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Publications

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2008

Neeley, W., Redenti, S., Klassen, H., Tao, Sarah, Desai, T., Young, M. and Langer, R., Microfabricated scaffold for retinal progenitor cell grafting, Biomaterials, 29:  418-426, 2008.

Karnik, R., Gu, F., Basto, P., Cannizzaro, C., Dean, L., Kyei-Manu, W., Langer, R. and Farokhzad, O., Microfluidic platform for controlled synthesis of polymeric nanoparticles, Nano Letters, 8:  2906-2912, 2008.

Urquhart, A., Taylor, M., Anderson, D., Langer, R., Alexander, M., Davies, M., TOF-SIMS analysis of a 576 micro-patterned co-polymer array reveals surface moieties that control wettability, Analytical Chemistry, 80:  135-142, 2008.

Fuller, J., Zugates, G., Ferreira, L., Ow, H., Nguyen, N., Wiesner, U. and Langer, R., Intercellular delivery of core-shell fluorescent silica nanoparticles, Biomaterials, 29:  1526-1532, 2008

Alexis, F., Rhee, J. Richie, J., Radovic-Moreno, A., Langer, R. and Farokhzad, O., New frontiers in nanotechnology for cancer treatment, Urol. Oncol., 26:  74-85, 2008.

Wright, D., Rajalingam, B., Karp, J., Selvarasah, S., Ling, Y., Yeh, J., Langer, R., Dokmeci, M., Khademhosseini, A., Reusable, reversibly sealable parylene membranes for cell and protein patterning, Journ. Biomed. Mat. Res., 85:  530-538, 2008.

Chau, Y., Luo, Y., Cheung, A., Nagai, Y., Zhang, S., Kobler, J., Zeitels, S. and Langer, R., Incorporation of a matrix metalloproteinase-sensitive substrate info self-assembling peptides:  A model for biofunctional scaffolds, Biomaterials, 29:  1713-1719, 2008.

Radisic, M., Park, H., Salazar-Lazaro, J., Geng, W., Wang, Y., Langer, R., Freed, L. and Vunjak-Novakovic, G., Pre-treatment of synthetic elastomeric scaffolds by cardiac fibroblasts improves engineered heart tissue, J. Biomed. Mat. Rsch, 86:  713-724, 2008.

Parsa, S., Wang, Y., Fuller, J., Langer, R. and Pfeifer, B., A comparison between polymeric microsphere and bacterial vectors for macrophage P388D1 gene delivery, Pharm. Res., 25:  1202-1208, 2008.

Moss, J., Langer, R., Drug Delivery Modalities, Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy, Second Edition, Chap. 54, pp. 935-941, Lippincott Williams & Wilkins, Baltimore, MD, 2008.

Wood, K., Azarin, S., Arap, W., Pasqualini, R., Langer, R., and Hammond, P., Tumor-targeting gene delivery using molecularly engineering hybrid polymers functionalized with a tumor-homing peptide, Bioconjugate Chemistry, 19:  403-405, 2008.

Gu, F., Zhang, F., Teply, B., Mann, N., Wang, A., Radovic-Moreno, A., Langer, R., and Farokhzad, O., Precise engineering of targeted nanoparticles using self-assembled biointegrated block copolymers, Proceedings of the National Academy of Sciences, 105:  2586-2591, 2008.

Mahdavi, A., Ferreira, L., Sundback, C., Nichol, J., Chan, E., Carter, D., Bettinger, C., Patanavanich, S., Chignozha, L., Joseph, E., Galakatos, A., Pryor, A., Pomerantseva, I., Masiakos, P., Faquin, W., Zumbuehl, A., Hong, S., Borenstein, J. Vacanti, J., Langer, R., and Karp, J., A biodegradable and biocompatible Gecko-inspired adhesive, Proceedings of the National Academy of Sciences, 105:  2307-2312, 2008.

Kochling, J., Rott, Y., Arndt, S., Green, J., Anderson, D., Langer, R., Stripecke, R., Schmidt, M., Henze, G. and Bucsky, P., Prevention of Ph+ acute lymphoblastic leukaemia by DNA vaccination using a non-viral vector system and nanoparticle delivery, European Journal of Pediatrics, 167:  371, 2008.

Kang, L., Chung, B.G., Langer, R. and Khademhosseini, A., Microfluidics for drug discovery and development:  From target selection to product lifecycle management, Drug Discovery Today, 13:  1-13, 2008.

