Nanyang Technological University                     PAP Webinar               22 May 2020

Modeling affinity maturation of antibodies targeting viral spikes

                  Assaf Amitai        Shenshen Wang    Arup K. Chakraborty      

Mehran Kardar (MIT)

Outline

I.       Introduction: B cells, Antibodies, Antigens, and the puzzle of low HIV spike density                                    

II.      Affinity Maturation: Germinal Center, Rapid evolution of antibodies, Fisher and Price equations

III.      Fitness & Evolution: Competition for virus capture and proliferation signal from helper T cells

IV.     Optimal density for eliciting potent antibodies, and implications for nanoparticle vaccination & HIV spikes

V.      Broadly neutralizing Antibodies: Controlling affinity maturation against a mutable virus

VI.    Predicting evolution of viral sequences: Mean-field dynamics on a fitness landscape

VII.  Summary

Next (Introduction) Outline Introduction Affinity Maturation Fitness & Evolution Optimal density Broadly neutralizing Abs EMF dynamics Summary