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Translocation of a knotted polypeptide through a pore

J. Chem. Phys. 129, 121107 (2008); DOI:10.1063/1.2968554

Published 30 September 2008
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Lei Huang and Dmitrii E. Makarov
Department of Chemistry and Biochemistry and Institute for Theoretical Chemistry, University of Texas at Austin, Austin, Texas 78712, USA
We use Langevin dynamics simulations to study how the presence of a deep knot affects the time it takes to thread a polypeptide chain through a narrow pore by pulling mechanically at its end. The polypeptide was designed to contain a knotted unstructured segment inserted between two beta-hairpins, which prevented the knot from slipping off the chain ends. In the range of forces studied (40–200  pN), the mean translocation time increased with the knot complexity. The type 52 knot, which was recently discovered in the structure of human ubiquitin hydrolase and is the most complex knot found in the protein databank, slows down translocation by about two orders of magnitude, as compared to the unknotted chain. In contrast to the unknotted chain case, the translocation mechanism of knotted chains involves multiple slippage events suggesting that the corresponding free energy landscape is rugged and involves multiple metastable minima. ©2008 American Institute of Physics

History:
Received 13 June 2008; accepted 17 July 2008; published 30 September 2008

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http://link.aip.org/link/?JCPSA6/129/121107/1
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KEYWORDS and PACS

Keywords
PACS
  • 87.15.B-
    Structure of biomolecules
  • 87.15.H-
    Biomolecular dynamics
  • 87.15.A-
    Theory, modeling and computer simulation in molecular biophysics
  • 36.20.Ey
    Macromolecular conformation (statistics and dynamics)
  • YEAR: 2008

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ISSN:
0021-9606 (print)   1089-7690 (online)
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REFERENCES (32)
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"DOM" : "IE4"; if(window.event + "" == "undefined") event = null; function f_PopUp(){return false}; function f_PopDown(){return false}; popUp = f_PopUp; popDown = f_PopDown; GL_MenuWidth = 150; GL_FontFamily = "Arial,sans-serif"; GL_FontSize = 10; GL_FontBold = true; GL_FontItalic = false; GL_FontColor = "black"; GL_FontColorOver = "white"; GL_BGColor = "transparent"; GL_BGColorOver = "transparent"; GL_ItemPadding = 3; GL_BorderWidth = 2; GL_BorderColor = "red"; GL_BorderStyle = "solid"; GL_SeparatorSize = 2; GL_SeparatorColor = "yellow"; GL_ImageSize = 5; GL_ImageHorizSpace = 5; GL_ImageVertSpace = 5; GL_KeepHilite = false; GL_ClickStart = false; GL_ClickKill = 0; GL_ChildOverlap = 40; GL_ChildOffset = 10; GL_ChildPerCentOver = null; GL_TopSecondsVisible = 2; GL_ChildSecondsVisible = .3; GL_StatusDisplayBuild = 0; GL_StatusDisplayLink = 1; GL_UponDisplay = null; GL_UponHide = null; //GL_RightToLeft = true; GL_CreateTopOnly = NS4 ? true : false; GL_ShowLinkCursor = true; // the following function is included to illustrate the improved JS expression handling of // the left_position and top_position parameters // you may delete if you have no use for it function f_CenterMenu(topmenuid) { var MinimumPixelLeft = 0; var TheMenu = DOM ? document.getElementById(topmenuid) : IE4 ? document.all(topmenuid) : eval("window." + topmenuid); var TheMenuWidth = DOM ? parseInt(TheMenu.style.width) : IE4 ? 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//array8 - top menu (about) Array8 = [ [160, // menu width 65, // left_position 87, // top_position "#000049", // font_color "#ffffff", // mouseover_font_color "#dadada", // background_color "#B2B2EF", // mouseover_background_color "#000066", // border_color "#000049", // separator_color 0, // top_is_permanent 0, // top_is_horizontal 0, // tree_is_horizontal 1, // position_under 0, // top_more_images_visible 1, // tree_more_images_visible "null", // evaluate_upon_tree_show "null", // evaluate_upon_tree_hide , // right-to-left ], // display_on_click [" Focus & Coverage",jcp_url+"/staff.jsp",1,0,0], [" Editors",jcp_url+"/staff.jsp#editor",1,0,0], [" Editorial Board",jcp_url+"/staff.jsp#board",1,0,0], [" Editorial Offices",jcp_url+"/staff.jsp#offices",1,0,0], [" AIP Production Office",jcp_url+"/staff.jsp#staff",1,0,0], [" Masthead Archive",jcp_url+"/mastarchive.jsp",1,0,0], [" Brochure (PDF)",jcp_url+"/brochure.pdf",1,0,0] ] // array9 - top menu (author info) Array9 = [ [165, // menu width 129, // left_position 75, // top_position "#000049", // font_color "#ffffff", // mouseover_font_color "#dadada", // background_color "#B2B2EF", // mouseover_background_color "#000066", // border_color "#000049", // separator_color 0, // top_is_permanent 0, // top_is_horizontal 0, // tree_is_horizontal 1, // position_under 0, // top_more_images_visible 1, // tree_more_images_visible "null", // evaluate_upon_tree_show "null", // evaluate_upon_tree_hide , // right-to-left ], // display_on_click [" Submit Manuscript","http://jcp.uchicago.edu",1,0,0], [" Info for Contributors",jcp_url+"/submit.jsp",1,0,0], [" Manuscript Categories","http://jcp.uchicago.edu/requirements",1,0,0], [" General Editorial Policies",jcp_url+"/policy.jsp",1,0,0], [" E-mail to Editorial Office","mailto:editor@jcp.uchicago.edu",1,0,0], [" Open Access Publication",jcp_url+"/au_select.jsp",1,0,0], [" Publication Charges",jcp_url+"/pubchgs.jsp",1,0,0], [" Web Posting Guidelines",sci_url+"/servlet/HelpSystem?KEY=JCPSA6&TYPE=HELP/AIPPOSTING",1,0,0], [" Author Responsibilities","http://www.aip.org/pubservs/ethics.html",1,0,0], [" Publication Forms","http://www.aip.org/pubservs/forms.html",1,0,0], [" E-mail AIP Production","mailto:jcp@aip.org",1,0,0], [" Auxiliary Material/EPAPS","http://www.aip.org/pubservs/epaps.html",1,0,0], [" PACS®","http://www.aip.org/pacs",1,0,0] ] // array10 - top menu (rights/permissions) Array10 = [ [160, // menu width 246, // left_position 35, // top_position "#000049", // font_color "#ffffff", // mouseover_font_color "#dadada", // background_color "#B2B2EF", // mouseover_background_color "#000066", // border_color "#000049", // separator_color 0, // top_is_permanent 0, // top_is_horizontal 0, // tree_is_horizontal 1, // position_under 0, // top_more_images_visible 1, // tree_more_images_visible "null", // evaluate_upon_tree_show "null", // evaluate_upon_tree_hide , // right-to-left ], // display_on_click [" Copyright",jcp_url+"/copyright.jsp#cpr",1,0,0], [" Online Journal License",jcp_url+"/copyright.jsp#lic",1,0,0], [" Web Posting",jcp_url+"/copyright.jsp#web",1,0,0], [" Copying",jcp_url+"/copyright.jsp#copy",1,0,0], [" Permission for Other Use",jcp_url+"/copyright.jsp#perm",1,0,0] ] // array11 - top menu (terms of use) Array11 = [ [160, // menu width 325, // left_position 70, // top_position "#000049", // font_color "#ffffff", // mouseover_font_color "#dadada", // background_color "#B2B2EF", // mouseover_background_color "#000066", // border_color "#000049", // separator_color 0, // top_is_permanent 0, // top_is_horizontal 0, // tree_is_horizontal 1, // position_under 0, // top_more_images_visible 1, // tree_more_images_visible "null", // evaluate_upon_tree_show "null", // evaluate_upon_tree_hide , // right-to-left ], // display_on_click [" Permitted/Prohibited Uses",sci_url+"/jhtml/scitation/pp_uses.jsp",1,0,0], [" Online User License",sci_url+"/jhtml/scitation/licenses.jsp",1,0,0] ] //array1 - top menu (search) Array1 = [ [150, // menu width 700, // left_position 87, // top_position "#000049", // font_color "#ffffff", // mouseover_font_color "#dadada", // background_color "#B2B2EF", // mouseover_background_color "#000066", // border_color "#000049", // separator_color 0, // top_is_permanent 0, // top_is_horizontal 0, // tree_is_horizontal 1, // position_under 0, // top_more_images_visible 1, // tree_more_images_visible "null", // evaluate_upon_tree_show "null", // evaluate_upon_tree_hide , // right-to-left ], // display_on_click [" Current Issue",sci_url+"/vsearch/servlet/VerityServlet?KEY=JCPSA6&CURRENT=YES",1,0,0], [" All Online Issues",sci_url+"/vsearch/servlet/VerityServlet?KEY=JCPSA6",1,0,0], [" Across Journals
(SPIN+Scitation)",sci_url+"/vsearch/servlet/VerityServlet?KEY=ALL",1,0,0], [" Multi-Publisher
(Scitopia Search)","http://www.scitopia.org/scitopia",1,0,0] ] // array2 - top menu (browse) Array2 = [ [150, // menu width 750, // left_position 87, // top_position "#000049", // font_color "#ffffff", // mouseover_font_color "#dadada", // background_color "#B2B2EF", // mouseover_background_color "#000066", // border_color "#000049", // separator_color 0, // top_is_permanent 0, // top_is_horizontal 0, // tree_is_horizontal 1, // position_under 0, // top_more_images_visible 1, // tree_more_images_visible "null", // evaluate_upon_tree_show "null", // evaluate_upon_tree_hide , // right-to-left ], // display_on_click [" Current Issue",sci_url+"/dbt/dbt.jsp?KEY=JCPSA6&Volume=CURVOL&Issue=CURISS",1,0,0], [" All Online Issues",sci_url+"/dbt/dbt.jsp?KEY=JCPSA6",1,0,0], [" Free Sample Issue",jcp_url+"/freesample.jsp",1,0,0] ] // *** the following arrays are for left-side navigation only!!! //array3 - left menu (about) Array3 = [ [160, // menu width 164, // left_position 175, // top_position "#000049", // font_color "#ffffff", // mouseover_font_color "#dadada", // background_color "#B2B2EF", // mouseover_background_color "#000066", // border_color "#000049", // separator_color 0, // top_is_permanent 0, // top_is_horizontal 0, // tree_is_horizontal 1, // position_under 0, // top_more_images_visible 1, // tree_more_images_visible "null", // evaluate_upon_tree_show "null", // evaluate_upon_tree_hide , // right-to-left ], // display_on_click [" Focus & Coverage",jcp_url+"/staff.jsp",1,0,0], [" Editors",jcp_url+"/staff.jsp#editor",1,0,0], [" Editorial Board",jcp_url+"/staff.jsp#board",1,0,0], [" Editorial Offices",jcp_url+"/staff.jsp#offices",1,0,0], [" AIP Production Office",jcp_url+"/staff.jsp#staff",1,0,0], [" Masthead Archive",jcp_url+"/mastarchive.jsp",1,0,0], [" Brochure (PDF)",jcp_url+"/brochure.pdf",1,0,0] ] //array4 - left menu (subscription & pricing) Array4 = [ [160, // menu width 164, // left_position 198, // top_position "#000049", // font_color "#ffffff", // mouseover_font_color "#dadada", // background_color "#B2B2EF", // mouseover_background_color "#000066", // border_color "#000049", // separator_color 0, // top_is_permanent 0, // top_is_horizontal 0, // tree_is_horizontal 1, // position_under 0, // top_more_images_visible 1, // tree_more_images_visible "null", // evaluate_upon_tree_show "null", // evaluate_upon_tree_hide , // right-to-left ], // display_on_click [" Subscription Prices",jcp_url+"/subpricing.jsp",1,0,0], [" Back Issues",jcp_url+"/subpricing.jsp#back",1,0,0], [" ISSN",jcp_url+"/subpricing.jsp#issn",1,0,0], [" General Inquiries",jcp_url+"/subpricing.jsp#general",1,0,0], [" Subscription Policies",jcp_url+"/subpricing.jsp#policy",1,0,0], [" Document Delivery",jcp_url+"/subpricing.jsp#docdel",1,0,0], [" Online Access",jcp_url+"/subpricing.jsp#online",1,0,0], [" Microform",jcp_url+"/subpricing.jsp#micro",1,0,0], [" Order Online (Members)","https://www.aip.org/forms/journal_catalog/order_form_fs.html",1,0,0], [" E-mail Customer Service","mailto:subs@aip.org",1,0,0] ] // array5 - left menu (terms of use) Array5 = [ [160, // menu width 164, // left_position 225, // top_position "#000049", // font_color "#ffffff", // mouseover_font_color "#dadada", // background_color "#B2B2EF", // mouseover_background_color "#000066", // border_color "#000049", // separator_color 0, // top_is_permanent 0, // top_is_horizontal 0, // tree_is_horizontal 1, // position_under 0, // top_more_images_visible 1, // tree_more_images_visible "null", // evaluate_upon_tree_show "null", // evaluate_upon_tree_hide , // right-to-left ], // display_on_click [" Permitted/Prohibited Uses",sci_url+"/jhtml/scitation/pp_uses.jsp",1,0,0], [" Online User License",sci_url+"/jhtml/scitation/licenses.jsp",1,0,0] ] // array6 - left menu (rights/permissions) Array6 = [ [160, // menu width 164, // left_position 250, // top_position "#000049", // font_color "#ffffff", // mouseover_font_color "#dadada", // background_color "#B2B2EF", // mouseover_background_color "#000066", // border_color "#000049", // separator_color 0, // top_is_permanent 0, // top_is_horizontal 0, // tree_is_horizontal 1, // position_under 0, // top_more_images_visible 1, // tree_more_images_visible "null", // evaluate_upon_tree_show "null", // evaluate_upon_tree_hide , // right-to-left ], // display_on_click [" Copyright",jcp_url+"/copyright.jsp#cpr",1,0,0], [" Online Journal License",jcp_url+"/copyright.jsp#lic",1,0,0], [" Web Posting",jcp_url+"/copyright.jsp#web",1,0,0], [" Copying",jcp_url+"/copyright.jsp#copy",1,0,0], [" Permission for Other Use",jcp_url+"/copyright.jsp#perm",1,0,0] ] // array7 - left menu (author info) Array7 = [ [165, // menu width 164, // left_position 270, // top_position "#000049", // font_color "#ffffff", // mouseover_font_color "#dadada", // background_color "#B2B2EF", // mouseover_background_color "#000066", // border_color "#000049", // separator_color 0, // top_is_permanent 0, // top_is_horizontal 0, // tree_is_horizontal 1, // position_under 0, // top_more_images_visible 1, // tree_more_images_visible "null", // evaluate_upon_tree_show "null", // evaluate_upon_tree_hide , // right-to-left ], // display_on_click [" Submit Manuscript","http://jcp.peerx-press.org",1,0,0], [" Info for Contributors",jcp_url+"/submit.jsp",1,0,0], [" Manuscript Categories","http://jcp.uchicago.edu/requirements",1,0,0], [" General Editorial Policies",jcp_url+"/policy.jsp",1,0,0], [" E-mail to Editorial Office","mailto:editor@jcp.uchicago.edu",1,0,0], [" Open Access Publication",jcp_url+"/au_select.jsp",1,0,0], [" Publication Charges",jcp_url+"/pubchgs.jsp",1,0,0], [" Web Posting Guidelines",sci_url+"/servlet/HelpSystem?KEY=JCPSA6&TYPE=HELP/AIPPOSTING",1,0,0], [" Author Responsibilities","http://www.aip.org/pubservs/ethics.html",1,0,0], [" Publication Forms","http://www.aip.org/pubservs/forms.html",1,0,0], [" E-mail AIP Production","mailto:jcp@aip.org",1,0,0], [" Auxiliary Material/EPAPS","http://www.aip.org/pubservs/epaps.html",1,0,0], [" PACS®","http://www.aip.org/pacs",1,0,0] ] ,-%._>http://scitation.aip.org/journals/doc/JCPSA6-home/ScriptDOM.jsO9bplist00 X$versionT$topY$archiverX$objects_WebResourceResponse_NSKeyedArchiver &,-345KLMNOPQRSTUVWXYZ[_`U$null  !"#$%V$classR$3R$8S$10S$11R$5R$6R$4R$7R$2R$9R$0R$1 '()$+WNS.base[NS.relative_>http://scitation.aip.org/journals/doc/JCPSA6-home/ScriptDOM.js./01X$classesZ$classname12UNSURLXNSObject#Al 6789BWNS.keysZNS.objects:;<=>?@A CDEFGHIJ]Accept-RangesVServer\Content-TypeTDate^Content-LengthTEtagZSet-Cookie]Last-ModifiedUbytes_Sun-Java-System-Web-Server/7.0_application/x-javascript_Tue, 25 Nov 2008 00:33:07 GMTU27413_"6b15-3d2dad9b"_7BIGipServerscitation_pool=1519780106.20480.0000; path=/_Thu, 11 Jul 2002 16:08:59 GMT./\]]^2_NSMutableDictionary\NSDictionaryk./abbc2_NSHTTPURLResponse]NSURLResponse)27:PRd KPYdgmv #)Je#&+/CdQOk//ScriptDOM.js // 4.0.12 IE5M = IE && Mac; IE5W = IE && !Mac; NS6 = (navigator.vendor == 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ParamName; if (typeof eval("window.PG_" + ParamName) == "undefined") { if (typeof eval("window.GL_" + ParamName) == "undefined") { eval(FullParamName + "= DefaultValue"); } else { eval(FullParamName + "= GL_" + ParamName); } } else { eval(FullParamName + "= PG_" + ParamName); } paramarray[0] = FullParamName; paramarray[1] = eval(FullParamName); } function f_EvalParameters(valuenew,valueold,valuetype){ var TestString, ParPosition; if(typeof valuenew == "undefined" || valuenew == null || (valuenew.isString && valuenew.length == 0)){ return valueold; } if(valuetype != "delayed"){ while(valuenew.isString) { ParPosition = valuenew.indexOf("("); if(ParPosition !=-1) { TestString = "window." + valuenew.substr(0,ParPosition); if (typeof eval(TestString) != "undefined" && eval(TestString).isFunction) { valuenew = eval(valuenew); } } else break } } while(valuenew.isFunction) {valuenew = valuenew()} switch(valuetype){ case "number": while (valuenew.isString) {valuenew = eval(valuenew)} break; 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[ymH*ӊf3Q(o6S~lqn1鶗/)r[e\^f-x^poN T&OB!Aq~*grY rrnO`4gm"xx߃1d,8걢И=66~#W#vnp* EHpֶJp,+)rGdIܠi'ɘ> RW7AvQݎ EzFNm.ל &ΝkEE+Qg'ZIG)O hHiBd8 >-bP6妛]&K~7q fO?E @"mc 'H `xe=ЏZ A78#рЛItK1) dL8ӕ@]";2(@5!DL5!ҬED6MZ"3( '@0Wve>]B\4I M8]ڥ).r3RI%)۽2YMdS ,L&Ҙǀ )nE/ wL2@<q%ҍznXR0ZD!ڑG<1E!*V8S(̱5&H$& Ҧ05420bESjbT%G2TrY"da,&YL0 Mڵ$aCj:O$02I pA Lb.%[(Q?}:ai_hk_2 0J_,18WsNz\#0Di@0pm 9~:9둈BWPC}~sJTHN0ٌE2:h &øq=>d50r8_`93$#6QzE;!t;n{pg4NwQXi~B4@ `A޺Ç"HbN H<qIsV#-Ҩ5!nnsCĮ|xĎvxX`6V"NE6r 4ZxC:9F8N<PvHCQjvA-s;(BH]Q$)P"R Q|&4)iR5hbs I q<':өulX'yҳ'>}?;%_Phttp://scitation.aip.org/journals/help_system/getabs/SpryAssets/SpryAccordion.jsOKbplist00 X$versionT$topY$archiverX$objects_WebResourceResponse_NSKeyedArchiver &,-345KLMNOPQRSTUVWXYZ[_`U$null  !"#$%V$classR$3R$8S$10S$11R$5R$6R$4R$7R$2R$9R$0R$1 '()$+WNS.base[NS.relative_Phttp://scitation.aip.org/journals/help_system/getabs/SpryAssets/SpryAccordion.js./01X$classesZ$classname12UNSURLXNSObject#A 6789BWNS.keysZNS.objects:;<=>?