Koechling, J., Rott, Y., Arndt, S., Green, J., Anderson, D., Langer, R., Stripecke, R., Wittig, B and Schmidt, M., Prevention of Ph+ acute lymphoblastic leukemia by nanoparticulate delivery of a DNA vaccine in syngeneic mice, Blood, 110:  366b, 2008.

Teply, B., Tong, R., Jeong, S.Y., Luther, G., Sherifi, I., Yim. C. Khademhosseini, A., Farokhzad, O., Langer, R. and Cheng, J., The use of charge-coupled polymeric microparticles and micromagnets for modulating the bioavailability of orally delivered macromolecules, Biomaterials, 29:  1216-1223, 2008.

Kushner, J., Blankschtein, D. and Langer, R., Heterogeneity in skin treated with low-frequency ultrasound, Journal of Pharmaceutical Sciences, 97:  4119-4128, 2008.

Karnik, R., Hong, S. Zhang, H. Mei, Y., Anderson, D., Karp, J. and Langer, R., Nanomechanical control of cell rolling in two dimensions through surface patterning of receptors, Nano Letters, 8:  1153-1158, 2008.

Bettinger, C., Zhang, Z, Gerecht, S., Borenstien, J. and Langer, R., Enhancement of in vitro capillary tube formation by substrate nanotopography, Advanced Materials, 20:  99-103, 2008.

Karp, J., Mahdavi, A., Hong, S., Khademhosseini, A., and Langer, R., Microscale approaches for bone tissue engineering, in Micro and nanoengineering of the cell microenvironment:  Technologies and applications, 2008, 417-430, Khademhosseini, A., Borenstein, J., Toner, M., Takayama, S., eds., Artech House, Boston, US and London, UK.

Bettinger, C., Bruggeman, J. Borenstein, J. and Langer, R., Amino alcohol-based degradable poly(ester amide) elastomers, Biomaterials, 29:  2315-2325, 2008.

Akinc, A., Zumbuehl, A., Goldberg, M., Leshchiner, E., Busini, V., Hossain, N., Bacallado, S., Nguyen, D., Fuller, J., Alvarez, R., Borodovsky, A. Borland, T., Constein, R., de Fougerolles, A., Dorkin, J., Jayaprakash, K., Jayaraman, M., John, M., Kotelianski, V., Manoharan, M., Nechev, L., Qin, J., Racie, T., Raitcheva, D., Rajeev, K., Sah, D., Soutschek, J., Toudjarska, I, Vornlocher, H.P., Zimmermann, T., Langer, R. and Anderson, D., A combinatorial library of lipid-like materials for delivery of RNAi therapeutics, Nature Biotechnology, 26:  561-569, 2008.

Yang, F., Neeley, W., Moore, M., Karp, J., Shukla, A. and Langer, R., Tissue engineering:  The therapeutic strategy of the 21st century, Nanotechnology and Tissue Engineering:  The Scaffold, CRC Press/Francis Group, pp: 3-32, 2008.

Levy-Nissenbaum, E., Radovic-Moreno, A., Wang, Z. Langer, R. and Farokhzad, Nanotechnology and aptamers:  Applications in drug delivery, Trends Biotechnol., 26:  442-449, 2008.

Bettinger, C., Borenstein, J., and Langer, R. Tissue engineering:  Microfabrication techniques in scaffold development, Nanotechnology and Tissue Engineering:  The Scaffold, CRC Press/Francis Group, pp: 87-119, 2008.

Guerrini, M., Beccati, D., Shriver, Z., Naggi, A., Viswanathan, K., Bisio, A., Capila,I., Lansig, J., Guglieri, S., Fraser, B., Al-Hakim, A.,  Gunay, N., Zhang, Z., Robinson, L., Buhse, L., Nasr, M., Woodock, J., Langer, R., Venkataraman, G., Linhardt, R., Casu, B., Torri, G., Sasisekharan, R., Oversulfated chondroitin sulfate is a contaminant in heparin associated with adverse clinical events, Nature Biotechnology, 26:  669-675, 2008.

Kishimoto, T., Viswanathan, K., Ganguly, T., Elankumaran, S., Smith, S., Pelzer, K., Lansing, J., Sriranganathan, N., Zhao, G., Galcheva-Gargova, Z., Al-Hakim, A., Bailey, G., Fraser, B., Roy, S., Rogers-Cotrone, T., Buhse, L., Whary, M., Fox, J., Nasr, M., Dal Pan, G., Shriver, Z., Langer, R., Venkataraman, G., Austen, F., Woodcock, J., Sasisekharan, R., Contaminated Heparin Associated with Adverse Clinical Events and Activation of the Contact System, New England Journal of Medicine, 358:  2457-2467, 2008.

