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| 2011 |
| Giusti-Rodriguei P, Gao J, Gräff J, Rei D, Soda T, Tsai L-H. Synaptic deficits are rescued in the p25/Cdk5 model of neurodegeneration by the reduction of ?-secretase (BACE1). J Neurosci (In Press) (PMC Journal- In Process). |
| Singh KK, DiRienzo G, Drane L, Mao Y, Flood Z, Madison J, Ferreira M, Bergen S, King C, Sklar P, Sive H, Tsai L-H. Common DISC1 polymorphisms disrupt Wnt/GSK3? signaling and brain development. Neuron (In Press) (PMC Journal- In Process). |
| Guan JS, Su SC, Gao J, Joseph N, Xie Z, Zhou Y, Durak O, Zhang L, Zhu JJ, Clauser KR, Carr S, Tsai L-H. Cdk5 is required for memory function and hippocampal plasticity via the cAMP signaling pathway. PLos One 6(9): e25735. doi:10.1371/journal.pone.0025735 (PMC Journal- In Process). |
| Buchman JJ, Durak O, Tsai LH. ASPM regulates Wnt signaling pathway activity in the developing brain. Genes Dev. 2011 Sep 15;25(18):1909-14.(PMC Journal- In Process). |
| Carlien M, Meletis K, Siegle JH, Cardin JA, Futai K, Vierling-Claassen D, Ruhlmann C, Jones SR, Deisseroth K, Sheng M, Moore CI, Tsai L-H. A critical role for NMDA receptors in parvalbumin interneurons for gamma rhythm induction and behavior. Molecular Psychiatry 2011 Apr 5. (PMC Journal- In Process). |
| 2010 |
| Schwer B, Schumcher B, Lombard DB, Xiao C, Kurtev MV, Gao J, Schneider JJ, Chai H, Bronson RT, Tsai LH, Deng CX, Alt FW. Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity. Proc Natl Acad Sci USA. 2010 Dec 14;107(50):21790-4.PMCID: PMC3003110 |
| Pimplikar SW, Nixon RA, Robakis NK, Shen J, Tsai LH. Amyloid-independent mechanisms in Alzheimer's disease pathogenesis. J Neurosci. 2010 Nov 10;30(45):14946-54. |
| Frank CL, Ge X, Xie Z, Zhou Y, Tsai LH. Control of ATF4 persistence by multisite phosphorylation impacts cell cycle progression and neurogenesis. J Biol Chem. 2010 Oct 22;285(43):33324-37. PMCID: PMC2963346 |
| de Anda FC, Meletis K, Ge X, Rei D, Tsai LH. Centrosome motility is essential for initial axon fomration in the neocortex. J Neurosci. 2010 Aug 4;30(31):10391-406. |
| Singh KK, Ge X, Mao Y, Drane L, Meletis K, Samuels BA, Tsai LH. Dixdc1 is a critical regulator of DISC1 and embryonic cortical development. Neuron. 2010 Jul 15;67(1):33-48. PMCID: PMC2938013 |
| Gao J, Wang WY, Mao YW, Gräff J, Guan JS, Pan L, Mak G, Kim D, Su SC, Tsai LH. A novel pathway regulates memory and plasticity via SIRT1 and miR-134. Nature. 2010 Aug 26;466(7310):1105-9.PMCID: PMC2928875 |
| Furuya T, Kim M, Lipinski M, Li J, Kim D, Lu T, Shen Y, Rameh L, Yankner B, Tsai L-H. Negative regulation of Vps34 by Cdk mediated phosphorylation. Mol Cell. 2010 May 28;38(4):500-11.PMCID: PMC2888511 |
| Buchman JJ, Tseng HC, Zhou Y, Frank CL, Xie Z, and Tsai L-H. Cdk5rap2 Interacts with Pericentrin to maintain the neural progenitor pool in the developing neocortex. Neuron. 2010 May 13;66(3):386-402. |