@A CDEFGHIJ]Accept-RangesVServer\Content-TypeTDate^Content-LengthTEtagZSet-Cookie]Last-ModifiedUbytes_Sun-Java-System-Web-Server/7.0_application/x-javascript_Tue, 25 Nov 2008 00:33:08 GMTU14405_"3845-4731c389"_7BIGipServerscitation_pool=1519780106.20480.0000; path=/_Wed, 07 Nov 2007 13:54:17 GMT./\]]^2_NSMutableDictionary\NSDictionary8E./abbc2_NSHTTPURLResponse]NSURLResponse)27:PRd ]bkvy'5;\w (58=AUdcO8E/* SpryAccordion.js - Revision: Spry Preview Release 1.4 */ // Copyright (c) 2006. Adobe Systems Incorporated. // All rights reserved. // // Redistribution and use in source and binary forms, with or without // modification, are permitted provided that the following conditions are met: // // * Redistributions of source code must retain the above copyright notice, // this list of conditions and the following disclaimer. // * Redistributions in binary form must reproduce the above copyright notice, // this list of conditions and the following disclaimer in the documentation // and/or other materials provided with the distribution. // * Neither the name of Adobe Systems Incorporated nor the names of its // contributors may be used to endorse or promote products derived from this // software without specific prior written permission. // // THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS" // AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE // IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE // ARE DISCLAIMED. IN NO EVENT SHALL THE COPYRIGHT OWNER OR CONTRIBUTORS BE // LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR // CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF // SUBSTITUTE GOODS OR SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS // INTERRUPTION) HOWEVER CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN // CONTRACT, STRICT LIABILITY, OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) // ARISING IN ANY WAY OUT OF THE USE OF THIS SOFTWARE, EVEN IF ADVISED OF THE // POSSIBILITY OF SUCH DAMAGE. var Spry; if (!Spry) Spry = {}; if (!Spry.Widget) Spry.Widget = {}; Spry.Widget.Accordion = function(element, opts) { this.element = this.getElement(element); this.defaultPanel = 0; this.hoverClass = "AccordionPanelTabHover"; this.openClass = "AccordionPanelOpen"; this.closedClass = "AccordionPanelClosed"; this.focusedClass = "AccordionFocused"; this.enableAnimation = true; this.enableKeyboardNavigation = true; this.currentPanel = null; this.animator = null; this.hasFocus = null; this.duration = 500; this.previousPanelKeyCode = Spry.Widget.Accordion.KEY_UP; this.nextPanelKeyCode = Spry.Widget.Accordion.KEY_DOWN; this.useFixedPanelHeights = true; this.fixedPanelHeight = 0; Spry.Widget.Accordion.setOptions(this, opts, true); // Unfortunately in some browsers like Safari, the Stylesheets our // page depends on may not have been loaded at the time we are called. // This means we have to defer attaching our behaviors until after the // onload event fires, since some of our behaviors rely on dimensions // specified in the CSS. if (Spry.Widget.Accordion.onloadDidFire) this.attachBehaviors(); else Spry.Widget.Accordion.loadQueue.push(this); }; Spry.Widget.Accordion.onloadDidFire = false; Spry.Widget.Accordion.loadQueue = []; Spry.Widget.Accordion.addLoadListener = function(handler) { if (typeof window.addEventListener != 'undefined') window.addEventListener('load', handler, false); else if (typeof document.addEventListener != 'undefined') document.addEventListener('load', handler, false); else if (typeof window.attachEvent != 'undefined') window.attachEvent('onload', handler); }; Spry.Widget.Accordion.processLoadQueue = function(handler) { Spry.Widget.Accordion.onloadDidFire = true; var q = Spry.Widget.Accordion.loadQueue; var qlen = q.length; for (var i = 0; i < qlen; i++) q[i].attachBehaviors(); }; Spry.Widget.Accordion.addLoadListener(Spry.Widget.Accordion.processLoadQueue); Spry.Widget.Accordion.prototype.getElement = function(ele) { if (ele && typeof ele == "string") return document.getElementById(ele); return ele; }; Spry.Widget.Accordion.prototype.addClassName = function(ele, className) { if (!ele || !className || (ele.className && ele.className.search(new RegExp("\\b" + className + "\\b")) != -1)) return; ele.className += (ele.className ? " " : "") + className; }; Spry.Widget.Accordion.prototype.removeClassName = function(ele, className) { if (!ele || !className || (ele.className && ele.className.search(new RegExp("\\b" + className + "\\b")) == -1)) return; ele.className = ele.className.replace(new RegExp("\\s*\\b" + className + "\\b", "g"), ""); }; Spry.Widget.Accordion.setOptions = function(obj, optionsObj, ignoreUndefinedProps) { if (!optionsObj) return; for (var optionName in optionsObj) { if (ignoreUndefinedProps && optionsObj[optionName] == undefined) continue; obj[optionName] = optionsObj[optionName]; } }; Spry.Widget.Accordion.prototype.onPanelTabMouseOver = function(panel) { if (panel) this.addClassName(this.getPanelTab(panel), this.hoverClass); }; Spry.Widget.Accordion.prototype.onPanelTabMouseOut = function(panel) { /* if (panel) this.removeClassName(this.getPanelTab(panel), this.hoverClass); */ }; Spry.Widget.Accordion.prototype.openPanel = function(panel) { var panelA = this.currentPanel; var panelB = panel; if (!panelB || panelA == panelB) return; var contentA; if( panelA ) contentA = this.getPanelContent(panelA); var contentB = this.getPanelContent(panelB); if (! contentB) return; if (this.useFixedPanelHeights && !this.fixedPanelHeight) { this.fixedPanelHeight = (contentA.offsetHeight) ? contentA.offsetHeight : contentA.scrollHeight; } if (this.enableAnimation) { if (this.animator) this.animator.stop(); this.animator = new Spry.Widget.Accordion.PanelAnimator(this, panelB, { duration: this.duration }); this.animator.start(); } else { if(contentA) contentA.style.height = "0px"; contentB.style.height = (this.useFixedPanelHeights ? this.fixedPanelHeight : contentB.scrollHeight) + "px"; } if(panelA) { this.removeClassName(panelA, this.openClass); this.addClassName(panelA, this.closedClass); } this.removeClassName(panelB, this.closedClass); this.addClassName(panelB, this.openClass); this.currentPanel = panelB; }; Spry.Widget.Accordion.prototype.openNextPanel = function() { var panels = this.getPanels(); var curPanelIndex = this.getCurrentPanelIndex(); if( panels && curPanelIndex >= 0 && (curPanelIndex+1) < panels.length ) this.openPanel(panels[curPanelIndex+1]); }; Spry.Widget.Accordion.prototype.openPreviousPanel = function() { var panels = this.getPanels(); var curPanelIndex = this.getCurrentPanelIndex(); if( panels && curPanelIndex > 0 && curPanelIndex < panels.length ) this.openPanel(panels[curPanelIndex-1]); }; Spry.Widget.Accordion.prototype.openFirstPanel = function() { var panels = this.getPanels(); if( panels ) this.openPanel(panels[0]); }; Spry.Widget.Accordion.prototype.openLastPanel = function() { var panels = this.getPanels(); if( panels ) this.openPanel(panels[panels.length-1]); }; Spry.Widget.Accordion.prototype.onPanelClick = function(panel) { // if (this.enableKeyboardNavigation) // this.element.focus(); if (panel != this.currentPanel) this.openPanel(panel); this.focus(); }; Spry.Widget.Accordion.prototype.onFocus = function(e) { // this.element.focus(); this.hasFocus = true; this.addClassName(this.element, this.focusedClass); }; Spry.Widget.Accordion.prototype.onBlur = function(e) { // this.element.blur(); this.hasFocus = false; this.removeClassName(this.element, this.focusedClass); }; Spry.Widget.Accordion.KEY_UP = 38; Spry.Widget.Accordion.KEY_DOWN = 40; Spry.Widget.Accordion.prototype.onKeyDown = function(e) { var key = e.keyCode; if (!this.hasFocus || (key != this.previousPanelKeyCode && key != this.nextPanelKeyCode)) return true; var panels = this.getPanels(); if (!panels || panels.length < 1) return false; var currentPanel = this.currentPanel ? this.currentPanel : panels[0]; var nextPanel = (key == this.nextPanelKeyCode) ? currentPanel.nextSibling : currentPanel.previousSibling; while (nextPanel) { if (nextPanel.nodeType == 1 /* Node.ELEMENT_NODE */) break; nextPanel = (key == this.nextPanelKeyCode) ? nextPanel.nextSibling : nextPanel.previousSibling; } if (nextPanel && currentPanel != nextPanel) this.openPanel(nextPanel); if (e.stopPropagation) e.stopPropagation(); if (e.preventDefault) e.preventDefault(); return false; }; Spry.Widget.Accordion.prototype.attachPanelHandlers = function(panel) { if (!panel) return; var tab = this.getPanelTab(panel); if (tab) { var self = this; Spry.Widget.Accordion.addEventListener(tab, "click", function(e) { return self.onPanelClick(panel); }, false); Spry.Widget.Accordion.addEventListener(tab, "mouseover", function(e) { return self.onPanelTabMouseOver(panel); }, false); Spry.Widget.Accordion.addEventListener(tab, "mouseout", function(e) { return self.onPanelTabMouseOut(panel); }, false); } }; Spry.Widget.Accordion.addEventListener = function(element, eventType, handler, capture) { try { if (element.addEventListener) element.addEventListener(eventType, handler, capture); else if (element.attachEvent) element.attachEvent("on" + eventType, handler); } catch (e) {} }; Spry.Widget.Accordion.prototype.initPanel = function(panel, isDefault) { var content = this.getPanelContent(panel); if (isDefault) { this.currentPanel = panel; this.removeClassName(panel, this.closedClass); this.addClassName(panel, this.openClass); } else { this.removeClassName(panel, this.openClass); this.addClassName(panel, this.closedClass); content.style.height = "0px"; } this.attachPanelHandlers(panel); }; Spry.Widget.Accordion.prototype.attachBehaviors = function() { var panels = this.getPanels(); for (var i = 0; i < panels.length; i++) { this.initPanel(panels[i], i == this.defaultPanel); } if (this.enableKeyboardNavigation) { // XXX: IE doesn't allow the setting of tabindex dynamically. This means we can't // rely on adding the tabindex attribute if it is missing to enable keyboard navigation // by default. var tabIndexAttr = this.element.attributes.getNamedItem("tabindex"); // if (!tabIndexAttr) this.element.tabindex = 0; if (tabIndexAttr) { var self = this; Spry.Widget.Accordion.addEventListener(this.element, "focus", function(e) { return self.onFocus(e); }, false); Spry.Widget.Accordion.addEventListener(this.element, "blur", function(e) { return self.onBlur(e); }, false); Spry.Widget.Accordion.addEventListener(this.element, "keydown", function(e) { return self.onKeyDown(e); }, false); } } }; Spry.Widget.Accordion.prototype.getPanels = function() { return this.getElementChildren(this.element); }; Spry.Widget.Accordion.prototype.getCurrentPanel = function() { return this.currentPanel; }; Spry.Widget.Accordion.prototype.getCurrentPanelIndex = function() { var panels = this.getPanels(); for( var i = 0 ; i < panels.length; i++ ) { if( this.currentPanel == panels[i] ) return i; } return 0; }; Spry.Widget.Accordion.prototype.getPanelTab = function(panel) { if (!panel) return null; return this.getElementChildren(panel)[0]; }; Spry.Widget.Accordion.prototype.getPanelContent = function(panel) { if (!panel) return null; return this.getElementChildren(panel)[1]; }; Spry.Widget.Accordion.prototype.getElementChildren = function(element) { var children = []; var child = element.firstChild; while (child) { if (child.nodeType == 1 /* Node.ELEMENT_NODE */) children.push(child); child = child.nextSibling; } return children; }; Spry.Widget.Accordion.prototype.focus = function() { if (this.element && this.element.focus) this.element.focus(); }; ///////////////////////////////////////////////////// Spry.Widget.Accordion.PanelAnimator = function(accordion, panel, opts) { this.timer = null; this.interval = 0; this.stepCount = 0; this.fps = 0; this.steps = 10; this.duration = 500; this.onComplete = null; this.panel = panel; this.panelToOpen = accordion.getElement(panel); this.panelData = []; Spry.Widget.Accordion.setOptions(this, opts, true); // If caller specified speed in terms of frames per second, // convert them into steps. if (this.fps > 0) { this.interval = Math.floor(1000 / this.fps); this.steps = parseInt((this.duration + (this.interval - 1)) / this.interval); } else if (this.steps > 0) this.interval = this.duration / this.steps; // Set up the array of panels we want to animate. var panels = accordion.getPanels(); for (var i = 0; i < panels.length; i++) { var p = panels[i]; var c = accordion.getPanelContent(p); if (c) { var h = c.offsetHeight; if (h == undefined) h = 0; if (p == panel || h > 0) { var obj = new Object; obj.panel = p; obj.content = c; obj.fromHeight = h; obj.toHeight = (p == panel) ? (accordion.useFixedPanelHeights ? accordion.fixedPanelHeight : c.scrollHeight) : 