Results
Simulations were performed for TCRs of length N=5, with amino-acid compositions typical of human proteome.
Selected fraction:
(Typical number of peptide encounters in thymus is 1,000-10,000)
The selection process biases the composition of amino-acids in mature TCRs:
Negative selection leads to a preference for weaker amino-acids.
This is more or less consistent with the limited available crystallographic data from TCR/peptide interfaces.
Specificity of TCRs and transgenic mice:
