Using long-term imaging of GFP-PARPs, we have characterized the localization of each of the 17 PARP proteins throughout the cell cycle. Here are a few examples.
PARP-1Time: 0:14 |
PARP-2Time: 0:14 |
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PARP-5aTime: 0:17 |
PARP-5bTime: 0:14 |
We are currently using these fusions to identify new PARP functions in both cell physiology, and during cell stress events