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SELECTED PUBLICATIONS
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Links
to PubMed citations and relevant journal
will take you to a new site.
Many of these articles are available for download
in PDF format. |
| Howland SW, Tsuji T, Gnjatic S, Ritter G, Old LJ, Wittrup KD. Inducing efficient cross-priming using antigen-coated yeast particles. J Immunother. 2008. [PubMed] |
| Thurber GM, Wittrup KD. Quantitative spatiotemporal analysis of antibody fragment diffusion and endocytic consumption in tumor spheroids. Cancer Res. 68(9):3334-41, 2008. [PubMed , Journal] |
| Howarth M, Liu W, Puthenveetil S, Zheng Y, Marshall LF, Schmidt MM, Wittrup KD, Bawendi MG, Ting AY. Monovalent, reduced-size quantum dots for imaging receptors on living cells. Nat Methods, 5(5):397-9, 2008. [PubMed , Journal] |
| Schmidt MM, Thurber GM, Wittrup KD. Kinetics of anti-carcinoembryonic antigen antibody internalization: effects of affinity, bivalency, and stability. Cancer Immunol Immunother. 2008. [PubMed , Journal] |
| Yeung YA, Finney AH, Koyrakh IA, Lebowitz MS, Chanbari HA, Wands JR, Wittrup KD. Isolation and characterization of human antibodies targeting human aspartyl (asparaginyl) beta-hydroxylase. Hum Antibodies, 16(3-4):163-176, 2007. [PubMed , Journal] |
| Ackerman ME, Chalouni C, Schmidt MM, Raman VV, Ritter G, Old LJ, Mellman I, Wittrup KD. A33 antigen displays persistent surface expression. Cancer Immunol Immunother, 2008. [PubMed , Journal] |
| Howland SW, Wittrup KD.
Antigen release kinetics in the phagosome are critical to cross-presentation efficiency. J Immunol. 180(3):1576-83, 2008. [PubMed , Journal] |
| Thurber GM, Schmidt MM, Wittrup KD.
Factors determining antibody distribution in tumors. Trends Pharmacol Sci. 29(2):57-61, 2008. [PubMed , Journal] |
| Liovsek D, Antipov E, Armstrong KA, Olsen MJ, Klibanov AM, Tidor B, Wittrup KD. Selection of horseradish peroxidase variants with enhanced enantioselectivity by yeast surface display. Chem Biol. 14(10):1176-85, 2007. [PubMed , Journal] |
| Lippow SM, Wittrup KD, Tidor B.
Computational design of antibody-affinity improvement beyond in vivo maturation. Nat Biotechnol. 25(10):1171-76, 2007. [PubMed , Journal] |
| Gai SA, Wittrup KD. Yeast surface display for protein engineering and characterization. Curr Opin Struct Biol. 17(4):467-73, 2007. [PubMed , Journal] |
| Thurber GM, Zajic SC, Wittrup KD. Theoretic Criteria for Antibody Penetration into Solid Tumors and Micrometastases.
