T Cell Mediated Cancer Immunotherapy
T cells are potent mediators of cell death and their ability to treat cancer in various forms is the focus of my graduate work. In particular, I am interested in three possible methods to utilize the cytolytic function of T cells to treat cancer. The first is a combination therapy using adoptive cell transfer, tumor targeting antibodies, and a cytokine fusion protein. The second is the development of a chimeric antigen receptor (CAR) to target T cells to tumors, initiate tumor cell lysis, and promote long term survival. The third is the design of bispecific T cell engager (BiTE) antibodies which target T cells to tumor cells by creating a bridge between tumor associated antigens and CD3ε domains. By utilizing a patient’s own immune system to fight off cancer, it is hoped that more durable treatments of cancer can be developed.