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Professor Robert Langer
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Recent Publications (2016)

  1. Vegas, A., Veiseh, O., Doloff, J., Ma, M., Tam, H., Bratlie, K., Li, J., Bader, A., Langan, E., Olejnik, K., Fenton, P., Kang, J., Hollister-Locke, J., Bochenek, M., Chiu, A., Siebert, S., Tang, K., Jhunjhunwala, S., Aresta-Dasilva, S., Dholakia, N., Thakrar, R., Vietti, T., Chen, M., Cohen, J., Siniakowicz, K., Qi, M., McGarrigle, J., Lyle, S., Harlan, D., Greiner, D., Oberholzer, J., Weir, G. Langer, R. and Anderson, D., Combinatorial development of hydrogels that mitigate the foreign body response in primates, Nature Biotechnology, 34:  345-352, 2016.
  2. Yin, H., Song, C., Dorkin, J., Zhu, L., Li, Y., Wu, Q., Park, A., Yang, J., Suresh, S., Bizhanova, A., Gupta, A., Bolukbasi, M., Walsh, S., Bogorad, R., Gao, G., Weng, Z., Dong, Y., Koteliansky, V., Wolfe, S., Langer, R., Xue, W., and Anderson, D., Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo, Nature Biotechnology, 34:  328-333, 2016.
  3. Dong, Y., Dorkin, J., Wang, W., Chang, P., Webber, M., Tang, B., Abutbul-Ionita, I., Danino, D., DeRosa, F, Heartlein, M. and Langer, R., Poly(glycoamidoamine) brushes formulated nanomaterials for systemic mRNA delivery in vivo, Nano Letters, 16:  842-848, 2016.
  4. Xue, Y., Xu, X., Zhang, X., Farokhzad, O. and Langer, R., Preventing diet-induced obesity in mice by inducing adipose tissue transformation and angiogenesis using targeting nanoparticles with drug delivery amplification, Proceedings of the National Academy of Sciences, 113:  5552-5557, 2016.
  5. Webber, M., Appel, E., Meijer, E. and Langer, R., Supramolecular biomaterials, Nature Materials, 15:  13-26, 2016.
  6. Tibbitt, Mark, Dahlman, J. and Langer, R., Emerging frontiers in drug delivery, Journal of the American Chemical Society, 138:  704-717, 2016.
  7. Vegas, A., Veiseh, O., Gurtler, M., Millman, J., Pagliuca, F., Bader, A., Doloff, J., Li, J., Chen, M., Olejnik, K., Tam, H., Jhunjhunwala, S., Langan, E., Aresta-Dasilva, S., Gandham, S., McGarrigle, J., Bochenek, M., Hollister-Lock, J., Oberholzer, J., Greiner, D., Weir, G., Melton, D, Langer, R. and Anderson, D., Long-term glycemic control using polymer encapsulated human stem cell-derived beta cells in immune-competent mice, Nature Medicine, 22:  306-211, 2016.
  8. Tzeng, S., Guarecuco, R., McHugh, K., Rose, S., Rosenberg, E., Zeng, Y., Langer, R. and Jaklenec, A., Thermostabilization of inactivated polio vaccine in PLGA-based microspheres for pulsatile release, Journal of Controlled Release, 233:  101-113, 2016.
  9. Lee, H., Ahsen, O., Liang, K., Wang, Z., Cleveland, C., Booth, L., Potsaid, B., Jayaraman, V., Cable, A., Mashimo, H., Langer, R., Traverso, G. and Fujimoto, J., Circumferential optical coherence tomography angiography imaging of the swine esophagus using a micromoto balloon catheter, Biomedical Optics Express, 7:  2927-2942, 2016.
  10. Yin, H., Bogorad, R., Barnes, C., Walsh, S., Zhuang, I., Nonaka, H., Ruda, V., Kuchimanchi, S., Nechev, L., Akinc, A., Xue, W., Zerial, M., Langer, R., Anderson, D. and Koteliansky, V., RNAi-nanoparticulate manipulation of gene expression as a new functional genomics tool in the liver, Journal of Hepatology, 64:  899-907, 2016.
  11. Oudin, M., Jonas, O., Kosciuk, T., Broye, L., Wyckoff, J., Riquelme, D., Lamar, J., Asokan, S., Whittaker, C., Ma, D., Langer, R., Cima, M., Wisinski, K., Hynes, R., Lauffenburger, D., Keely, P., Bear, J. and Gertler, F., Tumor cell-driven extracellular matrix remodeling enables haptotaxis during metastatic progression, Cancer Discovery, 6:  516-531, 2016.
