Massachusetts Institute of Technology Massachusetts Institute of Technology
Department of Chemical Engineering
Langer Lab
Professor Robert Langer
Lab Members
In the News
US - Japan Symposium on Drug Delivery
MIT Summer Professional Program
Useful Links
Contact Information


To view from the complete list of publications

Select a time frame:

Google Scholar Listing >>

Recent Publications (2016)

  1. Vegas, A., Veiseh, O., Doloff, J., Ma, M., Tam, H., Bratlie, K., Li, J., Bader, A., Langan, E., Olejnik, K., Fenton, P., Kang, J., Hollister-Locke, J., Bochenek, M., Chiu, A., Siebert, S., Tang, K., Jhunjhunwala, S., Aresta-Dasilva, S., Dholakia, N., Thakrar, R., Vietti, T., Chen, M., Cohen, J., Siniakowicz, K., Qi, M., McGarrigle, J., Lyle, S., Harlan, D., Greiner, D., Oberholzer, J., Weir, G. Langer, R. and Anderson, D., Combinatorial development of hydrogels that mitigate the foreign body response in primates, Nature Biotechnology, 34:  345-352, 2016.
  2. Yin, H., Song, C., Dorkin, J., Zhu, L., Li, Y., Wu, Q., Park, A., Yang, J., Suresh, S., Bizhanova, A., Gupta, A., Bolukbasi, M., Walsh, S., Bogorad, R., Gao, G., Weng, Z., Dong, Y., Koteliansky, V., Wolfe, S., Langer, R., Xue, W., and Anderson, D., Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo, Nature Biotechnology, 34:  328-333, 2016.
  3. Dong, Y., Dorkin, J., Wang, W., Chang, P., Webber, M., Tang, B., Abutbul-Ionita, I., Danino, D., DeRosa, F, Heartlein, M. and Langer, R., Poly(glycoamidoamine) brushes formulated nanomaterials for systemic mRNA delivery in vivo, Nano Letters, 16:  842-848, 2016.
  4. Webber, M., Appel, E., Meijer, E. and Langer, R., Supramolecular biomaterials, Nature Materials, 15:  13-26, 2016.
  5. Tibbitt, Mark, Dahlman, J. and Langer, R., Emerging frontiers in drug delivery, Journal of the American Chemical Society, 138:  704-717, 2016.
  6. Vegas, A., Veiseh, O., Gurtler, M., Millman, J., Pagliuca, F., Bader, A., Doloff, J., Li, J., Chen, M., Olejnik, K., Tam, H., Jhunjhunwala, S., Langan, E., Aresta-Dasilva, S., Gandham, S., McGarrigle, J., Bochenek, M., Hollister-Lock, J., Oberholzer, J., Greiner, D., Weir, G., Melton, D, Langer, R. and Anderson, D., Long-term glycemic control using polymer encapsulated human stem cell-derived beta cells in immune-competent mice, Nature Medicine, 22:  306-211, 2016.
  7. Yin, H., Bogorad, R., Barnes, C., Walsh, S., Zhuang, I., Nonaka, H., Ruda, V., Kuchimanchi, S., Nechev, L., Akinc, A., Xue, W., Zerial, M., Langer, R., Anderson, D. and Koteliansky, V., RNAi-nanoparticulate manipulation of gene expression as a new functional genomics tool in the liver, Journal of Hepatology, 64:  899-907, 2016.
  8. Oudin, M., Jonas, O., Kosciuk, T., Broye, L., Wyckoff, J., Riquelme, D., Lamar, J., Asokan, S., Whittaker, C., Ma, D., Langer, R., Cima, M., Wisinski, K., Hynes, R., Lauffenburger, D., Keely, P., Bear, J. and Gertler, F., Tumor cell-driven extracellular matrix remodeling enables haptotaxis during metastatic progression, Cancer Discovery, E-pub ahead of time, DOI:10.1158/2159-8290.CD-15-1183, 2016.
  9. Fischer, K., Morgan, K., Hearon, K., Sklaviadis, D., Tochka, Z., Fenton, O., Anderson, D., Langer, R. and Freed, L., Poly(limonene thioether) scaffold for tissue engineering, Advanced Healthcare Materials, E-pub ahead of time, DOI: 10.1002/adhm.201500892, 2016.