J Nucl Med. 48(6):995-9, 2007. [PubMed , Journal] |
| Chao G, Lau WL, Hackel BJ, Sazinsky SL, Lippow SM, Wittrup KD. Isolating and engineering human antibodies using yeast surface display. Nat Protoc. 1(2): 755-768, 2007. [Pubmed , Journal] |
| Lipovsek D, Lippow SM, Hackel BJ, Gregson MW, Cheng P, Kapila A, Wittrup KD. Evolution of an Interloop Disulfide Bond in High-Affinity Antibody Mimics Based on Fibronectin Type III Domain and Selected by Yeast Surface Display: Molecular Convergence with Single-Domain Camelid and Shark Antibodies. J. Mol. Biol. 368(4):1024-41, 2007. [PubMed , Journal] |
| Krauland EM, Peele BR, Wittrup KD, Belcher AM. Peptide tags for enhanced cellular and protein adhesion to single-crystalline sapphire. Biotechnol Bioeng. 97(5):1009-20, 2007. [PubMed , Journal] |
| Swers JS, Widom A, Phan U, Springer TA, Wittrup KD. A high affinity human antibody antagonist of P-selectin mediated rolling. Biochem Biophys Res Commun. 350(3): 508-513, 2006. [PubMed, Journal] |
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Jin M, Song G, Carman CV, Kim YS, Astrof NS,
Shimaoka M, Wittrup DK, Springer TA. Directed evolution to probe
protein allostery and integrin I domains of 200,000-fold higher affinity. Proc Natl Acad
Sci U S A. 103(15): 5758-5763, 2006. [PubMed , Journal] |
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Sivasubramanian A, Chao G, Pressler HM, Wittrup KD, Gray JJ. Structural Model of the
mAb 806-EGFR Complex Using Computational Docking followed by Computational and
Experimental Mutagenesis. Structure 14(3):401-14, 2006. [PubMed, Journal]
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J.A. Rakestraw, A. R. Baskaran, K.D. Wittrup. A Flow Cytometric Assay for Screening
Improved Heterologous Protein Secretion in Yeast. Biotechnol Prog. 22(4): 1200-1208, 2006. [PubMed, Journal] |
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Piatesi A, Howland SW, Rakestraw JA, Renner C, Robson N, Cebon J, Maraskovsky E, Ritter G, Old L, and Wittrup KD. Directed Evolution for Improved
Secretion of Cancer-Testis Antigen NY-ESO-1 from Yeast. Protein Expr. Purif. 48(2): 232-242, 2006. [PubMed , Journal] |
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Rakestraw A, Wittrup KD. Contrasting secretory processing of simultaneously expressed
heterologous proteins in Saccharomyces cerevisiae. Biotechnol Bioeng. 93 (5): 896-905,
2006. [PubMed, Journal]
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Cochran J.R., Rao, B.M., Kim, Y.-S., Wittrup, K.D. Improved Mutants from Directed
Evolution are Biased to Orthologous Substitutions. Protein Engineering, Design, &
Selection, 19(6): 245-253, 2006. [PubMed, Journal] |
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Colby, D.W., Cassady, J., Lin, G., Ingram, V.M., Wittrup, K.D. A stochastic model of
intracellular aggregate formation in Huntington's disease. Nature Chemical Biology, 2(6): 319-323, 2006. [PubMed, Journal] |
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Midelfort, K.S., Wittrup, K.D. Context-Dependent Mutations Predominate in an
Engineered High Affinity Single Chain Antibody Fragment. Protein Science, 15(2):324-34,
2006. [PubMed, Journal]
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Kim Y.S., Bhandari R., Cochran J.R., Kuriyan J., Wittrup K.D. Directed Evolution of
the Epidermal Growth Factor Receptor Extracellular Domain for Expression in Yeast.
Proteins: Structure, Function, & Bioinformatics, 62(4):1026-35, 2006. [PubMed, Journal]
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Rao BM, Driver I, Lauffenburger DA, Wittrup KD. High-affinity CD25-binding IL-2
mutants potently stimulate persistent T cell growth. Biochemistry. 44(31):10696-701, 2005. [PubMed, Journal]
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Peelle BR, Krauland EM, Wittrup KD, Belcher AM Design criteria for engineering
inorganic material-specific peptides. Langmuir. 2005 Jul 19;21(15):6929-33. [PubMed, Journal]
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Peelle, B.R., Krauland, E., Wittrup, K.D., Belcher, A.M. Probing the interface
between biomolecules and inorganic materials using yeast surface display and genetic
engineering. Acta Biomaterialia 1(2):145-154, 2005. [PubMed, Journal]
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Rao, BM, Lauffenburger, DA, Wittrup KD. Integrating cell-level kinetic modeling into
the design of engineered protein therapeutics. Nature Biotechnology, 23(2):191-4, 2005. [PubMed, Journal]
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Colby DW, Chu Y, Cassady JP, Duennwald M, Zazulak H, Webster JM, Messer A, Lindquist
S, Ingram VM, Wittrup KD. Potent inhibition of huntingtin aggregation and cytotoxicity by
a disulfide bond-free single-domain intracellular antibody. Proc Natl Acad Sci U S A.