  12. Fischer, K., Morgan, K., Hearon, K., Sklaviadis, D., Tochka, Z., Fenton, O., Anderson, D., Langer, R. and Freed, L., Poly(limonene thioether) scaffold for tissue engineering, Advanced Healthcare Materials, 5:  813-821, 2016.
  13. Kimball, A., Javorsky, E., Ron, E., Crowley, W. and Langer, R., A novel approach to administration of peptides in women:  Systemic absorption of a GnRH agonist via transvaginal ring delivery system, Journal of Controlled Release, 233: 19-28, 2016.
  14. Chahal, J., Khan, O., Cooper, C., McPartlan, J., Tsosie,  J., Tilley, L., Sidik, S., Lourido, S., Langer, R., Bavari, A., Ploegh, H. and Anderson, D., Dendrimer-RNA nanoparticles generate protective immunity against lethal ebola, H1N1 influenza and toxoplasma gondii challenges with a single dose, Proceedings of the National Academy of Sciences, 113: E4133-E4142, 2016.
  15. Lee, Y., Zhang, S., Lin, J., Langer, R. and Traverso, G., A janus mucoadhesive and omniphobic device for gastrointestinal retention, Advanced Healthcare Materials, 5:  1141-1146, 2016.
  16. Sager, H., Dutta, P., Dahlman, J., Courties, G., Heidt, T., Vinegoni, C., Borodovsky, A, Fitzgerald, K., Sun, Y., Wojtkiewicz, G., Iwamoto, Y., Khan, O., Xing, Y., Shaw, T., Libby, P., Langer, R., Weissleder, R., Sirski, F., Anderson, D. and Nahrendorf, M., RNAi targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarction, Science Translational Medicine, 8: 342ra80, 2016.
  17. Yang, Y., Andersson, P., Hosaka, K., Zhang, Y., Cao, R., Iwamoto, H., Yang, X., Nakamura, M., Wang, J., Zhuang, R., Morikawa, H., Xue, Y., Braun, H., Beyaert, R., Samani, N., Nakae, S., Hams, E., Dissing, S., Fallong, P., Langer, R., and Cao, Y., The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumor-associated macrophages, Nature Communications, DOI: 10.1038/ncomms11385, 2016.
  18. Chen, X., Wu, B., Jayawardana, K., Hao, N., Jayawardena, S., Langer, R., Jaklenec, A. and Yan, M., Magnetic multivalent trehalose glycopolymer nanoparticles for the detection of mycobacteria, Advanced Healthcare Materials, E-pub ahead of time, DOI:10.102/adhm.201600071, 2016.
  19. Zhao, X., Hwang, N., Bichara, D., Saris, D., Malda, J., Vacanti, J., Pomerantseva, I., Sundback, C., Langer, R., Anderson, D. and Randolph, M., Chondrogenesis by bone marrow-derived mesenchymal stem cells grown in chondrocyte-conditioned medium for auricular reconstruction, Journal of Tissue Engineering and Regenerative Medicine, E-pub ahead of time DOI:  10.1002/term.2171, 2016.
  20. Patel, A., Tibbitt, M., Celiz, M., Davies, M., Langer, R., Denning, C., Alexander, M. and Anderson, D., High throughput screening for discovery of materials that control stem cell fate, Current Opinion in Solid State and Materials Science, E-pub ahead of time, DOI:10.1016/j.cossms.2016.02.002, 2016.
  21. Jhunjhunwala, S., Alvarez, D., Aresta-DaSilva, S., Tang, K., Tang, B, Greiner, D., Newburger, P., von Andrian, U., Langer, R. and Anderson, D., Splenic progenitors aid in maintaining  high neutrophil numbers at sites of sterile chronic inflammation, Journal of Leukocyte Biology, E-pub ahead of time, DOI: 10.1189/jlb.1HI0615-248RR, 2016.
  22. Jonas, O., Kosciuk, T., Cima, M., Flaherty, K. and Langer, R., Parrallel in vivo assessment of drug phenotypes at various time points during systemic BRAF inhibition reveals tumor adaptation and altered treatment vulnerabilities, Clinical Cancer Research, E-pub ahead of time, DOI: 10.1158/1078-0432.CCR-15-2722, 2016.
  23. Morgan, K., Sklaviadis, D., Tochka, Z., Fischer, K., Hearon, K., Morgan, T., Langer, R. and Freed, L., Multi-material tissue engineering scaffold with hierarchical pore architecture, Advanced Functional Materials, E-pub ahead of time, DOI: 10.1002/adfm.201601146, 2016.
  24. Farah, S., Anderson, D. and Langer, R., Physical and mechanical properties of PLA and their functions in widespread applications:  A comprehensive review, Advanced Drug Delivery Reviews, E-pub ahead of time, DOI: 10.1016/j.addr2016.06.012, 2016.
  25. Yu, B., Kang, S., Akthakul, A., Ramadurai, N., Pilkenton, M. Sakamoto, F., Gilchrest, B., Anderson, R. and Langer, R., An elastic second skin, Nature Materials, E-pub ahead of time, DOI: 10.1038/nmat4635, 2016.
  26. Kollmannsperger, A., Sharei, A., Raulf, A., Heilemann, M., Langer, R., Jensen, K., Wieneke, R. and Tampe, R., Live-cell protein labeling with nanometer precision by cell squeezing, Nature Communications, DOI: 10.1038/ncomms10372, 2016.
  27. Hong, A., Tseng, Y., Cowley, G., Jonas, O., Cheah, J., Kynnap, B., Doshi, M., Oh, C., Meyer, S., Church, A., Gill, S., Bielski, C., Keskula, P., Imamovic, A., Howell, S., Kryukov, G., Clemons, P., Tsherniak, A., Vazquez, F., Crompton, B., Shamji, A., Rodriguez-Galindo, C., Janeway, K., Roberts, C., Stegmaier, K., van Hummelen, P., Cima, M., Langer, R., Garraway, L., Schreiber, S., Root, D., Hahn, W. and Boehm, J., Integrated genetic and pharmacologic interrogation of rare cancers, Nature Communications, DOI: 10.1038/ncomms11987, 2016.
  28. Bettinger, C. Green, J., Langer, R., Anderson, D. and Borenstein, J., Control of nanoparticle-mediated gene delivery to human endothelial cells through substrate nanotopography, ACS Nano, in press.
  29. Lu, Y., Langer, R. and Gu, Z., Bio-responsive materials, Nature Reviews Materials, in press.
  30. Khademhosseini, A. and Langer, R., A decade of progress in tissue engineering, Nature Protocols, in press.
  31. Yin, H., Bogorad, R., Barnes, C., Zhuang, I., Nonaka, H., Ruda, V., Kuchimanchi, S., Nechev, L., Akinc, A., Zerial, M., Langer, R., Anderson, D. and Koteliansky, V., Efficient multiplex knockdown mediated control of organ size and its application for rapid analyses of molecular interactions in vivo, Proceedings of the National Academy of Sciences, submitted.
  32. Jaklenec, A., Guarecuco, R., Lu, J., McHugh, K., Norman, J., Thapa, L., Lydon, E. and Langer, R., Immunogenicity of pulsatile release PLGA microspheres for single injection vaccination, Journal of Controlled Release, submitted.
  33. Han, M., Cha, Y., Jeong, H., Zoldan, J., Burkart, A., Kim, C., Kim, H., Cho, S., Kim, B., Langer, R., Kahn, R., Cha, H., Guarente, L. and Kim, K., Metabolic control of human pluripotent stem cell fate and function by deacetylase SIRT2, Science, submitted.
  34. Jhunjhunwala, S., Aresta-DaSilva, S., Tang, K., Webber, M., Lavin, D., Veiseh, O., Doloff, J., Bose, S., Vegas, A., Ma, M., Sahay, G., Chiu, A., Bader, A., Langan, E., Siebert, S., Li, J., Greiner, D., Newburger, P., Langer, R. and Anderson, D., Neutrophil extracellular trap formation on implanted materials, Biomaterials, submitted.
  35. Chertok, B., Langer, R. and Anderson, D., Spatial control of systemic gene delivery combining heparin masked gene nanocarriers and ultrasound mediated microbubble destruction, ACS Nano, submitted.
  36. Noh, S., Han, S., Shim, G., Lee, K., Kim, A., Han, S., Choi, Y., Kim, Y, Langer, R., Kim, W. and Oh, Y., Tocopheryl oligochitosan-based self assembling cationic oligomersomes for siRNA delivery, Nano Letters, submitted.
  37. Taylor, L., Arner, K., Kolewe, M., Pritchard, C., Hendy, G., Langer, R. and Ghosh, F., Tissue stabilization in vitro using surface modification of poly(glycerol-co-sebacic acid) membranes in adult porcine retinal explants, Biomaterials, submitted.
