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Professor Robert Langer
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Recent Publications (2015)

  1. Veiseh, O., Tang, B., Whitehead, K., Anderson, D. and Langer, R., Managing diabetes with nanomedicine:  Challenges and opportunities, Nature Reviews Drug Discovery, 14:  45-57, 2015.
  2. Langer, R. and Weissleder, R., Scientific discovery and the future of medicine:  Nanotechnology, Journal of the American Medical Association, 312:  135-136, 2015.
  3. Traverso, G., Schoellhammer, C., Schroeder, A., Maa, R., Lauwers, G., Polat, B., Anderson, D., Blankschtein, D. and Langer, R., Microneedles for drug delivery via the gastrointestinal tract, Journal of Pharmaceutical Sciences, 104:  362-367, 2015.
  4. Traverso, G. and Langer, R., Perspective:  Special delivery for the gut, Nature, 519: S19, 2015.
  5. Chou, D., Webber, M., Tang, B., Lin, A., Thapa, L., Deng, D., Truong, J., Cortinas, A., Langer, R. and Anderson, D., Glucose responsive insulin activity by covalent modification with aliphatic phenylboronic acid conjugates, Proceedings of the National Academy of Sciences,111:  2401-2406, 2015.
  6. Appel, E., Larson, B., Luly, K., Kim, J. and Langer, R., Non-cell-adhesive substrates for printing arrayed biomaterials, Advanced Healthcare Materials, 4:  501-505, 2015.
  7. Webber, M., Anderson, D. and Langer, R., Engineering synthetically modified insulin for glucose-responsive diabetes therapy, Expert Review of Endocrinology and Metabolism, 10:  483-489, 2015.
  8. Jonas, O., Landry, H., Fuller, J., Santini, J., Baselga, J., Tepper, R., Cima, M. and Langer, R., An implantable microdevice to perform high-throughput in vivo drug sensitivity testing in tumors, Science Translational Medicine, 7: 284ra57, 2015.
  9. Sanni, O., Chang, C., Anderson, D., Langer, R., Davies, M., Williams, P.M., Willimas, P., Alexander, M. and Hook, A., Bacterial attachment to polymeric materials correlates with molecular flexibility and hydrophilicity, Advanced Healthcare Materials, 4:  695-701: 2015.
  10. Khan, O., Zaia, E., Jhunjhunwala, S., Xue, W., Cai, W., Yun, D., Barnes, C., Dahlman, J., Dong, Y., Pelet, J., Webber, M., Tsosie, J., Jacks, T., Langer, R. and Anderson, D., Dendrimer-inspired nanomaterials for the in vivo delivery of siRNA to lung vasculature, Nano Letters, 15:  3008-3016, 2015.
  11. Traverso, G. and Langer, R., Engineering precision, Science Translational Medicine, 7: 289ed6, 2015.
  12. Appel, E., Tibbitt, M., Webber, M., Mattix, B., Veish, O. and Langer, R., Self-assembled hydrogels utilizing polymer-nanoparticle interactions, Nature Communications, 6: 6295, 2015.
  13. Patel, A., Celiz, A., Rajamohan, D., Anderson, D., Langer, R., Davies, M., Alexander, M., and Denning, C., A defined synthetic substrate for serum-free culture of human stem cell derived cardiomyocytes with improved functional maturity identified using combinatorial materials microarrays, Biomaterials, 61:  257-265, 2015.
  14. Maldonado, R., LaMothe, R., Ferrari, J., Zhang, A., Rossi, R., Griset, A., O’Neil, C., Altreuter, D., Johnston, L., Farokhzad, O., Langer, R., Scott, D., von Andrian, U. and Kishimoto, T., Polymeric synthetic nanoparticles for the induction of antigen-specific immunological tolerance, Proceedings of the National Academy of Sciences, 112: E156-E165, 2015.