0; obj.increment = (obj.toHeight - obj.fromHeight) / this.steps; obj.overflow = c.style.overflow; this.panelData.push(obj); c.style.overflow = "hidden"; c.style.height = h + "px"; } } } }; Spry.Widget.Accordion.PanelAnimator.prototype.start = function() { var self = this; this.timer = setTimeout(function() { self.stepAnimation(); }, this.interval); }; Spry.Widget.Accordion.PanelAnimator.prototype.stop = function() { if (this.timer) { clearTimeout(this.timer); // If we're killing the timer, restore the overflow // properties on the panels we were animating! if (this.stepCount < this.steps) { for (i = 0; i < this.panelData.length; i++) { obj = this.panelData[i]; obj.content.style.overflow = obj.overflow; } } } this.timer = null; }; Spry.Widget.Accordion.PanelAnimator.prototype.stepAnimation = function() { ++this.stepCount; this.animate(); if (this.stepCount < this.steps) this.start(); else if (this.onComplete) this.onComplete(); }; Spry.Widget.Accordion.PanelAnimator.prototype.animate = function() { var i, obj; if (this.stepCount >= this.steps) { for (i = 0; i < this.panelData.length; i++) { obj = this.panelData[i]; if (obj.panel != this.panel) obj.content.style.height = "0px"; obj.content.style.overflow = obj.overflow; obj.content.style.height = obj.toHeight + "px"; } } else { for (i = 0; i < this.panelData.length; i++) { obj = this.panelData[i]; obj.fromHeight += obj.increment; obj.content.style.height = obj.fromHeight + "px"; } } }; %_Ihttp://scitation.aip.org/journals/help_system/getabs/scripts/baby_ajax.jsOCbplist00 X$versionT$topY$archiverX$objects_WebResourceResponse_NSKeyedArchiver &,-345KLMNOPQRSTUVWXYZ[_`U$null  !"#$%V$classR$3R$8S$10S$11R$5R$6R$4R$7R$2R$9R$0R$1 '()$+WNS.base[NS.relative_Ihttp://scitation.aip.org/journals/help_system/getabs/scripts/baby_ajax.js./01X$classesZ$classname12UNSURLXNSObject#AvO 6789BWNS.keysZNS.objects:;<=>?@A CDEFGHIJ]Accept-RangesVServer\Content-TypeTDate^Content-LengthTEtagZSet-Cookie]Last-ModifiedUbytes_Sun-Java-System-Web-Server/7.0_application/x-javascript_Tue, 25 Nov 2008 00:33:08 GMTT6373_"18e5-47b1ddc2"_7BIGipServerscitation_pool=1519780106.20480.0000; path=/_Tue, 12 Feb 2008 17:56:18 GMT./\]]^2_NSMutableDictionary\NSDictionary./abbc2_NSHTTPURLResponse]NSURLResponse)27:PRd V[dorx .4Up  -059Md[Ovar renderCiting=new Boolean(true); /** * This Javascript function allows for some simple Ajax functionality. * * The function to be called is rewritePageElement(url, elementID), or rewritePageElement(url, query, elementID) * * What it provides is a basic way to load content into the page Asynchronously * This means that upon calling of this script a portion of the page specified by the elementID * will be rewritten with the contents of the file specified by the given URL. * * This does not cause the whole page to be reloaded, simply the portion specified. */ var xmlHttp; var divid = 'nameList'; var is_ie = (navigator.userAgent.indexOf('MSIE') >= 0) ? 1 : 0; var is_ie5 = (navigator.appVersion.indexOf("MSIE 5.5")!=-1) ? 1 : 0; var is_opera = ((navigator.userAgent.indexOf("Opera 6")!=-1)||(navigator.userAgent.indexOf("Opera/6")!=-1)) ? 1 : 0; //netscape, safari, mozilla behave the same??? var is_netscape = (navigator.userAgent.indexOf('Netscape') >= 0) ? 1 : 0; var loading = ''; /** * rewrites the HTML element on the page with the give ID with code loaded from the given URL. * @param url the location of the resource used to generate the HTML code to insert into the page. * @param elementID the ID of the HTML page element... most likely a DIV tag... * whose content is to be replaced by the HTML code generated by the given URL. */ function rewritePageElement(url, elementID) { rewritePageElement(url, '', elementID); } /** * rewrites the HTML element on the page with the give ID with code loaded from the given URL. * @param url the location of the resource used to generate the HTML code to insert into the page. * @param query if this method is being called directly, then the query string to append to the URL is specified here. * an example of using this would be to pass this.value from a form element. * @param elementID the ID of the HTML page element... most likely a DIV tag... * whose content is to be replaced by the HTML code generated by the given URL. */ function rewritePageElement(url, query, elementID, loadingin) { //set the id for the HTML element to overwrite divid = elementID; loading = loadingin; //alert("renderCiting: " + renderCiting + " | " + query.indexOf("checkifclicked")); if ((query.indexOf("checkifclicked") >= 0 && renderCiting == true) || query.indexOf("checkifclicked") == -1) { if (loading!=null && loading!='') { document.getElementById(loading).style.display = "inline"; } url = url + query; if (url.length > 0) { //Create the xmlHttp object to use in the request //stateChangeHandler will fire when the state has changed, i.e. data is received back // This is non-blocking (asynchronous) xmlHttp = GetXmlHttpObject(stateChangeHandler); //Send the xmlHttp get to the specified url xmlHttp_Get(xmlHttp, url); if (query.indexOf("checkifclicked") >= 0) { renderCiting=false; } } } } //stateChangeHandler will fire when the state has changed, i.e. data is received back // This is non-blocking (asynchronous) function stateChangeHandler() { //readyState of 4 or 'complete' represents that data has been returned if (xmlHttp.readyState == 4 || xmlHttp.readyState == 'complete') { //Gather the results from the callback var str = xmlHttp.responseText; //Populate the innerHTML of the div with the results document.getElementById(divid).innerHTML = str; if (loading!=null && loading!='') { document.getElementById(loading).style.display = "none"; } } } // XMLHttp send GET request function xmlHttp_Get(xmlhttp, url) { //Getting a permissions error here? Check the url string to // ensure it is accurate (defined above) xmlhttp.open('GET', url, true); xmlhttp.send(null); } function GetXmlHttpObject(handler) { var objXmlHttp = null; //Holds the local xmlHTTP object instance //Depending on the browser, try to create the xmlHttp object if (is_ie) { //The object to create depends on version of IE //If it isn't ie5, then default to the Msxml2.XMLHTTP object var strObjName = (is_ie5) ? 