native coronary artery disease. J Amer Coll of Cardiol. 2006 July 26; 48(3):453-461.[PDF]
  • Jonas M, Edelman ER, Groothuis A, Baker AB, Seifert P, Rogers C. Vascular neointimal formation and signaling pathway activation in response to stent injury in insulin-resistant and diabetic animals. Circ Res. 2005 Sep 30; 97(7):725-733. Epub 2005 Aug 25 [PDF]
  • Methe H, Brunner S, Wiegand D, Nabauer M, Koglin J, Edelman ER. T-helper-1 lymphocyte activation patterns in acute coronary syndroms. J Am Coll Cardiol. 2005 Jun 21; 45(12):1939-1945. [PDF]
  • Levin AD, Vukmirovic N, Huang CW, Edelman ER.. Specific binding to intracellular proteins determines arterial transport properties for rapamycin and paclitaxel. Proceedings of the National Academy of Sciences USA. 2004 Jun 22;101(25):9463-9467.[PDF]
  • Danenberg HD, Golomb G, Groothuis A, Gao J, Epstein H, Swaminathan RV, Seifert P, Edelman ER. Liposomal alendronate inhibit systematic innate immunity and reduces in-stent neointimalhyperplasia rabbits. Circulation 2003 Dec 2;108(22):2798-2804.[PDF][COVER]
  • Janicki C, Hwang CW, Edelman ER. Dose model for stent-based delivery of a radioactive compound for the treatment of restenosis in coronary arteries. Medical Physics 2003 Oct 30;(10):2622-2628.[PDF]
  • Danenberg HD, Szalai AJ, Swaminathan RV, Peng L, Chen Z, Seifert P, Fay WP, Simon DI, Edelman ER. Increased thrombosis after arterial injury in human C-reactive protein-transgenic mice. Circulation 2003 Aug 5;108(5):512-515.[PDF]
  • Edelman ER, Dannenberg HD. Rapamycin for cardiac transplant rejection and vasculopathy: one stone, two birds? Circulation. 2003 Jul 8; 108(1):6-8.[PDF]
  • Welt FG, Tso C, Edelman ER, Kjelsberg MA, Paolini JF, Seifert P, Rogers C. Leukocyte recruitment and expression of chemokines following different forms of vascular injury. Vascular Medicine. 2003; 8(1):17.[PDF]
  • Stultz CM, Levin AD, Edelman ER. Phosphorylation-induced conformational changes in a mitogen-activated protein kinase substrate. Implications for tyrosine hydroxylase activation. Journal of Biological Chemistry. 2002 Dec. 277(49):47653-47661.[PDF]
  • Welt FG, Rogers C. Inflammation and restenosis in the stent era. Arteriosclerosis, Thrombosis and Vascular Biology. 2002 Nov. 22(11):1769-1776.[PDF]
  • Danenberg HD, Welt FG, Walker M 3rd, Seifert P, Toegel GS, Edelman ER. Systemic inflammation induced by lipopolysaccharide increases neointimal formation after balloon and stent injury in rabbits. Circulation. 2002 Jun. 105(24):2917-2922.[PDF]
  • Balcells M, Edelman ER. Effect of pre-absorbed proteins on attachment, proliferation, and function of endothelial cells. Journal of Cellular Physiology. 2002 May. 191:155-161[PDF]
  • Woods TC, Blystone CR, Yoo J, Edelman ER. Activation of EphB2 and its ligands promote vascular smooth muscle cell proliferation. Journal of Biological Chemistry. 2002 Jan. 277(3): 1924-1927.[PDF]
  • Welt FG, Woods TC, Edelman ER. Oral heparin prevents neointimal hyperplasia after arterial injury: Inhibitory potential depends on type of vascular injury. Circulation. 2001 Dec. 104(25):3121-3124.[PDF]
  • Welt FG, Edelman ER, Simon DI, Rogers C. Neutrophil, not macrophage, infiltration precedes neointimal thickening in balloon-injured arteries. Arteriosclerosis Thrombosis and Vascular Biology. 2000 Dec. 20(12): 2553-2558.[PDF]
