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Professor Robert Langer
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Recent Publications (as of August 3, 2017)

  1. Spencer, K., Sy, J., Ramadi, K., Graybiel, A., Langer, R. and Cima, M., Characterization of mechanically matched hydrogel coatings to improve the biocompatibility of neural implants, Scientific Reports, 7: 1952: DOI:  10.1038/s41598-017-02107-2, 2017.
  2. Abid, A., O’Brien, J., Bensel, T., Cleveland, C., Booth, L., Smith, B., Langer, R., and Traverso, G., Wireless power transfer to millimeter sized gastrointestinal electronics validated in a swine model, Scientific Reports, 7: 46745: DOI:  doi:10.1038/srep46745, 2017.
  3. Doloff, J., Veiseh, O., Vegas, A., Tam, H., Farah, S., Ma, M., Li, J., Bader, A., Chiu, A., Sadraei, A., Aresta-DaSilva, S., Griffin, M., Jhunjhunwala, S., Webber, M., Siebert, S., Tang, K., Chen, M., Langan, E., Dholokia, N., Thakrar, R., Qi, M., Oberholzer, J., Greiner, D., Langer, R. and Anderson, D., Colony stimulating factor-1 receptor is a central component of foreign body response to biomaterial implants in rodents and non-human primates, Nature Materials, |DOI: 10.1038/nmat4866, 2017.
  4. Mitchell, M., Webster, J., Chung, A., Guimaraes, P., Khan, O. and Langer, R., Polymeric mechanical amplifiers of immune cytokine-mediated apoptosis, Nature Communications, 8:  DOI:10.1038/ncomms14179, 2017.
  5. Dahlman, J., Kauffman, K., Xing, Y., Shaw, T., Dlott, C., Mir, F., Langer, R., Anderson, D. and Wang, E., Barcoded nanoparticles for high throughput in vivo discovery of targeted therapeutics, Proceedings of the National Academy of Sciences, 114:  2060-2065, 2017.
  6. Kim, K., Cha, Y., Han, M., Cha, H., Zoldan, J., Burkart, A., Jung, J., Jang, Y., Kim, C., Jeong, H., Kim, B., Langer, R., Kahn, C. and Guarente, L., Metabolic control of primed human pluripotent stem cell fate and function by the miR-200c-SIRT2 axis, Nature Cell Biology, 19:  445-456, 2017.
  7. Ragelle, H., Naba, A., Larson, B., Zhou, F., Prijic, M., Whittaker, C., Del Rosario, A., Langer, R., Hynes, R. and Anderson, D., Comprehensive proteomic characterization of stem cell-derived extracellular matrices, Biomaterials, 128:  147-159, 2017.
  8. Fay, F., Hansen, L., Hectors, S., Sanchez-Gaytan, B., Zhao, Y., Tang, J., Munitz, J., Alaarg, A., Braza, M., Gianella, A., Aaronson, S., Reiner, T., Kjems, J., Langer, R., Hoeben, F., Janssen, H., Calcagno, C., Strijkers, G., Fayad, Z., Perez-Medina, C. and Mulder, W., Investingating the cellular specificity in tumors of a surface-converting nanoparticle by multimodal imaging, Bioconjugate Chemistry, i28:  1413-1421, 2017.
  9. Slotkin, J., Pritchard, C., Luque, B., Ye, J., Layer, r., Lawrence, M., O’Shea, T., Roy, R., Zhong, H., Vollenweider, I., Edgerton, V., Courtine, G., Woodard, E. and Langer, R., Biodegradable scaffolds promote tissue remodeling and fuctional improvement in non-human primates with acute spinal cord injury, Biomaterials, 123:  63-76, 2017.
  10. Schoellhammer, C., Lauwers, G., Goettel, J., Oberli, M., Cleveland, C., Park, J., Minahan, D., Chen, Y., Anderson, D., Jaklenec, A., Snapper, S., Langer, R. and Traverso, G., Ultrasound-mediated delivery of RNA to colonic mucosa of live mice, Gastroenterology, 152:  1151-1160, 2017.
  11. Oberli, M., Reichmuth, A., Dorkin, J., Mitchell, M., Fenton, O., Jaklenec, A., Anderson, D., Langer, R. and Blankschtein, D., Lipid nanoparticle-assisted mRNA delivery for potent cancer immunotherapy, Nano Letters, 17:  1326-1335, 2017.
  12. Giwa, S., Lewis, J., Alvarez, L., Langer, R., Roth, A., Church, G., Markmann, J., Sachs, D., Chandraker, A., Wertheim, J., Rothblatt, M., Boyden, E., Eidbo, E., Lee, W., Pomahac, B., Brandacher, g., Weinstock, D., Elliott, G., Nelson, D., Acker, J., Uygun, K., Schmalz, B., Weegman, B., Tocchio, A., Fahy, G., Storey, K., Rubinsky, B., Bishof, J., Elliott, J., Woodruff, T., Morris, J., Demirci, U., Brockbank, K., Woods, E., Ben, R., Baust, J., Gao, D., Fuller, B., Rabin, Y., Kravitz, D., Taylor, M., and Toner, M., The promise of organ and tissue preservation to transform medicine, Nature Communications, 35:  530-542, 2017.
  13. Tibbitt, M. and Langer, R., Living biomaterials, Accounts in Chemical Research, 50:  508-513, 2017.
  14. Polat, B., Schoellhammer, C., Langer, R. and Blankschtein, D., Combined use of ultrasound and other physical methods of Skin penetration enhancement, in Percutaneous Penetration Enhancers:  Physical Methods in Penetration Enhancement, pp. 369-377, 2017, eds: Dragicevic, N. and Maibach, H., Springer Link.
  15. Roper, J., Tammela, T., Cetinbas, N., Akkad, a., Roghanian, A., Rickelt, S., Almeqdadi, M., Wu, K., Oberli, M., Sanchez-Rivera, F., Park, Y., Liang, x., Eng., G., Taylor, M., Azimi, R., Kedrin, D., Neupane, R., Beyaz, S., Sicinska, E., Suarez, Y., Yoo, J., Chen, L., Zuckerbert, L., Katajisto, P., Deshpande, V., Bass, A., Tsichlis, P., Lees, J., Langer, R., Hynes, R., Chen, J., Bhutkar, A., Jacks, T. and Yilmaz, O., In vivo genome editing and orthotopic transplantation models of colorectal cancer and metastasis, Nature Medicine, 35:  569-579,2017.
  16. Langer, R., Advances in chemistry and their implications for studying and treating brain disease, Molecular Frontiers Journal, 1:  2-9, 2017.
  17. Zwang, Y., Jonas, O., Chen, C., Rinne, M., Doench, J., Piccioni, F., Tan, L., Huang, H., Wang, J., Ham, Y., O’Connell, J., Bhola, P., Doshi, M., Whitman, M., Cima, M., Letai, A., Root, D., Langer, R. Gray, N. and Hahn, C., Synergistic interactions with PI3K inhibition that induce apoptosis, eLife, 6:  e24523, 2017.
  18. Nadeau, P., El-Damak, D., Glettig, D., Kong, Y., Mo, S., Cleveland, C., Booth, L., Roxhed, N., Langer, R., Chandrakasan, A. and Traverso, G., Prolonged energy harvesting for ingestible devices, Nature Biomedical Engineering, E-pub ahead of time, DOI: 10.1038/s41551-016-0022, 2017.
  19. Yu, D., Khan, O., Suva, M., Dong, B., Panek, W., Xiao, T., Wu, M. Han, Y., Ahmed, A., Balyasnikova, I., Zhang, H., Sun, C., Langer, R., Anderson, D., Lesniak, M., Multiplexed RNAi therapy against brain tumor-initiating cells via lipopolymeric nanoparticle infusion delays glioblastoma progression, Proceedings of the National Academy of Sciences, E-pub ahead of time, DOI:  10.1073/pnas.1701911114, 2017.
  20. Fenton, O., Kauffman, K., Kaczmarek, J., McClellan, R., Jhunjhunwala, S., Tibbitt, M., Zeng, M., Appel, E., Dorkin, J., Mir, F., Yang, J., Oberli, M., Heartlein, M., DeRosa, F., Langer, R. and Anderson, D., Synthesis and biological evaluation of ionizable lipid materials for the in vivo delivery of messenger RNA to B lymphocytes, Advanced Materials, DOI:  10.1002/adma.201606944, 2017.
  21. Mahmoudi, M., Yu, M., Serpooshan, V., Wu, J., Langer, R., Lee, R., Karp, J. and Farokhzad, O, Multiscale technologies for treatment of ischemic cardiomyopathy, Nature Nanotechnology, in press.