101(51): 17616-17621, 2004. [PubMed, Journal]
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Mohr L, Yeung A, Aloman C, Wittrup D, Wands JR. Antibody-directed therapy for human
hepatocellular carcinoma. Gastroenterology. 127(5 Suppl 2):S225-31, 2004.
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| Midelfort, K.S.,
Hernandez, H.H., Lippow, S.M., Tidor, B., Drennan,
C.L., Wittrup, K.D. "Substantial Energetic
Improvement with Minimal Structural Perturbation
in a High Affinity Mutant Antibody." J. Mol.
Biol., 343(3):685-701. [PubMed, Journal] |
| Rao, B.M., Driver,
I., Lauffenburger D.A., Wittrup K.D. "IL-2
variants engineered for increased IL 2R-alpha
affinity exhibit increased potency arising
from a cell surface ligand reservoir effect." Molecular
Pharmacology 66(4):864-869, 2004. [PubMed, Journal] |
| Chao, G., Cochran,
J.R., Wittrup, K.D. "Fine Epitope Mapping of
anti-Epidermal Growth Factor Receptor Antibodies
through Random Mutagenesis and Yeast Surface
Display." J. Mol. Biol. 342(2):539-50,
2004. [PubMed, Journal] |
| Colby, D.W., Garg,
P., Holden, T., Chao, G., Webster, J.M., Messer,
A., Ingram, V.M., Wittrup, K.D. "Development
of a Human Light Chain Variable Domain (VL)
Intracellular Antibody Specific for the Amino
Terminus of Huntingtin via Yeast Surface Display." J.
Mol. Biol. 342(3):901-12, 2004. [PubMed, Journal] |
| Johns TG, Adams
TE, Cochran JR, Hall NE, Hoyne PA, Olsen MJ,
Kim YS, Rothacker J, Nice EC, Walker F, Ritter
G, Jungbluth AA, Old LJ, Ward CW, Burgess AW,
Wittrup KD, Scott AM. "Identification of the
Epitope for the Epidermal Growth Factor Receptor-specific
Monoclonal Antibody 806 Reveals That It Preferentially
Recognizes an Untethered Form of the Receptor." J.
Biol Chem. 279(29):30375-30384, 2004.
[PubMed, Journal] |
| Coughlan, C.M.,
Walker J.L., Cochran J.C., Wittrup K.D., Brodsky,
J.L. "Degradation of mutated bovine pancreatic
trypsin inhibitor (BPTI) in the yeast vacuole
suggests post-endoplasmic reticulum protein
quality control." J. Biol. Chem. 279(15):15289-97,
2004. [PubMed, Journal] |
| Graff, C.P., Chester
K., Begent R., Wittrup, K.D. "Directed Evolution
of an Anti-Carcinoembryonic Antigen scFv with
a Four-Day Monovalent Dissociation Half-time
at 37 ¡C." Protein Engineering, Design & Selection, 17:293,
2004. [PubMed, Journal] |
| Cochran, J.R.,
Kim, Y.S., Olsen, M.J., Bhandari, R., Wittrup,
K.D. "Domain-level antibody epitope mapping
through yeast surface display of epidermal
growth factor receptor fragments." J. Immunol.
