An Introduction to Genome Rearrangements in Evolution and Cancer: A Computational Perspective
Arjun(AJ) Bhutkar
Wed Jan 26, 02-03:30pm, 76-259
No enrollment limit, no advance sign up
Single session event
Prereq: None.
This non-credit class is intended to serve as a general introduction to computational models/formulations for analyzing the role of DNA rearrangements in shaping genomes and in genomic disorders. We will look at various types of rearrangements that occur during evolution (in the context of model organism and human genomes) and explore algorithms for comparative rearrangement analysis along with issues of computational complexity. Rearrangements can also lead to chromosomal abnormalities implicated in inherited diseases and cancer. We will survey genomic disorders with a focus on alterations frequently found in a variety of human cancers. Topics also include: Genome synteny, breakpoint analysis, comparative metrics, rearrangement phylogenies.
Contact: Arjun(AJ) Bhutkar, E18-366, (617) 324-7642, arjun@mit.edu
Sponsor: David H. Koch Inst. for Integrative Cancer Researc
Latest update: 16-Dec-2010
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