| Cardin JA, Carlén M, Meletis K, Knoblich U, Zhang F, Deisseroth K, Tsai L-H, Moore CI. Targeted optogenetic stimulation and recording of neurons in vivo using cell-type-specific expression of Channelrhodopsin-2.. Nat Protoc 2010 Feb;5(2):247-54. |
| Xe G, Frank CL, Calderon F, Tsai L-H. Hook3 interacts with PCM1 to regulate pericentriolar material assembly and the timing of neurogenesis. Neuron, 2010 Jan 28;65(2):191-203. PMCID: PMC2902371 |
| 2009 |
| Guan J-S, Haggarty SJ, Giacometti E, Dannenberg J-H, Joseph N, Gao J, Nieland TJF, Zhou Y, Wang X, Mazitschek R, Bradner JE, DePinho RA, Jaenisch, R, Tsai, L-H. HDAC2 negatively regulates memory formation and synaptic plasticity. Nature, 2009, 459: 55-60. |
| Cardin JA, Carlen M, Meletis K, Knoblich U, Zhang F, Deisseroth K, Tsai, L-H, Moore CI. Driving fast-spiking cells induces gamma rhythm and controls sensory responses. Nature, 2009, 459: 663-667. |
| Mao Y, Ge X, Frank CL, Madison JM, Koehler AN, Doud MK, Tassa C, Berry EM, Soda T, Singh KK, Biechele T, Petryshen TL, Moon RT, Haggarty SJ, Tsai L-H. Disrupted in Schizophrenia 1 regulates neural progenitor proliferation via modulation of GS3β/β-catenin signaling. Cell, 2009, 136: 1017-31.PMCID: PMC2704382 |
| Davis DA, Wilson MH, Giraud J, Xie Z, Tseng HC, England C, Herscovitz H, Tsai LH, Delalle I. Capzb2 interacts with beta-tubulin to regulate growth cone morphology and neurite outgrowth. PLoS Biol. 2009 Oct;7(10):e1000208. PMCID: PMC2748697 |
| 2008 |
| Kim D, Frank C, Dobbin M, Tsunemoto R, Wu D, Peng P, Guan J, Lee B-H, Moy L, Gusti P, Broodie N, Mazitschek R, Delalle I, Haggarty S, Neve R, Lu Y, and Tsai L-H. Deregulation of HDAC1 by p25/Cdk5 in neurodegeneration. Neuron, 2008, 60: 803-817. |
| Shim SY, Samuels BA, Wang J, Neumayer G, Belzil C, Ayala R, Shi Y, Tsai L-H, Nguyen MD. Ndel1 controls the dyein-mediated transport of vimentin during neurite outgrowth. J Biol Chem. 2008. 283(18): 12232-40. |
| Calderon de Anda F, Gartner A, Tsai L-H, Dotti C. Pyramidal neuron polarity axis is defined at the bipolar stage. J Cell Sci, 2008:121, 178-185. |
| 2007 |
| Samuels BA, Hsueh Y-P, Shu T, Liang H, Tseng H-C, Hong C-J, Su SC, Neve R, Yue DT, Tsai L-H. Cdk5 promotes synaptogenesis by regulating the subcellular distribution of the MAGUK family member CASK. Neuron 2007, 56: 823-837. |
| Xie Z, Moy L, Sanada K, Zhou Y, Buchman J, Tsai L-H. Cep120 and TACCs Control Interkinetic Nuclear Migration and the Neral Progenitor Pool. Neuron 2007, 56: 79-93. |
| Buchman JJ, Tsai L-H. Spindle regulation in neural precursors of flies and mammals. Nat Rev Neurosci; 2007: 89-100. |
| Ayala R, Shu T, Tsai L-H. Trekking across the brain: the journey of neuronal migration. Cell 2007; 128: 29-43. |
| Sananbenesi F, Fischer A, Schrick C, Neve R, Radulovic J, Tsai L-H. A hippocampal Cdk5 pathway regulates extinction of contextual fear. Nat Neurosci 2007, 10: 1012-1019. |
