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Professor Robert Langer
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Recent Publications (2015)

  1. Veiseh, O., Tang, B., Whitehead, K., Anderson, D. and Langer, R., Managing diabetes with nanomedicine:  Challenges and opportunities, Nature Reviews Drug Discovery, 14:  45-57, 2015.
  2. Langer, R. and Weissleder, R., Nanotechnology, Journal of the American Medical Association, 312:  135-136, 2015.
  3. Traverso, G., Schoellhammer, C., Schroeder, A., Maa, R., Lauwers, G., Polat, B., Anderson, D., Blankschtein, D. and Langer, R., Microneedles for drug delivery via the gastrointestinal tract, Journal of Pharmaceutical Sciences, 104:  362-367, 2015.
  4. Traverso, G. and Langer, R., Perspective:  Special delivery for the gut, Nature, 519: S19, 2015.
  5. Chou, D., Webber, M., Tang, B., Lin, A., Thapa, L., Deng, D., Truong, J., Cortinas, A., Langer, R. and Anderson, D., Glucose responsive insulin activity by covalent modification with aliphatic phenylboronic acid conjugates, Proceedings of the National Academy of Sciences,111:  2401-2406, 2015.
  6. Appel, E., Larson, B., Luly, K., Kim, J. and Langer, R., Non-cell-adhesive substrates for printing arrayed biomaterials, Advanced Healthcare Materials, 4:  501-505, 2015.
  7. Jonas, O., Landry, H., Fuller, J., Santini, J., Baselga, J., Tepper, R., Cima, M. and Langer, R., An implantable microdevice to perform high-throughput in vivo drug sensitivity testing in tumors, Science Translational Medicine, 7: 284ra57, 2015.
  8. Sanni, O., Chang, C., Anderson, D., Langer, R., Davies, M., Williams, P.M., Willimas, P., Alexander, M. and Hook, A., Bacterial attachment to polymeric materials correlates with molecular flexibility and hydrophilicity, Advanced Healthcare Materials, 4:  695-701: 2015.
  9. Khan, O., Zaia, E., Jhunjhunwala, S., Xue, W., Cai, W., Yun, D., Barnes, C., Dahlman, J., Dong, Y., Pelet, J., Webber, M., Tsosie, J., Jacks, T., Langer, R. and Anderson, D., Dendrimer-inspired nanomaterials for the in vivo delivery of siRNA to lung vasculature, Nano Letters, 15:  3008-3016, 2015.
  10. Appel, E., Tibbitt, M., Webber, M., Mattix, B., Veishe, O. and Langer, R., Self-assembled hydrogels utilizing polymer-nanoparticle interactions, Nature Communications, 6: 6295, 2015.
  11. Maldonado, R., LaMothe, R., Ferrari, J., Zhang, A., Rossi, R., Griset, A., O’Neil, C., Altreuter, D., Johnston, L., Farokhzad, O., Langer, R., Scott, D., von Andrian, U. and Kishimoto, T., Polymeric synthetic nanoparticles for the induction of antigen-specific immunological tolerance, Proceedings of the National Academy of Sciences, 112: E156-E165, 2015.
  12. O’Shea, T., Aimetti, A., Kim, E., Yesilyurt, V. and Langer, R., Synthesis and characterization of a library of in situ curing, nonswelling ethoxylated polyol thiol-ene hydrogels for tailorable macromolecule delivery, Advanced Materials, 27:  65-72, 2015.
  13. Sydlik, S., Jhunjhunwala, S., Webber, M., Anderson, D. and Langer, R., In vivo compatibility of graphene oxide of differing oxidation states, ACS Nano, s9:  3866-3874, 2015.
  14. Sharei, A., Trifonova, R., Jhunjhunwala, S., Hartoularos, G., Eyerman, A., Lytton-Jean, A., Angin, M., Sharma, S., Poceviciute, R., Mao, S., Heimann, M., Liu, S., Talkar, T., Khan, O., Addo, M., von Andrian, U., Anderson, D., Langer, R., Lieberman, J. and Jensen, K., Ex vivo cytosolic delivery of funcational macromolecules to immune cells, PLOS One, E-pub ahead of time, DOI: 10.1371/journal.pone.0118803.