  10. Jhunjhunwala, S., Alvarez, D., Aresta-DaSilva, S., Tang, K., Tang, B, Greiner, D., Newburger, P., von Andrian, U., Langer, R. and Anderson, D., Splenic progenitors aid in maintaining  high neutrophil numbers at sites of sterile chronic inflammation, Journal of Leukocyte Biology, E-pub ahead of time, DOI: 10.1189/jlb.1HI0615-248RR, 2016.
  11. Bettinger, C. Green, J., Langer, R., Anderson, D. and Borenstein, J., Control of nanoparticle-mediated gene delivery to human endothelial cells through substrate nanotopography, ACS Nano, in press.
  12. Patel, A., Tibbitt, M., Celiz, M., Davies, M., Langer, R., Denning, C., Alexander, M. and Anderson, D., High throughput screening for discovery of materials that control stem cell fate, Current Opinion in Solid State and Materials Science, in press.
  13. Yu, B., Kang, S., Akthakul, A., Ramadurai, N., Pilkenton, M. Sakamoto, F., Gilchrest, B., Anderson, R. and Langer, R., An elastic second skin, Nature Materials, in press.
  14. Kollmannsperger, A., Sharei, A., Raulf, A., Heilemann, M., Langer, R., Jensen, K., Wieneke, R. and Tampe, R., Live-cell protein labeling with nanometer precision by cell squeezing, Nature Communications, in press.
  15. Yin, H., Bogorad, R., Barnes, C., Zhuang, I., Nonaka, H., Ruda, V., Kuchimanchi, S., Nechev, L., Akinc, A., Zerial, M., Langer, R., Anderson, D. and Koteliansky, V., Efficient multiplex knockdown mediated control of organ size and its application for rapid analyses of molecular interactions in vivo, Proceedings of the National Academy of Sciences, submitted.
  16. Xue, Y., Xu, X., Zhang, X., Farokhzad, O. and Langer, R., Preventing diet-induced obesity in mice by inducing adipose tissue transformation and angiogenesis using targeting nanoparticles with drug delivery amplification, Proceedings of the National Academy of Sciences, submitted.
  17. Zhao, X., Hwang, N., Bichara, D., Saris, D., Malda, J., Vacanti, J., Pomerantseva, I., Sundback, C., Langer, R., Anderson, D. and Randolph, M., Chondrogenesis by bone marrow-derived mesenchymal stem cells grown in chondrocyte-conditioned medium for auricular reconstruction, Journal of Tissue Engineering and Regenerative Medicine, submitted.
  18. Jaklenec, A., Guarecuco, R., Lu, J., McHugh, K., Norman, J., Thapa, L., Lydon, E. and Langer, R., Immunogenicity of pulsatile release PLGA microspheres for single injection vaccination, Journal of Controlled Release, submitted.
  19. Han, M., Cha, Y., Jeong, H., Zoldan, J., Burkart, A., Kim, C., Kim, H., Cho, S., Kim, B., Langer, R., Kahn, R., Cha, H., Guarente, L. and Kim, K., Metabolic control of human pluripotent stem cell fate and function by deacetylase SIRT2, Science, submitted.
  20. Sager, H., Dutta, P., Dahlman, J., Courties, G., Heidt, T., Vinegoni, C., Borodovsky, A, Fitzgerald, K., Sun, Y., Wojtkiewicz, G., Iwamoto, Y., Khan, O., Xing, Y., Shaw, T., Libby, P., Langer, R., Weissleder, R., Sirski, F., Anderson, D. and Nahrendorf, M., Nanoparticle-enabled RNAi in endothelial cells reduces post-MI vascular inflammation, Science Translational Medicine, submitted.
  21. Jhunjhunwala, S., Aresta-DaSilva, S., Tang, K., Webber, M., Lavin, D., Veiseh, O., Doloff, J., Bose, S., Vegas, A., Ma, M., Sahay, G., Chiu, A., Bader, A., Langan, E., Siebert, S., Li, J., Greiner, D., Newburger, P., Langer, R. and Anderson, D., Neutrophil extracellular trap formation on implanted materials, Biomaterials, submitted.
  22. Chertok, B., Langer, R. and Anderson, D., Spatial control of systemic gene delivery combining heparin masked gene nanocarriers and ultrasound mediated microbubble destruction, ACS Nano, submitted.
