The Molecular Genetics and Immunology Program consists of eight Center members: Drs. Chen, Housman, Jaenisch, Langer, Lippard, Samson, Sharp, and Young. All members of this program are pursuing numerous overlapping lines of investigation, and significant intellectual interaction and scientific collaboration serve to link the members of this Program. The major research activity of the Molecular Genetics and Immunology Program is to investigate cancer processes from the perspective of gene regulation and DNA alterations. Some of the major themes of the Program are: the roles of RNA in gene regulation, the relationship of DNA hypomethylation and cancer, the signaling pathways controlling autoimmunity and cancer, the role of c-ROS receptor tyrosine kinase in glioblastomas, the changes in genome regulation networks during differentiation and the cell cycle, and the recognition of cisplatin/DNA adducts and other types of DNA damage. Investigators in the Program are related by common research interests, shared technology and frequent interactions.
Phillip Sharp, Program Leader
Jianzhu Chen
David Housman
Rudolf Jaenisch
Robert Langer
Stephen Lippard
Leona Samson
Richard Young