  15. O’Shea, T., Aimetti, A., Kim, E., Yesilyurt, V. and Langer, R., Synthesis and characterization of a library of in situ curing, nonswelling ethoxylated polyol thiol-ene hydrogels for tailorable macromolecule delivery, Advanced Materials, 27:  65-72, 2015.
  16. Sydlik, S., Jhunjhunwala, S., Webber, M., Anderson, D. and Langer, R., In vivo compatibility of graphene oxide of differing oxidation states, ACS Nano, s9:  3866-3874, 2015.
  17. Veiseh, O., Doloff, J., Ma, M., Vegas, A., Tam, H., Bader, A., Li, J., Langan, E., Wyckoff, J., Loo, W., Jhunjhunwala, S., Chiu, A., Siebert, S., Tang, K., Hollister-Lock, H., Aresta-Dasilva, S., Bochenek, M., Mendoza-Elias, J., Wang, Y., Qi, M., Lavin, D., Dholakia, N., Thakrar, R., Wier, G., Oberholzer, J., Greiner, D., Langer, R. and Anderson, D., Size and shape dependent foreign body immune response to materials implanted in rodents and non-human primates, Nature Materials, 14:  643-651, 2015.
  18. Tong, R. and Langer, R., Nanomedicine targeting the tumor microenvironment, The Cancer Journal: The Journal of Principles and Practice of Oncology, 21:  314-215, 2015.
  19. Veiseh, O. and Langer, R., A smart insulin patch, Nature, 524: 39-40, 2015.
  20. Zhang, S., Ermann, J., Succi, M., Zhou, A., Hamilton, M., Cao, B., Korzenik, J., Glickman, J., Vemula, P., Glimcher, L., Traverso, G., Langer, R. and Karp, J., An inflammation-targeted hydrogel as a novel approach for drug delivery in inflammatory bowel disease, Science Translational Medicine, 7:  300ra128, 2015.
  21. Celiz, Z., Smith J., Patel, A., Hook, A., Rajamohan, D., George, V., Flatt, L., Patel, M., Epa, V. Singh, T., Langer, R., Anderson, D., Allen, N., Hay, D., Winkler, D., Barrett, D., Davies, M., Young, L., Denning, C. and Alexander, M., Discovery of a novel polymer for human pluripotent stem cell expansion and multilineage differentiation, Advanced Materials, 27:  4006-4012, 2015.
  22. Zhang, S., Bellinger, A., Glettig, D., Barman, R., Lee, Y-A., Zhu, J., Cleveland, C., Montgomery, V., Gu, L., Nash, L., Maitland, D., Langer, R. and Traverso, R., A pH-responsive supramolecular polymer gel as an enteric elastomer for use in gastric devices, Nature Materials, E-pub ahead of time:  DOI:10.1038/nmat4355, 2015.
  23. Sharei, A., Trifonova, R., Jhunjhunwala, S., Hartoularos, G., Eyerman, A., Lytton-Jean, A., Angin, M., Sharma, S., Poceviciute, R., Mao, S., Heimann, M., Liu, S., Talkar, T., Khan, O., Addo, M., von Andrian, U., Anderson, D., Langer, R., Lieberman, J. and Jensen, K., Ex vivo cytosolic delivery of functional macromolecules to immune cells, PLOS One, E-pub ahead of time, DOI: 10.1371/journal.pone.0118803.
  24. White, K., Lu, Y., Annis, S., Hale, A., Chau, N., Dahlman, J., Hemann, C., Opotowsky, A., Vargas, S., Rosas, I., Perrella, M., Osorio, J., Haley, K., Graham, B., Kumar, R., Saggar, R., Wllance, W., Ross, D., Khan, O., Bader, A., Gochuico, B., Matar, M., Polach, K., Johannessen, N., Prosser, H., Anderson, D., Langer, R., Zweier, J., Bindoff, L., Systrom, D., Waxman, A. Jin, R. and Chan, S., Genetic and hypoxic alterations of tehh microRNA-210-ISCU1/2 axis promote iron-sulfur deficiency and pulmonary hypertension, EMBO Molecular Medicine, E-pub ahead of time, DOI: 10.15252/emmm.201404511, 2015.
