University of Colorado                      James Franck Institute Seminar               5 November 2019

Diversity, tolerance, and maturation of the adaptive immune response

Andrej Kosmrlj, Hanrong Chen

Tom Butler, John Barton, Assaf Amitai, Shenshen Wang

A. Jha, E. Shakhnovich, E. Huseby, Arup K. Chakraborty

Mehran Kardar (MIT)

Outline

I.       The adaptive immune system: B cells, T cells- diverse, self-tolerant, and specific                       

II.      Thymic Selection: positive and negative selection, specificity from weak amino-acids, extreme value distribution

[Quorum sensing for peripheral tolerance]

III.     Affinity Maturation: Dependence of affinity on target density

[Broadly neutralizing Antibodies: Sequential versus cocktail administration of antigen variants]

IV.    Mutations of virus in a host: Mean-field dynamics on a fitness landscape

V.      Summary

Next (Adaptive immunity) Outline Adaptive Immunity Thymic Selection Quorum sensing Affinity Maturation Broadly neutralizing Abs Summary