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Publications
Publications

Original Articles in Referred Journals
[click here for Reviews, Chapters & Editorials]

Selections by year:
1991| 1992 | 1993 | 1994 | 1996 | 1997 | 1998 | 1999 | 2000
2001 | 2002 | 2003 | 2004 | 2005 | 2006 | 2007 | 2008 | 2009
2009
Guan J-S, Haggarty SJ, Giacometti E, Dannenberg J-H, Joseph N, Gao J, Nieland TJF, Zhou Y, Wang X, Mazitschek R, Bradner JE, DePinho RA, Jaenisch, R, Tsai, L-H. HDAC2 negatively regulates memory formation and synaptic plasticity. Nature, 2009, 459: 55-60.
Cardin JA, Carlen M, Meletis K, Knoblich U, Zhang F, Deisseroth K, Tsai, L-H, Moore CI. Driving fast-spiking cells induces gamma rhythm and controls sensory responses. Nature, 2009, 459: 663-667.
Mao Y, Ge X, Frank CL, Madison JM, Koehler AN, Doud MK, Tassa C, Berry EM, Soda T, Singh KK, Biechele T, Petryshen TL, Moon RT, Haggarty SJ, Tsai L-H. Disrupted in Schizophrenia 1 regulates neural progenitor proliferation via modulation of GS3β/β-catenin signaling. Cell, 2009, 136: 1017-31.
Davis DA, Wilson MH, Giraud J, Xie Z, Tseng HC, England C, Herscovitz H, Tsai LH, Delalle I. Capzb2 interacts with beta-tubulin to regulate growth cone morphology and neurite outgrowth. PLoS Biol. 2009 Oct;7(10):e1000208. Epub 2009 Oct 6.
2008
Kim D, Frank C, Dobbin M, Tsunemoto R, Wu D, Peng P, Guan J, Lee B-H, Moy L, Gusti P, Broodie N, Mazitschek R, Delalle I, Haggarty S, Neve R, Lu Y, and Tsai L-H. Deregulation of HDAC1 by p25/Cdk5 in neurodegeneration. Neuron, 2008, 60: 803-817.
Shim SY, Samuels BA, Wang J, Neumayer G, Belzil C, Ayala R, Shi Y, Tsai L-H, Nguyen MD. Ndel1 controls the dyein-mediated transport of vimentin during neurite outgrowth. J Biol Chem. 2008. 283(18): 12232-40.
Calderon de Anda F, Gartner A, Tsai L-H, Dotti C. Pyramidal neuron polarity axis is defined at the bipolar stage. J Cell Sci, 2008:121, 178-185.
2007
Samuels BA, Hsueh Y-P, Shu T, Liang H, Tseng H-C, Hong C-J, Su SC, Neve R, Yue DT, Tsai L-H. Cdk5 promotes synaptogenesis by regulating the subcellular distribution of the MAGUK family member CASK. Neuron 2007, 56: 823-837.
Xie Z, Moy L, Sanada K, Zhou Y, Buchman J, Tsai L-H. Cep120 and TACCs Control Interkinetic Nuclear Migration and the Neral Progenitor Pool. Neuron 2007, 56: 79-93.
Buchman JJ, Tsai L-H. Spindle regulation in neural precursors of flies and mammals. Nat Rev Neurosci; 2007: 89-100.
Ayala R, Shu T, Tsai L-H. Trekking across the brain: the journey of neuronal migration. Cell 2007; 128: 29-43.
Sananbenesi F, Fischer A, Schrick C, Neve R, Radulovic J, Tsai L-H. A hippocampal Cdk5 pathway regulates extinction of contextual fear. Nat Neurosci 2007, 10: 1012-1019.
Kim D, Nguyen MD, Fischer A, Sananbenesi F, Dobbin MM, Rodgers JT, Delalle I, Baur JA, Sui G, Armour SM, Puigsrver P, Sinclair DA, Tsai L-H. SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer’s disease and amyotrophic lateral sclerosis. EMBO J 2007, 26: 3169-3179.
Yip YP, Capriotti C, Drill E, Tsai L-H, Yip J. Cdk5 Selectively Affects the Migration of Different Populations of Neurons in the Developing Spinal Cord. Journal of Comparative Neurology 2007, 503:297-307.
Fischer A, Sananbenesi F, Wang X, Dobbin M, Tsai, L-H. Recovery of learning and memory is associated with chromatin remodelling. Nature 2007, 447: 178-182.