Blossom, D., Kallen, A. Patel, R., Elward, A., Robinson, L., Gao, G., Langer, R., Perkins, K., Jaeger, J., Kurkjian, K., Jones, M., Schillie, S., Shehab, N., Ketterer, D., Venkataraman, G., Kishimoto, T., Shriver, Z., McMahon, A., Austen, K., Kozlowski, S., Srinivasasn, A., Turabelidze, G., Gould, C. Arduino, M. and Sasisekharan, R., Outbreak of adverse reactions associated with contaminated heparin, New England Journal of Medicine, 359:  2674-2684, 2008.

Kohane, D. and Langer, R., Polymeric biomaterials in tissue engineering, Pediatric Research, 63:  487-491, 2008.

Ferreira, L., Squire, T., Park, H., Choe, H., Kohane, D. and Langer, R., Human embryoid bodies containing nano- and micro-particulate delivery vehicles, Advanced Materials, 20:  2285-2291, 2008.

Park, H., Bhalla, R., Saigal, R., Radisic, M., Watson, N., Langer, R., Vunjak-Novakovi, G., Effects of the electrical stimulation in C2C12 muscle constructs, Journal of Tissue Engineering and Regenerative Medicine, 2: 279-287, 2008.

Zhang, L., Gu, F., Chan., J., Wang, A., Langer, R. and Farokhzad, O., Nanoparticles in medicine:  Therapeutic applications and developments, Clinical Pharmacology and Therapeutics, 83:  761-769, 2008.

Kushner, J., Blankschtein, D. and Langer, R., Evaluation of hydrophilic permeant transport parameters in the localized and non-localized transport regions of skin treated simultaneously with low-frequency ultrasound and sodium lauryl sulfate, Journal of Pharmaceutical Sciences, 97:  906-918, 2008.

Nguyen, D. Raghavan, S., Tashima, L., Lin, E., Fredette, S., Langer, R. and Wang, C., Enhancement of poly(orthoester) microchips for DNA vaccine delivery by blending with poly(ethylenimine), Biomaterials, 29:  2783-2793, 2008.

Brito, L., Little, S., Langer, R., Amiji, M., Poly(β-amino ester) and Cationic Phospholipid-Based Lipopolyplexes for Gene Delivery and Transfection in Human Aortic Endothelial and Smooth Muscle Cells, Biomacromolecules, 9:  1179-1187, 2008.

Bruggeman, J., deBruin, B-J., Bettinger, C. and Langer, R., Biodegradable poly(polyol sebacate) polymers, Biomaterials, 29:  4726-4735, 2008.

Cao, Y. and Langer, R., A review of Judah Folkman’s remarkable achievement in biomedicine, Proceedings of the National Academy of Sciences, 105:  13203-13205, 2008.

Green, J., Zhou, Y., Mitalipova, M., Beard, C., Langer, R., Jaenisch, R. and Anderson, D., Nanoparticles for gene transfer to human embryonic stem cell colonies, Nano Letters, in 8:  3126-3130, 2008.

Green, J., Langer, R., and Anderson, D., A combinatorial polymer library approach yields insights into non-viral gene delivery, Accounts of Chemical Research, 41:  749-759, 2008.

Ferreira, L., Karp, J., Nobre, L. and Langer, R., New opportunities:  The use of nanotechnologies to manipulate and track stem cells, Cell Stem Cell, 3:  136-146, 2008.

Wang, Z., Guimaraes, A., Zhang, L., Gu, F., Langer, R., Weissleder, R. and Farokhzad, O., Development of novel multifunctional nanoparticles for combined imaging and targeted delivery of chemoradiotherapy, Int. Journal of Radiation Oncology Biology Physics (Spe. Iss.), 72:  S707, 2008.

Auguste, D., Furman, K., Wong, A., Fuller, J., Armes, S., Deming, T. and Langer, R., Poly(ethylene glycol) protected, pH-dependent liposomes enhance RNAi delivery, Journal of Controlled Release, 130:  266-274, 2008.

Dhar, S., Gu, F., Langer, R., Farokhzad, O. and Lippard, S., Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized pt (IV) prodrug-PLGA-PEG nanoparticles, Proceedings of the National Academy of Sciences, 105:  17356-17361, 2008.

Prausnitz, M. and Langer, R., Transdermal drug delivery, Nature Biotechnology, 26:  1261-1268, 2008.

Nguyen, D., Green, J., Chan., J., Anderson, D. and Langer, R., Polymeric materials for gene delivery and DNA vaccination, Advanced Materials, 20:  1-21, 2008.