'Microsoft.XMLHTTP' : 'Msxml2.XMLHTTP'; //Attempt to create the object try { objXmlHttp = new ActiveXObject(strObjName); objXmlHttp.onreadystatechange = handler; } catch(e) { //Object creation errored alert('IE detected, but object could not be created. Verify that active scripting and activeX controls are enabled'); return; } } else if (is_opera) { //Opera has some issues with xmlHttp object functionality alert('Opera detected. The page may not behave as expected.'); return; } else { // Mozilla | Netscape | Safari objXmlHttp = new XMLHttpRequest(); objXmlHttp.onload = handler; objXmlHttp.onerror = handler; } //Return the instantiated object return objXmlHttp; } /** * Cleans all characters that would be a problem for HTTP from the given String. */ function cleanForHTTP(source) { if(source == null) { return ""; } source = source.replace("%", "%25"); source = source.replace("\r\n", "%0D"); source = source.replace("\n", "%0D"); return source.replace("\r", "%0D"); }%_Nhttp://scitation.aip.org/journals/help_system/getabs/scripts/getAbs_default.jsOIbplist00 X$versionT$topY$archiverX$objects_WebResourceResponse_NSKeyedArchiver &,-345KLMNOPQRSTUVWXYZ[_`U$null  !"#$%V$classR$3R$8S$10S$11R$5R$6R$4R$7R$2R$9R$0R$1 '()$+WNS.base[NS.relative_Nhttp://scitation.aip.org/journals/help_system/getabs/scripts/getAbs_default.js./01X$classesZ$classname12UNSURLXNSObject#A*(V 6789BWNS.keysZNS.objects:;<=>?@A CDEFGHIJ]Accept-RangesVServer\Content-TypeTDate^Content-LengthTEtagZSet-Cookie]Last-ModifiedUbytes_Sun-Java-System-Web-Server/7.0_application/x-javascript_Tue, 25 Nov 2008 00:33:09 GMTU15798_"3db6-490a1e78"_7BIGipServerscitation_pool=1519780106.20480.0000; path=/_Thu, 30 Oct 2008 20:52:08 GMT./\]]^2_NSMutableDictionary\NSDictionary=./abbc2_NSHTTPURLResponse]NSURLResponse)27:PRd [`itw}%39Zu &36;?SdaO= /** * These Javascript functions drives many of the main abstract functions. * * Page assembled by C. West 10/24/07 * */ function MM_swapImgRestore() { //v3.0 var i,x,a=document.MM_sr; for(i=0;a&&i0&&parent.frames.length) { d=parent.frames[n.substring(p+1)].document; n=n.substring(0,p);} if(!(x=d[n])&&d.all) x=d.all[n]; for (i=0;!x&&i myMax) { alert('You have selected '+ _countChecked + ' articles. Please select no more than '+myMax+ ' articles at a time.'); err = 1;} /* of is the count too low */ else if(_countChecked < myMin) { alert('You must select at least '+myMin+' article.'); err = 1;} if (err == 1) { return false; } if( (document.myform.fn.value == "" ) || (document.myform.fn.value == "multi" ) ){ alert ("Please select an Article Option"); return false; } if(document.myform.fn.options[3].selected == true ) { document.myform.action = '/myscitation/addToMyArticles-submit.do'; document.myform.target = "Scitation"; myArt=window.open('','Scitation','height=600,width=660,scrollbars=yes,resizable=yes,top=50,left=50,toolbar=yes,location=yes,menubar=yes'); myArt.focus(); document.myform.submit(); return false; } var bname = navigator.appVersion; if (bname.indexOf("Safari")<0) { document.myform.target='_blank' } document.myform.submit(); return false; } function PrintPage(){ if (window.print) { window.focus(); window.print(); } else { alert('This script does not work in your browser'); } //history.back(); //return false; } function opacity(id, opacStart, opacEnd, millisec) { //speed for each frame var speed = Math.round(millisec / 100); var timer = 0; //determine the direction for the blending, if start and end are the same nothing happens if(opacStart > opacEnd) { for(i = opacStart; i >= opacEnd; i--) { setTimeout("changeOpac(" + i + ",'" + id + "')",(timer * speed)); timer++; } } else if(opacStart < opacEnd) { for(i = opacStart; i <= opacEnd; i++) { setTimeout("changeOpac(" + i + ",'" + id + "')",(timer * speed)); timer++; } } } //change the opacity for different browsers function changeOpac(opacity, id) { var object = document.getElementById(id).style; object.opacity = (opacity / 100); object.MozOpacity = (opacity / 100); object.KhtmlOpacity = (opacity / 100); object.filter = "alpha(opacity=" + opacity + ")"; } function load_focus_window(pagetoLoad) { rewritePageElement('/journals/help_system/getabs/actions/loading.jsp', '', 'popup_viewingpane', ''); rewritePageElement(pagetoLoad, '', 'popup_viewingpane', ''); MM_showHideLayers('popup_backdrop','','show'); opacity('popup_backdrop', 0,50, 200); MM_showHideLayers('popup_viewingpane','','show'); opacity('popup_viewingpane', 0,100, 200); } function close_focus_window() { opacity('popup_backdrop', 50,0, 100); setTimeout('MM_showHideLayers(\'popup_backdrop\',\'\',\'hide\')',300); opacity('popup_viewingpane', 100,0, 200); setTimeout('MM_showHideLayers(\'popup_viewingpane\',\'\',\'hide\')',200); rewritePageElement('/journals/help_system/getabs/actions/loading.jsp', '', 'popup_viewingpane', ''); } function clickAbstract(citid) { if (document.getElementById("abs_sci")) { document.getElementById("abs_sci").style.backgroundColor = "#f8f8f8"; } if (document.getElementById("abs_cross")) { document.getElementById("abs_cross").style.backgroundColor = "#f8f8f8"; } if (document.getElementById("abs_all")) { document.getElementById("abs_all").style.backgroundColor = "#f8f8f8"; } if (document.getElementById("citid")) { document.getElementById(citid).style.backgroundColor = "#e9e9e9"; } } function clickTab(citid) { if (document.getElementById("abs_tab")) { document.getElementById("abs_tab").className = "nav_unselected"; } if (document.getElementById("refs_tab")) { document.getElementById("refs_tab").className = "nav_unselected"; } if (document.getElementById("cit_tab")) { document.getElementById("cit_tab").className = "nav_unselected"; } if (document.getElementById("supp_tab")) { document.getElementById("supp_tab").className = "nav_unselected"; } document.getElementById(citid).className = "nav_selected"; } function setActiveStyleSheet(title) { var i, a, main; for(i=0; (a = document.getElementsByTagName("link")[i]); i++) { if(a.getAttribute("rel").indexOf("style") != -1 && a.getAttribute("title")) { a.disabled = true; if(a.getAttribute("title") == title) a.disabled = false; } } } function convertToMobileCSS() { document.getElementById("absbottom_stand").style.display="inline"; document.getElementById("absbottom_refs").style.display="inline"; document.getElementById("absbottom_citings").style.display="inline"; MM_showHideLayers2('absbottom_refs','','show'); MM_showHideLayers2('absbottom_stand','','show'); MM_showHideLayers2('absbottom_citings','','show'); setActiveStyleSheet('abs_mobile'); } function convertBackToStandardCSS() { document.getElementById("absbottom_stand").style.display="inline"; document.getElementById("absbottom_refs").style.display="none"; document.getElementById("absbottom_citings").style.display="none"; /* MM_showHideLayers('absbottom_refs','','show'); MM_showHideLayers('absbottom_stand','','hide'); MM_showHideLayers('absbottom_citings','','hide'); */ setActiveStyleSheet('default'); clickTab('abs_tab') } function keyclosewindow(e) { if (e.keyCode==27) { close_focus_window(); } } function initializeObjects() { /* document.getElementById("absbottom_refs").style.display="inline"; document.getElementById("absbottom_citings").style.display="inline"; document.getElementById("absbottom_stand").style.display="inline"; */ } function addOpenSearch(name,ext,cat,pid,meth) { if ((typeof window.external == "object") && ((typeof window.external.AddSearchProvider == "unknown") || (typeof window.external.AddSearchProvider == "function"))) { if ((typeof window.external.AddSearchProvider == "unknown") && meth == "p") { alert("This plugin uses POST which is not currently supported by Internet Explorer's implementation of OpenSearch."); } else { window.external.AddSearchProvider( "http://mycroft.mozdev.org/installos.php/" + pid + "/" + name + ".xml"); } } else { alert("You will need a browser which supports OpenSearch to install this plugin."); } } function open_printversion(url) { window.open(url,'_blank','width=800,height=900,status=1,scrollbars=1,resizable=1'); } function isblank(s) { for(var i = 0; i < s.length; i++) { var c = s.charAt(i); if ((c != ' ') && (c != '\n') && (c != '\t')) { return false; } } return true; } function errata_formcheck() { var e = document.erratasignup.email.value; var e2 = document.erratasignup.email2.value; if ((e == null) || (e == "") || isblank(e)) { alert("Please enter your email."); return false; } if ((e != e2)) { alert("Email Addresses do not match."); return false; } if ((e.indexOf(".") < 0) || (e.indexOf("@") < 0)) { alert("Please enter a valid email address."); return false; } rewritePageElement('/journals/help_system/getabs/actions/submit_emailalerts.jsp', '?cvips=<%=getabsbean.getCvips()%>&email='+e, 'popup_viewingpane', ''); return false; } function colleague_formcheck() { var ce = document.colleagueemail.colleagueemail.value; var cn = document.colleagueemail.colleaguename.value; var se = document.colleagueemail.senderemail.value; var sn = document.colleagueemail.sendername.value; var mes = document.colleagueemail.sendermessage.value; var soc = document.colleagueemail.society.value; var cvips = document.colleagueemail.cvips.value; var title = document.colleagueemail.title.value; if ((ce == null) || (ce == "") || isblank(ce)) { alert("Please enter your colleague's email."); return false; } if ((ce.indexOf(".") < 0) || (ce.indexOf("@") < 0)) { alert("Please enter a valid colleague email address."); return false; } if ((cn == null) || (cn == "") || isblank(cn)) { alert("Please enter your colleague's name."); return false; } if ((sn == null) || (sn == "") || isblank(sn)) { alert("Please enter your name, so that your colleague knows who sent this email."); return false; } if ((se == null) || (se == "") || isblank(se)) { alert("Please enter your (the sender) email."); return false; } if ((se.indexOf(".") < 0) || (se.indexOf("@") < 0)) { alert("Please enter a valid email address for yourself."); return false; } if (mes.length > 200) { alert("Message cannot be larger than 200 pixels. You have " + mes.length); return false; } rewritePageElement('/journals/help_system/getabs/actions/submit_emailcolleague.jsp', '?cvips='+cvips+'&title='+title+'&colleagueemail='+ce+'&colleaguename='+cn+'&senderemail='+se+'&sendername='+sn+'&sendermessage='+mes+'&society='+soc, 'popup_viewingpane', ''); return false; } function howManyCheckedB(whichForm,whichCheckBoxArray,myMax,myMin) { document.myform.action = '/getabs/servlet/GetCitation'; var _countChecked = 0; var err = 0; alert("SIZE (document."+whichForm+"."+whichCheckBoxArray+"): " + document[whichForm][whichCheckBoxArray].length); alert("SIZE2: " + document.myform.SelectCheck.length); /* iterate through all the elements in the checkbox array */ for(i=0;i myMax) { alert('You have selected '+ _countChecked + ' articles. Please select no more than '+myMax+ ' articles at a time.'); err = 1;} /* of is the count too low */ else if(_countChecked < myMin) { alert('You must select at least '+myMin+' article.'); err = 1;} if (err == 1) { return false; } if( (document.myform.fn.value == "" ) || (document.myform.fn.value == "multi" ) ){ alert ("Please select an Article Option"); return false; } if(document.myform.fn.options[3].selected == true ) { document.myform.action = '/myscitation/addToMyArticles-submit.do'; document.myform.target = "Scitation"; myArt=window.open('','Scitation','height=600,width=660,scrollbars=yes,resizable=yes,top=50,left=50,toolbar=yes,location=yes,menubar=yes'); myArt.focus(); document.myform.submit(); return false; } var bname = navigator.appVersion; if (bname.indexOf("Safari")<0) { document.myform.target='_blank' } document.myform.submit(); return false; }  1<Ki$*4$\e߫ߴ)PY j<<<A A;JKKJONgp + 4 kT]#(M(V(,1H1Q15HHHQHLMMMR__`$dLdddhiRi[imnn nWruuuz6}z}}M >DzO/8{U^FOGRĊE|̱̺ @/fأج2ݟݨ- n )bS,,-@1iij-nt]fɾ