2006
Cruz JC, Kim D, Moy LY, Dobbin MM, Sun X, Bronson RT, Tsai, L-H. p25/cyclin-dependent kinase 5 induces production and intraneuronal accumulation of amyloid beta in vivo. J Neurosci 2006, 26: 10536-41.
Shu T, Tseng HC, Zhou Y, Fischer A, Stern P, Coquelle F, Reiner O, Tsai L-H. Doublecortin-like KinaseControls Neurogenesis by Regulating the Mitotic Spindle. Neuron 2006, 5;49(1):25-39.
2005
Fischer A, Sananbenesi F, Pang PT, Lu B, Tsai L-H. Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus-dependent memory. Neuron, 2005 , 48: 825-838.
Park SK, Nguyen MD, Fischer A, Luke MP, Affar EB, Dieffenbach PB, Tseng HC, Shi Y, Tsai L-H. Par4 links dopamine signaling and depression. Cell 2005, 122: 275-287.
Tseng HC, Ovaa H, Wei N, Ploegh H, Tsai L-H. Phosphoproteomic analysis using a novel solid-phase apture-release-tag approach. Chemistry and Biology 2005, 12: 769-777.
Sanada K, Tsai L-H. G Protein betagamma Subunits and AGS3 Control Spindle Orientation and Asymmetric Cell Fate of Cerebral Cortical Progenitors. Cell. 2005 Jul 15;122(1):119-31.
Mapelli M, Massimiliano L, Crovace C, Seeliger MA, Tsai L-H, Meijer L, Musacchio A. Mechanism of Cdk5/p25 binding by Cdk inhibitors. J Med Chem 2005, 48(3): 671-9.
2004
Tarricone C, Perrina F, Monzani S, Massimiliano L, Kim MH, Derewend ZS, Knapp S, Tsai L-H, Musacchio A. Coupling PAF signaling to dynein regulation; structure of Lis1 in complex with PAF-acetylhydrolase. Neuron 2004, 809-821.
Moy LY, Tsai L-H. Cyclin-dependent kinase 5 phosphorylates serine 31 of tyrosine hydroxylase and regulates its stability. J Biol Chem. 2004 Dec 24;279(52):54487-93.
Shu T, Ayala R, Nguyen MD, Xie Z, Gleeson JG, Tsai L-H. Ndel1 Operates in a Common Pathway with LIS1 and Cytoplasmic Dynein to Regulate Cortical Neuronal Positioning. Neuron 2004, 44(2):263-77.
Nguyen MD, Shu T, Sanada K, Lariviere RC, Tseng HC, Park SK, Julien JP, Tsai L-H. A NUDEL-dependent mechanism of Neurofilament assembly regulates the integrity of CNS neurons. Nat Cell Biol, 2004, 6: 597-608.
Sanada K, Gupta A, Tsai L-H. Disabled-1-regulated adhesion of migrating neurons to radial glial fiber contributes to neuronal positioning during early corticogenesis. Neuron 2004, 22: 197-211.
Beffert U, Weeber Ej, Morfini G, Ko J, Brady ST, Tsai L-H, Sweatt JD, Herz J. Reelin and cyclin-dependent kinase 5-dependent signals cooperate in regulating neuronal migration and synaptic transmission. J Neurosci 2004;24:1897-1906.
Morabito MA, Sheng M, Tsai L-H. Cyclin-dependent kinase 5 phosphorylates the N-terminal domain of the postsynaptic density protein PSD95 in neurons. J Neurosci, J Neurosci 2004;24:865-876.
Tanaka T, Serneo FF, Tseng H-C, Kulkarni AB, Tsai L-H, Gleeson JG. Cdk5 phosphorylation of doublecortin Ser297 regulates its effect on neuronal migration. Neuron 2004;41:215-227.
Hammond V, Tsai L-H, Tan SS. Control of cortical neuron migration and layering: cell and non cell-autonomous effects of p35. J Neurosci 2004;24:576-87.
Kao SC, Krichevsky AM, Kosic K, Tsai L-H . BACE1 suppression by RNA interference in primary cortical neurons. J Biol Chem, 2004, 279:1942-9.