  25. Stary, G., Olive, A., Radovic-Moreno, A., Gondek, D., Alvarez, D, Basto, P., Perro, M., Vrbanac, V., Tager, A., Shi, J., Yethon, J., Farokhzad, O., Langer, R. Starnbach, M. and von Andrian, U., A mucosal vaccine against chlamydia trachomatis generates two synergistic waves of protective memory T cells, Science, 348: 1331, 2015.
  26. Wang, Q., Cheng, H., Peng, H., Zhou, H. Li, P. and Langer, R., Non-genetic engineering of cells for drug delivery and cell-based therapy, Advanced Drug Delivery Reviews, E-pub ahead of time: DOI10.1016/j.addr.2014.12.003, 2015.
  27. Brandl, F., Bertrand, N., Lima, E. and Langer, R., Nanoparticles with photoinduced precipitation for the extraction of pollutants from water and soil, Nature Communications, E-pub ahead of time, DOI:  10.1038/ncomms8765, 2015.
  28. O’Shea, T., Webber, M., Aimetti, A. and Langer, R., Covalent incorporation of trehalose within hydrogels for enhanced long-term functional stability and controlled release of biomacromolecules, Advanced Healthcare Materials, E-pub ahead of time: DOI: 10.1002/adhm.201500334, 2015.
  29. Szeto, G., Van Egeren, D., Worku, H., Sharei, A., Alejandro, B., Park, C., Frew, K., Brefo, M., Mao, S., Heimann, M., Langer, R., Jensen, K. and Irvine, D., Microfluidic squeezing for intracellular antigen laoding in polyclonal B-cells as cellular vaccines, Scientific Reports, E-pub ahead of time: DOI:10.1038/srep10276, 2015.
  30. Bettinger, C. Green, J., Langer, R., Anderson, D. and Borenstein, J., Control of nanoparticle-mediated gene delivery to human endothelial cells through substrate nanotopography, ACS Nano, in press.
  31. McHugh, K., Guarecuco, R., Langer, R. and Jaklenec, A., Single-injection vaccines:  Progress, challenges and opportunities, Journal of Controlled Release, in press.
  32. Schoellhammer, C., Schroeder, A., Maa, R., Brugge, W., Lauwers, G., Anderson, D., Blankschtein, D., Langer, R. and Traverso, G., Ultrasound-mediated gastrointestinal drug delivery, Science Translational Medicine, in press.
  33. Noh, S., Han, S., Shim, G., Lee, K., Kim, A., Han, S., Choi, Y., Kim, Y, Langer, R., Kim, W. and Oh, Y., Tocopheryl oligochitosan-based self assembling cationic oligomersomes for siRNA delivery, Nano Letters, submitted.
  34. Yesilyurt, V., Webber, M., Appel, E., Godwin, C., Langer, R. and Anderson, D., Injectable self-healing glucose responsive hydrogels with pH-based regulated mechanical properties, Advanced Materials, submitted.
  35. Taylor, L., Arner, K., Kolewe, M., Pritchard, C., Hendy, G., Langer, R. and Ghosh, F., Tissue stabilization in vitro using surface modification of poly(glycerol-co-sebacic acid) membranes in adult porcine retinal explants, Biomaterials, submitted.
  36. LaKang, S., Hwang, N., Yeom, J., Park, S., Messersmith, P., Choi, I., Langer, R., Anderson, D. and Lee, Haeshin, One-step multipurpose surface functionalization by adhesive catecholamine, Journal of the American Chemical Society, submitted.
  37. Dong, Y., Dorkin, J., Wang, W., Chang, P., Webber, M., Tang, B., Abutbul-Ionita, I., Danino, D., DeRosa, F, Heartlein, M. and Langer, R., Poly(glycoamidoamine) brushes formulated nanomaterials for systemic mRNA delivery in vivo, Nano Letters, submitted.
