Platforms for Rapid Screening and Analysis of Biological and Chemical Processes

KFJ Group Home

DMA Home

Participants

Presentation (best viewed with Internet Explorer)

Recent Publications

Contact

A multidisciplinary research program funded by the DuPont MIT Alliance aimed at developing new platforms for bioprocess discovery and development, specifically banks of miniaturized, automated fermentors, each with integrated bioanalytical devices, and all operating in parallel. Such systems will address the continuing demand in bioprocess science and engineering for fast and accurate analytical information that can be used to rapidly evaluate the interactions between biological systems and bioprocess operations. Moreover, the microfermentors will provide the platforms for efficiently incorporating modern tools of biology (genetics, enzymology, bioinformatics) to improve bioprocess screening and development. We are addressing the following critical issues: (i) design and fabrication strategies for microfermentors; (ii) integration of novel optical sensors; (iii) sensitivity of the analytical devices; (iv) biocompatibility of the materials; (v) appropriate biological systems for evaluating performance of the microfermentors; and (vi) benchmarking of microfermentation against traditional bioprocessing methodologies.