  38. Kirtane, A., Langer, R. and Traverso, G., Past, present and future drug delivery systems for antiretrovirals, Journal of Pharmaceutical Sciences, submitted.
  39. LaKang, S., Hwang, N., Yeom, J., Park, S., Messersmith, P., Choi, I., Langer, R., Anderson, D. and Lee, Haeshin, One-step multipurpose surface functionalization by adhesive catecholamine, Journal of the American Chemical Society, submitted.
  40. Mizrahi, B., Khoo, X., Chiang, H., Sher, K., Feldman, R., Irusta, S., Langer, R. and Kohane, D., Multi-armed prepolymer for antifouling coatings, Journal of the American Chemical Society, submitted.
  41. Indolfi, L., Ligorio, M., Ting, D., Xega, K., Tzafriri, A., Bersani, F., Aceto, N., Deshpande, V., Ferrone, C., Haber, D., Langer, R., Clark, J. and Edelman, E., Overcoming pancreatic cancer chemoresistance with a locally directed biodegradable sustained drug delivery device, Gastroenterology, submitted.
  42. Dahlman, J., Kauffman, K., Xing, Y., Shaw, T., Dlott, C., Mir, F., Langer, R., Anderson, D. and Wang, E., Barcoded nanoparticles for high throughput discovery of targeted therapeutics in vivo, Nature Nanotechnology, submitted.
  43. Fenton, O., Kauffman, K., McClellan, R., Appel, E., Dorkin, J., Tibbitt, M., Heartlein, M., DeRosa, F., Langer, R. and Anderson, D., Bioinspired alkenyl amino alcohol ionizable lipid materials for highly potent in vivo mRNA delivery, Journal of the American Chemical Society, submitted.
  44. Indolfi, L., Ligorio, M., Ting, D., Xega, K., Tzafriri, A., Bersani, F., Aceto, N., Deshpande, V., Ferrone, C., Haber, D., Langer, R., Clark, J. and Edelman, E., A local drug delivery platform to enhance cytotoxic effects of chemotherapy in pancreatic cancer, Proceedings of the National Academy of Sciences, submitted.
  45. Lin, J., Dargazany, R., Zhang, S., Jafari, M., Lee, Y., Hurowitz, H., Langer, R. and Traverso, G., Corona molecular dynamics of poly(ethylene glycol)-coated nanoparticles, Nano Letters, submitted.
  46. Roper, J., Tammela, T., Cetinbas, N., Sanchez-Rivera, F., Almeqdadi, M., Park, Y., Oberli, M., Eng, G., Neupane, R., Azimi, R., Liang, X., Akkad, A., Bauer-Rowe, K., Schmidt, D., Beyaz, S., Sicinska, E., Bass, A., Suarez, Y., Yoo, J., Chen, L., Zukerberg, L, Katajisto, P., Deshpande, V., Langer, R., Bhutkar, A., Lees, J., Jacks, T. and Yilmaz, O., Epithelial genome editing and orthotopic transplantation models of sequential mutagenesis in colorectal cancer, Nature Medicine, submitted.
  47. Tam, H., Melo, M., Kang, M., Pelet, J., Ruda, V., Foley, M., Hu, J., Crampton, J., Baldeon, A., Sanders, R., Moore, J., Crotty, S., Langer, R., Anderson, D., Chakraborty, A. and Irvine, D., Sustained antigen availability during germinal center initiation enhances antibody responses to vaccination, Proceedings of the National Academy of Sciences, submitted.
  48. Oberli, M., Reichmuth, A., Dorkin, J., Mitchell, M., Fenton, O., Jaklenec, A., Anderson, D., Langer, R. and Blankschtein, D., Lipid nanoparticle-assisted mRNA delivery for potent cancer immunotherapy, ACS Nano, submitted.
  49. Kim, K., Cha, Y., Han, M., Cha, H., Zoldan, J., Burkart, A., Jung, J., Jang, Y., Kim, C., Jeong, H., Kim, B., Langer, R., Kahn, C. and Guarente, L., Metabolic control of primed human pluripotent stem cell fate and function by the miR-200c-SIRT2 axis, Nature Cell Biology, submitted.




Langer Lab, 77 Massachusetts Ave, Room 76-661, Cambridge, MA 02139-4307 | Phone: 617.253.3123 | Last updated: July 22, 2016