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Professor Robert Langer
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Recent Publications (2014)

Lim, J., Bertrand, N., Valencia, P., Rhee, M., Langer, R., Jon, S., Farokhzad, O. and Karnik, R., Parallel Microfluidic Synthesis of Size-Tunable Polymeric Nanoparticles using 3D flow focusing towards in vivo study, Nanomedicine: Nanotechnology, Biology and Medicine, 10:  401-409, 2014. PMID: 23969105.

Yin, X., Farin, H., van Es, J., Clevers, H., Langer, R. and Karp, J., Niche-independent high-purity culture of Lgr5+ intestinal stem cells and their progeny, Nature Methods, 11:  106-112, 2014. NIHMSID: 548435.

Lang, N., Pereira, J., Lee, Y., Friehs, I., Vasilyev, N., Feins, E., Ablasser, K., O’Cearbhaill, E., Xu, C., Fabozzo, A., Padera, R., Wasserman, S., Freudenthall, F., Ferreira, L., Langer, R., Karp, J. and del Nido, P., A blood-resistant surgical glue for minimally invasive repair of vessels and heart defects, Science Translational Medicine 6:  218ra6, 2014 (cover article).

Guo, Liang, Ma, M., Zhang, N., Langer, R., and Anderson, D., Stretchable polymeric multielectrode array for conformal neural interfacing, Advanced Materials, 26:  1427-1433, 2014.

Timko, B., Arruebo, M., Shankarappa, S., McAlvin, J., Okonkwo, O., Mizrahi, B., Stefanescu, C., Gomez, L., Zhu, J., Zhu, A., Santamaria, J., Langer, R. and Kohane, D., Near-infrared actuated devices for remotely controlled drug delivery, Proceedings of the National Academy of Sciences, 111:  1349-1354, 2014.

Kim, Y., Lobatto, M., Kawahara, T., Chung, B., Mieszawska, A., Sanchez-Gaytan, B., Fay, F., Senders, M., Calcagno, C., Becraft, J., Saung, M., Gordon, R., Stroes, E., Ma, M., Farokhzad, O., Fayad, Z., Mulder, W. and Langer, R., Probing nanoparticle translocation across the permeable endothelium in experimental atherosclerosis, Proceedings of the National Academy of Sciences 111:  1078-1083, 2014.

Schoellhammer, C., Blankschtein, D., Langer, R., Skin permeabilization for transdermal drug delivery: Recent advances and future prospects, Expert Opinion Drug Delivery, 11:  393-407, 2014. PMID: 24392787.

Sharei, A., Poceviciute, R., Jackson, E., Cho, N., Mao, S., Hartoularos, G., Jang, D., Jhunjhunwala, S., Eyerman, A., Schoettle, T., Langer, R. and Jensen, K., Plasma membrane recovery kinetics of a microfluidic intracellular delivery platform, Integrative Biology, 6:  470-475, 2014.

Dong, Y., Love, K., Dorkin, J., Sirirungruang, S., Zhang, Y., Chen, D., Bogorad, R., Yin, H., Chen, Y., Vegas, A., Alabi, C., Sahay, G., Olejnik, K., Wang, W., Schroeder, A., Lytton-Jean, A., Siegwart, D., Akinc, A., Barnes, C., Barros, S., Carioto, M., Fitzgerald, K., Hettinger, J., Kumar, V., Novobrantseva, T., Qin, J., Querbes, W., Kotelianski, V., Langer, R. and Anderson, D. Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates, Proceedings of the National Academy of Sciences, eprint ahead of pub, doi:10.1073/pnas.1322937111, 2014.

Hook, A., Chang, C-Y., Scurr, D., Langer, R., Anderson, D., Williams, P., Davies, M. and Alexander, M., Thermally switchable polymers achieve controlled Escherichia coli detachment, Advanced Healthcare Materials, epub ahead of print DOI: 10.1002/adhm.201300518, 2014.

Celiz, A., Smith, J., Langer, R., Anderson, D., Winkler, D., Barrett, D., Davies, M., Young, L., Denning, C. and Alexander, M., Materials for stem cell factories of the future, Nature Materials, 13:  570-579, 2014.

Dahlman, J., Barnes, C., Khan, O., Thiriot, A., Jhunjunwala, S., Shaw, T., Xing, Y., Sage, H., Sahay, G., Speciner, L., Bader, A., Bogorad, R., Yin, H., Racie, T., Dong, Y., Jiang, S., Seedorf, D., Dave, A., Sandu, K., Webber, M., Novobrantseva, T., Ruda, V., Lytton-Jean, A., Levins, C., Kalish, B., Mudge, D., Perez, M., Abezgauz, L., Dutta, P., Smith, L., Charisse, K., Kieran, M., Fitzgerald, K., Nahrendorf, M., Danino, D., Tuder, R., von Andrian, U., Akinc, A., Schroeder, A., Panigrahy, D., Kotelianski, V., Langer, R. and Anderson, D., In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight, Nature Nanotechnology, e-pub ahead of time doi:1038/nnano.2014.84. 

Chan, K., Li, R., Chapman, J., Trac, E., Kobler, J., Zeitels, S., Langer, R. and Karajanagi, S., Functionalizable hydrogel microparticles of tunable size and stiffness for soft tissue filler applications, Acta Biomaterialia, 10: 2563-2573, 2014. NIHMSID: 589854.

Ilyinskii, P., Roy, C., O’Neil, C., Browning, E., Pittet, L., Altreuter, D., Alexis, F., Tonti, E., Shi, J., Basto, P., Iannacone, M., Radovic-Moreno, A., Langer, R., Farokhzad, O., von Andrian, U., Johnston, L and Kishimoto, T., Adjuvant-carrying synthetic vaccine particles augment the immune response to encapsulated antigen and exhibit strong local immune activation without inducing systemic cytokine release, Vaccine, 32:  2882-2895, 2014. NIHMSID: 589859.

Lee, J., Jeong, K., Hashimoto, M., Kwon, A., Rwei, A., Shankarappa, S., Tsui, J. and Kohane, D., Synthetic ligand-coated magnetic nanoparticles for microfluidic bacterial separation from blood, Nano Letters, in press.

Bettinger, C. Green, J., Langer, R., Anderson, D. and Borenstein, J., Control of nanoparticle-mediated gene delivery to human endothelial cells through substrate nanotopography, ACS Nano, in press.

Novobrantseva, T., Borodovsky, A., Wong, J., Klebanov, B., Zafari, M., Yucius, K. Ge, P., Ruda, v., Querbes, Q., Milstein, S, Speciner, L, Duncan, R., Basha, G., Cullis, P., Akinc, A., Sullivan, J., Jayaprakash, N., Jayaraman, M., Bogorad, R., Love, K., Whitehead, K., Levins, C., Manoharan, M., Swirski, P., Weissleder, R., Langer, R., Anderson, R., de Fougerolles, A., Nahrendorf, M. and Koteliansky, V., Systemic RNAi-mediated gene silencing in non-human primate and rodent myeloid cells, Molecular Therapy Nucleic Acids, in press.

Dong, Y., Eltoukhy, A., Alabi, C., Khan, O., Veiseh, O., Dorkin, J., Sirirungruang, S., Yin, H., Tang, B., Pelet, J., Chen, D., Gu, Z., Xue, Y., Langer, R. and Anderson, D., Lipid-like nanomaterials for simultaneous gene expression and silencing in vivo, Advanced Healthcare Materials, in press.

Whitehead, K., Dorkin, R., Vegas, A., Chang, P., Veiseh, O., Matthews, J., Fenton, O., Zhang, Y., Olejnik, K., Yesilyurt, V., Chen, D., Barros, S., Klebanov, B., Novobrantseva, T., Langer, R. and Anderson, D., Degradable lipid nanoparticles with predictable in vivo siRNA delivery activitiy, Nature Communications, in press.

Lim, J. Swami, A., Gilson, L., Chopra, S., Choi, S., Wu, J., Langer, R., Karnik, R. and Farokhzad, O., Ultra-high throughput synthesis of nanoparticles with homogeneous size distribution using a soaxial turbulent jet mixer, Nano Letters, in press.

Mitragotri, S., Burke, P. and Langer, R., Overcoming the challenges in administering biopharmaceutical drugs:  Formulation and delivery strategies, Nature Reviews Drug Discovery, in press.

Chen, S., Xue, Y., Wu, X., Cong, L., Bhutkar, A., Bell, E., Zhang, F., Langer, R. and Sharp, P., Global microRNA depletion suppresses tumor angiogenesis, Genes and Development, in press.

Valencia, P., Pridgen, E., Rhee, M., Langer, R., Farokhzad, O., and Karnik, R., Microfluidic platform for combinatorial synthesis and optimization of targeted nanoparticles for cancer therapy, ACS Nano, in press.

Celiz, A., Smith, J., Patel, A., Langer, R., Anderson, D., Barrett, D., Young, L., Davies, M., Denning, C and Alexander, M., Chemically diverse polymer microarrays and high throughput surface characterization:  A method for discovery of materials for stem cell culture, Biomaterials Science, in press.

Zhang, S., Ermann, J., Succi, M., Zhou, A., Glimcher, L., Traverso, G., Karp, J. and Langer, R., Inflammation-targeted hydrogel as a novel approach for drug delivery in inflammatory bowel disease, Science Translational Medicine, submitted.

Chen, S., Xue, Y., Wu, X., Cong, L., Bhutkar, A., Bell, E., Zhang, F., Langer, R. and Sharp, P., MicroRNA regulation of factor inhibiting HIF-1 and tumour angiogenesis revealed by CRISPR/Cas9-mediated cellular genetics, Cancer Cell, submitted.

Peng, W., Anderson, D.G., Langer, R. and Sawicki, J., Nanoparticle-delivered suicide gene inhibits prostate tumor growth, Cancer Research, submitted.

Radovic-Moreno, A., Yuet, K., Langer, R. and Farokhzad, O., Perspectives on using nanoparticles for treatment in urological oncology, Nanotechnology Chapter, Interventional Techniques in Uro-oncology, submitted.

Noh, S., Han, S., Shim, G., Lee, K., Kim, A., Han, S., Choi, Y., Kim, Y, Langer, R., Kim, W. and Oh, Y., Tocopheryl oligochitosan-based self assembling cationic oligomersomes for siRNA delivery, Nano Letters, submitted.

Kang, S., Hwang, N., Yeom, J., Park, S., Messersmith, P., Choi, I., Langer, R., Anderson, D. and Lee, Haeshin, One-step multipurpose surface functionalization by adhesive catecholamine, Journal of the American Chemical Society, submitted.

Mizrahi, B., Khoo, X., Chiang, H., Sher, K., Feldman, R., Irusta, S., Langer, R. and Kohane, D., Multi-armed prepolymer for antifouling coatings, Journal of the American Chemical Society, submitted.

Cima, M., Lee, H., Daniel, K., Tanenbaum, L., Mantzavinou, A., Spencer, K., Ong, Q., Sy, J., Santini, J., Schoellhammer, C., Blankschtein, D. and Langer, R., Single compartment drug delivery, Journal of Controlled Release, submitted.

Kimball, A., Alora-Palli, M., Javorsky, E., Ron, E. and Langer, R., A new non-parenteral approach to administration of peptides in women:  Systemic absorption of a GnRH agonist (GnRHa) via a transvaginal ring delivery system, Proceedings of the National Academy of Sciences, submitted.

Sanchez-Gaytan, B., Lobatto, M., Fay, F., Tang, J., Ouimet, M., Kim, Y., van der Staay, S., van Rijs, S., Priem, B., Zhang, L., Fisher, E., Moore, K., Langer, R. and Fayad, Z., Hybrid polymer-HDL nanoparticle platform for atherosclerotic plaque macrophage targeting, Journal of Controlled Release, submitted.

Jonas, O., Landry, H., Fuller, J., Santini, J., Baselga, J., Tepper, R., Cima, M. and Langer, R., A novel device to perform rapid high-throughput in vivo drug sensitivity testing and identify optimal drug therapy for personalized medicine, Science Translational Medicin, submitted.

Barth, H., Crafoord, S., O’Shea, T., Pritchard, C., Langer, R., Ghosh, F., A new model for in vitro testing of vitreous substitute candidates, Graefe’s Archive for Clinical and Experimental Ophthalmology, submitted. PMCID: PMC Exempt—Non-NIH/PHS Funding.

Traverso, G., Ciccarelli, G., Hughes, T., Boettcher, T., Barman, R., Langer, R., Siston, A., Physiologic status monitoring via the gastrointestinal tract, Nature Communications, submitted.

Maldonado, R., LaMothe, R., Ferrari, J., Zhang, A., Rossi, R., Griset, A., O’Neil, C., Altreuter, D., Johnston, L., Farokhzad, O., Langer, R., Scott, D., von Andrian, U. and Kishimoto, T., Polymeric synthetic nanoparticles for the induction of antigen-specific immunological tolerance, Proceedings of the National Academy of Sciences, submitted. 

Sharei, A., Trifonova, R., Jhunjhunwala, S., Hartoularos, G., Eyerman, A., Lytton-Jean, A., Angin, M., Sharma, S., Poceviciute, R., Mao, S., Heimann, M., Liu, S., Talkar, T., Khan, O., Addo, M., von Andrian, U., Anderson, D., Langer, R., Lieberman, J. and Jensen, K., A microfluidic platform for ex vivo cytosolic delivery to funcational biomolecules to immune cells, Journal of Clinical Investigations, submitted.


Langer Lab, 77 Massachusetts Ave, Room 76-661, Cambridge, MA 02139-4307 | Phone: 617.253.3123 | Last updated: July 14, 2014