  • Ettenson DS, Koo EW, Januzzi JL, Edelman ER. Endothelial heparan sulfate is necessary but not sufficient for control of vascular smooth muscle cell growth. Journal of Cellular Physiology. 2000 Jul. 184(1): 93-100.[PDF]
  • Nugent MA, Nugent HM, Iozzo RV, Sanchack K, Edelman ER. Perlecan is required to inhibit thrombosis after deep vascular injury and contributes to endothelial cell-mediated inhibition of intimal hyperplasia. Proceedings of the National Academy of Sciences U S A. 2000 Jun 6. 97(12):6722-6727. [PDF]
  • Rogers C, Edelman E, Simon DI. A monoclonal antibody to Mac-1 (CD11b/CD18) blocks leukocyte recruitment and reduces intimal thickening after experimental angioplasty or stent implantation. Proceedings of the National Academy of Sciences U S A. 1998. 95: 10134-10139.
  • Edelman ER, Simons M, Sirois M, Rosenberg RD, c-myc in vasculoproliferative disease. Circulation Research. 1995. 76(2): 176-182.
  • Sirois MG and Edelman ER. VEGF effect on vascular permeability is mediated by synthesis of platelet-activating factor. The American Physiological Society 1997. H2746-H2756.
  • Sirois MG, Simons M, Kuter DJ, Rosenberg RD, Edelman ER. Rat arterial wall retains myointimal hyperplastic potential long after arterial injury. Circulation. 1997. 96: 1291-1298.
  • Sirois MG, Simons M, Edelman ER, Antisense oligonucleotide inhibition of PDGFR-b receptor subunit expression directs suppression of intimal thickening. Circulation. 1997. 95: 669-676.
  • Kozarsky K, Donahee M, Rigotti A, Iqbal S, Edelman ER, Krieger M. Overexpression of the HDL receptor SR-BI alters plasma HDL and bile cholesterol levels. Nature. 1997. 387: 414-417.
  • Rigotti A, Edelman ER, Seifert P, Iqbal S, DeMattos R, Temel R, Krieger M, Williams D. Regulation by adrenocorticotropic hormone of the in vivo expression of scavenger receptor class B Type I (SR-BI), a high density lipoprotein receptor, in steroidogenic cells of the murine adrenal gland. Journal of Biological Chemistry. 1996. 271(52): 33545-33549.
  • Dinbergs ID, Brown LR, Edelman ER, Cellular response to Transforming Growth Factor-b1 and Basic Fibroblast Growth Factor Depends on Release Kinetics and Extracellular Matrix Interactions. Journal of Biological Chemistry. 1996. 271(47): 29822-29829.
  • Nugent MA, Karnovsky MJ, Edelman ER. Vascular cell-derived heparan sulfate shows coupled inhibition of bFGF binding and mitogenesis in vascular smooth muscle cells. Circulation Research. 1993. 73: 1051-1060.
  • Nugent MA and Edelman ER. Transforming growth factor '1 stimulates the production of basic fibroblast growth factor binding proteoglycans in Balb/c3T3 cells. Journal of Biological Chemistry. 1992. 267(29): 21256-21264.
  • Nugent MA and Edelman ER. Kinetics of basic fibroblast growth factor binding to its receptor and heparan sulfate proteoglycan: A mechanism for cooperativity. Biochemistry. 1992. 31: 8876-8883.
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Research Fellows:
  • Aaron Baker
  • Mercedes Balcells-Camps
  • Yiannis Chatzizisis
  • David Ettenson
  • Michael Jonas
  • Vijaya Kolachalama
  • Shai Schubert
  • Rami Tazfriri

Graduates

  • Nedu Vukmirovic

Undergraduates:

  • Jacqueline Brazin

77 Massachusetts Avenue, Building E25-438, Cambridge, MA 02139. USA.
Tel: 617-253-1569. Fax: 617-253-2514. E-mail: ere@mit.edu.

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