2003
Gupta A, Sanada K, Miyamoto DT, Rovelstad S, Pearlman AL, Brunstrom J, Tsai L-H. Layering defect in p35 deficiency is linked to radial migration with improper neuronal-glial interaction. Nat Neurosci 2003;6:1284-1291.
Cruz JC, Tseng H-C, Goldman JA, Shih H, Tsai L-H. Aberrant Cdk5 Activation by p25 Triggers Pathological Events Leading to Neurodegeneration and Neurofibrillary Tangles. Neuron 2003;40:471-483.
Lee M-S, Kao S-c, Lemere CA, Xia W, Tseng H-C, Zhou Y, Neve R, Ahlijanian MK, Tsai L-H. APP Processing is Regulated by Cytoplasmic Phosphorylation. J Cell Bio 2003;163:83-95.
Xie Z, Sanada K, Samuels B, Shi H, Tsai L-H. Serine 732 Phosphorylation of FAK by Cdk5 is Important for Microtubule Organization, Nuclear Movement and Neuronal Migration. Cell 2003;114:469-482.
Toyo-oka K, Shionoya A, Gambello MJ, Cardoso C, Leventer R, Ward HL, Ayala R, Tsai L-H, Dobyns W, Ledbetter D, Hirotsune S, Wynshaw-Boris A. 14-3-3 epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome. Nat Genet. 2003; 34: 274-85.
Patzke H, Maddineni U, Ayala R, Morabito M, Volker J, Dikkes P, Ahlijanian MK, Tsai L-H. Partial rescue of the p35-/- brain phenotype by low expression of a NSE p25-transgene. J Neurosci 2003;23(7):2769.
2002
Dhavan R, Greer PL, Morabito MA, Orlando LR, and Tsai L-H. The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner. J Neurosci 2002;22(18):7879-7891.
Tseng HC, Zhou Y, Shen Y, Tsai L-H. A survey of Cdk5 activator p35 and p25 levels in Alzheimer's disease brains. FEBS Lett 2002; 523: 58-62.
Patzke H, Tsai L-H. Calpain-mediated cleavage of the Cyclin-dependent kinase-5 activator p39 to p29. J BIol Chem 2002 277: 8054-8060.
Ross S, Tienhaara A, Lee MS, Tsai L-H, Gill G. GC-box binding transcription factors control the neuronal specific transcription of the cyclin-dependent kinase 5 regulator p35. J Biol Chem 2002, 2002 277: 4455-4464.
2001
Tarricone C, Dhavan R, Peng J, Areces LB, Tsai L-H*, Musacchio A*. Structure and regulation of the CDK5-p25nck5a complex. Mol Cell 2001,8: 657-69.
*Contributed equally.
Ko J, Humbert S, Bronson RT, Takahashi S, Kulkarni AB, Li E, Tsai LH. p35 and p39 are essential for Cdk5 function during neurodevelopment. J. Neurosci 2001;21:6758-71.
2000
Niethammer M, Smith DS, Ayala R, Peng J, Ko J, Lee MS, Morabito M, Tsai L-H. Nudel is a novel Cdk5 substrate that assoicates with Lis1 and cytoplasmic dynein. Neuron 2000;28: 697-711.
Smith DS, Niethammer M, Ayala R, Zhou Y, Gambello MJ, Wynshaw-Boris A, Tsai L-H. Regulation of cytoplasmic dynein behavior and microtubule organization by mammalian Lis1. Nat Cell Biol 2000;2:767-75.
Humbert S, Lanier LM, Tsai L-H. Synaptic localization of p39, a neuronal activator of cdk5. Neuroreport 2000;11: 2213-16.
Zukerberg LR, Patrick GN, Nikolic M, Humbert S, Lanier LM, Gertler FB, Vidal M, Van Etten RA, Tsai L-H. Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase up-regulation, and neurite outgrowth. Neuron 2000;26: 633-46.
Lee MS, Kwon YT, Li M, Peng J, Friedlander RM, Tsai L-H. Neurotoxicity induces cleavage of p35 to p25 by calpain. Nature 2000;405: 360-64.
Kwon YT, Gupta A, Zhou Y, Nikolic M, Tsai L-H. Regulation of the N-cadherin-mediated adhesion by the p35/Cdk5 kinase. Curr Biol 2000;10:363-72.
1999
Humbert S, Dhavan R, Tsai L-H. p39 activates cdk5 in neurons, and is associated with the actin cytoskeleton. J Cell Sci 1999;113: 975-83.