Methods, 287(1-2):147-158, 2003. [PubMed, Journal] |
| Colby, D.W., Kellog,
B.A., Graff, C.P., Yeung, Y.A., Swers, J.S.,
Wittrup, K.D. "Engineering Antibody Affinity
by Yeast Surface Display." Methods in Enzymology, 388:348,
2004. [PubMed] |
| Swers, J.S., Kellogg,
B.A., Wittrup, K.D. "Shuffled Antibody Libraries
Created by In Vivo Homologous Recombination
and Yeast Surface Display." Nucleic Acids Research, 32(3):36,
2004. [PubMed, Journal] |
| Rao, B.M., Girvin,
A.T., Ciardelli, T., Lauffenburger, D.A., Wittrup,
K.D. "Interleukin-2 Mutants with Enhanced alpha-Receptor
Subunit Binding Affinity." Protein Engineering, 16(12):1081-7,
2003. [PubMed, Journal] |
| Grovender EA, Kellogg
B, Singh J, Blom D, Ploegh H, Wittrup KD, Langer
RS, Ameer GA. "Single-chain antibody fragment-based
adsorbent for the extracorporeal removal of
beta2-microglobulin." Kidney Int. 65(1):310-322,
2004. [PubMed, Journal] |
| Bhatia SK, Swers
JS, Camphausen RT, Wittrup KD, Hammer DA. "Rolling
Adhesion Kinematics of Yeast Engineered To
Express Selectins." Biotechnol Prog. 19(3):1033-1037,
2003. [PubMed, Journal] |
| Graff, C.P., Wittrup,
K.D. "Theoretical Analysis of Antibody Targeting
of Tumor Spheroids:Ê Importance of Dosage
for Penetration, and Affinity for Retention." Cancer
Research, 63:1288, 2003. [PubMed, Journal] |
| Feldhaus, M.J.,
Siegel, R.W., Opresko, L.K., Coleman, J.R.,
Weaver Feldhaus, J.M., Yeung, Y.A., Cochran,
J.R., Heinzelman, P., Colby, D., Swers, J.,
Graff, C., Wiley, H.S., Wittrup, K.D., "Flow-cytometric
isolation of human antibodies from a nonimmune
Saccharomyces cerevisiae surface display library," Nature
Biotechnology 21, 163-170, 2003. [PubMed, Journal] |
| Orr B.A., Carr
L.M., Wittrup K.D., Roy E.J., Kranz D.M., "Rapid
Method for Measuring ScFv Thermal Stability
by Yeast Surface Display", Biotechnol
Prog. 19(2):631-8 (2003). [PubMed] |
| Graff C.P., Wittrup
K.D., "Theoretical analysis of antibody
targeting of tumor spheroids: importance of
dosage for penetration, and affinity for retention," Cancer
Res. 63(6):1288-96 (2003). [PubMed] |
| Yeung Y.A., Wittrup
K.D., "Quantitative screening of yeast
surface-displayed polypeptide libraries by
magnetic bead capture," Biotechnol Prog.
18(2):212-20 (2002). [PubMed] |
| Wittrup, K.D., "Protein
Engineering by Cell-surface Display," Current
Opinion in Biotechnology 12 (4) 395-399, 2001.
[PubMed, Journal] |
| Kieke M.C., E. Sundberg, E.V.
Shusta, R.A. Mariuzza, K.D. Wittrup, D.M. Kranz, "High
Affinity T-cell Receptors from Yeast Display
Libraries Block T-cell Activation by Superantigens," J
Mol Biol 307(5), 1305-1315, 2001. [PubMed, Journal] |
| Boder, E.T., K.D. Wittrup, "Yeast
Surface Display for Directed Evolution of Protein
Expression, Affinity, and Stability," Methods
in Enzymology 328, Ed. J. Thorner and
S.D. Emr, 430-444, 2000. [PubMed,
Journal] |
| Wittrup, K.D., "The Single Cell
as a Microplate Well," Nature Biotechnolgy 18(10),
1039-1040, 2000. [PubMed, Journal] |
| Boder, E.T., K.S. Midelfort
, K.D. Wittrup, "Directed Evolution of Antibody
Fragments with Monovalent Femtomolar Antigen-binding
Affinity," Proc Natl Acad Sci USA, 97(20),
10701-10705, 2000. [PubMed, Journal] |
| Shusta, E.V., P.D. Holler, M.C.
Kieke, D.M. Kranz, K.D. Wittrup, "Directed
Evolution of a Stable Scaffold for T-cell Receptor
Engineering," Nature Biotechnology 18(7),
754-759, 2000. [PubMed, Journal] |
| Holler P.D., P.O. Holman, E.V.
Shusta, S. O'Herrin, K.D. Wittrup, D.M. Kranz, "In
Vitro Evolution of a T cell receptor with High
Affinity for peptide/MHC," Proc. Natl. Acad.
Sci. USA, 97(10) 5387-5392, 2000. [PubMed, Journal] |
| Bannister, S.J., K.D.