Wang, A., Bagalkot, V., Vasilliou,l C., Gu, F., Alexis, F., Zhang, L., Shaikh, M., Yuet, K., Cima, M., Langer, R., Kantoff, P., Bander, N., Jon, S. and Farokhzad, O., Superparamagnetic iron oxide nanoparticle aptamer bioconjugate for combined prostrate cancer imaging and therapy, ChemMedChem, 3:  1311-1315, 2008.

Bruggeman, J., Bettinger, C., Nijist, C., Kohane, D. and Langer, R., Biodegradable xylitol-based polymers, Advanced Materials, 20:  1922-1927, 2008.

Park, H., Williams, G., Goldman, N., Choe, H., Kobler, .J., Lopez Guerra, G., Heaton, J., Langer, R. and Zeitels, S., Comparison of effects of two harvesting methods on fat autograft, The Laryngoscope, 118:  1493-1499, 2008.

Adams, D., Toner, M., and Langer, R., Microflow and crack formation patterns in drying sessile droplets of liposome suspensions in trehalose solutions, Langmuir, 24:  7688-7697, 2008.

Showalter, S., Huang, Y., Witkiewicz, A., Constantino, C., Yeo, C., Green, J., Langer, R., Anderson, D., Sawicki, J. and Brody, J., Nanoparticle delivery of diphtheria toxin DNA effectively kills mesothelin expressing pancreatic cancer cells, Cancer Biology and Therapy, 7:  1584-1590, 2008.

Mei, Y., Cannizzaro, C., Park, H., Xu, Q., Bogatyrev, S., Yi, K., Goldman, N., Langer, R. and Anderson, D., Cell-compatible, multicomponent protein arrays with subcellular feature resolution, Small, 4:  1600-1604, 2008.

Hudson, S., Padera, R., Langer, R. and Kohane, D., The biocompatibility of mesoporous silicates, Biomaterials, 29:  4045-4055, 2008.

Zhang, L, Chan, J., Gu, F., Rhee, J., Wang, A., Radovic-Moreno, A., Alexis, F., Langer, R. and Farokhzad, O., Self-assembled lipid-polymer hybrid nanoparticles:  A robust drug delivery platform, ACS Nano, 2:  1696-1702, 2008.

Frank-Kamenetsky, M., Grefhorst, A., Anderson, A., Racie, T., Bramlage, B., Akinc, A., Butler, D., Charisse, K., Dorkin, R., Fan, Y. Gamba-Vitalo, C., Hadwiger, P., Jayaraman, M., John, M., Jayaprakash, K., Maier, M., Nechev, L., Rajeev, K., Read, T., Rohl, I., Soutschek, J., Tan, P., Wong, J., Wang, G., Zimmerman, T., de Fougerolles, A., Vornlocher, H., Langer, R., Anderson, D., Manoharan, lM., Koteliansky, V., Horton, J. and Fitzgerald, K., Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates, Proceedings of the National Academy of Sciences, 105:  11915-11920, 2008.

Engelmayr, G., Cheng, M., Bettinger, C., Borenstein, J. Langer, R. and Freed, L., Accordian like honeycombs for tissue engineering cardiac anisotropy, Nature Materials, 7:  1003-1010, 2008.

Taylor, M., Urquhart, A., Williams, P., Anderson, D., Langer, R, Alexander, M. and Davies, M., A method for investigating protein adhesion and adsorption to microarrayed combinatorial polymers, Macromolecular Rapid Communications, 29:  1298-1302, 2008.

Cho, S., Hartle, L., Son, S., Yang, F., Goldberg, M., Xu, Q., Langer, R. and Anderson, D., Delivery of small interfering RNA for inhibition of endothelial cell apoptosis by hypoxia and serum deprivation, Biochemical & Biophysical Research Communications, 376:  158-163, 2008.

Svensson, R., Shey, M., Ballas, Z., Dorkin, R., Goldberg, M., Akinc, A., Langer, R., Anderson, D., Bumcrot, D. and Henry, M., Assessing siRNA pharmacodynamics in a luciferase expressing mouse, Molecular Therapy, 16: 1995-2001, 2008.

Sawicki, J., Anderson, D. and Langer, R., Nanoparticle delivery of suicide DNA for epithelial ovarian cancer therapy, Advances in Experimental Medicine and Biology, Vol. 767:  Ovarian Cancer, Springer Verlag, New York, 622: 209-19, 2008.

 

Langer Lab, 77 Massachusetts Ave, Room 76-661, Cambridge, MA 02139-4307 | Phone: 617.253.3123 | Last updated: March 14, 2014