| Kim D, Nguyen MD, Fischer A, Sananbenesi F, Dobbin MM, Rodgers JT, Delalle I, Baur JA, Sui G, Armour SM, Puigsrver P, Sinclair DA, Tsai L-H. SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer’s disease and amyotrophic lateral sclerosis. EMBO J 2007, 26: 3169-3179. |
| Yip YP, Capriotti C, Drill E, Tsai L-H, Yip J. Cdk5 Selectively Affects the Migration of Different Populations of Neurons in the Developing Spinal Cord. Journal of Comparative Neurology 2007, 503:297-307. |
| Fischer A, Sananbenesi F, Wang X, Dobbin M, Tsai, L-H. Recovery of learning and memory is associated with chromatin remodelling. Nature 2007, 447: 178-182. |
| 2006 |
| Cruz JC, Kim D, Moy LY, Dobbin MM, Sun X, Bronson RT, Tsai, L-H. p25/cyclin-dependent kinase 5 induces production and intraneuronal accumulation of amyloid beta in vivo. J Neurosci 2006, 26: 10536-41. |
| Shu T, Tseng HC, Zhou Y, Fischer A, Stern P, Coquelle F, Reiner O, Tsai L-H. Doublecortin-like KinaseControls Neurogenesis by Regulating the Mitotic Spindle. Neuron 2006, 5;49(1):25-39. |
| 2005 |
| Fischer A, Sananbenesi F, Pang PT, Lu B, Tsai L-H. Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus-dependent memory. Neuron, 2005 , 48: 825-838. |
| Park SK, Nguyen MD, Fischer A, Luke MP, Affar EB, Dieffenbach PB, Tseng HC, Shi Y, Tsai L-H. Par4 links dopamine signaling and depression. Cell 2005, 122: 275-287. |
| Tseng HC, Ovaa H, Wei N, Ploegh H, Tsai L-H. Phosphoproteomic analysis using a novel solid-phase apture-release-tag approach. Chemistry and Biology 2005, 12: 769-777. |
| Sanada K, Tsai L-H. G Protein betagamma Subunits and AGS3 Control Spindle Orientation and Asymmetric Cell Fate of Cerebral Cortical Progenitors. Cell. 2005 Jul 15;122(1):119-31. |
| Mapelli M, Massimiliano L, Crovace C, Seeliger MA, Tsai L-H, Meijer L, Musacchio A. Mechanism of Cdk5/p25 binding by Cdk inhibitors. J Med Chem 2005, 48(3): 671-9. |
| 2004 |
| Tarricone C, Perrina F, Monzani S, Massimiliano L, Kim MH, Derewend ZS, Knapp S, Tsai L-H, Musacchio A. Coupling PAF signaling to dynein regulation; structure of Lis1 in complex with PAF-acetylhydrolase. Neuron 2004, 809-821. |
| Moy LY, Tsai L-H. Cyclin-dependent kinase 5 phosphorylates serine 31 of tyrosine hydroxylase and regulates its stability. J Biol Chem. 2004 Dec 24;279(52):54487-93. |
| Shu T, Ayala R, Nguyen MD, Xie Z, Gleeson JG, Tsai L-H. Ndel1 Operates in a Common Pathway with LIS1 and Cytoplasmic Dynein to Regulate Cortical Neuronal Positioning. Neuron 2004, 44(2):263-77. |
| Nguyen MD, Shu T, Sanada K, Lariviere RC, Tseng HC, Park SK, Julien JP, Tsai L-H. A NUDEL-dependent mechanism of Neurofilament assembly regulates the integrity of CNS neurons. Nat Cell Biol, 2004, 6: 597-608. |
| Sanada K, Gupta A, Tsai L-H. Disabled-1-regulated adhesion of migrating neurons to radial glial fiber contributes to neuronal positioning during early corticogenesis. Neuron 2004, 22: 197-211. |