  23. Noh, S., Han, S., Shim, G., Lee, K., Kim, A., Han, S., Choi, Y., Kim, Y, Langer, R., Kim, W. and Oh, Y., Tocopheryl oligochitosan-based self assembling cationic oligomersomes for siRNA delivery, Nano Letters, submitted.
  24. Taylor, L., Arner, K., Kolewe, M., Pritchard, C., Hendy, G., Langer, R. and Ghosh, F., Tissue stabilization in vitro using surface modification of poly(glycerol-co-sebacic acid) membranes in adult porcine retinal explants, Biomaterials, submitted.
  25. LaKang, S., Hwang, N., Yeom, J., Park, S., Messersmith, P., Choi, I., Langer, R., Anderson, D. and Lee, Haeshin, One-step multipurpose surface functionalization by adhesive catecholamine, Journal of the American Chemical Society, submitted.
  26. Mizrahi, B., Khoo, X., Chiang, H., Sher, K., Feldman, R., Irusta, S., Langer, R. and Kohane, D., Multi-armed prepolymer for antifouling coatings, Journal of the American Chemical Society, submitted.
  27. Kimball, A., Alora-Palli, M., Javorsky, E., Ron, E. and Langer, R., A new non-parenteral approach to administration of peptides in women:  Systemic absorption of a GnRH agonist (GnRHa) via a transvaginal ring delivery system, PLoS Medicine submitted.
  28. Indolfi, L., Ligorio, M., Ting, D., Xega, K., Tzafriri, A., Bersani, F., Aceto, N., Deshpande, V., Ferrone, C., Haber, D., Langer, R., Clark, J. and Edelman, E., Overcoming pancreatic cancer chemoresistance with a locally directed biodegradable sustained drug delivery device, Gastroenterology, submitted.
  29. Dahlman, J., Kauffman, K., Xing, Y., Shaw, T., Dlott, C., Mir, F., Langer, R., Anderson, D. and Wang, E., Barcoded nanoparticles for high throughput discovery of targeted therapeutics in vivo, Nature Nanotechnology, submitted.
  30. Fenton, O., Kauffman, K., McClellan, R., Appel, E., Dorkin, J., Tibbitt, M., Heartlein, M., DeRosa, F., Langer, R. and Anderson, D., Bioinspired alkenyl amino alcohol ionizable lipid materials for highly potent in vivo mRNA delivery, Journal of the American Chemical Society, submitted.
  31. Indolfi, L., Ligorio, M., Ting, D., Xega, K., Tzafriri, A., Bersani, F., Aceto, N., Deshpande, V., Ferrone, C., Haber, D., Langer, R., Clark, J. and Edelman, E., A local drug delivery platform to enhance cytotoxic effects of chemotherapy in pancreatic cancer, Proceedings of the National Academy of Sciences, submitted.
  32. Lin, J., Dargazany, R., Zhang, S., Jafari, M., Lee, Y., Hurowitz, H., Langer, R. and Traverso, G., Corona molecular dynamics of poly(ethylene glycol)-coated nanoparticles, Nano Letters, submitted.
  33. Lee, Y., Zhang, S., Lin, J., Langer, R. and Traverso, G., A janus mucoadhesive and omniphobic device for gastrointestinal retention, Advanced Materials, submitted.
  34. Bertrand, N., Lima, E., Appel, E., Dormont, F., Lim, J., Karnik, R., Langer, R. and Farokhzad, O., The synthetic and biological identities influence their early clearance from the bloodstream, Nature Nanotechnology, submitted.
  35. Jonas, O., Kosciuk, T., Cima, M., Flaherty, K. and Langer, R., Parrallel in vivo assessment of drug phenotypes at various time points during systemic BRAF inhibition reveals tumor adaptation and altered treatment vulnerabilities, Clinical Cancer Research, submitted.



Langer Lab, 77 Massachusetts Ave, Room 76-661, Cambridge, MA 02139-4307 | Phone: 617.253.3123 | Last updated: April 11, 2016