  38. Mizrahi, B., Khoo, X., Chiang, H., Sher, K., Feldman, R., Irusta, S., Langer, R. and Kohane, D., Multi-armed prepolymer for antifouling coatings, Journal of the American Chemical Society, submitted.
  39. Kimball, A., Alora-Palli, M., Javorsky, E., Ron, E. and Langer, R., A new non-parenteral approach to administration of peptides in women:  Systemic absorption of a GnRH agonist (GnRHa) via a transvaginal ring delivery system, PLoS Medicine submitted.
  40. Sanchez-Gaytan, B., Lobatto, M., Fay, F., Tang, J., Ouimet, M., Kim, Y., van der Staay, S., van Rijs, S., Priem, B., Zhang, L., Fisher, E., Moore, K., Langer, R. and Fayad, Z., Hybrid polymer-HDL nanoparticle platform for atherosclerotic plaque macrophage targeting, Journal of Controlled Release, submitted.
  41. Traverso, G., Ciccarelli, G., Hughes, T., Boettcher, T., Barman, R., Langer, R. and Siston, A., Physiologic status monitoring via the gastrointestinal tract, PLOS ONE, submitted.
  42. Indolfi, L., Ligorio, M., Ting, D., Xega, K., Tzafriri, A., Bersani, F., Aceto, N., Deshpande, V., Ferrone, C., Haber, D., Langer, R., Clark, J. and Edelman, E., Overcoming pancreatic cancer chemoresistance with a locally directed biodegradable sustained drug delivery device, Gastroenterology, submitted.
  43. Vegas, A., Veiseh, O., Doloff, J., Ma, M., Tam, H., Bratlie, K., Li, J., Bader, A., Langan, E., Olejnik, K., Fenton, P., Kang, J., Hollister-Locke, J., Bochenek, M., Chiu, A., Siebert, S., Tang, K., Jhunjhunwala, S., Aresta-Dasilva, S., Dholakia, N., Thakrar, R., Vietti, T., Chen, M., Cohen, J., Siniakowicz, K., Qi, M., McGarrigle, J., Lyle, S., Harlan, D., Greiner, D., Oberholzer, J., Weir, G. Langer, R. and Anderson, D., Combinatorial development of hydrogels that mitigate the foreign body response in primates, Nature Biotechnology, submitted.
  44. Jhunjhunwala, S., Alvarez, D., Aresta-DaSilva, S., Tang, K., Tang, B, Greiner, D., Newburger, P., von Andrian, U., Langer, R. and Anderson, D., Splenic progenitors maintain high neutrophil numbers at sites of sterile chronic inflammation, Journal of Experimental Medicine, submitted.
  45. Yin, H., Bizhanova, A., Dorkin, J., Wu, Q., Li, Y, Suresh, S., Bogorad, R., Gao, G., Weng, Z., Dong, Y, Koteliansky, V., Langer, R., Xue, W. and Anderson, D., Combined viral and nonviral delivery of CRISPR components corrects liver disease in adult rodents, Nature Biotechnology, submitted.
  46. Webber, M., Appel, E., Meijer, E. and Langer, R., Supramolecular biomaterials, Nature Materials, submitted.
  47. Yin, H., Bogorad, R., Barnes, C., Zhuang, I., Nonaka, H., Ruda, V., Kuchimanchi, S., Nechev, L., Akinc, A., Zerial, M., Langer, R., Anderson, D. and Koteliansky, V., Efficient multiplex knockdown mediated control of organ size and its application for rapid analyses of molecular interactions in vivo, Proceedings of the National Academy of Sciences, submitted.
  48. Xue, Y., Xu, X., Zhang, X., Farokhzad, O. and Langer, R., Preventing diet-induced obesity in mice by inducing adipose tissue transformation and angiogenesis using targeting nanoparticles with drug delivery amplification, Proceedings of the National Academy of Sciences, submitted.