| Beffert U, Weeber Ej, Morfini G, Ko J, Brady ST, Tsai L-H, Sweatt JD, Herz J. Reelin and cyclin-dependent kinase 5-dependent signals cooperate in regulating neuronal migration and synaptic transmission. J Neurosci 2004;24:1897-1906. |
| Morabito MA, Sheng M, Tsai L-H. Cyclin-dependent kinase 5 phosphorylates the N-terminal domain of the postsynaptic density protein PSD95 in neurons. J Neurosci 2004;24:865-876. |
| Tanaka T, Serneo FF, Tseng H-C, Kulkarni AB, Tsai L-H, Gleeson JG. Cdk5 phosphorylation of doublecortin Ser297 regulates its effect on neuronal migration. Neuron 2004;41:215-227. |
| Hammond V, Tsai L-H, Tan SS. Control of cortical neuron migration and layering: cell and non cell-autonomous effects of p35. J Neurosci 2004;24:576-87. |
| Kao SC, Krichevsky AM, Kosic K, Tsai L-H . BACE1 suppression by RNA interference in primary cortical neurons. J Biol Chem, 2004, 279:1942-9. |
| 2003 |
| Gupta A, Sanada K, Miyamoto DT, Rovelstad S, Pearlman AL, Brunstrom J, Tsai L-H. Layering defect in p35 deficiency is linked to radial migration with improper neuronal-glial interaction. Nat Neurosci 2003;6:1284-1291. |
| Cruz JC, Tseng H-C, Goldman JA, Shih H, Tsai L-H. Aberrant Cdk5 Activation by p25 Triggers Pathological Events Leading to Neurodegeneration and Neurofibrillary Tangles. Neuron 2003;40:471-483. |
| Lee M-S, Kao S-c, Lemere CA, Xia W, Tseng H-C, Zhou Y, Neve R, Ahlijanian MK, Tsai L-H. APP Processing is Regulated by Cytoplasmic Phosphorylation. J Cell Bio 2003;163:83-95. |
| Xie Z, Sanada K, Samuels B, Shi H, Tsai L-H. Serine 732 Phosphorylation of FAK by Cdk5 is Important for Microtubule Organization, Nuclear Movement and Neuronal Migration. Cell 2003;114:469-482. |
| Toyo-oka K, Shionoya A, Gambello MJ, Cardoso C, Leventer R, Ward HL, Ayala R, Tsai L-H, Dobyns W, Ledbetter D, Hirotsune S, Wynshaw-Boris A. 14-3-3 epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome. Nat Genet. 2003; 34: 274-85. |
| Patzke H, Maddineni U, Ayala R, Morabito M, Volker J, Dikkes P, Ahlijanian MK, Tsai L-H. Partial rescue of the p35-/- brain phenotype by low expression of a NSE p25-transgene. J Neurosci 2003;23(7):2769. |
| 2002 |
| Dhavan R, Greer PL, Morabito MA, Orlando LR, and Tsai L-H. The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner. J Neurosci 2002;22(18):7879-7891. |
| Tseng HC, Zhou Y, Shen Y, Tsai L-H. A survey of Cdk5 activator p35 and p25 levels in Alzheimer's disease brains. FEBS Lett 2002; 523: 58-62. |
| Patzke H, Tsai L-H. Calpain-mediated cleavage of the Cyclin-dependent kinase-5 activator p39 to p29. J BIol Chem 2002 277: 8054-8060. |
| Ross S, Tienhaara A, Lee MS, Tsai L-H, Gill G. GC-box binding transcription factors control the neuronal specific transcription of the cyclin-dependent kinase 5 regulator p35. J Biol Chem 2002, 2002 277: 4455-4464. |
| 2001 |
Tarricone C, Dhavan R, Peng J, Areces LB, Tsai L-H*, Musacchio A*. Structure and regulation of the CDK5-p25nck5a complex. Mol Cell 2001,8: 657-69.