Wittrup, "Glutathione Excretion in Response
to Heterologous Protein Secretion in Saccharomyces
cerevisiae," Biotechnology and Bioengineering 68(4),
389-395, 2000. [PubMed, Journal] |
| VanAntwerp, J.J., K.D. Wittrup, "Fine
Affinity Discrimination by Yeast Surface Display
and Flow Cytometry," Biotechnology Progress 16(1),
31-37, 2000. [PubMed, Journal] |
| Woycechowsky, K.J., K.D. Wittrup,
R.E. Raines, "A Small-molecule Catalyst of
Protein Folding in vitroand in vivo," Chemistry
and Biology 6(12), 871-879, 1999. [PubMed, Journal] |
| Wittrup, K.D., "Phage On Display," Trends
In Biotechnolgy 17(11), 423-424, 1999. [PubMed, Journal] |
| F. Becker, L. Block-Alper, G.
Nakamura, J. Harada, K.D. Wittrup, D.I. Meyer, "Expression
of the 180-kD Ribosome Receptor Induces Membrane
Proliferation and Increased Secretory Activity
in Yeast," J. Cell Biol. 146(2),
273-284, 1999. [PubMed, Journal] |
| E.V. Shusta, M.C. Kieke, E.
Parke, D.M. Kranz, K.D. Wittrup, "Yeast Polypeptide
Fusion Surface Display Levels Predict Thermal
Stability and Soluble Secretion Efficiency," J
Mol Biol 292(5), 949-956, 1999. [PubMed, Journal] |
| Wittrup, K.D., "Heterologous
Protein Secretion in Saccharomyces cerevisiae." Encyclopedia
of Bioprocess Engineering, Ed. M. Flickinger.
[PubMed, Journal] |
| Wittrup, K. D., "Engineering
Heterologous Secretion in Yeast,", Metabolic
Engineering, Ed. E. T. Papoutsakis, in press. [PubMed,
Journal] |
| Kieke, M. C., E.V. Shusta, E.
T. Boder, L. Teyton, K. D. Wittrup, D. M. Kranz, "Selection
of Functional T Cell Receptor Mutants from
a Yeast Surface-display Library," Proc. Natl.
Acad. Sci. USA, 96(10), 5651-5656, 1999. [PubMed, Journal] |
| VanAntwerp, J.J. and K. D. Wittrup, "Thermodynamic
Characterization of Affinity Maturation: The
D1.3 Antibody and a Higher Affinity Mutant," J.
Mol. Recog. 11(1-6), 10-13, 1998. [PubMed, Journal] |
| Shusta, E. V., J.J. VanAntwerp,
K. D. Wittrup, "Biosynthetic Polypeptide Libraries," Current
Opinion in Biotechnology 10(2), 117-122,
1999. [PubMed, Journal] |
| Shusta, E. V., R. T. Raines,
A. Plückthun, K. D. Wittrup, "Increasing
the Secretory Capacity of Saccharomyces cerevisiae
for Production of Single-chain Antibody Fragments," Nature
Biotechnology 16(8), 773-777, 1998.
[PubMed, Journal] |
| Kowalski, J. M., R. N. Parekh,
J. Mao, and K. D. Wittrup, "Protein Folding
Stability Can Determine the Efficiency of Escape
from Endoplasmic Reticulum Quality Control," J.
Biol. Chem. 273(31), 19453-19458, 1998.
[PubMed, Journal] |
| Cho, B. K., M. C. Kieke, E.
T. Boder, K. D. Wittrup and D. M. Kranz, "A
Yeast Surface Display System for the Discovery
of Ligands that Trigger Cell Activation," J.
Immunol. Meth. 220(1-2), 179-188, 1998.