  22. Bertrand, N., Grenier, P., Mahmoudi, M., Lima, E., Appel, E., Dormont, F., Lim, J., Karnik, R., Langer, R. and Farokhzad, O., Mechanistic understanding of in vivo protein corona formation on polymeric nanoparticles and impact on pharmacokinetics, Nature Communications, in press.
  23. Bakh, N., Cortinas, A., Weiss, M. Langer, R., Anderson, D., Gu, Z., Dutta, S. and Strano, M., Glucose responsive insulin by molecular and physical design, Nature Chemistry, in press.
  24. Kakkar, A., Traverso, G., Farokhzad, O., Weissleder, R. and Langer, R., Evolution of macromolecular complexity in drug delivery systems, Nature Reviews Chemistry, in press.
  25. Rwei, A., Langer, R. and Kohane, D. Ultrasound-triggered local anaesthesia, Nature Biomedical Engineering, in press.
  26. Aday, S., Zoldan, J., Besnier, M., Carreto, L., Saif, J., Fernandes, R., Santos, T., Bernardino, L., Langer, R., Emanueli, C. and Ferreira, L., Synthetic microparticles conjugated with VEGF165 improve the survival of endothelial progenitor cells via microRNA-17 inhibition, Nature Communications, in press.
  27. Mitchell, M., Jain, R. and Langer, R., Engineering and physical sciences in oncology:  Challenges and opportunities, Nature Reviews Cancer, in press.
  28. Liu, J., Pang, Y., Zhang, S., Cleveland, C., Yin, X., Booth, L., Lin, J., Lee, Y., Mazdiyasni, H., Saxton, S., Kirtane, A., von Erlach, T., Rogner, J., Langer, R. and Traverso, G., Triggerable tough hydrogels for gastric resident dosage forms, Nature Communications, 8: 124: DOI:  10.1038/s41467-017-00144-z, 2017.
  29. Jung, K., Heishi, T., Khan, O., Kowalski, P., Incio, J., Rahbari, N., Chung, E., Clark, J., Willett, Luster, A., Yun, S., Langer, R., Anderson, D., Padera, T., Jain, R. and Fukumura, D., Ly6C(low) monocytes drive immunosuppression and confer resistance to anti-VEGFR2 therapy in colorectal cancer, Journal of Clinical Investigation, in press.
  30. Yin, H., Bogorad, R., Barnes, C., Zhuang, I., Nonaka, H., Ruda, V., Kuchimanchi, S., Nechev, L., Akinc, A., Zerial, M., Langer, R., Anderson, D. and Koteliansky, V., Efficient multiplex knockdown mediated control of organ size and its application for rapid analyses of molecular interactions in vivo, Proceedings of the National Academy of Sciences, submitted.
  31. Abramson, A., Langer, R., and Caffarel-Salvador, E., Oral delivery of biologics using drug-device combinations, Current Opinion in Pharmacology, submitted.
  32. Jaklenec, A., Guarecuco, R., Lu, J., McHugh, K., Norman, J., Thapa, L., Lydon, E. and Langer, R., Immunogenicity of pulsatile release PLGA microspheres for single injection vaccination, Journal of Controlled Release, submitted.
  33. Han, M., Cha, Y., Jeong, H., Zoldan, J., Burkart, A., Kim, C., Kim, H., Cho, S., Kim, B., Langer, R., Kahn, R., Cha, H., Guarente, L. and Kim, K., Metabolic control of human pluripotent stem cell fate and function by deacetylase SIRT2, Science, submitted.
  34. DiCiccio, A., Lee, Y., Glettig, D., Walton, E., de La Serna, E., Montgomery, V., Grant, T., Langer, R. and Traverso, G., Caffeine-catalyzed gels, Advanced Materials, submitted.
  35. Jhunjhunwala, S., Aresta-DaSilva, S., Tang, K., Webber, M., Lavin, D., Veiseh, O., Doloff, J., Bose, S., Vegas, A., Ma, M., Sahay, G., Chiu, A., Bader, A., Langan, E., Siebert, S., Li, J., Greiner, D., Newburger, P., Langer, R. and Anderson, D., Neutrophil extracellular trap formation on implanted materials, Biomaterials, submitted.
  36. Noh, S., Han, S., Shim, G., Lee, K., Kim, A., Han, S., Choi, Y., Kim, Y, Langer, R., Kim, W. and Oh, Y., Tocopheryl oligochitosan-based self assembling cationic oligomersomes for siRNA delivery, Nano Letters, submitted.