*Contributed equally. |
| Ko J, Humbert S, Bronson RT, Takahashi S, Kulkarni AB, Li E, Tsai LH. p35 and p39 are essential for Cdk5 function during neurodevelopment. J. Neurosci 2001;21:6758-71. |
| 2000 |
| Niethammer M, Smith DS, Ayala R, Peng J, Ko J, Lee MS, Morabito M, Tsai L-H. Nudel is a novel Cdk5 substrate that assoicates with Lis1 and cytoplasmic dynein. Neuron 2000;28: 697-711. |
| Smith DS, Niethammer M, Ayala R, Zhou Y, Gambello MJ, Wynshaw-Boris A, Tsai L-H. Regulation of cytoplasmic dynein behavior and microtubule organization by mammalian Lis1. Nat Cell Biol 2000;2:767-75. |
| Humbert S, Lanier LM, Tsai L-H. Synaptic localization of p39, a neuronal activator of cdk5. Neuroreport 2000;11: 2213-16. |
| Zukerberg LR, Patrick GN, Nikolic M, Humbert S, Lanier LM, Gertler FB, Vidal M, Van Etten RA, Tsai L-H. Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase up-regulation, and neurite outgrowth. Neuron 2000;26: 633-46. |
| Lee MS, Kwon YT, Li M, Peng J, Friedlander RM, Tsai L-H. Neurotoxicity induces cleavage of p35 to p25 by calpain. Nature 2000;405: 360-64. |
| Kwon YT, Gupta A, Zhou Y, Nikolic M, Tsai L-H. Regulation of the N-cadherin-mediated adhesion by the p35/Cdk5 kinase. Curr Biol 2000;10:363-72. |
| 1999 |
| Humbert S, Dhavan R, Tsai L-H. p39 activates cdk5 in neurons, and is associated with the actin cytoskeleton. J Cell Sci 1999;113: 975-83. |
| Patrick GN, Zukerberg L, Nikolic M, de la Monte S, Dikkes P, Tsai L-H. Conversion of p35 to p25 deregulates cdk5 activity and promotes neurodegeneration. Nature 1999;402:615-22. |
| Kwon YT, Tsai L-H, Crandall JE. Callosal axon guidance defects in p35-/- mice. J Comp Neurol 1999;415: 218-29. |
| Huang D, Patrick G, Moffat J, Tsai L-H, Andrews B. Mammalian Cdk5 is a functional homologue of the budding yeast Pho85 cyclin-dependent protein kinase. Pro Natl Acad Sci USA 1999;96:14445-450. |
| 1998 |
| Nikolic M, Chou MM, Lu W, Mayer BJ, Tsai L-H. The p35/cdk5 kinase is a neuronal specific Rac effector that inhibits Pak1 activity. Nature 1998;395:194-98. |
| Patrick GN, Zhou P, Kwon YT, Howley PM, Tsai L-H. p35, the neuronal specific activator of cdk5, is degraded by the ubiquitin-proteasome pathway. J Biol Chem 1998;273:24057-63. |
| Kwon YT, Tsai L-H. A novel disruption of cortical development in p35-/- mice distinct from reeler. J Comp. Neurol 1998;395:510-22. |
| 1997 |
| Chae T, Kwon YT, Bronson R, Dikkes P, Li E, Tsai L-H. Mice Lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures and adult lethality. Neuron 1997;18,29-42 |
| Delalle I, Bhide PG, Caviness VS Jr, Tsai L-H. Temporal and spatial patterns of expression of p35, a regulator subunit of cyclin-dependent kinase 5, in the nervous system of the mouse. J Neurocytol 1997;26:283-396. |
| Philpott A, Porro EB, Kirschner MK, Tsai L-H. The role of cyclin-dependent kinase 5 and a novel regulatory subunit in regulating muscle differentiation and patterning. Genes and Devel 1997;11:1409-21. |
| 1996 |
| Nikolic M, Dudek H, Kwon YT, Ramos YFM, Tsai L-H. The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation. Genes and Devel 1996;8:816-25. |
| 1994 |