  49. Zhao, X., Hwang, N., Bichara, D., Saris, D., Malda, J., Vacanti, J., Pomerantseva, I., Sundback, C., Langer, R., Anderson, D. and Randolph, M., Chondrogenesis by bone marrow-derived mesenchymal stem cells grown in chondrocyte-conditioned medium for auricular reconstruction, Journal of Tissue Engineering and Regenerative Medicine, submitted.
  50. Jhunjhunwala, S., Aresta-Dasilva, S., Tang, K., Alvarez, D., Webber, M., Tang, B., Lavin, D., Veiseh, O., Doloff, J., Bose, S. Vegas, A., Ma, M., Sahay, G., Chiu, A., Bader, A., Langan, E., Siebert, S., Li, J., Greiner, D., Newburger, P., von Andrian, U., Langer, R. and Anderson, D., Neutrophil responses to sterile implant materials, Plos One, submitted.
  51. Chung, B., Toth, M., Kamaly, N., Sei, Y., Becraft, J. Mulder,  W., Fayad, Z., Farokhzad, O., Kim, YT and Langer, R., Nanomedicines for endothelial disorders, Nano Today, submitted.
  52. Jaklenec, A., Guarecuco, R., Lu, J., McHugh, K., Norman, J., Thapa, L., Lydon, E. and Langer, R., Immunogenicity of pulsatile release PLGA microspheres for single injection vaccination, Journal of Controlled Release, submitted.
  53. Han, M., Cha, Y., Jeong, H., Zoldan, J., Burkart, A., Kim, C., Kim, H., Cho, S., Kim, B., Langer, R., Kahn, R., Cha, H., Guarente, L. and Kim, K., Metabolic control of human pluripotent stem cell fate and function by deacetylase SIRT2, Science, submitted.
  54. Sager, H., Dutta, P., Dahlman, J., Courties, G., Heidt, T., Vinegoni, C., Borodovsky, A, Fitzgerald, K., Sun, Y., Wojtkiewicz, G., Iwamoto, Y., Khan, O., Xing, Y., Shaw, T., Libby, P., Langer, R., Weissleder, R., Sirski, F., Anderson, D. and Nahrendorf, M., Nanoparticle-enabled RNAi in endothelial cells reduces post-MI vascular inflammation, Science Translational Medicine, submitted.
  55. Jhunjhunwala, S., Aresta-DaSilva, S., Tang, K., Webber, M., Lavin, D., Veiseh, O., Doloff, J., Bose, S., Vegas, A., Ma, M., Sahay, G., Chiu, A., Bader, A., Langan, E., Siebert, S., Li, J., Greiner, D., Newburger, P., Langer, R. and Anderson, D., Neutrophil extracellular trap formation on implanted materials, Biomaterials, submitted.
  56. Appel, E., Tibbitt, M., Greer, J., Fenton, O., Kreuels, K., Anderson, D. and Langer, R., Exploiting electrostatic interactions in polymer nanoparticle hydrogels, ACS Macro Letters, submitted.
  57. Yu, B., Kang, S., Akthakul, A., Ramadurai, N., Pilkenton, M. Sakamoto, F., Gilchrest, B., Anderson, R. and Langer, R., An elastic second skin, Nature Materials, submitted.
  58. Yin, H., Bogorad, R., Barnes, C., Walsh, S., Zhuang, I., Nonaka, H., Ruda, V., Kuchimanchi, S., Nechev, L., Akinc, A., Xue, W., Zerial, M., Langer, R., Anderson, D. and Koteliansky, V., Control of liver size by RNAi-mediated multiplex knockdown and its application for discovery of regulatory mechanisms, Journal of Hepatology, submitted.


Langer Lab, 77 Massachusetts Ave, Room 76-661, Cambridge, MA 02139-4307 | Phone: 617.253.3123 | Last updated: September 8, 2015