  37. Taylor, L., Arner, K., Kolewe, M., Pritchard, C., Hendy, G., Langer, R. and Ghosh, F., Tissue stabilization in vitro using surface modification of poly(glycerol-co-sebacic acid) membranes in adult porcine retinal explants, Biomaterials, submitted.
  38. LaKang, S., Hwang, N., Yeom, J., Park, S., Messersmith, P., Choi, I., Langer, R., Anderson, D. and Lee, Haeshin, One-step multipurpose surface functionalization by adhesive catecholamine, Journal of the American Chemical Society, submitted.
  39. Mizrahi, B., Khoo, X., Chiang, H., Sher, K., Feldman, R., Irusta, S., Langer, R. and Kohane, D., Multi-armed prepolymer for antifouling coatings, Journal of the American Chemical Society, submitted.
  40. Indolfi, L., Ligorio, M., Ting, D., Xega, K., Tzafriri, A., Bersani, F., Aceto, N., Deshpande, V., Ferrone, C., Haber, D., Langer, R., Clark, J. and Edelman, E., Overcoming pancreatic cancer chemoresistance with a locally directed biodegradable sustained drug delivery device, Gastroenterology, submitted.
  41. Fenton, O., Kauffman, K., McClellan, R., Appel, E., Dorkin, J., Tibbitt, M., Heartlein, M., DeRosa, F., Langer, R. and Anderson, D., Bioinspired alkenyl amino alcohol ionizable lipid materials for highly potent in vivo mRNA delivery, Journal of the American Chemical Society, submitted.
  42. Chauhan, V., Chen, I., Tong, R., Ng, M., Martin, J., Naxerova, K., Wu, M., Boucher, Y., Kohane, D., Langer, R., and Jain, R., Tumor microenvironment activated angiotensin blockers enhance cancer immunotherapy, Science, submitted.
  43. Indolfi, L., Ligorio, M., Ting, D., Xega, K., Tzafriri, A., Bersani, F., Aceto, N., Deshpande, V., Ferrone, C., Haber, D., Langer, R., Clark, J. and Edelman, E., A local drug delivery platform to enhance cytotoxic effects of chemotherapy in pancreatic cancer, Proceedings of the National Academy of Sciences, submitted.
  44. Lin, J., Dargazany, R., Zhang, S., Jafari, M., Lee, Y., Hurowitz, H., Langer, R. and Traverso, G., Corona molecular dynamics of poly(ethylene glycol)-coated nanoparticles, Nano Letters, submitted.
  45. Yesilyurt, V., Veiseh, O., Doloff, J., Li, J., Bose, S., Xie, X., Bader, A., Chen, M., Webber, M., Vegas, A., Langer, R. and Anderson, D., A facile and versatile method to endow biomaterial devices with zwitterionic surface coatings, Journal of the American Chemical Society, submitted.
  46. Lee, Y., Glettig, D., Walton, E., de La Serna, E., Montgomery, V., Grant, T., DiCiccio, A., Langer, R., and Traverso, G., Caffeine catalyzed gels, Advanced Materials, submitted.
  47. McHugh, K., Nguyen, T., Linehand, A., Yang, D., Behrens, A., Rose, S., Tochka, Z., Tzeng, S., Norman, J., Anselmo, a., Xu, X., Tomasic, S., Lu, J., Guarecuco, R.,  Langer, R. and Jaklenec, A., Fabrication of fillable microparticles and other complex 3D microstructures, Science, submitted.
  48. Ragelle, H., Tibbitt, M., Wu, S., Castillo, M., Cheng, G., Gangadharan, S., Anderson, D., Cima, M. and Langer, R., Surface tension-assisted additive manufacturing, Nature Biomedical Engineering, submitted.
  49. Xie, X., Doloff, J., Sadraei, A., McGarrigle, J., Omani, M., Yesilyurt, V., Wang, W., Isa, D., Ghani, S., Joshi, I., Tam, H., Tao, J., Chen, H., Yang, B., Oberholzer, J., Langer, R. and Anderson, D., Elimination of continuous glucose monitor noise with zwitterionic polymer coating, Nature Biotechnology, submitted.
  50. Langer, R. and Traverso, G., Convergence for translation, Angewandte Chemie, submitted.
Langer Lab, 77 Massachusetts Ave, Room 76-661, Cambridge, MA 02139-4307 | Phone: 617.253.3123 | Last updated: August 8, 2017