| Tsai L-H, White L, Raines E, Ross R, Smith RG, Cushley W, Ozanne B. Expression of platelet derived growth factor and its receptors by two pre-B acute lymphocytic leukemia cell lines. Blood 1994:83: 51-5. |
| Tsai L-H, Delalle I, Caviness V, Chae T, Harlow E. p35, a neural specific regulatory subunit of the cdk5 kinase. Nature 1994;371: 419-23. |
| Caviness VS Jr, Takahashi T, Miyama S, Tsai L-H. Cytogenesis in the developing mouse neocortex. In: Brain lesions in the newborn. Alfred Benzon Symposium 1994; 37: 25-42. |
| 1993 |
| Tsai L-H, Lees E, Faha B, Harlow E, Riabowol K. The cdk2 kinase is required for the G1-to-S phase transition in mammalian cells. Oncogene 1993;8:1593-1602. |
| Tsai L-H, Takahashi T, Caviness V, Harlow E. Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system. Development 1993;119: 1029-40. |
| 1992 |
| Faha B, Ewen M, Tsai L-H, Livingston D, Harlow E. Interaction between human cyclin A and adenovirus E1A-associated p107 protein. Science 1992;255:87-90. |
| Meyerson M, Enders G, Wu CL, Su LK, Gorka C, Nelson C, Harlow E, Tsai L-H. A family of human cdc2-related protein kinases. EMBO J 1992;11:2909-17. |
| Stillman and J. Watson (eds), Cold Spring Harbor Laboratory Press. Faha B, Myerson M, Tsai L-H. Adenovirus E1A targets one of two cyclin A-kinase complexes. Pezcoller Foundation Symposium 1992; 3:107-30. |
| 1991 |
| Tsai L-H, Harlow E, Meyerson M. Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase. Nature 1991;353:174-77. |
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Reviews, Chapters & Editorials
[click here for Original articles in Referred Journals] |
| Selections by year: |
1998 | 2000 | 2001 | 2002 | 2003 | 2004 | 2005 | 2006 | 2007 | 2008 | 2009 | 2010 | 2011 |
| 2011 |
| Mungenast AE, Tsai L-H (2011) Addressing the complex etiology of Alzheimer's disease: the role of p25/Cdk5. Future Neurology 6:481-496. (In Press) |
| Su SC, Tsai LH. Cyclin-Dependent Kinases in Brain Development and Disease. Annu Rev Cell Dev Biol. (In Press) (PMC Journal- In Process). |
| Haggarty SJ, Tsai LH. Probing the role of HDACs and mechanisms of chromatin-mediated neuroplasticity. Neurobiol Learn Mem. 2011 Jul;96(1):41-52. (PMC Journal- In Process). |
| Gräff J, Kim D, Dobbin MM, Tsai L-H. Epigenetic regulation of gene expression in physiological and pathological brain processes. Physiological Review 2011 Apr;91(2):603-49. (PMC Journal- In Process). |
| Gräeff J, Tsai LH. Cognitive Enhancement: A molecular memory booster. Nature. 2011 Jan 27; 469:474-475. (PMC Journal- In Process). |
| 2010 |
| Marín O, Valiente M, Ge X, Tsai L-H. Guiding neuronal migrations. Cold Spring Harb Perspect Biol. 2010 Feb; 2(2):a001834. |
| Singh K, Tsai L-H. MicroTUB(B3)ules and Brain Development. Cell. 2010; 140:30-32. |
| 2009 |
| Kim D, Tsai LH. Linking cell cycle reentry and DNA damage in neurodegeneration. Ann N Y Acad Sci. 2009 Jul;1170:674-9. |
| Kim D, Tsai L-H. Bridging physiology and pathology in AD. Cell 2009;137:97-1000. |
| Frank CL, Tsai L-H. Alternative functions of core cell cycle regulators in neuronal migration, neuronal maturation, and synaptic plasticity. Neuron. 2009 May 14;62(3):312-26. Review. |
| 2008 |
| Buchman JJ, Tsai L-H. Putting a notch in our understanding of nuclear migration. Cell 2008;134:912-4. |
