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A
multidisciplinary research program funded by the DuPont MIT Alliance
aimed at developing new platforms for bioprocess discovery and
development, specifically banks of miniaturized, automated fermentors,
each with integrated bioanalytical devices, and all operating
in parallel. Such systems will address the continuing demand in
bioprocess science and engineering for fast and accurate analytical
information that can be used to rapidly evaluate the interactions
between biological systems and bioprocess operations. Moreover,
the microfermentors will provide the platforms for efficiently
incorporating modern tools of biology (genetics, enzymology, bioinformatics)
to improve bioprocess screening and development. We are addressing
the following critical issues: (i) design and fabrication strategies
for microfermentors; (ii) integration of novel optical sensors;
(iii) sensitivity of the analytical devices; (iv) biocompatibility
of the materials; (v) appropriate biological systems for evaluating
performance of the microfermentors; and (vi) benchmarking of microfermentation
against traditional bioprocessing methodologies.
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