  15. White, K., Lu, Y., Annis, S., Hale, A., Chau, N., Dahlman, J., Hemann, C., Opotowsky, A., Vargas, S., Rosas, I., Perrella, M., Osorio, J., Haley, K., Graham, B., Kumar, R., Saggar, R., Saggar, R., Wllance, W., Ross, D., Khan, O., Bader, A., Gochuico, B., Matar, M., Polach, K., Johannessen, N., Prosser, H., Anderson, D., Langer, R., Zweier, J., Bindoff, L., Systrom, D., Waxman, A. Jin, R. and Chan, S., Genetic and hypoxic alterations of tehh microRNA-210-ISCU1/2 axis promote iron-sulfur deficiency and pulmonary hypertension, EMBO Molecular Medicine, E-pub ahead of time, DOI: 10.15252/emmm.201404511, 2015.
  16. Bettinger, C. Green, J., Langer, R., Anderson, D. and Borenstein, J., Control of nanoparticle-mediated gene delivery to human endothelial cells through substrate nanotopography, ACS Nano, in press.
  17. Wang, Q., Cheng, H., Peng, H., Zhou, H. Li, P. and Langer, R., Non-genetic engineering of cells for drug delivery and cell-based therapy, Advanced Drug Delivery Reviews, in press.
  18. Farokhzad, O., Tager, A., Vrbanac, V., Langer, R., von Andrian, U., Radovic-Moreno, A., Stary, G., Olive, A., Gondek, D., Alvarez, D., Basto, P., Perro, M., Shi, J., Yethod, J and Starnbach, M., A mucosal vaccine against chlamydia trachomatis generates two synergistic waves of protective memory T cells, Science, in press.
  19. Zhang, S., Ermann, J., Succi, M., Zhou, A., Glimcher, L., Traverso, G., Karp, J. and Langer, R., Inflammation-targeted hydrogel as a novel approach for drug delivery in inflammatory bowel disease, Science Translational Medicine, in press.
  20. O’Shea, T., Webber, M., Aimetti, A. and Langer, R., Covalent incorporation of trehalose within hydrogels for enhanced long-term funcational stability and controlled release of biomacromolecules, Advanced Healthcare Materials, in press.
  21. Celiz, Z., Smith J., Patel, A., Hook, A., Rajamohan, D., George, V., Patel, M., Singh, V., Langer, R., Anderson, D., Allen, N., Hay, D., Winkler, D., Barrett, D., Davies, M., Young, L., Denning, C. and Alexander, M., Discovery of a novel polymer for human pluripotent stem cell expansion and multilineage differentiation, Advanced Materials, in press.
  22. Schoellhammer, C., Schroeder, A., Maa, R., Brugge, W., Lauwers, G., Anderson, D., Blankschtein, D., Langer, R. and Traverso, G., Ultrasound-mediated gastrointestinal drug delivery, Science Translational Medicine, in press.
  23. Veiseh, O., Doloff, J., Ma, M., Vegas, A., Tam, H., Bader, A., Li, J., Langan, E., Wyckoff, J., Loo, W., Jhunjhunwala, S., Chiu, A., Siebert, S., Tang, K., Hollister-Lock, H., Aresta-Dasilva, S., Bochenek, M., Mendoza-Elias, J., Wang, Y., Qi, M., Lavin, D., Dholakia, N., Thakrar, R., Wier, G., Oberholzer, J., Greiner, D., Langer, R. and Anderson, D., Size and shape dependent foreign body immune response to materials implanted in rodents and non-human primates, Nature Materials, in press.
  24. Szeto, G., Van Egeren, D., Worku, H., Sharei, A., Alejandro, B., Park, C., Frew, K., Brefo, M., Mao, S., Heimann, M., Langer, R., Jensen, K. and Irvine, D., Microfluidic squeezing for intracellular antigen laoding in polyclonal B-cells as cellular vaccines, Scientific Reports, in press.
  25. Noh, S., Han, S., Shim, G., Lee, K., Kim, A., Han, S., Choi, Y., Kim, Y, Langer, R., Kim, W. and Oh, Y., Tocopheryl oligochitosan-based self assembling cationic oligomersomes for siRNA delivery, Nano Letters, submitted.
  26. Kang, S., Hwang, N., Yeom, J., Park, S., Messersmith, P., Choi, I., Langer, R., Anderson, D. and Lee, Haeshin, One-step multipurpose surface functionalization by adhesive catecholamine, Journal of the American Chemical Society, submitted.
  27. Mizrahi, B., Khoo, X., Chiang, H., Sher, K., Feldman, R., Irusta, S., Langer, R. and Kohane, D., Multi-armed prepolymer for antifouling coatings, Journal of the American Chemical Society, submitted.