Patrick GN, Zukerberg L, Nikolic M, de la Monte S, Dikkes P, Tsai L-H. Conversion of p35 to p25 deregulates cdk5 activity and promotes neurodegeneration. Nature 1999;402:615-22.
Kwon YT, Tsai L-H, Crandall JE. Callosal axon guidance defects in p35-/- mice. J Comp Neurol 1999;415: 218-29.
Huang D, Patrick G, Moffat J, Tsai L-H, Andrews B. Mammalian Cdk5 is a functional homologue of the budding yeast Pho85 cyclin-dependent protein kinase. Pro Natl Acad Sci USA 1999;96:14445-450.
1998
Nikolic M, Chou MM, Lu W, Mayer BJ, Tsai L-H. The p35/cdk5 kinase is a neuronal specific Rac effector that inhibits Pak1 activity. Nature 1998;395:194-98.
Patrick GN, Zhou P, Kwon YT, Howley PM, Tsai L-H. p35, the neuronal specific activator of cdk5, is degraded by the ubiquitin-proteasome pathway. J Biol Chem 1998;273:24057-63.
Kwon YT, Tsai L-H. A novel disruption of cortical development in p35-/- mice distinct from reeler. J Comp. Neurol 1998;395:510-22.
1997
Chae T, Kwon YT, Bronson R, Dikkes P, Li E, Tsai L-H. Mice Lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures and adult lethality. Neuron 1997;18,29-42
Delalle I, Bhide PG, Caviness VS Jr, Tsai L-H. Temporal and spatial patterns of expression of p35, a regulator subunit of cyclin-dependent kinase 5, in the nervous system of the mouse. J Neurocytol 1997;26:283-396.
Philpott A, Porro EB, Kirschner MK, Tsai L-H. The role of cyclin-dependent kinase 5 and a novel regulatory subunit in regulating muscle differentiation and patterning. Genes and Devel 1997;11:1409-21.
1996
Nikolic M, Dudek H, Kwon YT, Ramos YFM, Tsai L-H. The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation. Genes and Devel 1996;8:816-25.
1994
Tsai L-H, White L, Raines E, Ross R, Smith RG, Cushley W, Ozanne B. Expression of platelet derived growth factor and its receptors by two pre-B acute lymphocytic leukemia cell lines. Blood 1994:83: 51-5.
Tsai L-H, Delalle I, Caviness V, Chae T, Harlow E. p35, a neural specific regulatory subunit of the cdk5 kinase. Nature 1994;371: 419-23.
Caviness VS Jr, Takahashi T, Miyama S, Tsai L-H. Cytogenesis in the developing mouse neocortex. In: Brain lesions in the newborn. Alfred Benzon Symposium 1994; 37: 25-42.
1993
Tsai L-H, Lees E, Faha B, Harlow E, Riabowol K. The cdk2 kinase is required for the G1-to-S phase transition in mammalian cells. Oncogene 1993;8:1593-1602.
Tsai L-H, Takahashi T, Caviness V, Harlow E. Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system. Development 1993;119: 1029-40.
1992
Faha B, Ewen M, Tsai L-H, Livingston D, Harlow E. Interaction between human cyclin A and adenovirus E1A-associated p107 protein. Science 1992;255:87-90.
Meyerson M, Enders G, Wu CL, Su LK, Gorka C, Nelson C, Harlow E, Tsai L-H. A family of human cdc2-related protein kinases. EMBO J 1992;11:2909-17.
Stillman and J. Watson (eds), Cold Spring Harbor Laboratory Press. Faha B, Myerson M, Tsai L-H. Adenovirus E1A targets one of two cyclin A-kinase complexes. Pezcoller Foundation Symposium 1992; 3:107-30.
1991
Tsai L-H, Harlow E, Meyerson M. Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase. Nature 1991;353:174-77.
Reviews, Chapters & Editorials
[click here for Original articles in Referred Journals]
Selections by year:

1998 | 2000 | 2001 | 2002 | 2003 | 2004 | 2005 | 2006 | 2007 | 2008 | 2009
2009
Kim D, Tsai LH. Linking cell cycle reentry and DNA damage in neurodegeneration. Ann N Y Acad Sci. 2009 Jul;1170:674-9.
Kim D, Tsai L-H. Bridging physiology and pathology in AD. Cell 2009;137:97-1000.