Samuels BA, Tsai L-H. Neuronal motility and structure: Cdk5 pathways. In Larry R. Squire, Editor-in-Chief, Encyclopedia of Neuroscience, Academic Press, Oxford, 2008 |
| Fischer A, Tsai L-H. Cyclin dependent kinase 5 (Cdk5): linking synaptic plasticity and neurodegeneration. In Cyclin dependent kinase 5 (Cdk5). Eds. Nancy Ip, & Li-Huei Tsai, Springer Science and Business Media LLC, New York, 2008; 261-282. |
| 2007 |
| Buchman JJ, Tsai L-H. Spindle regulation in neural precursors of flies and mammals. Nat Rev Neurosci 2007; 8:89-100. |
| Ayala R, Shu T, Tsai L-H. Trekking across the brain: the journey of neuronal migration. Cell 2007; 128: 29-43. |
| 2006 |
| Xie Z, Samuels BA, Tsai L-H. Cyclin-dependent kinase 5 permits efficient cytoskeletal remodeling - a hypothesis on neuronal migration. 2006 Jul;16 Suppl 1:i64-8. |
| 2005 |
| Tsai L-H, Gleeson JG. Nucleokinesis in neuronal migration. Neuron 2005;46:383-88. |
| 2004 |
| Samuels BA, Tsai L-H. Nucleokinesis illuminated. Nat Neurosci 2004;7:1169-70. |
| Cruz JC, Tsai L-H. Cdk5 deregulation in the pathogenesis of Alzheimer's disease. Trends Mol Med. 2004;10:452-8. |
| Cruz JC, Tsai L-H. A Jekyll and Hyde kinase: roles for Cdk5 in brain development and disease. Curr Opin Neurobiol. 2004;14:390-4. |
| Tsai L-H, Lee MS, Cruz JC. Cdk5, a therapeutic target for Alzheimer's disease? Biochim Biophys Acta. 2004;1697:137-42. |
| Xie Z, Tsai L-H. Cdk5 phosphorylation of FAK regulates centrosome-associated microtubules and neuronal migration. Cell Cycle. 2004;3:108-10. |
| 2003 |
| Gupta A, Tsai L-H. Cyclin-dependent kinase 5 and neuronal migration in the neocortex. Neurosignals. 2003 Sep-Oct;12(4-5):173-9. |
| Samuels BA, Tsai L-H. Cdk5 is a dynamo at the synapse. Nat Cell Biol. 2003; 5:689-90. |
| Lee M-S, Tsai L-H. Cdk5: One of the links between senile plaques and neurofibrillary tangles? J Alzh Dis. 2003; 5:127-37. |
| 2002 |
| Gupta A, Tsai L-H, Wynshaw-Boris A. Life is a journey: a genetic look at neocortical development. Nat. Rev Gene, 2002; 3:342-55. |
| Patzke H, Tsai L-H. Cdk5 sinks into ALS. Trends Neurosci. 2002; 25: 8-10. |
| Gupta A, Tsai L-H, Wynshaw-Boris A. Life is a journey: a genetic look at neocortical development. Nat. Rev Gene, 2002; 3:342-55. |
| 2001 |
| Dhavan R, Tsai L-H. A decade of Cdk5. Nat Rev Mol Cell Biol. 2001; 2:749-59. |
| Smith DS, Greer PL, Tsai L-H. Cdk5 on the brain. Cell Growth Differ 2001; 12:277-83. |
| Gupta A, Tsai L-H. A kinase to dampen the effects of cocaine? Science 2001 Apr 13;292(5515):236-7. |
| Lee M-S, Tsai L-H. Cdk5 at the junction. News and Views, Nat Neurosci. 2001 Apr;4(4):340-2. |
| 2000 |
| Nikolic M, Tsai L-H. Activity and regulation of p35/Cdk5 kinase complex. In: Methods in Enzymology, Academic Press 2000; 325:200-13. |
| Kwon YT, Tsai L-H. The role of the p35/Cdk5 kinase in cortical development. In: Mouse Brain Development, Springer-Verlag 2000; 30:241-51. |
| 1998 |
| Tsai L-H. Stuck on the ECM. Trends Cell Biol. 1998 Jul;8(7):292-5. |
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The Tsai Lab |
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77 Massachusetts Ave., Room 46-4235 |
Cambridge, MA 02139 |
p: 617-324-1658 ~ f: 617-324-1657 |
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