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Publications

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1993

Freed, L., Vunjak-Novakovic, G., Bernstein, H., Cooney, C., Langer, R. "The Kinetics of Immobilized Heparinase in Human Blood", Annals of Biomed. Eng.; 21: 67-76, 1993.

Mikos, A., Bao, Y., Ingber, D., Vacanti, J. Langer, R. "Preparation of poly(glycolic acid) bonded fiber structures for cell transplantation", J. Biomed. Med. Res.; 27: 183-189, 1993.

Tamada, J., Langer, R. "Erosion Kinetics of Hydrolytically Degradable Polymers", PNAS; 90: 552-556, 1993.

Gross, A., Langer, R., Mathiowitz, E., Mayberg, M. "Sustained Release of Acetylcholine in Rat Hippocampus Using a Polyanhydride Drug Delivery System", Poly. for Adv. Tech.; 3: 331-335, 1993.

Freed, L., Marquis, J., Nohria, A., Mikos, A., Emmanual, J., Langer, R. "Neocartilage formation in vitro and in vivo using Cells Cultured on Synthetic Biodegradable Polymers", J. Biomed. Mat. Res.; 27: 11-23, 1993.

Shefer, S., Ferreira, J., Mullon, C., Langer, R. "Extracorporeal Enzymatic Removal of Low density Lipoproteins in Rabitts: Efficacy and Safety", The Inter. J. Artif. Organs; 16: 115-125, 1993.

Wald, H.L., Sarakinos, G., Mikos, A., Vacanti, J., Langer, R. "Cell seeding in porous transplantation devices", Biomaterials; 14: 270-278, 1993.

Tabata, Y., Langer, R. "Polyanhydride Microspheres that Display Near-constant Release of Water soluble drugs", Pharm. Res.; 10: 391-399, 1993.

Tabata, Y., Gutta, S., Langer, R. "Controlled Delivery Systems for Proteins Using polyanhydride Microspheres", Pharm. Res.; 10: 487-496, 1993.

Brem, H., Walter, K., Langer, R. "Polymers as Controlled Drug Delivery Devices for the treatment of Malignant Brain Tumors", Eur. J. Pharm. and Biopharm.; 39: 2-7, 1993.

Mikos, A., Sarakinos, G., Leite, S., Vacanti, J., Langer, R. "Laminated Three-dimensional Biodegradable Foams for Use in Tissue Engineering", Biomaterials; 14: 323-330, 1993.

Sasisekharan, R., Bulmer, M., Moremen, K.W., Cooney, C., Langer, R. "Cloning and expression of heparinase I gene from flavobacterium heparinum", PNAS; 90: 3660-3664, 1993.

Gilbert, J., Takeda, T., Stein, J., Langer, R., Vacanti, J. "Cell Transplantation of Genetically Altered Cells on Biodegradable Polymer Scaffolds in Syngeneic Rats", Transplantation; Vol. 56, No. 2: 423-427, 1993.

Labeque, R., Mullon, C., Ferreira, J., Lees, R., Langer, R. "Enzymatic modification of plasma low density dipoproteins: a potential treatment for hypercholesterolemia", PNAS; 90: 3476-3480, 1993.

Laurencin, C., Gerhart, T., Witschger, P., Satcher, R., Domb, A., Hanff, P., Edsberg, L., Hayes, W., Langer, R. "Bioerodible poly(anhydrides) for antibiotic drug delivery: in vivo osteomyelitis treatment in a rat model system", J. Orthoped. Res.; 11: 256-262, 1993.

Ron, E., Turek, T., Mathiowitz, E., Chasin, M., Hageman, M., Langer, R. "Release of Polypeptides from Polyanhydrides", PNAS; 90: 4176-4180, 1993.

Fontaine, M., Hansen L., Thompson, S., Uyama S., Ingber, D., Mulligan, R., Langer, R., Vacanti, J. "Transplantation of genetically altered hepatocytes using cell-polymer constructs leads to sustained human growth hormone secretion in vivo", Transplant. Proc.; 25: 1002-1004, 1993.

Langer, R., Vacanti, J. "Tissue Engineering", Science; 260: 920-926, 1993.

Bhagat, H., Langer, R. "Implants and Implantation Technology", Encyclopedia of Pharm. Tech.; 8: 53-82, 1993.

Gupta, R., Siber, G., Alonso, M., Langer, R. "Development of a Single-dose tetanus toxoid based on controlled release from biodegradable and biocompatible polyester microspheres"; 93: 391-396, 1993.

Cima, L., Langer, R. "Tissue Engineering", Chem Eng. Progress; 6: 54-46, 1993.

Prausnitz, M., Lau, B., Milano, C., Conner, S., Langer, R., Weaver, J. "A quantitative study of electroporation showing a plateau in net molecular transport", Biophys. J.; 65:414-422, 1993.

Edelman, E., Langer, R. "Optimization of release from magnetically controlled polymeric drug release devices", Biomaterials; 14: 8, 621-626, 1993.

Prausnitz, M., Bose, V., Langer, R., Weaver, J. "Transtissue Molecular Transport Due to Electroporation of Skin", Electricity and Magnetism in Bio. and Med.; M. Blank, ed. San Francisco Press, San Francisco, CA, 122-124, 1993.

Lau, B., Milano, C., Prausnitz, M., Langer, R., Weaver, J. "Quantitative Determination of Molecular Transport Across Erythrocyte Ghost Membranes by Electroporation", Electricity and Magnetism in Bio. and Med.; M. Blank, ed. San Francisco Press, San Francisco, CA, 141-143, 1993.