  28. Kimball, A., Alora-Palli, M., Javorsky, E., Ron, E. and Langer, R., A new non-parenteral approach to administration of peptides in women:  Systemic absorption of a GnRH agonist (GnRHa) via a transvaginal ring delivery system, PLoS Medicine submitted.
  29. Brandl, F., Bertrand, N., Lima, E. and Langer, R., Nanoparticles with photoinduced precipitation for the extraction of pollutants from water and soil, Nature Communications, submitted.
  30. Sanchez-Gaytan, B., Lobatto, M., Fay, F., Tang, J., Ouimet, M., Kim, Y., van der Staay, S., van Rijs, S., Priem, B., Zhang, L., Fisher, E., Moore, K., Langer, R. and Fayad, Z., Hybrid polymer-HDL nanoparticle platform for atherosclerotic plaque macrophage targeting, Journal of Controlled Release, submitted.
  31. Traverso, G., Ciccarelli, G., Hughes, T., Boettcher, T., Barman, R., Langer, R. and Siston, A., Physiologic status monitoring via the gastrointestinal tract, PLOS ONE, submitted.
  32. Indolfi, L., Ligorio, M., Ting, D., Xega, K., Tzafriri, A., Bersani, F., Aceto, N., Deshpande, V., Ferrone, C., Haber, D., Langer, R., Clark, J. and Edelman, E., Overcoming pancreatic cancer chemoresistance with a locally directed biodegradable sustained drug delivery device, Gastroenterology, submitted.
  33. Jhunjhunwala, S., Alvarez, D., Aresta-DaSilva, S., Tang, K., Tang, B, Greiner, D., Newburger, P., von Andrian, U., Langer, R. and Anderson, D., Splenic progenitors maintain high neutrophil numbers at sites of sterile chronic inflammation, Journal of Experimental Medicine, submitted.
  34. Yin, H., Bizhanova, A., Dorkin, J., Wu, Q., Li, Y, Suresh, S., Bogorad, R., Gao, G., Weng, Z., Dong, Y, Koteliansky, V., Langer, R., Xue, W. and Anderson, D., Combined viral and nonviral delivery of CRISPR components corrects liver disease in adult rodents, Science, submitted.
  35. Yin, H., Bogorad, R., Barnes, C., Zhuang, I., Nonaka, H., Ruda, V., Kuchimanchi, S., Nechev, L., Akinc, A., Zerial, M., Langer, R., Anderson, D. and Koteliansky, V., Efficient multiplex knockdown mediated control of organ size and its application for rapid analyses of molecular interactions in vivo, Proceedings of the National Academy of Sciences, submitted.
  36. Zhao, X., Hwang, N., Bichara, D., Saris, D., Malda, J., Vacanti, J., Pomerantseva, I., Sundback, C., Langer, R., Anderson, D. and Randolph, M., Chondrogenesis by bone marrow-derived mesenchymal stem cells grown in chondrocyte-conditioned medium for auricular reconstruction, Journal of Tissue Engineering and Regenerative Medicine, submitted.
  37. Jaklenec, A., Guarecuco, R., Lu, J., McHugh, K., Norman, J., Thapa, L., Lydon, E. and Langer, R., Immunogenicity of pulsatile release PLGA microspheres for single injection vaccination, Journal of Controlled Release, submitted.
  38. Han, M., Cha, Y., Jeong, H., Zoldan, J., Burkart, A., Kim, C., Kim, H., Cho, S., Kim, B., Langer, R., Kahn, R., Cha, H., Guarente, L. and Kim, K., Metabolic control of human pluripotent stem cell fate and function by deacetylase SIRT2, Science, submitted.
  39. Jhunjhunwala, S., Aresta-DaSilva, S., Tang, K., Webber, M., Lavin, D., Veiseh, O., Doloff, J., Bose, S., Vegas, A., Ma, M., Sahay, G., Chiu, A., Bader, A., Langan, E., Siebert, S., Li, J., Greiner, D., Newburger, P., Langer, R. and Anderson, D., Neutrophil extracellular trap formation on implanted materials, Biomaterials, submitted.
  40. Appel, E., Tibbitt, M., Greer, J., Fenton, O., Kreuels, K., Anderson, D. and Langer, R., Exploiting electrostatic interactions in polymer nanoparticle hydrogels, ACS Macro Letters, submitted.




Langer Lab, 77 Massachusetts Ave, Room 76-661, Cambridge, MA 02139-4307 | Phone: 617.253.3123 | Last updated: May 14, 2015