Frank CL, Tsai L-H. Alternative functions of core cell cycle regulators in neuronal migration, neuronal maturation, and synaptic plasticity. Neuron 2009;62:312-26.
2008
Buchman JJ, Tsai L-H. Putting a notch in our understanding of nuclear migration. Cell 2008;134:912-4.

Samuels BA, Tsai L-H. Neuronal motility and structure: Cdk5 pathways. In Larry R. Squire, Editor-in-Chief, Encyclopedia of Neuroscience, Academic Press, Oxford, 2008;

Fischer A, Tsai L-H. Cyclin dependent kinase 5 (Cdk5): linking synaptic plasticity and neurodegeneration. In Cyclin dependent kinase 5 (Cdk5). Eds. Nancy Ip, & Li-Huei Tsai, Springer Science and Business Media LLC, New York, 2008; 261-282.
2007
Buchman JJ, Tsai L-H. Spindle regulation in neural precursors of flies and mammals. Nat Rev Neurosci 2007; 8:89-100.
Ayala R, Shu T, Tsai L-H. Trekking across the brain: the journey of neuronal migration. Cell 2007; 128: 29-43.
2006
Xie Z, Samuels BA, Tsai L-H. Cyclin-dependent kinase 5 permits efficient cytoskeletal remodeling - a hypothesis on neuronal migration. 2006 Jul;16 Suppl 1:i64-8.
2005
Tsai L-H, Gleeson JG. Nucleokinesis in neuronal migration. Neuron 2005;46:383-88.
2004
Samuels BA, Tsai L-H. Nucleokinesis illuminated. Nat Neurosci 2004;7:1169-70.
Cruz JC, Tsai L-H. Cdk5 deregulation in the pathogenesis of Alzheimer's disease. Trends Mol Med. 2004;10:452-8.
Cruz JC, Tsai L-H. A Jekyll and Hyde kinase: roles for Cdk5 in brain development and disease. Curr Opin Neurobiol. 2004;14:390-4.
Tsai L-H, Lee MS, Cruz JC. Cdk5, a therapeutic target for Alzheimer's disease? Biochim Biophys Acta. 2004;1697:137-42.
Xie Z, Tsai L-H. Cdk5 phosphorylation of FAK regulates centrosome-associated microtubules and neuronal migration. Cell Cycle. 2004;3:108-10.
2003
Gupta A, Tsai L-H. Cyclin-dependent kinase 5 and neuronal migration in the neocortex. Neurosignals. 2003 Sep-Oct;12(4-5):173-9.
Samuels BA, Tsai L-H. Cdk5 is a dynamo at the synapse. Nat Cell Biol. 2003; 5:689-90.
Lee M-S, Tsai L-H. Cdk5: One of the links between senile plaques and neurofibrillary tangles? J Alzh Dis. 2003; 5:127-37.
2002
Gupta A, Tsai L-H, Wynshaw-Boris A. Life is a journey: a genetic look at neocortical development. Nat. Rev Gene, 2002; 3:342-55.
Patzke H, Tsai L-H. Cdk5 sinks into ALS. Trends Neurosci. 2002; 25: 8-10.
Gupta A, Tsai L-H, Wynshaw-Boris A. Life is a journey: a genetic look at neocortical development. Nat. Rev Gene, 2002; 3:342-55.
2001
Dhavan R, Tsai L-H. A decade of Cdk5. Nat Rev Mol Cell Biol. 2001; 2:749-59.
Smith DS, Greer PL, Tsai L-H. Cdk5 on the brain. Cell Growth Differ 2001; 12:277-83.
Gupta A, Tsai L-H. A kinase to dampen the effects of cocaine? Science 2001 Apr 13;292(5515):236-7.
Lee M-S, Tsai L-H. Cdk5 at the junction. News and Views, Nat Neurosci. 2001 Apr;4(4):340-2.
2000
Nikolic M, Tsai L-H. Activity and regulation of p35/Cdk5 kinase complex. In: Methods in Enzymology, Academic Press 2000; 325:200-13.
Kwon YT, Tsai L-H. The role of the p35/Cdk5 kinase in cortical development. In: Mouse Brain Development, Springer-Verlag 2000; 30:241-51.
1998
Tsai L-H. Stuck on the ECM. Trends Cell Biol. 1998 Jul;8(7):292-5.
MIT
The Tsai Lab
 
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