[PubMed, Journal] |
| Kowalski, J. M., R. M. Kelly,
J. Konisky, D. S. Clark and K. D. Wittrup, "Purification
and Functional Characterization of a Chaperone
from Methanococcus jannaschii," Systematic & Applied
Microbiology 21(2), 173-178, 1998. [PubMed, Journal] |
| Arnold, C. E., R. N. Parekh,
W. Yang, and K. D. Wittrup, "Leader Peptide
Efficiency Correlates with Signal Recognition
Particle Dependence in Saccharomyces cerevisiae," Biotechnology & Bioengineering 59(3),
286-293, 1998. [PubMed, Journal] |
| Boder, E. T. and K. D. Wittrup, "Optimal
Screening of Surface-Displayed Polypeptide
Libraries," Biotechnology Progress 14(1),
55-62, 1998. [PubMed, Journal] |
| Kowalski, J. M., R. N. Parekh,
and K. D. Wittrup, "Secretion Efficiency in
Saccharomyces cerevisiae of Bovine Pancreatic
Trypsin Inhibitor Mutants Lacking Disulfide
Bonds Is Correlated with Thermodynamic Stability," Biochemistry 37(5),
1264-1273, 1998. [PubMed, Journal] |
| Kieke, M. C., B. K. Cho, E.
T. Boder, D. M. Kranz, and K. D. Wittrup, "Isolation
of Anti-T Cell Receptor scFv Mutants by Yeast
Surface Display," Protein Engineering 10(11),
1303-1310, 1997. [PubMed, Journal] |
| Boder, E. T. and K. D. Wittrup, "Yeast
Surface Display for Screening Combinatorial
Polypeptide Libraries," Nature Biotechnology 15(6),
553-537, 1997. [PubMed, Journal] |
| Parekh, R. N. and K. D. Wittrup, "Expression
Level Tuning for Optimal Heterologous Protein
Secretion in Saccharomyces cerevisiae," Biotechnology
Progress 13(2), 117-122, 1997. [PubMed, Journal] |
| Robinson, A. S., J. A. Bockhaus,
A. C. Voegler, and K. D. Wittrup, "Reduction
of BiP Levels Decreases Heterologous Protein
Secretion in Saccharomyces cerevisiae," J.
Biol. Chem. 271(17), 10017, 1996. [PubMed, Journal] |
| Parekh, R. N., M. R. Shaw, and
K. D. Wittrup, "An Integrating Vector for Tunable,
High Copy, Stable Integration into the Dispersed
Ty-d Sites
of Saccharomyces cerevisiae," Biotechnology
Progress 12(1), 16-21, 1996. [PubMed, Journal] |
| Robinson, A. S. and K. D. Wittrup, "Constitutive
Overexpression of Secreted Heterologous Proteins
Decreases Extractable BiP and Protein Disulfide
Isomerase Levels in Saccharomyces cerevisiae," Biotechnology
Progress 11(2), 171-177, 1995. [PubMed, Journal] |
| Wittrup, K. D. "Disulfide Bond
Formation and Eukaryotic Secretory Productivity," Current
Opinion in Biotechnology 6(2), 203-208,
1995. [PubMed, Journal] |
| Parekh, R. N., K. Forrester,
and K. D. Wittrup "Multicopy Overexpression
of Bovine Pancreatic Trypsin Inhibitor Saturates
the Protein Folding and Secretory Capacity
of Saccharomyces cerevisiae," Protein Expression
and Purification 6(4), 537-545, 1995. [PubMed, Journal] |
| Arnold, C. E. and K. D. Wittrup "The
Stress Response to Loss of Signal Recognition
Particle Function in Saccharomyces cerevisiae," J.
Biol. Chem. 269(48), 30412-30418, 1994. [PubMed, Journal] |
| Wittrup, K. D., A. S. Robinson,
R. N. Parekh, and K. J. Forrester, "Existence
of an Optimum Expression Level for Secretion
of Foreign Proteins in Yeast," Annals of NY
Academy of Sciences 745, 321-330, 1994.