Mikos, A., Sarakinos, G., Leite, S., Vacanti, J., Langer, R. "Preperation of Poly(glycolic acid) Bonded Fiber Structures for Cell Attachment and Transplantation", J. Biomed. Mater. Res.; Vol. 27, No. 2: 183-189, 1993.

Mikos, A., Sarakinos, G., Leite, S., Vacanti, J., Langer, R. "Laminated Three Dimensional Biodegradable Foams for use in Tissue Engineering", Biomaterials; Vol. 14, No. 5: 323-330, 1993.

Alonso, M., Cohen, S., Park, T., Gupta, R., Siber, G., Langer R. "Determinants of release rate of tetanus vaccine from polyester microspheres", Pharm Res.; 10: 945-953, 1993.

Goepferich, A., Langer, R. "The influence of microstructure and monomer properties on the erosion mechanism of a class of polyanhydrides", J. Poly. Sci.; 31: 2445-2458, 1993.

Goepferich, A., Langer, R. "Modeling of Polymer Erosion", Macromolecules; 22: 4105-4112, 1993.

Mikos, A., Sarakinos, G., Lyman, M., Ingber D., Vacanti, J., Langer, R. "Prevascularization of biodegradable polymer scaffolds for hepatocyte transplantation", Biotech. & Bioeng.; 42: 716-723, 1993.

Ferreira, J., Sasisikharan, R., Louie, O., Langer, R. "Influence of chemistry in immobilization of cobra venom phospholipase A2 - Implications as to mechanism", Biochemistry; 32: 8098-8102, 1993.

Masters, D., Berde, C., Dutta, S., Turek, T., Langer, R. "Sustained local anesthetic release from bioerodible polymer matrices: A potential method for prolonged regional anesthesia", Pharm. Res.; 10: 1527-1532, 1993.

Masters, D., Berde, C., Dutta, S., Griggs, C., Hu, D., Kupsky, W., Langer, R. "Prolonged Regional Nerve Blockage by Controlled Release of Local Anesthetic from a Biodegradable Polymer Matrix", Anesthesiology; 79: 340-346, 1993.

Andrianov, A., Cohen, S., Visscher, K., Payne L., Allcock, H., Langer, R. "Controlled Release Using Ionotropic Polyposphazene Hydrogels", J. Contr. Rel.; 27: 69-77, 1993.

Langer, R. "Polymer Controlled Drug Delivery Systems", Accts. of Chem. Res.; 26: 537-542, 1993.

Shefer, S., Payne, R., Langer, R. "Design of a biomedical reactor for plasma Low Density Lipoprotein removal", Biotech. and Bioeng.; 42: 1252-1262, 1993.

Barrera, D., Zylstra, E., Lansbury, P., Langer, R. "Synthesis and RGD Peptide Modification of a New Biodegradable Copolymer System: Poly(Lactic Acid-co-Lysine)", J. of Amer. Chem. Soc.; 115: 11010-11011, 1993.

Prausnitz, M., Langer, Weaver, J. "Electroporation of mammalian skin: A new mechanism to enhance transdermal drug delivery", PNAS; 90: 10504-10508, 1993.

Prausnitz, M., Seddick, D., Kon, A., Bose, V., Frankenburg, S., Klaus, S., Langer, R., Weaver, J. "Methods for in vivo tissue electroporation using surface electrodes", Drug Del.; 1: 125-131, 1993.

Cohen, S., Bano, M., Cima, L., Allcock, H., Vacanti, J., Vacanti, C., Langer, R. "Design of synthetic polymeric structures for cell transplantation and tissue engineering", Clinical Mat.; 0.881944444, 1993.

Gilbert, J., Takeda, T., Stein, J., Langer, R., Vacanti, J. "Cell transplantation of genetically altered cells on biodegradable polymer scaffolds in syngeneic rats", Transplantation; 56: 423-427, 1993.

Kost, J., Langer, R. "Ultrasound-mediated transdermal drug delivery", Topical Drug Bioavailiability Bioequivalence. Penetration, ; Plenium Press, NY, V. Shah, H. Maibach, eds., 91-104, 1993.

Freed, L., Vunjak-Novakovic, G., Langer, R. "Cultivation of cell-polymer cartilage implants in bioreactors", J. Cell. Biochem.; 51: 257-64, 1993.

Freed, L., Vunjak-Novakovic, G., Drinker, P., Langer, R. "A Bioreactor based on Suspended Particles of Immobilized Enzyme", Annals of Biomed. Eng.; 21: 57-65, 1993.


Sheppard, N., Langer, R. "The Use of Ultrasound Attenuation to Characterize Release of Proteins from Polymer Matrix Devices", J. Cont. Rel.; 22: 245-242, 1992.

Cohen, S., Allcock, H., Langer, R. "Cell and Enzyme Ionotropic Synthetic Hydrogels", Recent Adv. in Pharm. and Indust. Biotech.; 3648, 1992.

Wintermantel, E., Cima, L., Schloo, B., Langer, R. "Angiopolarity of cell carriers: directional angiogenesis in resorbable liver cell transplantation devices", Angiogenesis: Key Principles- Science Technology, Medicine; 331-334, 1992.

 

Langer Lab, 77 Massachusetts Ave, Room 76-661, Cambridge, MA 02139-4307 | Phone: 617.253.3123 | Last updated: July 14, 2014