Asymmetry of ssDNA translocation

J. Mathe, A. Aksimentiev, D.R. Nelson, K. Shulten, A. Meller, PNAS 102, 12377 (2005)

• Unforced translocation of polyA(60) with loop:

• Asymmetry between times to excape the pore:

R.C. Lua and A.Y. Grosberg, PRE 72, 061918 (2005)

• Two symmetrically unrelated configurations; 4 translocation types, from 2 diffusion coefficients

• Lua & Grosberg calculate asymmetry in Mean First Passage Time in a saw-tooth potential

• We (MK & P. Chen) obtained similar results from a discrete hopping model:

• In case of anomalous dynamics, we expect:

Next Outline Introduction Brownian translocation Anomalous dynamics Forced translocation Asymmetry Sub-diffusive distributions