[PubMed, Journal] |
| Robinson, A. S., V. Hines, and
K. D. Wittrup, "Protein Disulfide Isomerase
Overexpression Increases Secretion of Foreign
Proteins in Saccharomyces cerevisiae," Bio/Technology
(NY) 12(4), 381-384, 1994. [PubMed, Journal] |
| Wittrup, K. D. and V. Benig, "Optimization
of Amino Acid Supplements for Heterologous
Protein Secretion in Saccharomyces cerevisiae," Biotechnology
Techniques 8, 161-166, 1994. [PubMed, Journal] |
| Wittrup, K. D., R. J. Westerman,
and R. Desai "Fluorescence Array Detector for
Large Field Quantitative Fluorescence Cytometry," Cytometry 16(3),
206-213, 1994. [PubMed, Journal] |
| Shaw, M. R., R. Schiek, and
K. D. Wittrup, "Stochastic Simulation of 2m Multicopy
Plasmid Amplification in Yeast," Biotechnology
Progress 9(2), 160-165, 1993. [PubMed, Journal] |
| Robinson, A. S. and K. D. Wittrup, "The
Role of the Protein Folding Chaperone BiP in
Secretion of Foreign Proteins in Eukaryotic
Cells," ACS Symp. Series 526, 121-132,
1993. [PubMed, Journal] |
| Wittrup, K. D., A. L. Weber,
and P. Tsai, "Microencapsulation Selection
for Isolation of Yeast Mutants with Increased
Secretion of Aspergillus awamori Glucoamylase," Biotechnology & Bioengineering 42,
351-356, 1993. [PubMed, Journal] |
| Wittrup, K. D. and J. E. Bailey, "Comments
on a segregated model of recombinant cultures: authors'
reply," Biotechnology & Bioengineering 38,
1364-1365, 1991. [PubMed, Journal] |
| Meilhoc, E., K. D. Wittrup,
and J. E. Bailey, "Influence of Dissolved Oxygen
Concentration on Growth, Mitochondrial Function
and Antibody Production of Hybridoma Cells
in Batch Culture." Bioprocess Engineering 5,
263, 1990. [PubMed, Journal] |
| Wittrup, K. D., B. Ratzkin,
A. Patel, and J. E. Bailey, "Propagation of
an Amplifiable Recombinant Plasmid in Saccharomyces
cerevisiae: Flow Cytometry Studies and
Segregated Modeling," Biotechnology & Bioengineering 35,
565-577, 1990. [PubMed, Journal] |
| Wittrup, K. D. and J. E. Bailey, "Mathematical
Modeling of a Single-Cell Enzyme Assay in Saccharomyces
cerevisiae Using a Fluorogenic Substrate," Biotechnology & Bioengineering 35,
525-532, 1990. [PubMed, Journal] |
| Budd, M. E., K. D. Wittrup,
J. E. Bailey, and J. L. Campbell, "DNA polymerase
I is required for premeiotic DNA replication
and sporulation but not for X-ray repair in
Saccharomyces cerevisiae," Mol Cell Biol. 9(2),
365-376, 1989. [PubMed, Journal] |
| Meilhoc, E., K. D. Wittrup,
and J. E. Bailey, "Application of flow cytometric
measurement of surface IgG in kinetic analysis
of monoclonal antibody synthesis and secretion
by murine hybridoma cells," J. Immunol. Meth. 121(2),
167-174, 1989. [PubMed, Journal] |
| Wittrup, K. D. and J. E. Bailey, "A
Single-cell Assay of b-galactosidase
Activity in Saccharomyces cerevisiae Using
a Fluorogenic Substrate," Cytometry 9(4),
394-404, 1988. [PubMed, Journal] |
| Wittrup, K. D. and J. E. Bailey, "A
Mathematical Model of Recombinational Amplification
of the 2m Plasmid
in the Yeast Saccharomyces cerevisiae," J.
of Theor. Biol. 130(4), 481-492, 1988. [PubMed, Journal] |
| Wittrup, K. D., M. Mann, D.
Fenton, L. Tsai, and J. E. Bailey, "Single-cell
Light Scatter as a Probe of Refractile Body
Formation in Recombinant E. coli," Bio/Technology
(NY) 6, 423-427, 1988. [PubMed, Journal] |
| Wittrup, K. D. and J. E. Bailey, "A
Segregated Model of Recombinant Multicopy Plasmid
Propagation," Biotechnology & Bioengineering 31,
304-310, 1988. [PubMed, Journal]
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